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Combining an SSRI with an anticonvulsant in depressed patients with dysphoric mood: an open study  [cached]
Pasquini Massimo,Picardi Angelo,Speca Azzurra,Orlandi Valerio
Clinical Practice and Epidemiology in Mental Health , 2007, DOI: 10.1186/1745-0179-3-3
Abstract: Background Several patients with unipolar depression present with prominent dysphoric mood. We aimed at examining the effectiveness of the combination of an SSRI with an anticonvulsant in such patients. Methods Thirty-five newly admitted outpatients with substantial anger, irritability, aggressiveness or hostility who were diagnosed a DSM-IV unipolar depressive disorder were rated on the Hamilton Depression Rating Scale (HDRS), the Clinical Global Improvement (CGI) scale, and a scale for the rapid dimensional assessment (SVARAD), were prescribed an SSRI and an anticonvulsant (usually valproate), and were followed up for 12 weeks. Repeated measures analysis of variance was used to test for within-subject changes in scale scores over time. Results Thirty-two and 23 patients attended the follow-up visits 4 and 12 weeks later, respectively. Significant decreases (p < .001) were observed in HDRS total score, HDRS and SVARAD anxiety factors, HDRS and SVARAD core depression factors, and SVARAD anger/irritability factor. Adjusting for age or gender did not change the results. Most patients (82%) were rated as improved or much improved on the CGI. Conclusion Although our study has several limitations, we observed a remarkable improvement in most unipolar depressed outpatients with dysphoric mood treated with an SSRI and an anticonvulsant. The effectiveness of anticonvulsants might be linked to their action on symptoms of aggression and behavioural activation.
Dysphoric Mood States are Related to Sensitivity to Temporal Changes in Contingency  [PDF]
Rachel M. Msetfi,Robin A. Murphy,Diana E. Kornbrot
Frontiers in Psychology , 2012, DOI: 10.3389/fpsyg.2012.00368
Abstract: A controversial finding in the field of causal learning is that mood contributes to the accuracy of perceptions of uncorrelated relationships. When asked to report the degree of control between an action and its outcome, people with dysphoria or depression are claimed to be more realistic in reporting non-contingency (e.g., Alloy and Abramson, 1979). The strongest evidence for this depressive realism (DR) effect is derived from data collected with experimental procedures in which the dependent variables are verbal or written ratings of contingency or cause, and, perhaps more importantly, the independent variable in these procedures may be ambiguous and difficult to define. In order to address these possible confounds, we used a two-response free-operant causal learning task in which the dependent measures were performance based. Participants were required to respond to maximize the occurrence of a temporally contiguous outcome that was programmed with different probabilities, which also varied temporally across two responses. Dysphoric participants were more sensitive to the changing outcome contingencies than controls even though they responded at a similar rate. During probe trials, in which the outcome was masked, their performance recovered more quickly than that of the control group. These data provide unexpected support for the DR hypothesis suggesting that dysphoria is associated with heightened sensitivity to temporal shifts in contingency.
Emotional Reasoning Processes and Dysphoric Mood: Cross-Sectional and Prospective Relationships  [PDF]
David Berle, Michelle L. Moulds
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0067359
Abstract: Emotional reasoning refers to the use of subjective emotions, rather than objective evidence, to form conclusions about oneself and the world [1]. Emotional reasoning appears to characterise anxiety disorders. We aimed to determine whether elevated levels of emotional reasoning also characterise dysphoria. In Study 1, low dysphoric (BDI-II≤4; n = 28) and high dysphoric (BDI-II ≥14; n = 42) university students were administered an emotional reasoning task relevant for dysphoria. In Study 2, a larger university sample were administered the same task, with additional self-referent ratings, and were followed up 8 weeks later. In Study 1, both the low and high dysphoric participants demonstrated emotional reasoning and there were no significant differences in scores on the emotional reasoning task between the low and high dysphoric groups. In Study 2, self-referent emotional reasoning interpretations showed small-sized positive correlations with depression symptoms. Emotional reasoning tendencies were stable across an 8-week interval although not predictive of subsequent depressive symptoms. Further, anxiety symptoms were independently associated with emotional reasoning and emotional reasoning was not associated with anxiety sensitivity, alexithymia, or deductive reasoning tendencies. The implications of these findings are discussed, including the possibility that while all individuals may engage in emotional reasoning, self-referent emotional reasoning may be associated with increased levels of depressive symptoms.
Late-Life Depressive Symptoms, Religiousness, and Mood in the Last Week of Life  [PDF]
Arjan W. Braam,Marianne Klinkenberg,Henrike Galenkamp,Dorly J. H. Deeg
Depression Research and Treatment , 2012, DOI: 10.1155/2012/754031
Abstract: Aim of the current study is to examine whether previous depressive symptoms modify possible effects of religiousness on mood in the last week of life. After-death interviews with proxy respondents of deceased sample members of the Longitudinal Aging Study Amsterdam provided information on depressed mood in the last week of life, as well as on the presence of a sense of peace with the approaching end of life. Other characteristics were derived from interviews with the sample members when still alive. Significant interactions were identified between measures of religiousness and previous depressive symptoms (CES-D scores) in their associations with mood in the last week of life. Among those with previous depressive symptoms, church-membership, church-attendance and salience of religion were associated with a greater likelihood of depressed mood in the last week of life. Among those without previous depressive symptoms, church-attendance and salience of religion were associated with a higher likelihood of a sense of peace. For older adults in the last phase of life, supportive effects of religiousness were more or less expected. Fore those with recent depressive symptoms, however, religiousness might involve a component of existential doubt. 1. Introduction One important aspect of religion is how it may guide people through questions about the end of life. For some religious believers, it is clear that death only implies a transition. Others are less convinced, and may doubt about the existence of a transition, or about the conclusion of a judgement on their moral behaviour. In a previous study, we focused on the role of religiousness with respect to aspects of mood in the last week of life, as observed in a sample of older adults in The Netherlands [1]. Several aspects of religiousness were included, but none of them was associated with depressed mood in the last week of life, as reported by surviving relatives. Nonetheless, church attendance earlier in life predicted a “sense of peace” with the approaching end of life. Therefore, only modest support was found for the adaptive potential of religion in the last week of life. A possibly maladaptive aspect was not identified in this first report. Furthermore—although the analyses were adjusted for effects of previous depressive symptoms—the first study did not focus on those who were prone to depression during their lifetime. The Netherlands represents a highly secularized country, but the older generation has still grown up in a society in which religious traditions had a prominent role, and many older
The Effect of Mastectomy on Mood and Quality of Life in Breast Cancer Patients
A Fazel,B Tirgari,N Mokhber,MM Koushyar
Journal of Shahid Sadoughi University of Medical Sciences , 2008,
Abstract: Introduction: Breast cancer with 22.6% is the most common cancer in Iranian women and mastectomy is the treatment of choice in 81% of cases posted for surgery. Mastectomy can evoke feelings of mutilation, altered body image and decreased sexual attractiveness and function leading to mood disorders. In the last decades, final purpose of treatment strategies in breast cancer is creation of a life with good quality. In this regards, concern is rising about the impact of surgical treatments, especially mastectomy on patient`s quality of life. This study was conducted to determine the relationship of mastectomy with mood and quality of life in breast cancer patients. Methods: This descriptive-analytic study was done in 2005.Case group included mastectomy patients referring to the oncology clinics (n=50).The comparison group consisted of mammography candidates referring to women clinics in Imam Reza and Ghaeem Hospitals. Data collected was based on non-probability and purposeful sampling. The information collected included: demographic and medical information, social support questionnaire, POMS survey for measurement of mood. Quality of life was assessed with FPQOLI. Results: Pearson correlation coefficient showed a significant converse statistical relation between mood and quality of life score in mastectomy women (P<0.001). Independence T test showed that mood and quality of life in mastectomy group were lower than mammography candidate women (P=0.001, P<0.049). The general linear model test showed that group variable had the most effect on women`s mood (P<0.001). Also , mood was the most important factor that predicted level of quality of life in these women (P<0.001). Conclusion: Lack of attention to psychological and spiritual status of the patients after mastectomy may provide conditions for unstable mood and can finally disrupt their quality of life. But, nurses can identify patients with psychological tensions and introduce them to consultancy centers to prevent mood disorders and promote their quality of life.
Regular group exercise is associated with improved mood but not quality of life following stroke  [PDF]
Michelle N. McDonnell,Shylie F. Mackintosh,Susan L. Hillier,Janet Bryan
PeerJ , 2015, DOI: 10.7717/peerj.331
Abstract: Purpose. People with stroke living in the community have an increased prevalence of depression and lower quality of life than healthy older adults. This cross-sectional observational study investigated whether participation in regular exercise was associated with improved mood and quality of life.
An Open Question about Dependency of Life Time of Hardware Components and Dynamic Voltage Scaling  [PDF]
Nasrin Jaberi
Computer Science , 2012,
Abstract: Open question about Dependency of Life Time of Hardware Components and Dynamic Voltage Scaling (A primary idea)
Correlation between mood and heart rate variability indices during daily life  [PDF]
Kohzoh Yoshino, Katsunori Matsuoka
Health (Health) , 2011, DOI: 10.4236/health.2011.39094
Abstract: We investigated the correlation between mood and heart rate variability (HRV) indices during daily life. The RR-interval and body acceleration of 40 normal male subjects were recorded using ambulatory device for 48 to 72 hours. Every hour that the subjects were awake they registered their current mood on a Visual Analogue Scale questionnaire. The questionnaire scales eight of the subjects’ current moods. Those are happiness, tension, fatigue, worry, depression, anger, vigor, and confusion. The following four HRV indices were calculated. Those are heart rate, root mean square of successive differences of RR-interval sequence, the normalized high-frequency (0.15 - 0.4 Hz) power of RR-in- terval variability, and mean frequency in the high-frequency band of RR-interval variability. The calculated HRV indices data and the mood data were normalized individually, the data with body acceleration exceeding 30 mG were excluded from the analysis to reduce the effect of exercise, and the differences from the first day (?mood and ?HRV-index) were taken to reduce the effect of circadian rhythm. The most three highly correlated combinations were ?vigor and ?HFnu (R = –0.24, p < 0.0001), ?vigor and ?RMSSD (R = –0.24, p < 0.0001), and ?vigor and ?HR (R = 0.22, p < 0.001). Vigor exhibited the most significant correlations with HRV indices of eight moods.
Psicoterapia interpersonal en el tratamiento de la depresión mayor Interpersonal Psychotherapy in the Treatment of Major Depressive Disorder
Andrés Heerlein
Revista Chilena de Neuro-Psiquiatría , 2002,
Abstract: Introducction. Interpersonal psychotherapy (IPT), a time-limited psychotherapy, was developed in the 1970s as a treatment for outpatient adults with major depression. It has been subsequently modified for different age groups and types of mood and non mood disorders and for use as a long-term treatment. It has grown since in its range of research applications and in its clinical accessibility. Method. Review of recent research and educational developments on IPT. Results. IPT has demonstrated efficacy in several randomized controlled trials for acute major depression, for other psychiatric conditions and for long-term treatment of depression. Conclusions. By enhancing interpersonal functioning of the depressed patient IPT initiates the reduction of depressive symptomatology and helps solving current life problems as dual goal of therapy. The publication of efficacy data and the appearance of two North American practice guidelines that include IPT among validated treatments for depression have increased the interest among clinicians in many countries
Interpersonal Trust and Quality-of-Life: A Cross-Sectional Study in Japan  [PDF]
Yasuharu Tokuda, Masamine Jimba, Haruo Yanai, Seiji Fujii, Takashi Inoguchi
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0003985
Abstract: Background There is growing interest in psychosocial factors with positive attitudes, such as interpersonal trust, as determinants for Quality-of-life (QOL) or subjective well-being. Despite their longevity, Japanese people report a relatively poor subjective well-being, as well as lower interpersonal trust. Our aim in this study was to evaluate the possible association between interpersonal trust and QOL among Japanese people. Methodology and Principal Findings Based on the cross-sectional data for Japanese adults (2008), we analyzed the relationship between interpersonal trust and each of four domains of the WHOQOL-BREF. Interpersonal trust was assessed using three scales for trust in people, in human fairness and in human nature. In a total of 1000 participants (mean age: 45 years; 49% women), greater trust was recognized among women (vs. men), those aged 60–69 (vs. 20–29), or the high-income group (vs. low-income). Each of three trust scales was positively correlated with all domains of QOL. Multiple linear-regression models were constructed for each of QOL and the principal component score of the trust scales, adjusted for age, gender, area size of residence, income, education, and occupation. For all QOL domains, interpersonal trust was significantly and positively associated with better QOL with p<0.001 for all four domains including physical, psychological, social, and environmental QOL. Other factors associated with QOL included gender, age class, area size of residence, and income. Education and occupation were not associated with QOL. Conclusions and Significance Greater interpersonal trust is strongly associated with a better QOL among Japanese adults. If a causal relationship is demonstrated in a controlled interventional study, social and political measures should be advocated to increase interpersonal trust for achieving better QOL.
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