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Counterflow in Evacuations  [PDF]
Tobias Kretz
Computer Science , 2011, DOI: 10.1007/978-3-642-39669-4_13
Abstract: It is shown in this work that the average individual egress time and other performance indicators for egress of people from a building can be improved under certain circumstances if counterflow occurs. The circumstances include widely varying walking speeds and two differently far located exits with different capacity. The result is achieved both with a paper and pencil calculation as well as with a micro simulation of an example scenario. As the difficulty of exit signage with counterflow remains one cannot conclude from the result that an emergency evacuation procedure with counterflow would really be the better variant.
Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health  [PDF]
Garth L. Nicolson
International Journal of Clinical Medicine (IJCM) , 2016, DOI: 10.4236/ijcm.2016.72015
Abstract: Functional oral supplements containing cell membrane glycerolphospholipids and antioxidants have been used to safely replace damaged membrane lipids that accumulate during aging and in various clinical conditions. This approach differs from other dietary and intravenous interventions in the composition of phospholipids and the presence of fructooligosaccharides that protect the phospholipids against oxidation and bile and enzymatic damage. Various chronic clinical conditions are characterized by membrane phospholipid oxidative damage, resulting in loss of cellular function. Recent clinical trials have shown the benefits of Membrane Lipid Replacement in replenishing damaged membrane lipids and restoring mitochondrial function, resulting in reductions in fatigue in aged subjects and patients with a variety of clinical diagnoses. Recent in vitro experiments with nonphysiological concentrations of phospholipids did not result in enhancement of mitochondrial electron transport enzyme activities. This can be explained by the use of the wrong phospholipid fatty acids, over-dilution of membrane constituents and mitochondrial swelling. A similar phenomenon was seen when human sperm were incubated in vitro with high concentrations of glycerolphospholipids and their motility was assessed. Only lower, more physiological concentrations of glycerolphospholipids stimulated sperm motility. Additional studies are needed to determine the functional effects of Membrane Lipid Replacement on other cellular membranes, such as the plasma membrane and other intracellular membranes of various cells and tissues.
Development and Applications of High Performance Membrane Chromatography
高效膜色谱的发展和应用

Wang Jinfang,Meng Zihui,Zhou Liangmo,Wang Qinghai,Zhu Daoqian,
王进防
,孟子晖,周良模,王清海,朱道乾

色谱 , 1998,
Abstract: Development and applications of high performance membrane chromatography (HPMC) are introduced. Base membranes, membrane geometries and separations of biomolecules using high performance affinity membrane chromatography (HPAMC), high performance ion exchange membrane chromatography (HPIEMC) and high performance hydrophobic interaction membrane chromatography (HPHIMC) are reviewed . Enantiomeric separation using HPMC are prospected. Seventy six references are cited.
Establishment of the model of white blood cell membrane chromatography and screening of antagonizing TLR4 receptor component from Atractylodes macrocephala Koidz
Cuiqin Li,Langchong He
Science China Life Sciences , 2006, DOI: 10.1007/s11427-006-0182-7
Abstract: A model of white blood cell membrane chromatography (WB-CMC) was established to screen active component from Atractylodes macrocephala Koidz. The component can antagonize Toll-like receptor 4 (TLR4) and inhibit inflammatory reaction. In the model of WB-CMC, cell membrane stationary phase (CMSP) was prepared by immobilizing the rabbit white blood cell membrane (WBCM) onto the surface of silica carrier and taxinol was used as a model molecule. The active component which can act on WBCM and its receptor (such as TLR4) as an effective target in A. macrocephala was determined by using a replacement experiment. The anti-inflammatory effects of the active component were tested by using pharmacological methods in vivo. The results indicated that the retention characteristics of atractylenolide I as active component was similar to that of taxinol in the model of WB-CMC. And so, atractylenolide I acted on the WBCM and TLR4 and its anti-inflammatory activity was related with antagonizing TLR4. Therefore, the interaction between the active component and WBCM and its receptor can be simulated by the model of WB-CMC in vitro. This model can be used to screen active components and to study effective characteristics for acting on definite targets.
Establishment of the model of white blood cell membrane chromatography and screening of antagonizing TLR4 receptor component from Atractylodes macrocephala Koidz

Cuiqin Li,Langchong He,

中国科学C辑(英文版) , 2006,
Abstract: A model of white blood cell membrane chromatography (WB-CMC) was established to screen active component from Atractylodes macrocephala Koidz. The component can antagonize Toll-like receptor 4 (TLR4) and inhibit inflammatory reaction. In the model of WB-CMC, cell membrane stationary phase (CMSP) was prepared by immobilizing the rabbit white blood cell membrane (WBCM) onto the surface of silica carrier and taxinol was used as a model molecule. The active component which can act on WBCM and its receptor (such as TLR4) as an effective target in A. macrocephala was determined by using a replacement experiment. The anti-inflammatory effects of the active component were tested by using pharmacological methods in vivo. The results indicated that the retention characteristics of atractylenolide I as active component was similar to that of taxinol in the model of WB-CMC. And so, atractylenolide I acted on the WBCM and TLR4 and its anti-inflammatory activity was related with antagonizing TLR4. Therefore, the interaction between the active component and WBCM and its receptor can be simulated by the model of WB-CMC in vitro. This model can be used to screen active components and to study effective characteristics for acting on definite targets.
Establishment of the model of vascular endothelial cell membrane chromatography and its preliminary application
YiPing Li,LangChong He
Chinese Science Bulletin , 2007, DOI: 10.1007/s11434-007-0149-5
Abstract: A model of vascular endothelial cell membrane chromatography was established by using an ECV304 cell membrane stationary phase (ECV304 CMSP) prepared by immobilizing the ECV304 cell membrane onto the surface of silica carrier. The surface and chromatographic characteristics of ECV304 CMSP were studied. The active component from Caulophyllum robustum was screened by using the model of vascular endothelial cell membrane chromatography. The interaction between the active component and membrane receptor was determined by using a replace experiments. The effect of the active component was tested by using tube formation of ECV304 cell. The results indicated that the model of ECV304 cell membrane chromatograph (ECV304 CMC) can stimulate the interaction between drug and receptor in vitro and the retention characteristics of taspine as active component was similar to that of model molecule in the model of ECV304 CMC. And therefore, taspine acted on VEGFR2 and inhibited the tube formation of ECV304 cell induced by VEGF. This model can be used to screen definite active component as a screening model.
Establishment of the model of vascular endothelial cell membrane chromatography and its preliminary application
Li Yiping,
LI
,YiPing,HE,LangChong

科学通报(英文版) , 2007,
Abstract: A model of vascular endothelial cell membrane chromatography was established by using an ECV304 cell membrane stationary phase (ECV304 CMSP) prepared by immobilizing the ECV304 cell membrane onto the surface of silica carrier. The surface and chromatographic characteristics of ECV304 CMSP were studied. The active component from Caulophyllum robustum was screened by using the model of vascular endothelial cell membrane chromatography. The interaction between the active component and membrane receptor was determined by using a replace experiments. The effect of the active component was tested by using tube formation of ECV304 cell. The results indicated that the model of ECV304 cell membrane chromatograph (ECV304 CMC) can stimulate the interaction between drug and receptor in vitro and the retention characteristics of taspine as active component was similar to that of model molecule in the model of ECV304 CMC. And therefore, taspine acted on VEGFR2 and inhibited the tube formation of ECV304 cell induced by VEGF. This model can be used to screen definite active component as a screening model.
Mitral Valve Replacement and Subaortic Membrane Resection Following Pneumonectomy
Melih Hulusi Us,Murat Ugurlucan,Murat Basaran,Ozer Selimoglu,Ali Kocailik
Case Reports in Medicine , 2010, DOI: 10.1155/2010/480703
Abstract: The pulmonary status is a vital factor for patients undergoing open heart surgery. The cardiac surgery itself deteriorates the actual pulmonary functions. Today, patients are no longer living with a cardiac disease due to compromised respiratory functions secondary to various pathologies, patients with lung disorders more often seek solutions for their cardiac disease and they are commonly operated. However, the resection of a lobe or a whole lung is a major challenge for the patients planned for cardiac surgery. In this report, we present a 65-year-old patient, who had left pnemonectomy which had been performed 8 years ago and was admitted for mitral valve replacement and subaortic membrane resection.
Development of the model of pancreatic β-cell membrane chromatography and its chromatographic characteristics
Guangde Yang,Langchong He,Xiaoli Bian,Liang Zhao
Chinese Science Bulletin , 2005, DOI: 10.1007/BF03183631
Abstract: A new model of pancreatic β-cell membrane chromatography has been established by using a β-cell membrane stationary phase (β-CMSP) prepared by immobilizing the β-cell membrane onto the surface of silica carrier. The protein level and K+, Na+-ATP enzymatic activity of the β-CMSP were detected respectively. The surface characteristics of the β-CMSP were tested by using the scanning electron microscope and surface energy spectrometer. In this model, the column (10 mm × 2 mm, I.D.) packed with β-CMSP, 25 mmol/L ammonium sulfate buffer solution (pH 7.4) as mobile phase with the flow rate of 0.2 mL/min at 37 ± 0.5°C were used in the following studies. The retention characteristics of the sulfonylureas (gliquidone, glibenclamide, gliclazide and glipizide) were investigated under the Chromatographic conditions above. The affinities of the sulfonylureas on β-cell membrane and receptor will be expressed by using the logk′ values (the logarithm of capacity factor of a solute) in the model. The correlation of the affinity with the pharmacological effect of the sulfonylureas was analyzed also.
Generalised cascades
Queirós, Sílvio M. Duarte;
Brazilian Journal of Physics , 2009, DOI: 10.1590/S0103-97332009000400019
Abstract: in this manuscript we give thought to the aftermath on the stable probability density function when standard multiplicative cascades are generalised cascades based on the q-product of borges that emerged in the context of non-extensive statistical mechanics.
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