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A review on studies of secondary metabolites from marine fungi
海洋真菌生物活性物质研究之管见

ZHU Wei-Ming,WANG Jun-Feng,
朱伟明
,王俊锋

菌物学报 , 2011,
Abstract: Marine fungi are a kind of important source for active marine natural products. Up to now, 1,117 new compounds have been isolated and identified from the fermentation broth of marine fungi. In this paper, the history, status quo, methods and issues in studying secondary metabolites from marine fungi are presented. The compounds originated from marine fungi and their perspective in drug discovery were also discussed.
Phylogenetic Identification of Fungi Isolated from the Marine Sponge Tethya aurantium and Identification of Their Secondary Metabolites  [PDF]
Jutta Wiese,Birgit Ohlendorf,Martina Blümel,Rolf Schmaljohann,Johannes F. Imhoff
Marine Drugs , 2011, DOI: 10.3390/md9040561
Abstract: Fungi associated with the marine sponge Tethya aurantium were isolated and identified by morphological criteria and phylogenetic analyses based on internal transcribed spacer (ITS) regions. They were evaluated with regard to their secondary metabolite profiles. Among the 81 isolates which were characterized, members of 21?genera were identified. Some genera like Acremonium, Aspergillus, Fusarium, Penicillium, Phoma, and Trichoderma are quite common, but we also isolated strains belonging to genera like Botryosphaeria, Epicoccum, Parasphaeosphaeria, and Tritirachium which have rarely been reported from sponges. Members affiliated to the genera Bartalinia and Volutella as well as to a presumably new Phoma species were first isolated from a sponge in this study. On the basis of their classification, strains were selected for analysis of their ability to produce natural products. In addition to a number of known compounds, several new natural products were identified. The scopularides and sorbifuranones have been described elsewhere. We have isolated four additional substances which have not been described so far. The new metabolite cillifuranone ( 1) was isolated from Penicillium chrysogenum strain LF066. The structure of cillifuranone ( 1) was elucidated based on 1D and 2D NMR analysis and turned out to be a previously postulated intermediate in sorbifuranone biosynthesis. Only minor antibiotic bioactivities of this compound were found so far.
Secondary metabolites from marine microorganisms
KELECOM, ALPHONSE;
Anais da Academia Brasileira de Ciências , 2002, DOI: 10.1590/S0001-37652002000100012
Abstract: after 40 years of intensive research, chemistry of marine natural products has become a mature field. since 1995, there are signals of decreased interest in the search of new metabolites from traditional sources such as macroalgae and octocorals, and the number of annual reports on marine sponges stabilized. on the contrary, metabolites from microorganisms is a rapidly growing field, due, at least in part, to the suspicion that a number of metabolites obtained from algae and invertebrates may be produced by associated microorganisms. studies are concerned with bacteria and fungi, isolated from seawater, sediments, algae, fish and mainly from marine invertebrates such as sponges, mollusks, tunicates, coelenterates and crustaceans. although it is still to early to define tendencies, it may be stated that the metabolites from microorganisms are in most cases quite different from those produced by the invertebrate hosts. nitrogenated metabolites predominate over acetate derivatives, and terpenes are uncommon. among the latter, sesquiterpenes, diterpenes and carotenes have been isolated; among nitrogenated metabolites, amides, cyclic peptides and indole alkaloids predominate.
Secondary metabolites from marine microorganisms  [cached]
KELECOM ALPHONSE
Anais da Academia Brasileira de Ciências , 2002,
Abstract: After 40 years of intensive research, chemistry of marine natural products has become a mature field. Since 1995, there are signals of decreased interest in the search of new metabolites from traditional sources such as macroalgae and octocorals, and the number of annual reports on marine sponges stabilized. On the contrary, metabolites from microorganisms is a rapidly growing field, due, at least in part, to the suspicion that a number of metabolites obtained from algae and invertebrates may be produced by associated microorganisms. Studies are concerned with bacteria and fungi, isolated from seawater, sediments, algae, fish and mainly from marine invertebrates such as sponges, mollusks, tunicates, coelenterates and crustaceans. Although it is still to early to define tendencies, it may be stated that the metabolites from microorganisms are in most cases quite different from those produced by the invertebrate hosts. Nitrogenated metabolites predominate over acetate derivatives, and terpenes are uncommon. Among the latter, sesquiterpenes, diterpenes and carotenes have been isolated; among nitrogenated metabolites, amides, cyclic peptides and indole alkaloids predominate.
SECONDARY METABOLITES FROM MARINE PENICILLIUM BREVICOMPACTUM
ROVIROSA,JUANA; DIAZ-MARRERO,ANA; DARIAS,JOSE; PAINEMAL,KARIN; SAN MARTIN,AURELIO;
Journal of the Chilean Chemical Society , 2006, DOI: 10.4067/S0717-97072006000100004
Abstract: in a screening of basidiomycete cultures isolated from marine invertebrates collected along the chilean coastline for the production of antibiotics we identified a penicillium brevicompactum strain as a producer of metabolites inhibiting the growth of bacteria and fungi. bioactivity guided purification resulted in the isolation of four known metabolites. their structures were elucidated by spectroscopic methods
SECONDARY METABOLITES FROM MARINE PENICILLIUM BREVICOMPACTUM  [cached]
JUANA ROVIROSA,ANA DIAZ-MARRERO,JOSE DARIAS,KARIN PAINEMAL
Journal of the Chilean Chemical Society , 2006,
Abstract: In a screening of Basidiomycete cultures isolated from marine invertebrates collected along the Chilean coastline for the production of antibiotics we identified a Penicillium brevicompactum strain as a producer of metabolites inhibiting the growth of bacteria and fungi. Bioactivity guided purification resulted in the isolation of four known metabolites. Their structures were elucidated by spectroscopic methods
Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea  [PDF]
Li-yang Tao,Jian-ye Zhang,Yong-ju Liang,Li-ming Chen,Li-sheng Zheng,Fang Wang,Yan-jun Mi,Zhi-gang She,Kenneth Kin Wah To,Yong-cheng Lin,Li-wu Fu
Marine Drugs , 2010, DOI: 10.3390/md8041094
Abstract: Marine-derived fungi provide plenty of structurally unique and biologically active secondary metabolites. We screened 87 marine products from mangrove fungi in the South China Sea for anticancer activity by MTT assay. 14% of the compounds (11/86) exhibited a potent activity against cancer in vitro. Importantly, some compounds such as compounds 78 and 81 appeared to be promising for treating cancer patients with multidrug resistance, which should encourage more efforts to isolate promising candidates for further development as clinically useful chemotherapeutic drugs. Furthermore, DNA intercalation was not involved in their anticancer activities, as determined by DNA binding assay. On the other hand, the structure-activity analysis indicated that the hydroxyl group was important for their cytotoxic activity and that bulky functional groups such as phenyl rings could result in a loss of biological activity, which will direct the further development of marine product-based derivatives.
Production of Bioactive Secondary Metabolites by Marine Vibrionaceae  [PDF]
Maria Mansson,Lone Gram,Thomas O. Larsen
Marine Drugs , 2011, DOI: 10.3390/md9091440
Abstract: Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to produce bioactive secondary metabolites and studies have been limited to only a few species. Most of the compounds isolated from vibrios so far are non-ribosomal peptides or hybrids thereof, with examples of N-containing compounds produced independent of nonribosomal peptide synthetases (NRPS). Though covering a limited chemical space, vibrios produce compounds with attractive biological activities, including antibacterial, anticancer, and antivirulence activities. This review highlights some of the most interesting structures from this group of bacteria. Many compounds found in vibrios have also been isolated from other distantly related bacteria. This cosmopolitan occurrence of metabolites indicates a high incidence of horizontal gene transfer, which raises interesting questions concerning the ecological function of some of these molecules. This account underlines the pending potential for exploring new bacterial sources of bioactive compounds and the challenges related to their investigation.
Diversity of Secondary Metabolites from Marine Bacillus Species: Chemistry and Biological Activity  [PDF]
Muhammad Abdul Mojid Mondol,Hee Jae Shin,Mohammad Tofazzal Islam
Marine Drugs , 2013, DOI: 10.3390/md11082846
Abstract: Marine Bacillus species produce versatile secondary metabolites including lipopeptides, polypeptides, macrolactones, fatty acids, polyketides, and isocoumarins. These structurally diverse compounds exhibit a wide range of biological activities, such as antimicrobial, anticancer, and antialgal activities. Some marine Bacillus strains can detoxify heavy metals through reduction processes and have the ability to produce carotenoids. The present article reviews the chemistry and biological activities of secondary metabolites from marine isolates. Side by side, the potential for application of these novel natural products from marine Bacillus strains as drugs, pesticides, carotenoids, and tools for the bioremediation of heavy metal toxicity are also discussed.
ANTIOXIDANT PROSPECTIVE AND SECONDARY METABOLITES IN ABUTILON INDICUM AT DIFFERENT ENVIRONMENT  [PDF]
Kandasamy Selvam et al.
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: To investigate the antioxidant property and secondary metabolites of Abutilon indicum Plant at various Habitats were compared with those of relevant callus cultures induced from every explant in in-vitro. The callus cultures were effectively initiated on Murashige and Skoog (MS) medium supplemented with 2, 4-D (1 mg/L) pooled with different concentrations (0.1–1.0 mg/L) of kinetin as plant growth regulators. The circulation of Flavonoids and phenolic compounds in the plant extracts were analyzed by using Aluminium (III) Chloride Colorimetric assay with standards. Flavonoids were found in all callus extracts in comparison with in their natural habitat plant parts at various Habitats. In this study, the antioxidant activities of the extracts were evaluated in vitro antioxidant-testing systems. The secondary metabolites of flavonoid and phenolic acid contents of Abutilon indicum were studied at dissimilar habitats and in-vitro callus culture extract. Among these studies hills and wet soil habit plants showed maximum secondary metabolites than the other habitats. The antioxidant potential was studied by dot blot assay. Between these results, we fulfilled that, the ecological stress factors such as dryness, temperature, salt and soil pH is a crucial factor for liberate secondary metabolites and antioxidant potent of Abutilon indicum.
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