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PRELIMINARY PHYTOCHEMICAL SCREENING OF SEEDS OF PSORALEA CORYLIFOLIA  [PDF]
Mohammed RafiqKhan,Ranjini R
International Research Journal of Pharmacy , 2013,
Abstract: Psoralea corylifolia known as “Babchi” is a medicinal plant for the treatment of skin diseases. In India, indigenous herbal remedies such as Ayurveda and other Indian traditional medicines have since ancient times used plants in treatment of various disorders. In our present investigation preliminary phytochemical analysis of Psoralea corylifolia has been evaluated for the presence of bioactive constituents using various polarity solvents including hexane, butanol, ethanol and water. The phytochemical screening of the plant extracts revealed the presence of maximum compounds including carbohydrates, terpenoids, alkaloids, phenols, tannins, amino acid and proteins, cardiac glycosides. The results suggest that the ethanolic extract of Psoralea corylifolia has promising therapeutic potential and can be used as a base for the development of novel potent drugs in phytomedicine.
The Botany, Chemistry, Pharmacological and Therapeutic Application of Psoralea corylifolia L. – A Review  [cached]
Shilandra Kumar Uikey,A. S. Yadav,Ajit K. Sharma,Atul K. Rai
International Journal of Phytomedicine , 2011,
Abstract: Psoralea corylifolia Linn. is an endangered and medicinally important plant indigenous to tropical and subtropical regions of the world. Its medicinal usage is reported in Indian pharmaceutical codex, the Chinese, British and the American pharmacopoeias and in different traditional system of medicines such as Ayurveda, Unani and Siddha. The review reveals that wide ranges of phytochemical constituents have been isolated from the plant and it possesses important activities like antibacterial, anti-inflammatory and antitumer. Various other activities like hepatoprotective, antioxidants and antithelminitic have also been reported. These repots are very encouraging and indicate that herb should be studied more expensively for its therapeutic benefits.This article briefly reviews the botany, pharmacology, biochemistry and therapeutic application of the plant. This is an attempt to compile and document information on different aspects of Psoralea corylifolia and highlight the need for research and development. Keywords: - Psoralen, Isopsoralen, Pharmacological activities, Psoralea corylifolia Linn.
Isolation and identification of furocoumarins from the seeds of Psoralea corylifolia linn.  [cached]
Sah Pramilla,Agarwal D,Garg S
Indian Journal of Pharmaceutical Sciences , 2006,
Abstract: Isolation of isomeric furocoumarins from the seeds of Psoralea corylifolia Linn. (Family Leguminosae) is being reported for the first time from the variety found in western Rajasthan. On the basis of physical and spectral parameters, i.e., UV, IR, NMR, mass and chemical reactions such as hydrolysis, alkali fusion and oxidation, they have been identified as 2H-furo[3′,2′-g][1] benzopyran-2-one (1) and 2H-furo[2′,3′-h] [1-] benzopyran-2-one (2).
Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds
Yi Wang,Chengtao Hong,Chenguang Zhou,Dongmei Xu,Hai-bin Qu
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nen087
Abstract: Psoralea corylifolia L. (Fabaceae) is a widely used medical plant in China. This study was designed to screen and identify bioactive compounds with anticancer activity from the seeds of Psoralea corylifolia L. One volatile fraction (fraction I) and three other fractions (fraction II, III, IV) from methanol extraction of P. corylifolia L. were obtained. Bioactivities of these fractions were evaluated by the cytotoxicity on KB, KBv200, K562, K562/ADM cancer cells with MTT assay. Major components in the active fraction were identified by HPLC/MSn. Fraction IV significantly inhibits the growth of cancer cells in a dose-dependent manner. The IC50 values were 21.6, 24.4, 10.0 and 26.9, respectively. Psoralen and isopsoralen, isolated from fraction IV, were subject to bioactive assay and presented a dose-dependent anticancer activity in four cancer cell lines (KB, KBv200, K562 and K562/ADM). The IC50 values of psoralen were 88.1, 86.6, 24.4 and 62.6, which of isopsoralen were 61.9, 49.4, 49.6 and 72.0, respectively. Apoptosis of tumor cell significantly increased after treated with psoralen and isopsoralen. Induction of apoptotic activity was confirmed by flow cytometry after staining with Annexin V/PI. These results suggested psoralen and isopsoralen contribute to anticancer effect of P. corylifolia L.
STUDIES ON THE COMPOSITION AND STANDARDIZATION OF “BAKUCHI OIL”, AN AYURVEDIC MEDICINAL OIL PREPARED FROM PSORALEA CORYLIFOLIA L. USED IN THE TREATMENT OF VITILIGO
Abeysekera Ajita Mahendra,Gunaherath Kamal Bandara,Gunawardena Ajantha Rohinie,Jayaweera Champa Disala
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: “Bakuchi oil” is Ayurvedic medicinal oil prepared from the dried fruits of Psoralea corylifolia L. (Fabaceae) and Sesame oil is used widely in the treatment of vitiligo in Sri Lanka. The standardization of the oil is important for its safe and effective clinical use. A method was developed to quantitatively extract psoralen, the major photoactive compound in the oil and quantify it by TLC fluorodensitometry. The precision of the method was 4.3% CV (n = 6). A TLC fingerprint of the oil highlighting six fluorescent secondary metabolites of Psoralea corylifolia (psoralen, isopsoralen, corylin, psoralidin, dehydroisopsoralidin and isobavachalcone) was also developed. Of these dehydroisopsoralidin is being reported for the first time from a natural source. Analysis of the oil indicates that Bakuchiol, a major secondary metabolite of Psoralea corylifolia is not incorporated into the medicinal oil.
ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY OF HEXANE EXTRACT OF SEED OF PSORALEA CORYLIFOLIA LINN.  [cached]
Bina Gidwani
International Journal of Pharmaceutical Research and Development , 2010,
Abstract: The main objective of this study is to determine anti-inflammatory and antimicrobial activity of hexane extract of seeds of of Psoralea corylifolia Linn. Anti-inflammatory activity of Psoralea corylifolia Linn. was evaluated by carrageenan induced rat paw oedema assay. The seed of plant was extracted in soxhlet apparatus using hexane as solvent. Nine healthy swiss albino rats of either sex were divided into 3 groups, each consisting of 3 rats. The evaluation was done by Hind paw method and compared with standard and control groups. Further, the antimicrobial activity of Psoralea corylifolia Linn was studied by Disc diffusion method using different gram positive and gram negative bacterial and fungal strains, which showed that it has prominent activity compared with the standard used. The hexane extract of Psoralea Corylifolia showed significant anti- inflammatory activity (44%) when compared with the standard (55%). For antimicrobial activity, zone of inhibition were found to be in concentration of 5μg / ml for bacterial strains and 4μg / ml for fungal strains.
Induced High Frequency Shoot Regeneration and Enhanced Isoflavones Production in Psoralea corylifolia  [PDF]
Amit N. Shinde,Nutan Malpathak,Devanand P. Fulzele
Records of Natural Products , 2009,
Abstract: High frequency shoot regeneration and evaluation of product synthesis at various stages in Psoralea corylifolia were investigated. In vitro regenerated shoots were induced from germinated seedling on MS medium supplemented with 2, 4, 8, 20 and 40 μM of thidiazuron and N 6–benzylaminopurine. The results revealed that optimum concentrations of thidiazuron (8 μM) into the medium increased shoot regeneration frequency. Root differentiation was achieved from regenerated shoots on growth regulator free MS medium with frequency of 91.2% and mean number of 4.5 roots per shoot. High concentrations of Indole-3-aceticacid (IAA) into the rooting medium resulted in slow growth. Regenerated shoots and roots enhanced isoflavones production compared to field grown plants. A reverse phase high performance liquid chromatography analysis revealed that in vitro regenerated shoots accumulated 0.85% dry wt of daidzein and 0.06% dry wt of genistein. Maximum daidzein (1.23% dry wt) and genistein (0.38% dry wt) were accumulated by roots which obtained from regenerated shoots, which is 6.3-fold more daidzein and 77-fold more genistein respectively than field grown plants. The regeneration protocol developed successfully in this study showed the possibility for rapid propagation of P. corylifolia and enhanced isoflavones production.
Chemical Composition and Insecticidal Activity of Essential oil obtained from DCM Extracts of Psoralea corylifolia against Agricultural pest  [cached]
Monika Gupta,Aditi Gupta,Sudhakar Gupta
Current World Environment , 2013, DOI: http://dx.doi.org/10.12944/cwe.8.2.18
Abstract: The insecticidal activity of essential oils obtained from DCM extracts of Psoralea corylifolia (Fabaceae) against pupa of Epilachna insect was investigated in a series of laboratory experiments. Insecticidal activity was determined at 24 ± 4 C and 68 ± 5% R.H., in dark conditions. The DCM extracts of the dried seeds of the plants were subjected to Column chromatography and the oil obtained was then subjected to hydrodistillation using a Clevenger type apparatus. The major components in these essential oils are identified using GC-MS spectroscopy and their insecticidal activity was tested. The predominant components in the oil of Psoralea corylifolia are toluene, alpha-pinene, L-beta-pinene, beta-pinene, 3-carene, limonene, Gamma terpinene, terpinolene, alpha santolina alcohol, 4-terpineol, Cyclohexene, 1-methyl-4-(1-methyl ethenyl), caryophyllene, alpha caryophyllene, thumbergene. The mortality rate of the agricultural pests was checked against 1%, 5% and 10% conc. of essential oil. The essential oil from Psoralea corylifolia shows strong toxic effect against pupa of Epilachna insect. Finding insecticidal activity is of great importance as using plant extracts as insecticides, are biodegrable and do not leave toxic residues results in better crop and better human health.
ANTIMICROBIAL AND ANTIOXIDANT SYNERGY OF PSORALEA CORYLIFOLIA LINN. AND PLUMBAGO ZEYLANICA LINN.  [PDF]
P. Suman , P.V. Smitha , K.Y. Ramkumar , A. Siva , Ch. Murali Mohan and S. Hara Sreeramulu*
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: Objectives: Psoralea corylifolia L. (seeds) and Plumbago zeylanica L. (bark) were combined in the ratio of 8: 2 and named as “Swithranasini” and used for the treatment of skin diseases in ayurvedic medicine. Scientific studies validating the therapeutic properties for this indigenous medicine are lacking. This study focused on determining antimicrobial efficacy of methanol and butter milk extracts along with antioxidant efficacies of these plant parts independently and in combination. Materials and Methods: Antimicrobial activity was tested against seven pathogenic bacteria and six pathogenic fungi by measuring the zone of inhibition. In vitro antioxidant activities were assayed by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method and Ferric reducing antioxidant power (FRAP) method. Results: Individual extracts of the two plants showed better zone of inhibition (12- 40 mm) when applied alone but the activity was more when applied in combination (18-50 mm) against the tested pathogens. DPPH activity of methanol extracts showed higher radical scavenging activity when compared with the positive control, ascorbic acid. The IC50 values are 442.080, 457.825, 432.040 and 394.563 ug/ml for A, B, A+B and ascorbic acid respectively. The FRAP method also showed excellent antioxidant potential in combination (85.454 mg of Gallic acid equivalents/g) when compared with individual extracts A (78.571 mg GAE/g) and B (75.472 mg GAE/g).Conclusion: The results validate the potent use of “Swithranasini” against skin infections and results are an evidence for the existence of synergism among the compounds.
Effects of serum containing Fructus Cnidii and Psoralea corylifolia on highly metastatic human breast cancer cell line MDA-MB-231BO and bone marrow stromal cell line ST-2  [cached]
Sheng Liu
Zhong Xi Yi Jie He Xue Bao , 2010,
Abstract: Objective: To explore the effects of different proportions of Fructus Cnidii (Shechuangzi) and Psoralea corylifolia (Buguzhi) on highly metastatic human breast cancer cell line MDA-MB-231BO and bone marrow stromal cell line ST-2 in vitro.Methods: Thirty-six female SD rats were randomly divided into 6 groups to prepare the drug-medicated sera by administering with different proportions of Fructus Cnidii and Psoralea corylifolia, including 4︰0 group, 3︰1 group, 1︰1 group, 1︰3 group, 0︰4 group and control group. MDA-MB-231BO cells and ST-2 cells were cultured in Dulbecco’s modified Eagle’s medium containing drug-medicated serum. Inhibition rates of MDA-MB-231BO cells and ST-2 cells were measured by methyl thiazolyl tetrazolium (MTT) method; migration ability of MDA-MB-231BO cells was tested by a cell migration experiment; alkaline phosphatase activity (ALP) of ST-2 cells was measured by using 4-nitrophenyl phosphate disodium salt, and mineralized nodule formation of ST-2 cells was measured by alizarin red staining.Results: Sera contaning different proportions of Fructus Cnidii and Psoralea corylifolia inhibited the migration activity of MDA-MB-231BO cells as compared with the blank serum, and serum contaning Fructus Cnidii and Psoralea Corylifolia at proportion of 1︰1 had the best function (P<0.01). Fructus Cnidii and Psoralea corylifolia at ratio of 1︰1 also enhanced the ALP activity of ST2 cells (P<0.05) and increased the number of mineralized nodules of ST2 cells (P<0.01).Conclusion: Kidney-warming recipe of Fructus Cnidii and Psoralea corylifolia can inhibit proliferation and migration of MDA-MB-231BO cells and increase the activity of ST-2 cells.
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