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Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a case report  [cached]
Garcia-Arnes Juan,Bernal-Lopez M,Gallego-Perales Jose,Vazquez-Camu?as M
Journal of Medical Case Reports , 2012, DOI: 10.1186/1752-1947-6-340
Abstract: Introduction Kikuchi-Fujimoto disease, or histiocytic necrotizing lymphadenitis, is a rare, benign, autoimmune condition characterized by lymphadenopathy, fever and neutropenia. It is a self-limited condition of unknown etiology. Case presentation We report the case of a 45-year-old Caucasian man with the first known case of Kikuchi disease associated with dramatic weight loss after bariatric surgery. Conclusion Although the association between Kikuchi disease and bariatric surgery may be entirely coincidental, we speculate whether the immune dysfunction associated with weight loss may have played an etiologic role in this process.
Linfadenitis necrotizante en lupus eritematoso sistémico y enfermedad de Kikuchi Fujimoto Necrotizing lymphadenitis in systemic lupus erythematosus and Kikuchi Fujimoto disease
Lizet Paola Moreno Moreno,Juan Martín Gutiérrez,Ana María Uribe
Revista Colombiana de Reumatología , 2011,
Abstract: La enfermedad de Kikuchi Fujimoto se caracteriza histológicamente por la presencia de linfadenitis necrotizante, que igualmente se encuentra descrita en Lupus Eritematosos Sistémico, con características clínicas y patológicas comunes que pueden sugerir una posible relación entre estas dos enfermedades. Es la enfermedad de Kikuchi Fujimoto una manifestación del Lupus Eritematoso Sistémico?. A continuación se presenta un caso de una mujer con Lupus Eritematoso Sistémico con linfadenitis necrotizante y linfadenopatía generalizada.
Linfadenitis necrotizante histiocitaria o enfermedad de Kikuchi-Fujimoto: A propósito de 2 observaciones Histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoti disease: Apropos of two observations  [cached]
Tamara Guerra Alfonso,Julio D. Fernández águila,Maritza Cabrera Zamora,Julián Viera Ya?iz
Revista Cubana de Medicina , 2007,
Abstract: La linfadenitis necrotizante histiocitaria o enfermedad de Kikuchi-Fujimoto es un proceso benigno poco frecuente. Se presentaron 2 casos diagnosticados con poco tiempo de aparición entre uno y otro. El primero fue una mujer blanca, de 26 a os, con astenia, pérdida de peso, sudación nocturna, escalofríos, prurito generalizado y anorexia. Al realizar examen clínico se demostró la presencia de adenopatías y en los exámenes de laboratorio no se halló nada significativo. Se obsevaron varias estructuras ganglionares peque as con preservación parcial de la citoarquitectura y cambios hiperplásticos ligeros. El segundo paciente, un hombre negro, de 34 a os, que se presentó con fiebre vespertina, escalofríos, odinofagia, cefalea y dolores articulares. Se observó orofaringe enrojecida con aumento del tama o de las amígdalas, sin exudados y adenopatías en la cadena lateral derecha del cuello y submaxilares. No se encontró ningún resultado anormal en los estudios de laboratorio y en el examen histológico del ganglio se observó preservación casi total de su arquitectura, con cambios hiperplásticos corticales y paracorticales. Se observó remisión clínica espontánea en ambos enfermos. Histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoti disease is a rare benign process. Two cases diagnosed with little time of appearance between one and other were presented. The first one was a 26-year-old white female with asthenia, weight loss, night sweating, chills, generalized pruritus and anorexia. On the physical examination, it was proved the presence of adenopathies, and nothing signficant was found in the lab tests. Various small ganglionar structures with partial preservation of the citoarchitecture and mild hyperplastic changes were observed. The second patient, a 34-year-old black male, presented morning fever, chills, odynophagia, headache and articular pain. It was deteced a reddened oropharynx with increase of the size of the tonsills , without exudates and adenopathies on the right lateral chain of the neck and submaxilla . No abnormal result was reported in the lab studies. In the histological examination of the ganglion, it was observed a nearly total preservation of its architecture, with hyperplastic cortical and paracortical changes. A spontaneous clinical remission was noticed in both patients.
Kikuchi-Fujimoto disease
Xavier Bosch, Antonio Guilabert
Orphanet Journal of Rare Diseases , 2006, DOI: 10.1186/1750-1172-1-18
Abstract: Kikuchi-Fujimoto diseaseKikuchi's diseaseHistiocytic necrotizing lymphadenitisKikuchi-Fujimoto disease (KFD) is an enigmatic, benign and self-limited syndrome characterized by regional lymphadenopathy with tenderness, predominantly in the cervical region, usually accompanied by mild fever and night sweats.Initially described in Japan, KFD was first reported in 1972 almost simultaneously by Kikuchi [1] and by Fujimoto et al. [2] as a lymphadenitis with focal proliferation of reticular cells accompanied by numerous histiocytes and extensive nuclear debris [3].Kikuchi-Fujimoto disease is an extremely rare disease known to have a worldwide distribution with a higher prevalence among Japanese and other Asiatic individuals [4]. Only isolated cases are reported in Europe. Affected patients are most often young adults under the age of 30 years; the disease is seldom reported in children. A female preponderance of cases has been underlined in the literature (female to male ratio 4:1). Recent reports seem to indicate that the female preponderance was overemphasized in the past and that the actual ratio is closer to 1:1 [4,5].There is much speculation about the etiology of KFD. A viral or autoimmune cause has been suggested. The role of Epstein-Barr virus, as well as other viruses (HHV6, HHV8, parvovirus B19) in the pathogenesis of KFD remains controversial and not convincingly demonstrated [4]. A viral infection is, nonetheless, possible by virtue of clinical manifestations, as described by Unger et al. [6] that include upper respiratory prodrome, atypical lymphocytosis and lack of response to antibiotic therapy, and certain histopathologic features (i.e., T-cells as revealed by immunological marker studies). KFD has also been recorded in HIV- and HTLV-1-positive patients [7].On the other hand, electron microscopic studies have identified tubular reticular structures in the cytoplasm of stimulated lymphocytes and histiocytes in patients with KFD [3]. Since these structures ha
Kikuchi-fujimoto disease  [PDF]
?oki? Milomir,Begovi? Vesna,Boji? Ivanko,Tasi? Olga
Vojnosanitetski Pregled , 2003, DOI: 10.2298/vsp0305625d
Abstract: Kikuchi-Fujimoto disease (KFD), also know as histiocytic necrotizing lymphadenitis, is a benign disorder characterized histologically by necrotic foci surrounded by histiocytic aggregates, and with the absence of neutrophils. KFD was recognized in Japan, where it was first described in 1972. The disease is most commonly affecting young women. The cause of the disease is unknown, and its exact pathogenesis has not yet been clarified. Many investigators have postulated viral etiology of KFD, connecting it with Epstein Barr virus, human herpes simplex virus 6 parvo B 19, but also with toxoplasmic infection. Kikuchi-Fujimoto disease is usually manifested with lymphadenopathy and high fever, and is associated with lymphopenia splenomegaly, and hepatomegaly with abnormal liver function tests arthralgia, and weight loss. The disease has the tendency of spontaneous remission, with mean duration of three months. Single recurrent episodes of KFD have been reported with many years’ pauses between the episodes. Kikuchi-Fujimoto disease may reflect systemic lupus erythematosus (SLE), and self-limited SLE-like conditions. Final diagnosis could only be established on the basis of typical morphological changes in the lymph node, and lymph node biopsy is needed for establishing the diagnosis. Lymphadenopathy in a patient with fever of the unknown origin could provide a clue to the diagnosis of lymphoma, tuberculosis, metastatic carcinoma, toxoplasmosis and infectious mononucleosis. As KFD does not have any classical clinical features and laboratory characteristics, it may lead to diagnostic confusion and erroneous treatment. We described a case of KFD, and suggested that this disease should be considered as a possible cause of fever of the unknown origin with lymphadenopathy.
Linfadenitis histiocítica necrosante (enfermedad de Kikuchi-Fujimoto)
Pallares-Trujillo, Vanessa Carolina;Hernández-Delgado, Lorena;Estrada-Moscoso, Isaías;Flores-Nava, Gerardo;Lavalle-Villalobos, Antonio;
Boletín médico del Hospital Infantil de México , 2005,
Abstract: introduction. kikuchi-fujimoto's disease is a histiocytic necrotizing lymphadenitis, not frequent in children. case report. nine year-old girl with history of fever, adenomegaly and loss of weight that required a lymph node biopsy which was interpreted as necrotizing lymphadenitis (kikuchi-fujimoto's disease), she responded to anti inflammatory medication but presented a relapse 5 years later. conclusion. kikuchi-fujimoto's disease should be suspected in the patients with fever, lymphadenitis, and weight loss after infectious and malignant etiologies have been ruled out. the definitive diagnosis is skin biopsy.
Enfermedad de Kikuchi-Fujimoto: estudio de cuatro casos
Montejo,M.; Lekerika,N.; Astigarraga,I.; Aguirrebengoa,K.; Goikoetxea,J.; Erdozain,J. G.; Bidaurrazaga,N.;
Anales de Medicina Interna , 2006, DOI: 10.4321/S0212-71992006000400006
Abstract: kikuchi fujimoto disease is an uncommon form of lymphadenitis, firstly described in japan. etiology is unknown. it affects mainly young women. it commonly manifests as a painful cervical lymphadenitis usually associated with fever and leukopenia. clinical course users to be benign, leading spontaneously to a complet recovery. histological findings include necrotizing changes with cariorrhesis, partial loss of ganglionar architecture and foci of histiocytic infiltrates in the cortical and/or paracortical zones of the lymph nodes. a common findings is the absence of neutrophil granulocytes in the inflammatory infiltrates, in contrast to other necrotizing lymphadenitis. we report four cases of kikuchi fujimoto disease, recently identified in our hospital.
Kikuchi-Fujimoto Disease in a 30-Year-Old Caucasian Female  [PDF]
David J. Archibald,Matthew L. Carlson,Ray O. Gustafson
International Journal of Otolaryngology , 2009, DOI: 10.1155/2009/901537
Abstract: Kikuchi-Fujimoto disease is a rare, self-limited, histiocytic, necrotizing lymphadenitis first described in Japan in 1972. Necrosis of lymph node tissue is caused by apoptosis and may be virally induced. It commonly presents with cervical lymphadenitis and fever. Despite its low incidence, Kikuchi-Fujimoto disease should be considered in patients with persistent lymphadenopathy. Originally thought to occur only in young Asian women, it is now recognized in other geographic regions. We report a 30-year-old white woman with Kikuchi-Fujimoto disease. We discuss the clinical features, differential diagnosis, radiography, pathology, and outcome.
Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV-positive patient
VASSALLO, José;COELHO FILHO, Jo?o Carlos;AMARAL, Vania Gondin Pires do;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2002, DOI: 10.1590/S0036-46652002000500006
Abstract: histiocytic necrotizing lymphadenitis, or kikuchi's lymphadenitis (kl), is an unusual form of lymphadenitis, generally with self-limited clinical course. kl has been reported in rare patients infected with the human immunodeficiency virus (hiv). pathogenesis of the lesion is probably related to an impaired immune function. the purpose of the present article is to report on one case in which kl was diagnosed in an hiv-infected patient. histomorphology and immunophenotype were similar to previous reports, but a focus of activated cd30+ macrophages was seen, what might be due to the immunological status of the patient. ebv was not detected on the sections using the in situ hybridization technique. although rare, the occurrence of kl in hiv-infected subjects must be emphasized, because of the potential misdiagnosis of malignancy, especially in the presence of cd30+ cells.
Histiocytic necrotizing lymphadenitis (Kikuchi lymphadenitis) in an HIV-positive patient  [cached]
VASSALLO José,COELHO FILHO Jo?o Carlos,AMARAL Vania Gondin Pires do
Revista do Instituto de Medicina Tropical de S?o Paulo , 2002,
Abstract: Histiocytic necrotizing lymphadenitis, or Kikuchi's lymphadenitis (KL), is an unusual form of lymphadenitis, generally with self-limited clinical course. KL has been reported in rare patients infected with the human immunodeficiency virus (HIV). Pathogenesis of the lesion is probably related to an impaired immune function. The purpose of the present article is to report on one case in which KL was diagnosed in an HIV-infected patient. Histomorphology and immunophenotype were similar to previous reports, but a focus of activated CD30+ macrophages was seen, what might be due to the immunological status of the patient. EBV was not detected on the sections using the in situ hybridization technique. Although rare, the occurrence of KL in HIV-infected subjects must be emphasized, because of the potential misdiagnosis of malignancy, especially in the presence of CD30+ cells.
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