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Fucoidan in Some Indian Brown Seaweeds Found along the Coast Gulf of Mannar
T. Eluvakkal,S.R. Sivakumar,K. Arunkumar
International Journal of Botany , 2010,
Abstract: Fucoidan is a hetero-polymer of sulfated L-fucose extracted from brown seaweeds, sea urchin, sea cucumber etc. that display diverse bioactivity. In this investigation, yield, total carbohydrate, L-fucose and sulphate content of crude fucoidan extracted from 11 abundantly occurring brown seaweeds along the coast of Gulf of Mannar (Rameswaram regions), India were evaluated by adopting two different methods. A maximum amount of crude fucoidan was recorded from Sargassum wightii (7.15 % alga dry wt.) followed by Dictyota dichotoma, Turbinaria ornata, T. conoides, T. decurrens, Sargassum myriocystum, S. ilicifolium, S. marginatum, Padina boergesenii, P. gymnospora and Stoechospermum marginatum (2.13% alga dry wt.). Highest L-fucose content of 232.5 mg g-1 dry crude fucoidan (23.25% in crude fucoidan ) was extracted in Sargassum wightii among the 11 seaweeds studied. Maximum sulphate content of 98.7 mg g-1 dry crude fucoidan (9.87% in crude fucoidan ) was also recorded in Sargassum wightii. A method that yield maximum crude fucoidan constitute less L-fucose whereas the other method that extracted low crude fucoidan constitute high L-fucose content. Some of the brown seaweeds occurring along the coast of Gulf of Mannar contained potential yield of fucoidan. The yield and quality of fucoidan extracted from seaweeds were depending on the method followed for the extraction. The yield of fucoidan was varied among the brown seaweeds likely to be species specific.
Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma  [PDF]
Ryuichiro Kimura,Takayoshi Rokkaku,Shinji Takeda,Masachika Senba,Naoki Mori
Marine Drugs , 2013, DOI: 10.3390/md11114267
Abstract: In this study, we analyzed the size-dependent bioactivities of fucoidan by comparing the cytotoxic effects of native fucoidan and fucoidan lipid nanoparticles on osteosarcoma in vitro and in vivo. In vitro experiments indicated that nanoparticle fucoidan induced apoptosis of an osteosarcoma cell line more efficiently than native fucoidan. The more potent effects of nanoparticle fucoidan, relative to native fucoidan, were confirmed in vivo using a xenograft osteosarcoma model. Caco-2 cell transport studies showed that permeation of nanoparticle fucoidan was higher than native fucoidan. The higher bioactivity and superior bioavailability of nanoparticle fucoidan could potentially be utilized to develop novel therapies for osteosarcoma.
Fucoidan: Structure and Bioactivity  [PDF]
Bo Li,Fei Lu,Xinjun Wei,Ruixiang Zhao
Molecules , 2008, DOI: 10.3390/molecules13081671
Abstract: Fucoidan refers to a type of polysaccharide which contains substantial percentages of L-fucose and sulfate ester groups, mainly derived from brown seaweed. For the past decade fucoidan has been extensively studied due to its numerous interesting biological activities. Recently the search for new drugs has raised interest in fucoidans. In the past few years, several fucoidans’ structures have been solved, and many aspects of their biological activity have been elucidated. This review summarizes the research progress on the structure and bioactivity of fucoidan and the relationships between structure and bioactivity.
Therapies from Fucoidan; Multifunctional Marine Polymers  [PDF]
Janet Helen Fitton
Marine Drugs , 2011, DOI: 10.3390/md9101731
Abstract: Published research on fucoidans increased three fold between 2000 and 2010. These algal derived marine carbohydrate polymers present numerous valuable bioactivities. This review discusses the role for fucoidan in the control of acute and chronic inflammation via selectin blockade, enzyme inhibition and inhibiting the complement cascade. The recent data on toxicology and uptake of fucoidan is detailed together with a discussion on the comparative activities of fractions of fucoidan from different sources. Recent in vivo, in vitro and clinical research related to diverse clinical needs is discussed. Targets include osteoarthritis, kidney and liver disease, neglected infectious diseases, hemopoietic stem cell modulation, protection from radiation damage and treatments for snake envenomation. In recent years, the production of well characterized reproducible fucoidan fractions on a commercial scale has become possible making therapies from fucoidan a realizable goal.
Biological activity of fucoidan from leafy bladderwort (Utricularia aurea Lour.)
Choosawad, D.,Phongdara, A.,Chotigeat, W.
Songklanakarin Journal of Science and Technology , 2005,
Abstract: Fucoidan extracted from aquatic plant Utricularia aurea was 1.3% of dry weight and comprised glucuronic acid 62.5% and fucose 4.98% of the crude extract and 28.74% of the fucose was sulfate. The fucoidan was investigated for antibacterial activity. The minimal inhibitory concentration (MIC) of crude fucoidan against Vibrio harveyi and Escherichia coli was 20 and 10 mg/ml. Moreover, the fucoidan had anticoagulant activity. The crude fucoidan had activated partial thromboplastin time (APTT) at 4.47 IU/mg.
Solvent Extraction of Fucoidan and Its Stripping with Salt Solution

WU Zhi-chun,ZHAO Bing,FANG Yan-li,OUYANG Fan,

过程工程学报 , 2001,
Abstract: The effect of inorganic salt added into aqueous fucoidan solution on fucoidan extraction was investigated. It is found that extraction of fucoidan decreases rapidly with the increase of inorganic salt concentration in the aqueous solution. Based on this phenomenon, the stripping of fucoidan was carried out with aqueous salt solution. The experimental results show that the stripping of fucoidan increases with the concentration of inorganic salt in the aqueous solution and decreases with the increase of fucoidan concentration in the organic phase. In addition, the stripping efficiency of NaCl solution is higher than that of CaCl2 solution at the same chloride ion concentration. The effect of organic solvent as diluent on the stripping of fucoidan was also studied. It is shown that the stripping of fucoidan with carbon tetrachloride as diluent is more difficult than that with the other organic solvents.
Sharma Vaishali J.,Patel Piyush M.
International Research Journal of Pharmacy , 2013,
Abstract: Phag described in classical text of Ayurveda is botanically identified as Rivea ornata. In present study methanolic extract of plant Rivea ornata was screened for in- vitro antibacterial activity against gram positive and gram negative bacteria by cup-plate method. The methanolic extract of the plant significantly inhibit the growth of bacteria as compared to the standard bactericide. The study reveals that the methanolic fraction of plant Rivea ornata possess significant antibacterial activity.
Chemometric analysis of ESIMS and NMR data from Piper species
Yamaguchi, Lydia F.;Freitas, Giovana C.;Yoshida, Nidia C.;Silva, Renata A.;Gaia, Anderson M.;Silva, Adalberto M.;Scotti, Marcus T.;Emerenciano, Vicente de P.;Guimar?es, Elsie F.;Floh, Eny I. S.;Colombo, Carlos A.;Siqueira, Walter J.;Kato, Massuo J.;
Journal of the Brazilian Chemical Society , 2011, DOI: 10.1590/S0103-50532011001200019
Abstract: the metabolomic profiling based on the application of multivariate analysis (principal component analysis, pca) of positive mode electrospray ionization mass spectrometric (esims) and 1h nuclear magnetic resonance (nmr) data of crude extracts highlighted some species characterized by lignans (p. solmsianum, p. truncatum and p. cernuum), neolignans (p. regnellii) and chromenes (p. gaudichaudianum). a specific analysis focusing on species having pendant and globular inflorescences (p. caldense, p. carniconnectivum, p. bowiei and p. permucronatum) or amides-producing species indicated higher potential of the methodology in determining similarities and establishing priorities for further phytochemical investigation. such intraspecific analysis applied to analyzed seedling leaves of the p. solmsianum, p. regnellii and p. gaudichaudianum species revealed the production of dillapiole and apiole instead of lignans, neolignans or prenylated benzoic acid, produced by the adult leaves, respectively. in case of amides-producing species, a similar profile was observed regardless the developmental stage.
Low molecular fucoidan and its macromolecular complex with bee venom melittin  [PDF]
G. T. Mavlonov, J. M Lee, Lee Shin, T. H. Yi, I. Y. Abdurakhmonov
Advances in Bioscience and Biotechnology (ABB) , 2011, DOI: 10.4236/abb.2011.24043
Abstract: Low molecular weight (LMW) fucoidan, obtained by free radical depolymerization of high molecular polysaccharide extract of brown algae Hizikia fusiformis, was complexed with HPLC purified bee venom melittin. Water soluble form of the LMW fucoidan – melittin complex shows increased anti-inflammatory activity, inhibiting the production of nitric oxide in murine macrophage cell line Raw 264.7. The LMW fucoidan:melitin complex obtained in this study showed good biological activities, resulting in 2-fold reduction of the melittin toxicity. The fucoidan: melittin macromolecular complex obtained should be useful in future therapeutic applications.
Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection  [cached]
Naoki Mori,Kazunori Nakasone,Koh Tomimori,Chie Ishikawa
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i18.2225
Abstract: AIM: To evaluate the effects of fucoidan, a complex sulfated polysaccharide extract from marine seaweed, on hepatitis C virus (HCV) RNA load both in vitro and in vivo. METHODS: HCV-1b replicon-expressing cells were cultured in the presence of fucoidan obtained from Cladosiphon okamuranus Tokida cultivated in Okinawa, Japan, and quantified the level of HCV replication. In an open-label uncontrolled study, 15 patients with chronic hepatitis C, and HCV-related cirrhosis and hepatocellular carcinoma were treated with fucoidan (0.83 g/d) for 12 mo. The clinical symptoms, biochemical tests, and HCV RNA levels were assessed before, during, and after treatment. RESULTS: Fucoidan dose-dependently inhibited the expression of HCV replicon. At 8-10 mo of treatment with fucoidan, HCV RNA levels were significantly lower relative to the baseline. The same treatment also tended to lower serum alanine aminotransferase levels, and the latter correlated with HCV RNA levels. However, the improved laboratory tests did not translate into significant clinical improvement. Fucoidan had no serious adverse effects. CONCLUSION: Our findings suggest that fucoidan is safe and useful in the treatment of patients with HCV-related chronic liver diseases. Further controlled clinical trials are needed to confirm the present findings.
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