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PENETAPAN STANDAR NASIONAL VAKSIN DIFTERI, PERTUSSIS, TETANUS: Penetapan Standar Nasional Toksoid Serap Difteri  [cached]
Muljati Prijanto,Sumarno Sumarno,Pudjo Prajitno
Bulletin of Health Research , 2012,
Abstract: To check the potency of DPT vaccine, standard preparations of the components, namely Adsorbed Diphtheria Toxoid, Pertussis Vaccine and Adsorbed Tetanus Toxoid, are needed. Since WHO International Standard Preparations are distributed only in limited amounts, WHO has suggested that each member country should develop a National Standard, which is matched against In-ternational Standard Preparation. An Indonesian National Standard of DPT vaccine (lot 1) has been prepared and lyophilized at the National Institute of Health in Tokyo. The potency of the National Standard of Adsorbed Diphtheria Toxoid is determined by antibody ti-tration in guinea pigs. Antitoxin titres are determined by cell culture method. After several experiments, the potency of the National Standard of Adsorbed Diphtheria Toxoid has been decided of being 59 IU/ml. Using the same standard preparations, namely the National Standards, it is hoped that from the same lot of DPT vaccine, similar results of potency could be achieved when determined by the Government Vaccine Quality Control laboratory and the Manufacturer's laboratory.
PENETAPAN STANDAR NASIONAL DARI VAKSIN DPT: Penetapan Standar Nasional Vaksin Pertussis  [cached]
Muljanti Prijanto
Bulletin of Health Research , 2012,
Abstract: To check the potency of DPT vaccine, standard preparations of the components, namely Adsorbed Diphtheria Toxoid, Pertussis Vaccine, and Adsorbed Tetanus Toxoid are necessary. Since WHO International Standard Preparations are distributed only in limited amounts, WHO has suggested that each member country shold develop a National Standard, which is to be matched with International Standard Preparations. An Indonesian National Standard of DPT vaccine (lot 1) has been prepared and lyophilized at the National Institute of Health in Tokyo. The potency of the National Standard of Pertussis Vaccine was determined by Active Mouse Protection Test (AMPT). After several experiments, the potency of the National Standard of Pertussis Vaccine has been decided of being 12 IU/ml. Using the same standard preparations, namely the National Standards, it is hoped that from a lot of DPT vaccine, similar results of potency could be achieved when determined by Government Vaccine Quality Control laboratory and the Manufacturer's laboratory.
EFEKTIVITAS VAKSINASI TOKSOID SERAP TETANUS PADA IBU-IBU HAMIL DAN BAYI YANG DILAHIRKANNYA, DI YOGYAKARTA  [cached]
Muljati Prijanto,Eko Suprijanto,Dyah Widianingrum I.,Haryanto Haryanto
Bulletin of Health Research , 2012,
Abstract: A study was carried out in 6 Kecamatans in Yogyakarta. A total of 56 and 163 blood samples were collected from 4—7 month pregnant women and mothers 17—35 years of age. The objectives of this study was to know the immune respons against tetanus after being vaccinated with tetanus toxoid adsorbed during pregnancy (a prospective study) and to know the decrease of the antibody level 1—4 years after vaccination (a retrospective study). Tetanus antitoxin titration was performed by passive haemaglutination (PHA) test. Tetanus toxoid adsorbed used in this study was produced by Biofarma, Bandung. Two immunization doses against tetanus with 1—2 months interval gives 100 % protection to the babies at birth, and at the age of 3 month the babies still have protective titres against tetanus. The percentage of mothers with tetanus protective titres decreased from 80,70 % to 53,57 % with the mean antibody titres decreased from 0.415 HAU/ml to 0.066 HAU/ml after 1—4 years vaccination.
EFEKTIVITAS IMUMSASI DPT PADA BAYI USIA 2 BULAN DI YOGYAKARTA: I. Efektivitas imunisasi toksoid serap difteri dan tetanus  [cached]
Muljati Prijanto,Rini Pangastuti,Dewi Parwati,Farida Siburian
Bulletin of Health Research , 2012,
Abstract: Since 1987 the Expanded Program on Immunization in Indonesia started to administer DPT and Polio vaccines in 2 month infants. The titer of maternal antibodies against diphtheria and tetanus in new born babies was high. The objective of this study is to determine the effectiveness of diphtheriae and tetanus toxoid of DPT vaccine administered in 2 months infant. The study was carried out in Tresnawati hospital in Yogyakarta. Samples of 83 of 2 month infants and 36 of 3 month infants were given 3 dozes of DPT vaccines. Blood was taken before and after immunization of DPT 1, 2 and 3. Antibodies against diphtheriae and tetanus were measured by passive haemaglutination test. The maternal antibody against diphtheriae was effected immune response after DPT 1 and DPT 2 and for tetanus after DPT 1. The percentage of protected infants and mean titer of tetanus in group of 2 month infants was lower than control but there was no significant difference between the 2 groups. They were protected 100% after DPT 2, and 3. The percentage of protected infants against diphtheriae before and after DPT 1, 2, 3 in the group of 2 month infants were 98,7%, 36,4%, 58,9 % and 83,6 % compared with 61,5%, 42,3%, 88,5% and 100%. There was significant difference between the 2 groups. There was a different effect of maternal antibodies between diphtheriae and tetanus. The high titer of diphtheriae antibody was caused by natural infection while the high titer tetanus was caused by immunization of TT given to their mothers during pregnancy. This study suggest the importance of avoiding drop out of DPT 3.
SURVEI KESEHATAN NASIONAL (SURKESNAS): Survei Terpadu Mendukung Indonesia Sehat 2010  [cached]
S. Soemantri,Supraptini Supraptini
Bulletin of Health Research , 2012,
Abstract: SURVEI KESEHATAN NASIONAL (SURKESNAS): Survei Terpadu Mendukung Indonesia Sehat 2010
ANALISIS MODEL PENETAPAN DANA ALOKASI KHUSUS NON DANA REBOISASI BIDANG KESEHATAN TAHUN ANGGARAN 2005  [cached]
Ana Sariasih,Wiku Adisasmito
Bulletin of Health Research , 2012,
Abstract: ANALISIS MODEL PENETAPAN DANA ALOKASI KHUSUS NON DANA REBOISASI BIDANG KESEHATAN TAHUN ANGGARAN 2005
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PELAKSANAAN DRAFT STANDAR PELAYANAN KEFARMASIAN DI APOTEK DI DKI JAKARTA  [cached]
Harianto Harianto,Angki Purwanti,Sudibyo Supardi
Bulletin of Health Research , 2012,
Abstract: FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PELAKSANAAN DRAFT STANDAR PELAYANAN KEFARMASIAN DI APOTEK DI DKI JAKARTA
PENETAPAN RESIDU DAN PERKIRAAN PENETAPAN BATAS MAKSIMUM RESIDU (BMR) ORGANOKLORIN PADA SIMPLISIA  [cached]
Ani Isnawati,Sukmayati Alegantina
Media of Health Research and Development , 2012,
Abstract: Penggunaaan bahan obat tradisional (simplisia) untuk skala industri dan peningkatan produksi tanaman obat dalam skala besar menjadi tidak ekonomis tanpa pestisida. Disatu sisi penggunaan pestisida dapat menguntungkan yaitu menyebabkan toksis pada hama namun disisi lain toksisitas dapat terjadi juga pada manusia, sehingga residu pestisida dalam tanaman obat yang dikonsumsi dalam jangka panjang akan merugikan kesehatan. Batas maksimum Residu (BMR) pestisida dalam simplisia baik di Indonesia maupun di negara lain belum ditetapkan. Sehingga untuk itu untuk mengetahui adanya residu pestisida jenis organoklorin yang telah dilarang penggunaannya melalui Permentan No.434.1/kpts/TP.270/7/2001 dan untuk mengetahui batas keamanannya, maka perlu dilakukan penetapan residu organoklorin dalam simplisia dan menetapkan batas keamanan berdasarkan perhitungan secara teoritis. Pengujian residu dilakukan terhadap golongan pestisida organoklorin pada 4 jenis simplisia (daun wungu (Graptophyllum pictum (L) Grifl), daun sambiloto Andrographis paniculata Ness), herba pegagan (Centella asiatica (L) Urban), daun tempuyung (Sonchus arvensis (L) yang berasal dari 3 lokasi penanaman, yaitu : perkebunan Tanaman Obat Manako (Jawa Barat), Balai Penelitian Tanaman Obat Tawangmangu (BPTO) di Jawa Tengah dan Perkebunan Tanaman Obat Purwodadi (Jawa Timur). Pemeriksaan residu pestisida organoklorin menggunakan kromatografi gas dan perhitungan batas keamanan dihitung dengan adanya nilai ADI (Acceptable daily intake) yang telah ditetapkan bersama antara JAO dan WHO serta perkiraan banyaknya konsumsi simplisia. Hasil Pengujian residu pestisida organoklorin diperoleh bahwa simplisia daun Wungu (Tawangmangu) mengandung residu lindan dengan kadar 0,24 mg/kg, pegagan (Purwodadi), mengandung lindan 0,36 mg/kg dan aldrin 0,31 mg/kg serta pegagan (Manako) mengandung heptaklor 0,15 mg/kg dan op-DDE 0,11 mg/kg. Adapun penghitungan BMR heptaklor dan lindan secara teoritis dengan asumsi rata-rata konsumsi jamu bungkus (Sachet) dengan pemakaian 2 kali sehari dan dikonsumsi selama 2 bulan dalam 1 tahun, maka diperoleh BMR heptaklor 0,05 mg/kg dan lindan 0,5 mg/kg. Untuk jenis pestisida lain yang positif tidak dapat dihitung karena tidak ada nilai ADJ.
PENETAPAN KADAR RESIDU SPIRAMISIN DALAM DAGING AYAM DI JAKARTA, CIBINONG DAN SUKABUMI  [cached]
Indri Rooslamiati
Media of Health Research and Development , 2012,
Abstract: Spiramisin adalah antibiotika golongan makrolida yang dapat digunakan untuk pengobatan maupun untuk pemacu pertumbuhan ternak. Penggunaan spiramisin dapat meninggalkan residu yang dapat merugikan kesehatan konsumen apabila waktu henti obat tidak dipatuhi. Penelitian ini dimaksudkan untuk mengetahui adanya perbedaan residu dalam daging ayam yang berasa! dari dua tempat berbeda yaitu pasar swalayan dan pasar tradisional yang berada di wilayah Jakarta, Bogar, Cibinong dan Sukabumi. Umur ayam 40 hari. Penetapan kadar residu spiramisin menggunakan metode Kromatografi Cair Kinerja Tinggi Hasil analisa menunjukkan adanya residu spiramisin pada contoh daging ayam tetapi tidak ada yang melebihi batas maksimum SNI No:01-6366-2000 yaitu 0,05 ppm. Kata kunci: spiramisin, residu, penetapan kadar
Abstrak Konggres dan Seminar Nasional Penggalang Taksonomi Tumbuhan Indonesia (PTTI) Universitas Sebelas Maret Surakarta, 19-20 Desember 2003  [PDF]
AHMAD DWI SETYAWAN
Biodiversitas , 2004,
Abstract: Abstrak Konggres dan Seminar Nasional Penggalang Taksonomi Tumbuhan Indonesia (PTTI) Universitas Sebelas Maret Surakarta, 19-20 Desember 2003
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