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Calcifying Epithelioma of Malherbe-A Diagnostic Challenge on FNAC  [PDF]
Kuldeep Singh, Satish Sharma,M.Barbotra,V.K Dubey
JK Science : Journal of Medical Education & Research , 2002,
Abstract: Pilomatrixoma or calcifYing epithelioma ofMalherbe is one ofbenign adenexal tumors ofthe skin.!toccurs in all the age groups with common locations in the head and neck region. Fine needle aspirationcytolog) has a challenge in the diagnosis of these tumors.We report a similar case of calcifyingepithelioma.
Pilomatricoma: epitelioma calcificado de Malherbe Pilomatricoma: calcifying epithelioma of Malherbe  [cached]
Rebeca Paohwa Liu da Fonseca,José de Souza Andrade Filho,Izabella Costa Araujo,Aloísio Ferreira da Silva Filho
Revista Brasileira de Cirurgia Plástica , 2012,
Abstract: INTRODU O: Pilomatricoma (epitelioma calcificante de Malherbe) representa cerca de 1% dos tumores benignos de pele. O objetivo deste estudo retrospectivo é rever as características clínicas e histopatológicas dessa les o em pacientes tratados nos Departamentos de Cirurgia Plástica e Anatomia Patológica de um hospital geral. MéTODO: Dados relacionados a 68 les es, presentes em 56 pacientes, foram revisados. Todos os pacientes foram submetidos a excis o cirúrgica dos tumores. Os seguintes aspectos foram estudados: gênero, idade, localiza o e tamanho das les es, diagnóstico pré-operatório, recorrência e características peculiares à histopatologia. RESULTADOS: Trinta e um pacientes eram do sexo masculino (55,4%) e 25, do feminino (44,6%). As les es estavam localizadas na face (42,4%), membros superiores (19,7%), tronco (13,6%), membros inferiores (12,1%), pesco o (9,1%) e couro cabeludo (3,1%). Em um paciente, foi observada recorrência após o primeiro tratamento cirúrgico. Outra paciente apresentou les es em vários locais, em cinco ocasi es diferentes. Um terceiro paciente teve o diagnóstico de pilomatricoma proliferante. Todos os tumores eram benignos. O diagnóstico clínico de pilomatricoma foi realizado pelo cirurgi o em apenas 19,7% dos casos. CONCLUS ES: Pilomatricomas devem ser considerados no diagnóstico diferencial, especialmente dos nódulos de cabe a e pesco o. Exame clínico cuidadoso e conhecimento da les o favorecem o diagnóstico preciso e, portanto, o tratamento adequado. BACKGROUND: Pilomatricoma (calcifying epithelioma of Malherbe) represents approximately 1% of all benign skin tumors. The aim of this retrospective study was to review the clinical and histopathological characteristics of this lesion in patients presenting to the Departments of Plastic Surgery and Pathology of a general hospital. METHODS: Data regarding 68 lesions in 56 patients were reviewed. All patients underwent surgical excision of the tumors. The medical records were reviewed for gender, age, lesion location and size, preoperative diagnosis, recurrence, and particular histopathological characteristics. RESULTS: Thirty-one patients (55.4%) were male and 25 (44.6) female. The lesions were distributed in the face (42.4%), upper limbs (19.7%), trunk (13.6%), lower limbs (12.1%), neck (9.1%), and scalp (3.1%). In one patient, the condition recurred following the first surgical treatment. Another patient had multiple presentation of her lesions, that appeared in several locations and five different occasions. A third patient was diagnosed with proliferating pilomatricoma. All
Multiple Calcifying Epitheliomas of Malherbe’s of Axilla: A Case Report of Rare Variety  [PDF]
Mushtaq Chalkoo, Shahnawaz Ahangar, Naseer Awan, Mujahid Ahmad Mir, Aarif Bashir, Nida Shafiq
Surgical Science (SS) , 2014, DOI: 10.4236/ss.2014.56042
Abstract:

Pilomatrixoma, a rare benign tumour of sebaceous gland is commonly known as calcifying epithelioma of Malherbe or Tricholemmal cyst. We came across even the rarest form of this benign tumour of skin. Our case report was interestingly detected at a higher age group, unusual site of the body, multiple in nature following postoperative incision drainage of abscess in left axilla.

A Very Rare Presentation of Pilomatrixoma: Pilonoidal Sinus  [cached]
Ali Güner,Dündar Barlas,Faik ?elik
Erciyes Medical Journal , 2007,
Abstract: Pilomatrixoma (calcifying epithelioma of Malherbe) is a rare, benign skin tumor derived from the outer sheath cells of the hair follicle. Pilomatrixoma has been reported not only as a benign lesion, but also as a highly malignant tumor. Basaloid (shadow) cells with or with no focal calcifications in shadow cell areas are typical. They occur predominantly on the face or neck, but may also arise on the extremities. We aim to report a case who presented with pilonidal disease located on the sacrococcygeal area. This is a very rare location for such a benign tumor. The ehoicey treetmont was surgical excision.
Epithelioma of Malherbe: new ultrasound patterns
Francesco M Solivetti, Fulvia Elia, Alessandra Drusco, Chiara Panetta, Ada Amantea, Aldo Di Carlo
Journal of Experimental & Clinical Cancer Research , 2010, DOI: 10.1186/1756-9966-29-42
Abstract: We retrieved 124 histologically Pilomatricoma cases: 28 patients with 32 lesions were preoperatively evaluated with ultrasound.22/32 have shown a solid formation, hypoechoic, with a sharp outline. Of these 22, 10 lesions were completely calcifying and 12 partially calcified. In 3/32 lesions with uncertain diagnosis, ultrasounds showed a complex/mixed pattern with pseudo-fluid areas and microspots. 7/32 lesions with US different diagnosis included 3 complex lesions, 2 cystic lesions and 2 solid nodular lesions.In addition to well-known ultrasound patterns (completely calcified and partially calcified) we identified three new, not yet described, patterns that constitute the 31% of the cases: complex, pseudocistyc and pseudotumoral.Calcifying Epithelioma of Malherbe - or Trichomatricoma, Pilomatricoma, Pilomatrixoma (PM) - is an uncommon tumour [1], with an incidence of 1/800-1000 cutaneous tumours and about 20 new reports per year [2,3], affecting predominantly women. It is more common at a young age, especially in the first two decades of life, with an onset below 10 years in 40% of cases [4,5]. Although multiple localizations have been described in literature [6,7], PM occurs as a solitary lesion on the face (47% of cases), neck [8] and upper trunk and can be associated to other diseases, e.g. Steinert's Myotonic Dystrophy and Gardner Syndrome [4,7,9,10].Recent studies have shown that recurrent activating mutations in the ss-catenina gene (CTNNB1), induce PM tumourigenesis through activation of the WNT signalling pathway [11,12]. Despite the benign biological behaviour of the majority of cases, the treatment is still surgical. However, in recent years, aggressive cases with local post-surgery recurrences or metastasis have been described [2,3,13,14], accounting for variable percentage rates in literature, with 6 cases out of 228 in the Forbis series [6]. According to some authors [13], local recurrences are related to tumour aggressiveness, while for others, these c
Pilomatrixoma of the Arm: A Rare Case with Cytologic Diagnosis  [PDF]
Ruchika Gupta,Sarika Verma,Pankaj Bansal,Anup Mohta
Case Reports in Dermatological Medicine , 2012, DOI: 10.1155/2012/257405
Abstract: Pilomatrixoma, a benign skin appendageal tumor, is seen commonly in head and neck. Occurrence of pilomatrixoma in the upper extremities is not common and has been reported infrequently in the available literature. Only a few cases with preoperative aspiration cytology have been reported in the literature. A five-year-old girl underwent fine needle aspiration (FNA) of a firm subcutaneous nodule on the lateral aspect of left arm. FNA smears showed scattered and few fragments of round to oval cells along with multinucleated giant cells. Few shadow cells were seen. A cytologic impression of pilomatrixoma was rendered, which was confirmed on histopathology. Pilomatrixoma, a common skin appendageal tumor in head and neck region, should be considered in the cytologic differential diagnoses of subcutaneous masses even in unusual locations like arm. The varied cytomorphology should be remembered to avoid misdiagnosis. 1. Introduction Pilomatrixoma, also known as calcifying epithelioma of Malherbe, is a skin appendageal tumor seen in head and neck regions. Occurrence of this lesion in the arm is unusual and has been described in few reports in the available English literature [1–4]. Though histologic diagnosis of pilomatrixoma, even in unusual locations, is straightforward, the same is not true for aspiration cytology. There have been quite a few reports of misdiagnosis of pilomatrixoma on aspiration smears, as other benign as well malignant lesions [5, 6]. One case of pilomatrixoma of the arm was diagnosed as round cell tumor on cytology. The final diagnosis was rendered on histopathology of the resected mass [3]. An accurate diagnosis of this benign lesion on cytology is imperative, considering that excision is curative. We describe the clinical, cytologic, and histologic features of a case of pilomatrixoma in the arm of a young girl. 2. Case Report A five-year-old girl presented to the pediatric surgery outpatient department with history of gradually increasing swelling in the left arm for the last 3-4 months. There was no associated pain or history of trauma prior to the appearance of the swelling. Local examination showed a firm subcutaneous swelling, 0.8?×?0.6?cm in size on the lateral aspect of the left arm. The swelling was nontender with no fixity to the overlying skin or underlying structures. The overlying skin appeared unremarkable. With a clinical diagnosis of a soft tissue lesion, fine needle aspiration (FNA) was performed from the swelling. Following the cytologic impression, an excision of the mass was carried out. 2.1. Cytologic Features FNA was
Peripheral calcifying cystic odontogenic tumour of the maxillary gingiva
Ana Lima, Dárcio Kitakawa, Janete Almeida, Adriana Aigotti Brand?o, Ana Anbinder
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-455
Abstract: Authors report a rare case of a peripheral calcifying cystic odontogenic tumor of the maxillary gingiva. A 39-year-old male patient presented with a fibrous mass on the attached buccal gingiva of the upper left cuspid teeth. It was 0.7-cm-diameter, painless and it was clinically diagnosed as a peripheral ossifying fibroma. After an excisional biopsy, the diagnosis was peripheric calcifying cystic odontogenic tumor. The patient was monitored for five years following the excision, and no recurrence was detected.All biopsy material must be sent for histological examination. If the histological examination of gingival lesions with innocuous appearance is not performed, the frequency of peripheral calcifying cystic odontogenic tumor and other peripheral odontogenic tumors may be underestimated.A calcifying cystic odontogenic tumor (CCOT) is an extremely rare benign cystic neoplasm that is characterized by an ameloblastoma-like epithelium and ghost cells that have the potential to undergo calcification [1]. Originally, CCOTs were referred to as calcifying odontogenic cysts (COC). The structure was first described by Gorlin in 1962 as a distinct entity and was therefore called Gorlin cyst [2]. COC was considered as a developmental odontogenic cyst in the jaw. In their first report, Gorlin et al. [2] considered this lesion to be a possible analogue of the cutaneous calcifying epithelioma of Malherbe (the pilomatrixoma). COC accounted for approximately 1% of jaw cysts. In 1981, Praetorius et al. [3] studied and reevaluated 16 cases of COC and proposed that the group actually contained two entities, a cyst and a neoplasm. Since then, neoplastic potential has been investigated.In 2005, the World Health Organization (WHO) designated Gorlin’s cyst as a tumor and described it as belonging to a group of related neoplasms, including the benign cystic-type (CCOT), the benign solid-type dentinogenic ghost cell tumor, and the malignant ghost cell odontogenic carcinoma [1]. The dentino
Recurrent Giant Pilomatrixoma of the Face: A Case Report and Review of the Literature  [PDF]
Mohammed Nadershah,Ahmad Alshadwi,Andrew Salama
Case Reports in Dentistry , 2012, DOI: 10.1155/2012/197273
Abstract: Pilomatrixoma, also known as pilomatricoma, is a benign tumor that originates from the matrix of the hair root. It usually presents as a single, slow-growing subcutaneous or intradermal firm nodule with a general size of less than 3 centimeters (cm) in diameter. However, giant pilomatrixomas (more than 5?cm) have been reported infrequently. It is more common in females and usually presents during the first two decades of life (60%) as an asymptomatic, mobile, hard, elastic mass. Most of the cases are benign and affect the face. The authors report a rare case of a giant pilomatricoma of the cheek and discuss the surgical management of these lesions, histopathological findings, and review of the literature. 1. Introduction Pilomatrixoma, also known as pilomatricoma or calcifying epithelioma of Malherbe, was first described in 1880 by Malherbe and Chenantais [1]. In 1961, Forbis and Helwig proposed the term pilomatrixoma to emphasize the lesion origin, the matrix of the hair root [2]. pilomatrixoma is a benign skin neoplasm that usually presents as a single, slow-growing subcutaneous or intradermal firm nodule with a general size of less than 3 centimeters (cm) in diameter. However, giant pilomatrixomas (more than 5?cm) have been reported infrequently. It is more common in females and usually presents during the first two decades of life (60%) as an asymptomatic, mobile, hard, elastic mass. Most of the cases are benign and affect the face [3, 4]. We report a rare case of a giant pilomatricoma of the cheek and discuss the surgical management of these lesions, histopathological findings, and review of the literature. 2. Case Report A 28-year-old male was referred to the department of oral and maxillofacial surgery for evaluation and management of a left facial mass. He had no other medical problems and no known food or drug allergies. At the age of 15 years, he noticed a mass on his left cheek eminence, which was excised and was told that it was a sebaceous cyst. Three years later, he had a local recurrence of the facial mass that was surgically excised again showing the same pathology. A third recurrence in the same area occurred 4 years later and was excised with the overlying skin. However, at this time the pathology specimen proved to be pilomatrixoma. The mass recurred again few years later and has been growing slowly over the past 3 years prior to presentation. Clinical examination of the face showed a firm, nontender mass infiltrating the overlying skin of the left buccal subunit measuring about ?cm. The overlaying skin had bluish discoloration
Calcifying Tumor of Malherbe  [cached]
Dr.Bharti Padmakar Baviskar,Dr. Ravindra Karle,Dr. Shubhangi Prashant Nigwekar,DR. SOMEN MISRA
International Journal of Biomedical and Advance Research , 2013, DOI: 10.7439/ijbar.v4i3.321
Abstract: ABSTRACT Tumours of the eyelid are not very common. Frequently we come across squamous cell carcinoma. We are reporting a rare case of calcifying epithelioma of eye. The usual presenting region is the hair bearing areas of body and upper extremity. A 15 years old male presented with swelling over upper lid. Clinically diagnosed as molluscum contagiosum. Surgical excision was carried out. Histopathology confirmed it as calcifying epithelioma of the eye. Epithelioma situated over the eyelid is very rare.
Pilomatricoma: A dermal analog of calcifying odontogenic cyst  [cached]
Kaveri H,Punnya A
Indian Journal of Dental Research , 2008,
Abstract: Pilomatricoma, also known as "Calcifying Epithelioma of Malherbe" is an uncommon, benign, cutaneous tumor originating from the hair matrix. Most often, its precise preoperative diagnosis is not possible. Rarity of this lesion and its histological resemblance to the calcifying odontogenic cyst (the Gorlin′s cyst) make it relevant, both to the maxillofacial surgeons and the pathologists. Here, we describe a case of pilomatricoma of the periorbital region in a young Indian female patient. We believe that its inclusion is essential in the differential diagnosis of hard masses of the maxillofacial and paraoral regions.
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