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Simultaneous chickenpox and measles infection among migrant children who stayed in Italy during the second half of June 2011  [cached]
Igor Ivi?-Hofman,Ante Cvitkovi?,Bernard Kai?,Tatjana Vilibi?-?avlek
Clinics and Practice , 2011, DOI: 10.4081/cp.2011.e113
Abstract: We are reporting on a household outbreak of measles, in which cases of simultaneous measles and chickenpox infection occured in children of a family who resided in Italy during the incubation period (June 2011). In three children, fever and generalized confluent macular rash were the dominant symptoms. Serology testing revealed simultaneous measles and chickenpox infection in four children.
Association of the shuffling of Streptococcus pyogenes clones and the fluctuation of scarlet fever cases between 2000 and 2006 in central Taiwan
Chien-Shun Chiou, You-Wun Wang, Pei-Ling Chen, Wan-Ling Wang, Ping-Fuai Wu, Hsiao-Lun Wei
BMC Microbiology , 2009, DOI: 10.1186/1471-2180-9-115
Abstract: A total of 23 emm types were identified in 1,218 S. pyogenes isolates. The five most prevalent emm types were emm12 (50.4%), emm4 (23.2%), emm1 (16.4%), emm6 (3.8%) and emm22 (3.0%). PFGE analysis with SmaI suggested that, with a few exceptions, strains with a common emm type belonged to the same clone. There were two large emm12 clones, one with DNA resistant to cleavage by SmaI. Each prevalent emm clone had major PFGE strain(s) and many minor strains. Most of the minor strains emerged in the population and disappeared soon after. Even some major strains remained prevalent for only 2–3 years before declining. The large fluctuation of scarlet fever cases between 2000 and 2006 was associated with the shuffling of six prevalent emm clones. In 2003, the dramatic drop in scarlet fever cases in central Taiwan and throughout the whole country was associated with the occurrence of a severe acute respiratory syndrome (SARS) outbreak that occurred between late-February and mid-June in Taiwan.The occurrences of scarlet fever in central Taiwan in 2000–2006 were primarily caused by five emm types, which accounted for 96.8% of the isolates collected. Most of the S. pyogenes strains (as defined by PFGE genotypes) emerged and lasted for only a few years. The fluctuation in the number of scarlet fever cases during the seven years can be primarily attributed to the shuffling of six prevalent emm clones and to the SARS outbreak in 2003.Streptococcus pyogenes (Group A streptococcus) is a common pathogen responsible for a number of human suppurative infections, including pharyngitis, impetigo, pyoderma, erysipelas, cellulitis, necrotizing fasciitis, toxic streptococcal syndrome, scarlet fever, septicemia, pneumonia and meningitis. It also causes non-suppurative sequelae, including acute rheumatic fever, acute glomerulonephritis and acute arthritis [1]. Scarlet fever, characterized by a sore throat, skin rash and strawberry tongue, is most prevalent in school children aged four to seven
Chickenpox Pneumonia
Ayperen Kundurac?o?lu,Sibel Ay?k,Ay?e ?zs?z,Aydan ?akan
Turk Toraks Dergisi , 2009,
Abstract: Chickenpox is a mild progressive disease mostly seen in childhood which iscaused by varicella zoster. It is characterized byfever and rashes in childhood. Pneumonia is one of the most serious complications of chickenpox seen during the course of the disease in adults. For adults, the incidence of varicella pneumonia is 0.25-1.8%. Tachypnea, cough, fever and dyspnea are the most common symptoms. Two female cases, 46 and 34 years old were admitted to our clinic with complaints of cough, dyspnea, tachypnea and mild vesicular skin rashes. Bilateral nodular infiltrations were established on radiological examination. These two cases, diagnosed as varicella pneumonia by clinical and radiological findings, are reported due to their uncommon occurrence.
The Complete Genome Sequence of Yersinia pseudotuberculosis IP31758, the Causative Agent of Far East Scarlet-Like Fever  [PDF]
Mark Eppinger,M. J Rosovitz,Wolfgang Florian Fricke,David A Rasko,Galina Kokorina,Corinne Fayolle,Luther E Lindler,Elisabeth Carniel,Jacques Ravel
PLOS Genetics , 2007, DOI: 10.1371/journal.pgen.0030142
Abstract: The first reported Far East scarlet-like fever (FESLF) epidemic swept the Pacific coastal region of Russia in the late 1950s. Symptoms of the severe infection included erythematous skin rash and desquamation, exanthema, hyperhemic tongue, and a toxic shock syndrome. The term FESLF was coined for the infection because it shares clinical presentations with scarlet fever caused by group A streptococci. The causative agent was later identified as Yersinia pseudotuberculosis, although the range of morbidities was vastly different from classical pseudotuberculosis symptoms. To understand the origin and emergence of the peculiar clinical features of FESLF, we have sequenced the genome of the FESLF-causing strain Y. pseudotuberculosis IP31758 and compared it with that of another Y. pseudotuberculosis strain, IP32953, which causes classical gastrointestinal symptoms. The unique gene pool of Y pseudotuberculosis IP31758 accounts for more than 260 strain-specific genes and introduces individual physiological capabilities and virulence determinants, with a significant proportion horizontally acquired that likely originated from Enterobacteriaceae and other soil-dwelling bacteria that persist in the same ecological niche. The mobile genome pool includes two novel plasmids phylogenetically unrelated to all currently reported Yersinia plasmids. An icm/dot type IVB secretion system, shared only with the intracellular persisting pathogens of the order Legionellales, was found on the larger plasmid and could contribute to scarlatinoid fever symptoms in patients due to the introduction of immunomodulatory and immunosuppressive capabilities. We determined the common and unique traits resulting from genome evolution and speciation within the genus Yersinia and drew a more accurate species border between Y. pseudotuberculosis and Y. pestis. In contrast to the lack of genetic diversity observed in the evolutionary young descending Y. pestis lineage, the population genetics of Y. pseudotuberculosis is more heterogenous. Both Y. pseudotuberculosis strains IP31758 and the previously sequenced Y. pseudotuberculosis strain IP32953 have evolved by the acquisition of specific plasmids and by the horizontal acquisition and incorporation of different genetic information into the chromosome, which all together or independently seems to potentially impact the phenotypic adaptation of these two strains.
Multifocal choroiditis following simultaneous hepatitis A, typhoid, and yellow fever vaccination  [cached]
Escott S,Tarabishy AB,Davidorf FH
Clinical Ophthalmology , 2013,
Abstract: Sarah Escott, Ahmad B Tarabishy, Frederick H DavidorfHavener Eye Institute, The Ohio State University, Columbus, OH, USAAbstract: The paper describes the first reported case of multifocal choroiditis following simultaneous hepatitis-A, typhoid, and yellow fever vaccinations. A 33-year-old male developed sudden onset of flashing lights and floaters in his right eye 3 weeks following hepatitis A, typhoid, and yellow fever vaccinations. Fundus examination and angiography confirmed the presence of multiple peripheral chorioretinal lesions. These lesions demonstrated characteristic morphologic changes over a period of 8 weeks which were consistent with a diagnosis of self-resolving multifocal choroiditis. Vaccine-induced intraocular inflammation has been described infrequently. We demonstrate the first case of self-resolving multifocal choroiditis following simultaneous administration of hepatitis A, yellow fever, and typhoid immunizations.Keywords: multifocal choroiditis, vaccination, hepatitis A, typhoid, yellow fever
Investigation of Streptococcus pyogenes Carriage in Population Vulnerable to Scarlet Fever during 2015-2017 in Shanghai, China  [PDF]
Mingliang Chen, Chi Zhang, Dechuan Kong, Hao Pan, Xi Zhang, Min Chen
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.611009
Abstract:
This study aimed to investigate the carriage of Streptococcus pyogenes in population vulnerable to scarlet fever and to compare their genotypic characterization between different age groups. Pharyngeal swabs were collected from 120 - 150 students in each of the three districts in Shanghai in May and December during 2015 to 2017, while emm typing and detection of 12 superantigen genes were performed to characterize the isolates. During 2015-2017, the average carriage rate in students was 5.7% (135/2,371), without significant difference between different years or districts. The carriage rate was significantly different between children from the three age groups, with 2.4% in 3 - 4 years, 5.4% in 5 - 9 years, and 9.1% in 10 - 14 years. Eight emm types were found, including emm 1, emm 4, emm 12, emm 22, emm 75, emm 89, emm 70 and emm 241, among which emm 12 accounted for 60%, and emm 1 27.5%. The predominance of emm 12 was found in each year, but the proportion of emm 12 was lower in 10 - 14 years (43.3%) than in 3 - 4 years (86.7%) and in 5 - 9 years (73.3%) (P = 0.002 and 0.003). Superantigen genes of speB, speC, speG, ssa and smeZ were found in almost all the isolates. The average carriage of S. pyogenes in population vulnerable to scarlet fever was 5.7% in Shanghai, highest in 10 - 14 years (9.1%), while emm 12 was the predominant type.
113例儿童猩红热临床特征分析
Clinical Analysis of 113 Cases with Scarlet Fever in Children
 [PDF]

黄辉, 邓莉, 黄立勇, 温雯, 王恒伟, 郑崇光
Asian Case Reports in Pediatrics (ACRP) , 2016, DOI: 10.12677/ACRP.2016.43003
Abstract:
目的:分析近年儿童猩红热的临床特征。方法:对113例有发热皮疹等临床表现并经咽拭子培养A组β型溶血性链球菌阳性的儿童猩红热确诊病例的临床特征进行回顾性分析。结果:113例患儿中男70例,女43例,4~7岁年龄段儿童占77.9%;90例有发热,占79.6%;全部患儿均有皮疹,典型充血性鸡皮样粟粒疹73例(64.6%),口腔黏膜明显充血83例(73.4%),口周苍白圈14例(12.4%),巴氏线20例(17.7%);皮疹以躯干部位最为常见,占91.2%;首诊临床诊断为“猩红热”14例;全部患儿均未出现严重并发症表现。结论:学龄前期及学龄期儿童是猩红热的高发人群,临床症状趋于轻症化、不典型化,临床缺少快速实验室诊断方法,易延误早期临床诊治。除典型皮疹外,口腔黏膜明显充血可能是猩红热的早期表现之一,可进一步深入研究。
Objective: To analyze the clinical features of scarlet fever in children. Methods: The medical rec-ords of 113 cases with fever and erythema that had been confirmed scarlet fever by bacterial culture of throat swab were analyzed retrospectively. Results: In total, 113 cases of scarlet fever in children with etiological diagnosis were analyzed, including 70 males and 43 females. Age distribution ranged from 1 to 12 years, including 88 cases (77.9%) of 4 - 7 years old group. 90 cases (79.6%) have fever. All have erythema and 73 cases (64.6%) with the typical congestive chicken- skin miliary erythema. 83 cases (73.4%) have obviously congestion on oral mucosa; 14 cases (12.4%) have cicumoral pallor and 20 cases (17.7%) have Pastia’s lines. 103 cases (91.2%) have erythema at trunk. 14 cases of primary diagnosis have scarlet fever. There is no severe complication in all cases. Conclusions: The high risk populations of scarlet fever are pre-school and school children. The clinical symptoms tend to slightly and atypical. There are no rapid laboratory methods to diagnose, and hardly to diagnose and treat early. Obviously congestion on oral mucosa is an early clinical manifestation of scarlet fever except for typical erythema, and should be intensely researched.
Multifocal choroiditis following simultaneous hepatitis A, typhoid, and yellow fever vaccination
Escott S, Tarabishy AB, Davidorf FH
Clinical Ophthalmology , 2013, DOI: http://dx.doi.org/10.2147/OPTH.S37443
Abstract: ltifocal choroiditis following simultaneous hepatitis A, typhoid, and yellow fever vaccination Case report (466) Total Article Views Authors: Escott S, Tarabishy AB, Davidorf FH Published Date February 2013 Volume 2013:7 Pages 363 - 365 DOI: http://dx.doi.org/10.2147/OPTH.S37443 Received: 28 August 2012 Accepted: 22 September 2012 Published: 18 February 2013 Sarah Escott, Ahmad B Tarabishy, Frederick H Davidorf Havener Eye Institute, The Ohio State University, Columbus, OH, USA Abstract: The paper describes the first reported case of multifocal choroiditis following simultaneous hepatitis-A, typhoid, and yellow fever vaccinations. A 33-year-old male developed sudden onset of flashing lights and floaters in his right eye 3 weeks following hepatitis A, typhoid, and yellow fever vaccinations. Fundus examination and angiography confirmed the presence of multiple peripheral chorioretinal lesions. These lesions demonstrated characteristic morphologic changes over a period of 8 weeks which were consistent with a diagnosis of self-resolving multifocal choroiditis. Vaccine-induced intraocular inflammation has been described infrequently. We demonstrate the first case of self-resolving multifocal choroiditis following simultaneous administration of hepatitis A, yellow fever, and typhoid immunizations.
A notable reason for fever of unknown origin: Adult onset still disease  [PDF]
Levent Alt?ntop,Engin Kut,Fatih Mehmet ?ilingir,Abdurrahim Y?ld?r?m
Journal of Clinical and Experimental Investigations , 2013,
Abstract: Fever of unknown origin is a symptom that is recognizedin all medical branches. Even though fever is a symptomof infectious diseases, not all fever cases are related withinfectious diseases. In the event of long term fever, besidethe infectious diseases, collagen tissue lesions andmalignancies must also be recognized.1 Here, we presenttwo adult-onset Still disease patients who were diagnosedwith fever of unknown origin. Our aim is to point outthe importance of remembering adult-onset Still diseasein patients who were diagnosed with fever of unknownorigin. J Clin Exp Invest 2013; 4 (1): 119-122Key words: Fever of unknown origin, adult onset still disease,collagen tissue
Hemorrhagic Chickenpox  [cached]
sengupta B,Sarkar J N,Sharma M K,Bhattacharya P
Indian Journal of Dermatology , 1995,
Abstract: A case of chickenpox in a boy of 16 years is described for its uncommon presentation with hemorrhagic vesicles, gum-bleeding without being preceded by any prodromal symptom and unassociated with any immunosuppressive disorder.
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