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Effects of ethyl-cyanoacrylate and octyl-cyanoacrylate on experimental corneal lesions in rabbits
Barbosa, V.T.;Thiesen, R;Soares, E.G.;Machado, M.R.F.;Laus, J.L.;
Arquivo Brasileiro de Medicina Veterinária e Zootecnia , 2009, DOI: 10.1590/S0102-09352009000500009
Abstract: the use of ethyl-cyanoacrylate and octyl-cyanoacrylate were clinically and histopathologically compared on the corneas of 36 rabbits after lamellar keratectomy (standardized diameter and depth). the animals were distributed into two groups, one for each type of adhesive. from each group, six subgroups were histopathologically evaluated on the 3rd, 7th, 14th, 21st, 30th, and 60th day post-operative. general (daily) and ophthalmic (days 0, 1, 3, 5, 7, 14, 21, 30, 44, and 60) evaluations clinically indicated that there were significant differences for the variables water intake, attitude, blepharitis, corneal edema, and fluorescein test. the adhesive permanence time for octyl-cyanoacrylate (17.22 days) was greater than that for ethyl-cyanoacrylate (7.66 days). with respect to the histopathological evaluation, corneal epithelization and collagen organization occurred without severe complications. however, treatment with ethyl-cyanoacrylate led to a moderate inflammatory reaction in the initial phases. with octyl-cyanoacrylate, re-epithelization and collagen organization proceeded more slowly with a discrete inflammatory reaction in the initial phases. from clinical and histopathologic points of view, octyl-cyanoacrylate showed advantages over ethyl-cyanoacrylate, whereas wound healing was achieved in both groups without major complications.
Application of 2-octyl-cyanoacrylate for corneal perforation and glaucoma filtering bleb leak  [cached]
Okabe M,Kitagawa K,Yoshida T,Koike C
Clinical Ophthalmology , 2013,
Abstract: Motonori Okabe,1 Kiyotaka Kitagawa,2 Toshiko Yoshida,1 Chika Koike,1 Takeshi Katsumoto,2 Etsuko Fujihara,2 Toshio Nikaido1 1Department of Regenerative Medicine, University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Toyama, 2Division of Ophthalmology, Matsue Red Cross Hospital, Japanese Red Cross Society, Shimane, Japan Background: This paper reports on the efficacy of a tissue adhesive, 2-octyl-cyanoacrylate, in the treatment of corneal perforation and glaucoma filtering bleb leak. Methods: Two eyes from two patients with corneal perforation or laceration and two eyes from two patients with bleb leak were included. The patients underwent application of 2-octyl-cyanoacrylate onto the perforated or leaking site, and a hydrogel contact lens was applied as a bandage. We also evaluated the in vitro cell toxicity of 2-octyl-cyanoacrylate in HeLa cells. Results: The two cases of corneal perforation were repaired within 22 days with one application of the tissue adhesive. The two cases of bleb leak were repaired with 2–4 applications of the tissue adhesive over 134 (range 17–134) days). There were no recurrences or adverse effects during a mean follow-up period of 12.7 months. In vitro testing revealed that 2-octyl-cyanoacrylate was markedly toxic to HeLa cells. Conclusion: Four patients with corneal perforation or bleb leak were successfully managed using 2-octyl-cyanoacrylate tissue adhesive. This simple and easy surgical technique may become an alternative therapeutic option for corneal perforation or bleb leak, although several applications of this tissue adhesive may be required. Although 2-octyl-cyanoacrylate was toxic to HeLa cells, no adverse clinical effects were noted using this adhesive. Keywords: corneal perforation, bleb leak, tissue adhesive, 2-octyl-cyanoacrylate
Temporary management of involutional entropion with octyl-2-cyanoacrylate liquid bandage application
Osaki, Teissy;Osaki, Midori Hentona;Osaki, Tammy Hentona;
Arquivos Brasileiros de Oftalmologia , 2010, DOI: 10.1590/S0004-27492010000200004
Abstract: purpose: to evaluate the use of octyl-2-cyanoacrylate liquid bandage (band-aid liquid?, ethicon, johnson & johnson, new jersey, usa) as a temporary treatment in patients awaiting surgical repair for involutional entropion. methods: thirteen patients (15 eyelids) with involutional entropion were evaluated while they waited for surgical intervention. the lids were repositioned by the application of octyl-2-cyanoacrylate liquid bandage in the malar fold. patients were followed-up at days 1, 7 and 15. assessment and duration of correction were recorded. results: all the patients presented successful correction at day 1, with significant improvements in signs and symptoms. the mean duration of action of the octyl2-cyanoacrylate liquid bandage was three days. no ocular or dermatological reactions were noted. conclusion: octyl-2-cyanoacrylate liquid bandage showed to be a simple, safe and effective option to temporarily treat involutional entropion, while patients waited for surgical intervention.
2-Octyl-Cyanoacrylate Skin Adhesive Used as a Splinting Material in Auricular Surgery  [PDF]
Naoto Yamamoto, Satoshi Yanagibayashi, Ryuichi Yoshida, Hiroyuki Ogi, Megumi Takikawa, Akio Nishijima, Eri Maruyama
Modern Plastic Surgery (MPS) , 2016, DOI: 10.4236/mps.2016.64004
Abstract: In cases of auricular surgery, postoperative dressings are thought to be important for keeping auricular contour and in helping to prevent from dressing failures due to edema or subcutaneous hematoma, which may result in fibrous or cartilaginous proliferation. However, it is often difficult to achieve success with standard dressings because of the complicated shape of the auricle. We used 2-octyl-cyanoacrylate skin adhesive to dress the auricle after different types of auricular procedures (five cases of cryptotia, two of prominent ear, two of severe auricular laceration, two of skin grafting and one of flap repair of the partial auricle defect). The 2-octyl-cyanoacrlaate skin adhesive was applied to the suture line and the operated and peripheral areas for wider coverage. No dressing materials were placed over the surface. In all cases, the desired outcome was achieved, without subcutaneous hematoma, wound dehiscence, and wound infection. Contact dermatitis caused by the skin adhesive was not observed in any of the cases. Dressing and splinting after auricular surgery can be simply and successfully achieved using 2-octyl-cyanoacrylate skin adhesive. There is no need for more complicated dressings and post-surgical dressing changes, resulting in higher patient satisfaction.
Efficacy of percutaneous transhepatic variceal embolization with 2-Octyl-cyanoacrylate in patients with severe recurrent hepatic encephalopathy  [cached]
WANG Guangchuan
Journal of Clinical Hepatology , 2013,
Abstract: ObjectiveTo investigate the efficacy and safety of percutaneous transhepatic variceal embolization (PTVE) performed with 2-Octyl-cyanoacrylate (2-OCA) tissue adhesive for treating recurrent hepatic encephalopathy (HE) involving large portosystemic shunts. MethodsTwelve cirrhotic patients (8 males, 4 females; mean age: 62 years old) with recurrent HE (≥3 episodes/year, despite drug therapy) were treated by PTVE with 2-OCA. The surgery was performed under local anesthesia with B ultrasound- or X-ray-guided percutaneous needle injection of the adhesive into the hepatic portal vein with balloon dilation to occlude the portosystemic shunts. Preoperative and postoperative clinical and laboratory parameters, including HE episodes, with or without gastrointestinal bleeding, markers of liver and renal function and coagulation indicators, were recorded. Significance of surgery-induced change in portal vein pressure was assessed by paired t-test. ResultsThe PTVE was performed successfully in all 12 patients. The average injected volume of 2-OCA was 8.6 ml (range: 4-16 ml). The most frequent postoperative complications were pyrexia (6/12, 50.0%) and abdominal pain (5/12, 41.7%). The mean follow-up period was 22.7±9.8 months (range: 6-37 months). During the follow-up period, two patients (16.7%) developed transient ascites and two (16.7%) patients developed upper gastrointestinal bleeding (due to esophageal varices and portal hypertensive gastropathy, respectively). In addition, three patients (25.0%) experienced HE recurrence (at postoperative months 16, 19, and 30, respectively). Two patients (16.7%) died, one from progression of hepatic failure and the other from liver cancer. In general, the PTVE procedure significantly increased the portal pressure (preoperative: (21.9±1.8) mm Hg vs. postoperative: (26.3±3.2) mm Hg; P=000). ConclusionPTVE with 2-OCA is an effective and safe procedure for managing recurrent HE with large portosystemic shunts.
2-Octyl Cyanoacrylate Skin Adhesive for Topical Skin Incision Closure in Female Pelvic Surgery  [PDF]
Rebecca L. James, Marilyn Alejandro-Rodriquez, Elba Adriana Perez, Jeffrey Mangel
Open Journal of Obstetrics and Gynecology (OJOG) , 2015, DOI: 10.4236/ojog.2015.55041
Abstract: Background: 2-octyl cyanoacrylate (2OCA) high viscosity tissue adhesive (Medline Industries, Inc., Mundelein, IL) is a liquid topical skin adhesive. 2OCA offers the same design features and clinical utility in terms of flexibility, strength, and low complication rate as the commercially available 2OCA tissue adhesives. Additionally, 2OCA features high viscosity allowing for better control during the application process, polymerization without the use of an external activator, and a distinctive violet color for ease of application visualization. Objective: The aim of this prospective case series is to descriptively report clinical data with the application of 2OCA as a topical incision closure system in female pelvic surgery. The primary outcomes included: incisional pain, incisional dehiscence, and post-operative bleeding. The secondary outcome included drying times of the adhesive with regard to incision length. Methods: A prospective open-label observational case series study was conducted to evaluate the use of 2OCA in surgical wound closure of the topical skin in adult patients undergoing gynecologic surgical procedures. A total of 50 adult women undergoing gynecologic surgery were enrolled. 2OCA was applied only by surgeons who had undergone product training to the incisions in a standardized, protocol-defined fashion. Drying times for the adhesive and photography were recorded intraoperatively. Post treatment follow-up was conducted with queries of pain level, incisional dehiscence, and incisional bleeding immediately post-operatively, 48 hours, 5 - 10 days and 14 days post-treatment. Adverse events were documented. Results: 2OCA was applied to a total of 154 incisions from the 50 patients enrolled to the study. The procedures included: 16 laparoscopic total hysterectomies, 4 diagnostic laparoscopies, 2 laparoscopic myomectomies, 2 laparoscopic bilateral or unilateral salpingo-oophorectomies, 5 total robotic-assisted laparoscopic surgeries (2 total hysterectomies, 1 supracervical hysterectomy, 1 sacrocolpopexy, and one excision of endometriosis), 7 sacral neuromodulation procedures, and 18 midurethral slings. The overall rate of incisional dehiscence was 3% (4/154). The rate of reported incisional bleeding was 3% (4/154). There was 1 incisional infection. The pain reports based on a 10-point scale had a mean of 4.96 immediately post-operatively, which decreased to a mean score < 1 (0.2) by post-op day (POD) 14. The mean drying times for the various lengths of incisions included the following: 1.28 minutes for incisions ≤ 5 mm, 1.53 minutes for
Evaluation of the permeability of the furcation area of deciduous molars conditioned with Er:YAG laser and cyanoacrylate
Lopes-Silva, Adriene Mara Souza;Lage-Marques, José Luiz;
Pesquisa Odontológica Brasileira , 2003, DOI: 10.1590/S1517-74912003000300003
Abstract: the purpose of this study was to evaluate in vitro the dentin permeability of the deciduous pulp chamber floor after employing 2-octyl cyanoacrylate and er:yag laser. twenty four deciduous molars were used, divided into four groups. after chemical-surgical preparation each group received a different treatment: group 1 - control, without treatment; group 2 - the floor of the pulp chamber was covered with a fine layer of 2-octyl cyanoacrylate; group 3 - the floor of the pulp chamber was irradiated with er:yag laser (250 mj, 10 hz for 30 seconds, 80 j of energy and 320 pulses), and covered with a fine layer of 2-octyl cyanoacrylate; and group 4 - the floor of the pulp chamber was irradiated with er:yag laser set at the parameters already described. after that the specimens received application of 0.5% methylene blue, for 15 minutes. the teeth were cut, photographed, and the digitalized images were analyzed using the imagelab program. the results obtained were submitted to statistical analysis. group 4 (er:yag) presented the largest averages in percentage of dye penetration area (19.5%), followed by group 1 (11.1%), group 3 (1.4%) and group 2 (0.2%). the experimental model allowed to conclude that the specimens conditioned with 2-octyl cyanoacrylate (group 2) and er:yag laser associated to 2-octyl cyanoacrylate (group 3) presented a decrease in permeability, and the specimens treated with er:yag laser (group 4) presented an increase in permeability of the analyzed area.
Evaluation of the permeability of the furcation area of deciduous molars conditioned with Er:YAG laser and cyanoacrylate
Lopes-Silva Adriene Mara Souza,Lage-Marques José Luiz
Pesquisa Odontológica Brasileira , 2003,
Abstract: The purpose of this study was to evaluate in vitro the dentin permeability of the deciduous pulp chamber floor after employing 2-octyl cyanoacrylate and Er:YAG laser. Twenty four deciduous molars were used, divided into four groups. After chemical-surgical preparation each group received a different treatment: Group 1 - control, without treatment; Group 2 - the floor of the pulp chamber was covered with a fine layer of 2-octyl cyanoacrylate; Group 3 - the floor of the pulp chamber was irradiated with Er:YAG laser (250 mJ, 10 Hz for 30 seconds, 80 J of energy and 320 pulses), and covered with a fine layer of 2-octyl cyanoacrylate; and Group 4 - the floor of the pulp chamber was irradiated with Er:YAG laser set at the parameters already described. After that the specimens received application of 0.5% methylene blue, for 15 minutes. The teeth were cut, photographed, and the digitalized images were analyzed using the ImageLab program. The results obtained were submitted to statistical analysis. Group 4 (Er:YAG) presented the largest averages in percentage of dye penetration area (19.5%), followed by Group 1 (11.1%), Group 3 (1.4%) and Group 2 (0.2%). The experimental model allowed to conclude that the specimens conditioned with 2-octyl cyanoacrylate (Group 2) and Er:YAG laser associated to 2-octyl cyanoacrylate (Group 3) presented a decrease in permeability, and the specimens treated with Er:YAG laser (Group 4) presented an increase in permeability of the analyzed area.
SUBTOTAL THYROIDECTOMY
KHALIL-UR-REHMAN
The Professional Medical Journal , 2004,
Abstract: Objective: Autoimmunity is common in thyroid diseases. Antibodylevel is affected after subtotal thyroidectomy and radio iodine treatment. We studied microsomal &thyroglobulin autoantibody level in patients with toxic diffuse goitre and multinodular goitre before andafter surgery & radio iodine to determine effects of therapy. Design: Prospective study. Settings:Postgraduate Medical Institute, Lahore. Material & Methods: Three serial blood samples from each of atotal of 30 seropositive patients ( 15 of multinodular goitre, undergoing thyroid surgery. 15 of toxic diffusegoitre receiving radioiodine) were analyzed for microsomal & thyroglobulin autoantibody using tagged redcell haemagglutination technique. Results: We found a female preponderance in thyroid diseases. Themicrosomal & thyroglobulin autoantibody level in patients with multinodular goitre, decreased gradually andprogressively after subtotal thyroidectomy while subjects with toxic diffuse goitre receiving radioiodineshowed a rise in antibody level as compared to pretreatment period. The change became evident just after10 days of therapy. Conclusion: The autoimmune status of thyroid disease patients is altered after subtotalthyroidectomy & radioiodine therapy. The autoantibody levels after subtotal thyroidectomy are graduallydecreased while after radioiodine therapy the antibody levels have been found to increase.
Abdominal Rectopexy with Absorbable and Non-Absorbable Materials in the Treatment for Rectal Prolapse
Tomasz Ko ciński, Wiktor Meissner, Honorata Stadnik
Polish Journal of Surgery , 2011, DOI: 10.2478/v10035-011-0107-4
Abstract: The aim of the study was to present and compare own results of abdominal rectopexy performed with absorbable and nonabsorbable materials used in surgical repair of rectal prolapse. Material and methods. In the years 1991-2009, 50 patients were operated on for rectal prolapse. The first 8 patients (group I) were operated using absorbale polyglycolic acid mesh. The next 42 patients were operated using non-absorbable polypropylene mesh (group II). 12 patients with chronic, incurable constipation had sigmoidectomy and rectopexy performed at the same operation. Rectopexy was performed with the mesh and fixed to the pelvic fascia and periosteum and mesorectum, leaving the anterior one third of the rectum free. 6 months after surgery functional outcomes were evaluated. Statistic analysis with the level of statistical significance p<0,005 was applied to obtained functional results. Results. On the follow up visits, there were no symptoms of the recurrence of rectal prolapse in 5 patients (62.5%) from group I and in 25 patients (92.6%) from group II. Patients relapsing were reoperated 24 to 98 months after primary surgery. In all patients from group I (absorbable mesh), prosthetic material was not found at reoperation. In redo surgery only non-absorbable mesh was used. Conclusions. The effectiveness of rectal fixation depends on the on the durability of the prosthetic material. In the studied group polypropylene mesh was superior in rectopexy to absorbable mesh.
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