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Extensive necrosis of visceral melanoma metastases after immunotherapy
David Stoeter, Nicola de Liguori Carino, Ernest Marshall, Graeme J Poston, Andrew Wu
World Journal of Surgical Oncology , 2008, DOI: 10.1186/1477-7819-6-30
Abstract: We present the case of a 54-year-old Caucasian male with completely resected metastatic cutaneous melanoma after immunotherapy. The patient initially progressed during adjuvant high-dose interferon, with metastases to the liver, spleen, and pelvic lymph nodes. During an 18-month treatment period with PF-3512676 (formerly known as CPG 7909), a synthetic cytosine-phosphorothioate-guanine rich oligodeoxynucleotide, slow radiologic disease progression was demonstrated at the original disease sites. Subsequent excision of splenic and pelvic nodal metastases was performed, followed by resection of the liver metastases. Histologic examination of both hepatic and splenic melanoma metastases showed extensive necrosis. Subsequent disease-free status was demonstrated by serial positron emission tomography (PET).Existing evidence from phase I/II trials suggests systemic treatment with PF-3512676 is capable of provoking a strong tumor-specific immune response and may account for the prolonged tumor control in this instance.Metastasis is by far the most common cause of death in patients with malignant melanoma, with estimated rates of cutaneous malignant melanoma metastasis of approximately 14% [1]. Furthermore, only about 7% of metastatic melanoma cases are suitable for metastasectomy. In general, less than 6% of patients with metastatic disease survive up to 5 years, but in those undergoing complete resection, survival approaches 25% at 5 years [2,3]. In patients unsuitable for surgical intervention, systemic therapy with dacarbazine remains the standard of care with few long-term survivors and a median survival of only 6 months [4]. A number of novel agents are currently undergoing evaluation with the hope of improving outcomes beyond traditional therapy [5,6]. The case report we present describes unique radiological and histopathological responses to one particular new agent: PF-3512676.A 54-year-old Caucasian male presented with a 1.5 mm Breslow malignant melanoma on his lef
Prediction of cannon barrel life  [PDF]
R.A. Mahdavinejad
Journal of Achievements in Materials and Manufacturing Engineering , 2008,
Abstract: Purpose: Calculation of the fatigue life based on attaining a critical defect size for fast fracture is very important. Cannon is one of the most used parts in military industries and analysis of this component is under consideration. Therefore, the prediction of its longevity to say, the number of cannon ball that can be fired till it is broken down should be under consideration.Design/methodology/approach: Obviously the number of the cracks and their sizes dictate the life of the cannon’s barrel. Since the life of this component directly depends on the inner micro-cracks after numerous firing, the study of these cracks is very important. From this point of view, the stress analysis on crack tip is carried out via ANSYS software in this research. This research was to demonstrate the large changes in total fatigue life caused by the initial crack number and the residual stress at the cannon bore, the fatigue with several cracks is analyzed in the barrel according to the critical explosion pressure.The research is carried out with one, two, three, four and twenty five cracks.Findings: The methods of testing and analysis are believed to be generally applicable to problems in fatigue life evaluation This analysis shows that the stress intensity on the tip of the crack is a function of its length and increases with the number of these cracks. Since the cannon barrel life is a convert function of the stress intensity of the cracks, multi-cracks condition passes the most fatigue cycling. The shape function of the cracks is also decreased with the number of the cracks. Originality/value: Characterization of the cracking at a cannon bore is a difficult problem.This analysis shows that the critical cycle life of the cannon barrel occurs at two numbers of the cracks.
Chondroid chordoma of petrous temporal bone with extensive recurrence and pulmonary metastases  [cached]
Agrawal Amit
Journal of Cancer Research and Therapeutics , 2008,
Abstract: Chondroid chordoma is a variant of chordoma; it may rarely involve the petrous temporal bone and has a high propensity for recurrence. Chordoma rarely metastasizes but it is, nevertheless, associated with a poor outcome. We report a rare case of chondroid chordoma with extensive recurrence and pulmonary metastases.
Fatigue study on the cracks of a cannon  [PDF]
R.A. Mahdavinejad
Journal of Achievements in Materials and Manufacturing Engineering , 2008,
Abstract: Purpose: Cannon is one of the most usage parts in military industries and analysis of its pipe is very important. Therefore, the prediction of its longevity to say, the number of cannon ball that can be fired till it is break down should be under consideration.Design/methodology/approach: Since the life of cannon,s barrel directly depends on the inner micro-cracks under numerous firing, the study of these cracks are very important. From this point of view, the stress analysis on crack tip is carried out via ANSYS software in this research.Findings: This analysis shows that the stress intensity on the tip of the crack is a function of its length and increases with the number of these cracks.Research limitations/implications: In this research the fatigue with several cracks is analyzed in the barrel according to the explosion pressure in order to find the critical conditions.Originality/value: Since the cannon barrel life is a convert function of the stress intensity of the cracks, multi-cracks condition passes the most fatigue cycling. The shape function of the cracks is also decreased with the number of the cracks.
Normal serum alkaline phosphatase in the presence of extensive skeletal metastases of prostate cancer
A Abdul-Mohsen, E O Kehinde, E Loutfi, Y Ali, O O Roberts
African Journal of Urology , 2007,
Abstract: Alkaline phosphatase (ALP) is a nonspecific tumor marker as it is neither organ nor tumor specific. An elevation of the enzyme in relation to carcinoma of the prostate is usually due to bone or liver involvement, or both, by metastatic disease. We report the case of a 91-year-old man who presented with chronic urinary retention. Investigations revealed prostate specific antigen (PSA) of 831.4 ng/ml, biochemical evidence of moderate renal impairment, normal liver function tests and normal alkaline phosphatase. Whole body skelektal scintigraphy with 99mTc-MDF showed widespread skeletal metastases. Transrectal ultrasound of the prostate revealed a 40 gm prostate gland with a hypoechoic defect in the periphery of the gland. Prostate biopsy revealed prostate cancer (Gleason score 8). Total serum testosterone, zinc and magnesium were below the normal range. Bone densitometry revealed osteoporosis. Channel transurethral resection of the prostate was performed together with bilateral orchidectomy. Testicular histology revealed atrophic testes. Normal serum alkaline phosphatase in this patient in the presence of extensive skeletal metastases may be due to the combination of the following factors: relative hypogonadism, osteoporosis, low serum zinc and magnesium. This case report may provide a possible explanation for the observation that about 10% of men with widespread skeletal metastases from prostate cancer may not have elevated serum alkaline phosphatase. La phosphatase alcaline (ALPES) est un marqueur non spécifique de tumeur. Une élévation de l'enzyme en cas de carcinome de la prostate est habituellement due à la sécrétion par l'os ou le foie, ou les deux, par la maladie métastatique. Nous rapportons le cas d'un homme de 91 ans qui s'est présenté avec rétention urinaire chronique. Les examens ont montré un antigène spécifique de prostate (PSA) de 831.4 ng/ml, une insuffisance rénale modérée, une fonction hépatique normale et un taux de phosphatase alcaline normal. La scintigraphie osseuse du corps entier a montré des métastases osseuses étendues. L'échographie transrectale de la prostate a montré une prostate de 40 g avec une lésion hypo-échogène dans la périphérie de la glande. La biopsie de prostate a confirmé le cancer de prostate (score 8 de Gleason). La testostérone, le zinc et le magnésium totaux du sérum étaient au-dessous de la normale. La densimétrie osseuse a montré une ostéoporose. La résection trans urétrale de la prostate a été réalisée ainsi qu'une orchidectomie bilatérale. L'histologie testiculaire a montré des testicules atrophiques. La phosphatase alcaline normale chez ce patient en présence des métastases osseuses étendues peut être due à la combinaison des facteurs suivants : hypogonadisme relatif, ostéoporose, taux bas de zinc et de magnésium dans le sérum. Ce cas peut fournir une explication possible pour l'observation qu'environ 10% des hommes avec métastases osseuses de cancer de prostate ne présentent pas une élévation de la
The Bulgarian Glory [In Bulgarian]
V. Kachev
Venets : The Belogradchik Journal for Local History, Cultural Heritage and Folk Studies , 2011,
Abstract: This poem was written specially for the concert “Bulgarian Symbols”, held on 19th of December 2010 in the Great Hall of the National Palace of Culture in Sofia. It marks the most important moments in the Bulgaria history.
Criterion for Cannon's Conjecture  [PDF]
Vladimir Markovic
Mathematics , 2012,
Abstract: The Cannon Conjecture from the geometric group theory asserts that a word hyperbolic group that acts effectively on its boundary, and whose boundary is homeomorphic to the 2-sphere, is isomorphic to a Kleinian group. We prove the following Criterion for Cannon's Conjecture: A hyperbolic group $G$ (that acts effectively on its boundary) whose boundary is homeomorphic to the 2-sphere is isomorphic to a Kleinian group if and only if every two points in the boundary of $G$ are separated by a quasi-convex surface subgroup. Thus, the Cannon's conjecture is reduced to showing that such a group contains "enough" quasi-convex surface subgroups.
Golden Fund of Bulgarian Science [In Bulgarian]  [PDF]
R. Vladova
Venets : The Belogradchik Journal for Local History, Cultural Heritage and Folk Studies , 2011,
Abstract: “The Golden Fund of the Bulgarian Science” contains interviews with 57 eminent Bulgarian scientists. These people are asked to sketch their course of life and their scientific achievements in their fields in natural sciences, social sciences and art and humanities; they share with the readers their opinions on the basic problems of research, education and science/education policy and management.
Metastatic calcification as a result of extensive bone metastases in a paediatric patient with Parameningeal Embryonal Rhabdomyosarcoma
F Ismail, Z Lockhat, M Sathekge, N Khan, I van de Werke, N Adroos, D Reynders, M Kruger
South African Journal of Radiology , 2008,
Abstract: We present a case of parameningeal embryonal rhabdomyosarcoma with the primary lesion arising in the middle and inner ear, with associated diffuse skeletal metastases and metastatic calcifications. South African Journal of Radiology Vol. 12 (1) 2008: pp. 10-12
Bulgarian Toponyms as a Reflection of the Ancient Bulgarian Culture and Traditions [In Bulgarian]  [PDF]
G. Simeonova
Venets : The Belogradchik Journal for Local History, Cultural Heritage and Folk Studies , 2012,
Abstract: A detailed analysis of the Bulgarian toponyms as a reflection of the ancient Bulgarian culture and traditions is presented. The paper studies a number of place names, their origins, meaning, use and typology.
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