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Primary Transitional Cell Carcinoma of the Fallopian Tube  [cached]
Kavita Mardi,Vijay Kaushal
Online Journal of Health & Allied Sciences , 2012,
Abstract: Primary carcinoma of the fallopian tube is a rare entity that accounts for 0.2-0.5% of all gynecologic malignancies, and most are discovered during or after surgery. Primary transitional cell carcinoma of the fallopian tube is an extremely rare tumor that is reported only occasionally in the worldwide literature. As primary transitional cell carcinoma (TCC) of the fallopian tube is so rare, the clinicopathologic characteristics are as yet unknown. The authors recently experienced a case of primary transitional cell carcinoma arising in the left fallopian tube and thus report the clinical features, management, and also a review of the past pertinent literature. A 52 years old woman presenting with lower abdominal pain was found to have a left adnexal mass. Exploratory laparotomy revealed a mass arising from the left fallopian tube with the histologic features of transitional cell carcinoma.
Prognostic Value of Mitotic Index and Bcl2 Expression in Male Breast Cancer  [PDF]
Miangela M. Lacle, Carmen van der Pol, Arjen Witkamp, Elsken van der Wall, Paul J. van Diest
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060138
Abstract: The incidence of male breast cancer (MBC) is rising. Current treatment regimens for MBC are extrapolated from female breast cancer (FBC), based on the assumption that FBC prognostic features and therapeutic targets can be extrapolated to MBC. However, there is yet little evidence that prognostic features that have been developed and established in FBC are applicable to MBC as well. In a recent study on FBC, a combination of mitotic index and Bcl2 expression proved to be of strong prognostic value. Previous papers on Bcl2 expression in MBC were equivocal, and the prognostic value of Bcl2 combined with mitotic index has not been studied in MBC. The aim of the present study was therefore to investigate the prognostic value of Bcl2 in combination with mitotic index in MBC. Immunohistochemical staining for Bcl2 was performed on tissue microarrays of a total of 151 male breast cancer cases. Mitotic index was scored. The prognostic value of Bcl2 expression and Bcl2/mitotic index combinations was evaluated studying their correlations with clinicopathologic features and their prediction of survival. The vast majority of MBC (94%) showed Bcl2 expression, more frequently than previously described for FBC. Bcl2 expression had no significant associations with clinicopathologic features such as tumor size, mitotic count and grade. In univariate survival analysis, Bcl2 had no prognostic value, and showed no additional prognostic value to tumor size and histological grade in Cox regression. In addition, the Bcl2/mitotic index combination as opposed to FBC did not predict survival in MBC. In conclusion, Bcl2 expression is common in MBC, but is not associated with major clinicopathologic features and, in contrast to FBC, does not seem to have prognostic value, also when combined with mitotic index.
Inmunohistochemical expression of p53, Bcl-2, COX-2, C-erb-B2, EPO-R, ?-catenin, and E-cadherin in non tumoral gastric mucous membrane  [cached]
M Sereno,MA García-Cabezas,J De Castro,P Cejas
European Journal of Histochemistry , 2006, DOI: 10.4081/998
Abstract: Different authors have investigated the immunohistochemical expression of some proteins in the adenocarcinoma of the stomach, including cell cycle regulators proteins like p53 and Bcl-2; growth factors (c-erb-B2 and EPO-R); angiogenesis- related markers such as COX-2 and cellular adhesion molecules (?-catenin and E-cadherin). While these proteins have been studied in gastric adenocarcinoma, their immunophenotyping in non tumoral gastric mucous membrane remains unexplored. In the present study, we investigated the expression, function and behavior of these proteins in normal gastric mucous membrane to contribute to gain further knowledge on the significance of their loss or overexpression in malignant gastric tumors.
The Association between Smoking and Ectopic Pregnancy: Why Nicotine Is BAD for Your Fallopian Tube  [PDF]
Andrew W. Horne, Jeremy K. Brown, Junko Nio-Kobayashi, Hazirah B. Z. Abidin, Zety E. H. A. Adin, Lyndsey Boswell, Stewart Burgess, Kai-Fai Lee, W. Colin Duncan
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089400
Abstract: Epidemiological studies have shown that cigarette smoking is a major risk factor for tubal ectopic pregnancy but the reason for this remains unclear. Here, we set out to determine the effect of smoking on Fallopian tube gene expression. An oviductal epithelial cell line (OE-E6/E7) and explants of human Fallopian tubes from non-pregnant women (n = 6) were exposed to physiologically relevant concentrations of cotinine, the principle metabolite of nicotine, and changes in gene expression analyzed using the Illumina Human HT-12 array. Cotinine sensitive genes identified through this process were then localized and quantified in Fallopian tube biopsies from non-pregnant smokers (n = 10) and non-smokers (n = 11) using immunohistochemistry and TaqMan RT-PCR. The principle cotinine induced change in gene expression detected by the array analysis in both explants and the cell line was significant down regulation (P<0.05) of the pro-apoptotic gene BAD. We therefore assessed the effect of smoking on cell turnover in retrospectively collected human samples. Consistent with the array data, smoking was associated with decreased levels of BAD transcript (P<0.01) and increased levels of BCL2 transcript (P<0.05) in Fallopian tube biopsies. BAD and BCL2 specific immunolabelling was localized to Fallopian tube epithelium. Although no other significant differences in levels of apoptosis or cell cycle associated proteins were observed, smoking was associated with significant changes in the morphology of the Fallopian tube epithelium (P<0.05). These results suggest that smoking may alter tubal epithelial cell turnover and is associated with structural, as well as functional, changes that may contribute to the development of ectopic pregnancy.
A Rare Case Of Fallopian Tube Cancer  [cached]
Joydeb Roychowdhury,Madhavi Panpalia
Online Journal of Health & Allied Sciences , 2008,
Abstract: Fallopian tube carcinoma is a very rare malignancy and we report a case of stage IIC primary fallopian tube cancer.
Isolated fallopian tube torsion in pregnancy: Case report
Ebru Akbay,Nadire Sevda ?dil,Levent Yazar,Cihangir Uzun?akmak
Medical Journal of Bakirk?y , 2009,
Abstract: Isolated torsion of the fallopian tube is a very rare condition. It occurs without ipsilateral ovarian involvement associated with pregnancy, haemosalpinx, hydrosalphinx, ovarian or paraovarian cysts and other adnexal alterations or even with an otherwise normal fallopian tube. We presented a case of isolated torsion of the right fallopian tube. The ipsilateral ovary appeared normal, but the fallopian tube was gangrenous and right salpingectomy was performed. Isolated torsion of the fallopian tube should be considered in the differential diagnosis of patients with acute abdomen and previous medical history of hydrosalphinx.
Primary Squamous Cell Carcinoma of the Fallopian Tube- Report of a Case and Short Review of Primary Malignancies of the Fallopian Tube  [cached]
Dr. Rama Srivastava,Professor N. Hariharanadha Sarma
Internet Journal of Medical Update - EJOURNAL , 2007,
Abstract: Primary squamous cell carcinoma of the fallopian tube is the rarest of all the gynecological malignancies, which is often diagnosed as a benign entity or as ovarian pathology. We present the fourth case of primary squamous cell carcinoma of the fallopian tube in the English language literature. The clinicopathological characteristics of the primary malignancies of the fallopian tube are also briefly reviewed.
Primary fallopian tube carcinoma.  [cached]
Pardeshi S,Kulkarni M,Hishikar V
Journal of Postgraduate Medicine , 1996,
Abstract: Although Fallopian tubes are frequently involved in benign gynaecological conditions, primary malignant involvement is rare, and because of its rarity, lack of diagnostic accuracy, nonpresenting symptoms and physical findings, primary fallopian tube carcinoma is seldom diagnosed before laparotomy. We are reporting one such rare case.
Duplication of the fallopian tube  [cached]
Narayanan R,Rajeev M
Journal of Human Reproductive Sciences , 2008,
Abstract: Hysterosalpingography accurately delineates the uterine and tubal lumen, and hence is routinely performed for the evaluation of infertility.We observed a case of infertility where uterine cavity was normal but fallopian tubes were bifurcated at the ampullary region. Mullerian duct anomalies are reported in literature, but maldevelopment of fallopian tube in isolation is rare. This abnormality can present as infertility, ectopic pregnancy, in association with urinary tract anomalies or as failure of sterilisation method.
Primary Fallopian Tube Serous Adenocarcinoma  [PDF]
Swasti,Urvashi P. Jha,Sumaid Kaul
JK Science : Journal of Medical Education & Research , 2008,
Abstract: Tumours of the fallopian tube can be suspected pre-operatively with current radiological facilities. Aggressivesearch should also be made for a concomitant primary or as an isolated metastatic secondary of anotherprimary cancer. Presentation and management on the lines of ovarian cancer in a 79 year old with primaryfallopian tube cancer is described.
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