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Patient with Churg Strauss Syndrome and Myocarditis Treated with Cyclophosphamide  [PDF]
Liam Mullen, Janice Harper, Sukumaran Binukrishnan
Open Journal of Nephrology (OJNeph) , 2012, DOI: 10.4236/ojneph.2012.23006
Abstract: Cardiac involvement in Churg Strauss Syndrome is common and a poor prognostic indicator. Myocarditis in Churg Strauss Syndrome can present in different ways. It has been shown that basic cardiac investigations including echocardiography can be normal even in symptomatic patients. More recently cardiac magnetic resonance imaging (MRI) has been shown to be more sensitive in its diagnosis. Our case report describes a 45 year old male who presented with palpitations and breathlessness. Echocardiography was normal but cardiac MRI demonstrated abnormalities consistent with Myocarditis. He was treated with Cyclophosphamide and follow up MRI imaging demonstrated complete resolution of these abnormalities which was accompanied by resolution of symptoms. This case therefore supports the use of cardiac MRI in Churg Strauss Syndrome as a sensitive diagnostic tool in and as a means of monitoring response to therapy. It also supports the therapeutic effectiveness of Cyclophosphamide therapy in Churg Strauss related Myocarditis, something that has yet to be assessed on a large scale.
Central retinal artery occlusion in a patient with ANCA-negative Churg-Strauss syndrome
Kumano Y, Yoshida N, Fukuyama S, Miyazaki M, Enaida H, Matsui T
Clinical Ophthalmology , 2012, DOI: http://dx.doi.org/10.2147/OPTH.S34195
Abstract: tral retinal artery occlusion in a patient with ANCA-negative Churg-Strauss syndrome Case report (1346) Total Article Views Authors: Kumano Y, Yoshida N, Fukuyama S, Miyazaki M, Enaida H, Matsui T Published Date July 2012 Volume 2012:6 Pages 1225 - 1228 DOI: http://dx.doi.org/10.2147/OPTH.S34195 Received: 24 May 2012 Accepted: 29 June 2012 Published: 31 July 2012 Yuji Kumano,1 Noriko Yoshida,2 Satoru Fukuyama,3 Masanori Miyazaki,2 Hiroshi Enaida,2 Takaaki Matsui1 1Ohshima Hospital of Ophthalmology, Fukuoka, 2Department of Ophthalmology, 3Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Abstract: Ocular involvement in Churg-Strauss syndrome is infrequent. We describe the case of a 54-year-old woman with eosinophilia and involvement of the respiratory tract, skin, and peripheral nervous system, fulfilling the American College of Rheumatology criteria for Churg-Strauss syndrome. The patient presented with acute, painless vision loss in her right eye. Central retinal artery occlusion (CRAO) without accompanying retinal vasculitis was diagnosed by angiographic findings and funduscopic findings of retinal whitening with a cherry-red spot. Although her antineutrophil cytoplasmic antibody (ANCA) status was negative, CRAO was thought to be an ocular manifestation of Churg-Strauss syndrome, and appropriate treatment was planned. She was treated with high-dose corticosteroids and anticoagulant therapy. Her macular edema improved, but visual recovery was poor. Specific therapy to alter inflammation, blood coagulation, and rheology reportedly plays an important role in ANCA-positive patients with Churg-Strauss syndrome who develop CRAO. Regardless of ANCA status, high-dose corticosteroids should be considered for CRAO in patients with Churg-Strauss syndrome, as discussed in this case.
Central retinal artery occlusion in a patient with ANCA-negative Churg-Strauss syndrome  [cached]
Kumano Y,Yoshida N,Fukuyama S,Miyazaki M
Clinical Ophthalmology , 2012,
Abstract: Yuji Kumano,1 Noriko Yoshida,2 Satoru Fukuyama,3 Masanori Miyazaki,2 Hiroshi Enaida,2 Takaaki Matsui11Ohshima Hospital of Ophthalmology, Fukuoka, 2Department of Ophthalmology, 3Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanAbstract: Ocular involvement in Churg-Strauss syndrome is infrequent. We describe the case of a 54-year-old woman with eosinophilia and involvement of the respiratory tract, skin, and peripheral nervous system, fulfilling the American College of Rheumatology criteria for Churg-Strauss syndrome. The patient presented with acute, painless vision loss in her right eye. Central retinal artery occlusion (CRAO) without accompanying retinal vasculitis was diagnosed by angiographic findings and funduscopic findings of retinal whitening with a cherry-red spot. Although her antineutrophil cytoplasmic antibody (ANCA) status was negative, CRAO was thought to be an ocular manifestation of Churg-Strauss syndrome, and appropriate treatment was planned. She was treated with high-dose corticosteroids and anticoagulant therapy. Her macular edema improved, but visual recovery was poor. Specific therapy to alter inflammation, blood coagulation, and rheology reportedly plays an important role in ANCA-positive patients with Churg-Strauss syndrome who develop CRAO. Regardless of ANCA status, high-dose corticosteroids should be considered for CRAO in patients with Churg-Strauss syndrome, as discussed in this case.Keywords: CRAO, ANCA, Churg-Strauss syndrome
Churg-strauss syndrome
Brar B,Mehta Vivek,Chopra Dimple,Kubba Asha
Indian Journal of Dermatology , 2009,
Abstract: We report a case of 29-year-old man who presented with cutaneous vasculitis and was subsequently diagnosed as a case of Churg-Strauss syndrome. The patient fulfilled five out of the six criteria of the syndrome developed by American College of Rheumatology.
Churg–Strauss syndrome associated with antiphospholipid antibodies in a patient with recurrent myocardial and cerebral ischemia  [cached]
Paroli M,Polidoro A,Romano S,Accapezzato D
International Medical Case Reports Journal , 2012,
Abstract: Marino Paroli,1 Alessandro Polidoro,1 Simone Romano,1 Daniele Accapezzato21Department of Biotechnology and Medical-Surgical Sciences, 2Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, ItalyAbstract: We report on a case of Churg–Strauss syndrome (CSS) associated with the presence of antiphospholipid antibodies. The patient had a history of recurrent myocardial infarction and presented with acute ischemic cerebral disease. Eosinophilia with typical lung and skin lesions led us to diagnose the patient with CCS. We hypothesize that the presence of antiphospholipid antibodies significantly contributed to the ischemic events. We suggest that the search for antiphospholipid antibodies should be included in the laboratory work-up in CSS patients and patients affected by primary systemic vasculitides in general. Moreover, anticoagulant treatment appears to be warranted in all CSS patients and antiphospholipid antibodies to counteract this thrombosis-favoring association.Keywords: Churg–Strauss syndrome, antiphospholipid antibodies, ischemic disease
Síndrome de Churg Strauss
López Rengifo,Diana Milena; Contreras Zú?iga,Eduardo; Osio,Luis Fernando;
Revista Colombiana de Reumatología , 2007,
Abstract: the churg-strauss syndrome, also called allergic granulomatosis and angiitis, is a multisystem disorder characterized by allergic rhinitis, asthma, and prominent peripheral blood eosinophilia. the most common organ involved is the lung, followed by the skin. the churg-strauss syndrome, however, can affect any organ system, including the cardiovascular, gastrointestinal, renal, and central nervous systems.
Double-balloon endoscopy-diagnosed multiple small intestinal ulcers in a Churg-Strauss syndrome patient  [cached]
Takayoshi Suzuki,Masashi Matsushima,Yoshitaka Arase,Mia Fujisawa
World Journal of Gastrointestinal Endoscopy , 2012, DOI: 10.4253/wjge.v4.i5.194
Abstract: Churg-Strauss syndrome (CSS) is a systemic vascular disorder characterized by severe bronchial asthma, hypereosinophilia, and allergic rhinitis. Small intestinal ulcers associated with CSS are a relatively rare manifestation that causes gastrointestinal bleeding. Multiple deep ulcers with an irregular shape are characteristic of small intestinal involvement of CSS. Video-capsule-endoscopy (VCE), double-balloon endoscopy (DBE) and Spirus assisted enteroscopy have been developed recently and enabled observation of the small intestine. In this case report, we have described a patient with CSS who had multiple deep ulcers in the jejunum detected by oral DBE. Since severe gastrointestinal (GI) involvement has been identified as an independent factor associated with poor outcome, the careful investigation of GI tract must be needed for CSS patients with GI symptoms. We describe the usefulness of DBE for diagnosis of small intestinal ulcers in patient with CSS.
Síndrome de Churg-Strauss
Barros, Juliana Monteiro de;Antunes, Telma;Barbas, Carmen Sílvia Valente;
Jornal Brasileiro de Pneumologia , 2005, DOI: 10.1590/S1806-37132005000700008
Abstract: churg-strauss syndrome is characterized by asthma, eosinophilia and various degrees of systemic vasculitis. the most severe forms of the disease, presenting cardiac, gastrointestinal, central nervous system and renal involvement, require cyclophosphamide therapy.
Síndrome de Churg Strauss Churg Strauss Syndrome  [cached]
Diana Milena López Rengifo,Eduardo Contreras Zú?iga,Luis Fernando Osio
Revista Colombiana de Reumatología , 2007,
Abstract: El síndrome de Churg Strauss, también llamado angeítis y granulomatosis alérgica, es un síndrome multisistémico caracterizado por rinitis alérgica, asma y eosinofilia importante en el extendido periférico. El órgano más comúnmente comprometido es el pulmón, seguido de la piel. Sin embargo, el síndrome de Churg Strauss puede afectar cualquier órgano sistema, incluyendo el sistema cardiovascular, el gastrointestinal, el renal y el sistema nervioso central. The Churg-Strauss syndrome, also called allergic granulomatosis and angiitis, is a multisystem disorder characterized by allergic rhinitis, asthma, and prominent peripheral blood eosinophilia. The most common organ involved is the lung, followed by the skin. The Churg-Strauss syndrome, however, can affect any organ system, including the cardiovascular, gastrointestinal, renal, and central nervous systems.
Churg–Strauss syndrome associated with antiphospholipid antibodies in a patient with recurrent myocardial and cerebral ischemia
Paroli M, Polidoro A, Romano S, Accapezzato D
International Medical Case Reports Journal , 2012, DOI: http://dx.doi.org/10.2147/IMCRJ.S37516
Abstract: rg–Strauss syndrome associated with antiphospholipid antibodies in a patient with recurrent myocardial and cerebral ischemia Case report (1045) Total Article Views Authors: Paroli M, Polidoro A, Romano S, Accapezzato D Published Date November 2012 Volume 2012:5 Pages 79 - 81 DOI: http://dx.doi.org/10.2147/IMCRJ.S37516 Received: 30 August 2012 Accepted: 02 October 2012 Published: 01 November 2012 Marino Paroli,1 Alessandro Polidoro,1 Simone Romano,1 Daniele Accapezzato2 1Department of Biotechnology and Medical-Surgical Sciences, 2Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy Abstract: We report on a case of Churg–Strauss syndrome (CSS) associated with the presence of antiphospholipid antibodies. The patient had a history of recurrent myocardial infarction and presented with acute ischemic cerebral disease. Eosinophilia with typical lung and skin lesions led us to diagnose the patient with CCS. We hypothesize that the presence of antiphospholipid antibodies significantly contributed to the ischemic events. We suggest that the search for antiphospholipid antibodies should be included in the laboratory work-up in CSS patients and patients affected by primary systemic vasculitides in general. Moreover, anticoagulant treatment appears to be warranted in all CSS patients and antiphospholipid antibodies to counteract this thrombosis-favoring association.
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