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Comparison of implant stability after different implant surface treatments in dog bone
Kim, Sun-Jong;Kim, Myung-Rae;Rim, Jae-Suk;Chung, Sung-Min;Shin, Sang-Wan;
Journal of Applied Oral Science , 2010, DOI: 10.1590/S1678-77572010000400016
Abstract: objectives: the purpose of this investigation was to evaluate the effects of different implant surface treatments on implant stability in dog mandibles. material and methods: a total of 30 implants (dentium co, seoul, korea) were placed in 5 dog mandibles. bone quality was assessed at each site. implant stability was evaluated using 2 different methods. an osstelltm resonance frequency analyzer (rfa) was used to determine the stability at baseline (day 1), and 3, 6 and 10 weeks after surgery. animals were euthanized 10 weeks after implant installation. specimens were obtained and submitted to the laboratory processing. sections were stained with hematoxylin and eosin for histologic and histomorphometric analyses. all implantation sites in dog mandibles demonstrated bone types ii and iii. results and conclusions: all implants showed good primary stability at baseline in terms of insertion torque. the results of this study suggest that surface treatment may have significant effects on biological stability 3 weeks after implant placement. further studies are needed to confirm these initial observations in poor quality bone.
Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features
Fredrik Mertens, Salvatore Romeo, Judith VMG Bovée, Roberto Tirabosco, Nick Athanasou, Marco Alberghini, Pancras CW Hogendoorn, Angelo P Dei Tos, Raf Sciot, Henryk A Domanski, Kristina ?str?m, Nils Mandahl, Maria Debiec-Rychter
Clinical Sarcoma Research , 2011, DOI: 10.1186/2045-3329-1-10
Abstract: In the present study, the cytogenetic data on 11 of these tumors (three myoepithelioma-like sarcomas, two leiomyosarcomas, one undifferentiated pleomorphic sarcoma with incomplete myogenic differentiation, two undifferentiated pleomorphic sarcomas, one osteosarcoma, one spindle cell sarcoma, and one unclassifiable biphasic sarcoma) are presented.All tumors were high-grade lesions and showed very complex karyotypes. Neither the overall pattern (ploidy level, degree of complexity) nor specific cytogenetic features distinguished any of the subtypes. The subgroup of myoepithelioma-like sarcomas was further investigated with regard to the status of the EWSR1 and FUS loci; however, no rearrangement was found. Nor was any particular aberration that could differentiate any of the subtypes from osteosarcomas detected.chromosome banding analysis is unlikely to reveal potential genotype-phenotype correlations between morphologic subtypes among so-called MFH of bone.Only some decades ago, malignant fibrous histiocytoma (MFH) was considered the most common soft tissue sarcoma among adults. However, with the introduction of more stringent morphologic and immunohistochemical criteria, it turned out that it was possible to reclassify the vast majority of those tumors as, e.g., poorly differentiated leiomyosarcomas or dedifferentiated liposarcomas [1]. For the few cases in which no signs of differentiation could be discerned, the term undifferentiated pleomorphic sarcoma (UPS) was introduced [2,3]. Importantly, the subclassification of MFH tumors into different lineages of differentiation was shown to be of prognostic significance, with immunohistochemical expression of smooth muscle actin (incomplete myogenic differentiation) being associated with worse outcome [4].In the latest edition of the WHO classification of soft tissue and bone tumors [2], the new view on MFH tumors was introduced for the soft tissue lesions [3], but not for bone tumors [5]. According to the WHO description
Microbiological and physicochemical treatments applied to metallurgic industry aiming water reuse
Bello, Antonio Roberto Crystal;Angelis, Dejanira de Franceschi de;Domingos, Roberto Naves;
Brazilian Archives of Biology and Technology , 2008, DOI: 10.1590/S1516-89132008000200020
Abstract: a study was conducted on the reuse of the water in a system composed of a sewage treatment plant (stp) using prolonged aeration with activated sludge and a compact water treatment plant (cwtp) in a metallurgic industry. the processes for obtaining the water for reuse were microbiological and physicochemical. the domestic sewage was then pumped to the stp, where biological flocks were formed and clarified water was obtained. the efficiency of the microbiological process in the stp was evaluated for removal of biochemical oxygen demand (bod), chemical oxygen demand (cod) and sedimentary solids (ss). the efficiency of physicochemical processes for clarifying the water and disinfection was evaluated through analysis of ph, turbidity, color, aerobic heterotrophic bacterial count, free chlorine, hardness, alkalinity, chlorides, sulfates and dissolved total solids (dts). in the reuse of the water, acute toxicity for the microcrustaceans daphnia similis was also evaluated.
Cerebral Metastases from Malignant Fibrous Histiocytoma of Bone  [PDF]
Susanne J. Rogers,Jeremy S. Whelan
Sarcoma , 2000, DOI: 10.1080/13577140020008093
Abstract: Four patients with malignant fibrous histiocytoma of bone (MFH-B) metastasizing to brain are reported. In two cases, signs of cerebral involvement developed between 4 and 28 months after diagnosis. Both patients had known pulmonary or bony metastases. As a consequence of this experience, two further patients were subsequently identified, one with a definite cerebral metastasis and one who had an asymptomatic supratentorial lesion, possibly metastatic. It is suggested that patients with MFH-B and widespread metastatic disease at presentation or developing within a short interval should undergo cerebral imaging.
Primary malignant bone tumour in a tropical African University Teaching Hospital
AB Omololu, JO Ogunbiyi, SO Ogunlade, TO Alonge, A Adebisi, EE Akang
West African Journal of Medicine , 2002,
Abstract: Bone tumours are relatively rare tumours as compared with all other tumours. The relative frequency has not been well documented in this environment. The aim of the study was to define the frequency of primary malignant bone tumours in an African University teaching hospital in Ibadan. The medical records of 114 patients with malignant bone tumours recorded in the Cancer Registry of the University College Hospital, Ibadan, Nigeria between January 1977 and December 2000 were reviewed retrospectively. Primary malignant bone tumours represented 0.53% of all the 21390 cancers seen in the teaching hospital in the period studied, with a male female ratio of 1.4:1. About 45% of tumours occurred among patients<20 years of age. Osteogenic sarcoma was the most common primary malignant bone tumour while the mandible was the most commonly affected bone. In contrast to previous studies, Burkitt's lymphoma affected the mandible more commonly than the maxilla. The relative frequency of primary malignant bone tumours is low in our environment as observed in other developing countries.
Clinicopathological Correlation of Primary Malignant Bone Tumors—An Observational Study  [PDF]
Palash Bhattacharya, Anadi Roy Chowdhury, Bhaskar Mitra, Biswanath Paul
Open Journal of Orthopedics (OJO) , 2015, DOI: 10.4236/ojo.2015.54013
Abstract: Background: Primary malignant tumors arising from bone are uncommon but important malignant neoplasms which account for 0.2% of all primary cancers in adults and approximately 5% of all childhood malignancies. Aim: No comprehensive surveillance data about primary malignant bone tumors is available from this region of West Bengal in the literature. An attempt is undertaken to correlate clinicopathological findings, both histological & cytological features of primary bone tumours. Method: This observational study of clinical presentation was corroborated with cytology and histopathology of 67 cases of primary malignant bone tumors in 2005-2007 in a tertiary health care centre. Results: Among the primary malignant tumors, 39 cases (58.20%) were male and 28 (41.80%) were female. Sixty one lesions (91%) were located in the long bones and 6 (9%) involving flat and short bones. Osteosarcomas are found to be the predominant primary malignant bone tumors (44.77%), followed by Ewing’s sarcomas (20.89%), chondrosarcomas (13.43%), high grade giant cell tumor, and plasmacytoma (5.97%). Predilection for male (M: F 2:1) found in both osteosarcoma and chondrosarcoma, but it was reverse in cases of Ewing’s sarcomas. Conclusion: Osteosarcoma is the most common around knee joint and chondrosarcoma is frequent in long bones in this region. We made an attempt to correlate FNAC findings with the histopathology and it was seen that overall sensitivity of FNAC of primary malignant bone tumors was 56.71%.
Biological Reconstruction Following the Resection of Malignant Bone Tumors of the Pelvis  [PDF]
Frank Traub,Dimosthenis Andreou,Maya Niethard,Carmen Tiedke,Mathias Werner,Per-Ulf Tunn
Sarcoma , 2013, DOI: 10.1155/2013/745360
Abstract: Background. Surgical treatment of malignant pelvic bone tumors can be very challenging. The objective of this retrospective study was to evaluate the oncological as well as the clinical and functional outcome after limb salvage surgery and biological reconstruction. Methods. The files of 27 patients with malignant pelvic bone tumors, who underwent surgical resection at our department between 2000 and 2011, were retrospectively analyzed (9 Ewing's sarcoma, 8 chondrosarcoma, 4 osteosarcoma, 1 synovial sarcoma, 1 malignant fibrous histiocytoma, and 4 carcinoma metastases). Results. After internal hemipelvectomy reconstruction was performed by hip transposition ( ), using autologous nonvascularised fibular graft ( ) or autologous iliac crest bone graft ( ). In one patient a proximal femor prothetis and in three patients a total hip prosthesis was implanted at the time of resection. The median follow-up was 33 months. Two- and five-year disease-specific survival rates of all patients were 86.1% and 57.7%, respectively. The mean functional MSTS score was 16.5 (~55%) for all patients. Conclusion. On the basis of the oncological as well as the clinical and functional outcome, biological reconstruction after internal hemipelvectomy seems to be a reliable technique for treating patients with a malignant pelvic bone tumor. 1. Introduction Chondrosarcomas, Ewing’s sarcomas, and osteosarcomas are the most common primary bone sarcomas of the pelvis and account for 5% to 10% of all malignant bone tumors.[1, 2]. The prognosis and survival of patients with bone sarcomas in this location are much less favorable than for patients with tumors of the extremities. Additionally the pelvis is the second most common site of bone metastases after the spine. The treatment of malignant bone tumors involving the pelvis is a great challenge to the orthopaedic surgeon in terms of local control owing to the complexity of pelvic anatomy, which increases the difficulty of resection and reconstruction. First attempts to excise malignant bone tumors of the pelvis were reported by Enneking in 1966 [3] and Steel in 1978 [4]. Resection of the tumor can be performed either by internal or external hemipelvectomy. Pelvic resections have been classified by the Musculoskeletal Tumor Society into 4 resection types: type I (iliac), type II (periacetabular), type III (os pubis, ischii), and type IV (sacrum) [5–8]; see also Figure 1. Figure 1: A Classification of pelvic resection [ 5]. Because of the improvements in imaging modalities and in multimodal treatment plans, leading to a prolonged patient
Comparison of Aerobic and Lime Stabilization Methods for Evaluation of Sewage Sludge Reuse  [PDF]
Akram Jamal,Nafise Norieh,Mahdi Farzadkia
Journal of Environmental Science and Technology , 2011,
Abstract: The main objective of this research was the examination of effectiveness of lime dose in order to stabilization of sewage sludge and comparison of lime stabilized sludge reuse with aerobic digested sludge reuse. Lime and aerobic stabilization were carried out in two laboratory reactor with 40 L capacity. The sludge samples were taken from the return activated sludge line in four times. Lime was used at various ratios and the mixture was stabilized for 30 days. During the lime hydrated stabilization pH values were significantly increased from 7 to 12.5. Also, aerobic digester was loaded with raw sludge and mixed by sufficient amount of air for 30 days. The results indicate that the lime addition with the dose of 0.4 g Ca(OH)2 g-1 DS could completely inactive a high amount of fecal coliforms within 1 h and in all of the times was lower than 1000 MPN g-1 DS after 30 days (p<0.01). But after 30 days, fecal coliforms density in aerobic digested sludge could not achieve to Class A of USEPA category. In two stabilization methods, density of viable helminths ova could not reduce to 1 ova/4 g DS and could not achieve to Class A of USEPA category. Therefore, these methods could be achieved the reduction requirement set by USEPA for class B (p<0.01) and the products could be well used as a landfill cover or a soil conditioner. Finally, our study confirmed that lime sludge stabilization has a higher hygienic effect and more cost-effective than aerobic stabilization, specially, when such sludge is used to dung and modify acid soils.
Profile of Malignant Bone Tumors among Rheumatology Inpatients in Lome (Togo)  [PDF]
Kodjo Kakpovi, Prénam Houzou, Eyram Fianyo, Messanvi Kpoti, Viwalé E. S. Koffi-Tessio, Komi C. Tagbor, Owonayo Oniankitan, Moustafa Mijiyawa
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2016, DOI: 10.4236/ojra.2016.63009
Abstract: Background: The reel impact of malignant bone tumors in adults seems unclear in Black Africa. Aim: The aim of this study is to determine the epidemiological and the semiological profile of malignant bone tumors in rheumatology inpatients at Hospital University Center Sylvanus Olympio in Lome. Methods: It was a retrospective study of recorded cases conducted over a period of 19 years in the rheumatology department at Hospital University center Sylvanus Olympio in Lome, Togo. Results: One hundred and sixty-six patients (68 women and 98 men) suffered from a bone tumor. The average age of patients was 55 years old with some extremes cases of 14 and 98 years old. The most affected age group was the one between 46 and 55 years old (40 cases, 24.1%). The disease’s average duration was 17 months. These tumors were primary in 43 cases (26%) and secondary in 123 (74%). Metastases were those of prostate (44 cases, 35.7%), breast (12 cases, 9.7%), bronchus (7 cases, 5.7%), cervix (5.7%), and liver (2 cases, 1.6%). Myeloma (34 cases; 79.0%) and osteosarcoma (9 cases; 20.9%) were the main primary malignant bone tumors. However, 41 cases (33.3%) of malignant bone tumors had not been able to label. The spine was the predilection part for all above-mentioned tumors. Conclusion: This study shows the significant part occupied by malignant bone tumors in musculoskeletal diseases within the sub-Saharan population in general and Togo in particular.
Comparison of Calcitonin and Pamidronate Treatments in Children with Osteogenesis Imperfecta  [cached]
Neslihan Onenli Mungan,Fatih Gurbuz,Eda Mengen,Ozden Ozgur
Cukurova Medical Journal , 2013,
Abstract: Purpose: The main objective of this study was to compare the treatments of calcitonin and pamidronate by clinical, biochemical, and radiological findings in children with osteogenesis imperfecta and evaluate the efficiency of pamidronate treatment. Patients and methods: A total of 12 patients, aged 41±38 (1-120) months were studied. Group 1 was consisted of six patients who had received intranasal calcitonin at a dosage of 4-6 U/kg three times a week before switching to pamidronate treatment. Group 2 was also consisted of six patients who had received only pamidronate infusion at a dosage of 0.5-2 mg/kg every two months. Results: Annual fracture rates decreased from 2.72 ± 0.80 to 0.40 ± 0.70 (p<0.05) in group 1, from 3.50 ± 0.54 to 0.40 ± 0.49 (p<0.001) in group 2, and from 4.50 ± 3.30 to 0.32 ± 0.41 (p<0.001) in total 12 patients. The Z-score of bone mineral density increased from -4.12 ± -0.60 to -3.80 ± -1.0 in calcitonin group (p>0.05), and from -3.08 ± -0.61 to -2.29 ± -0.56 in pamidronate group. The difference between the Z-scores of bone mineral density after calcitonin and pamidronate treatments was statistically significant (p<0.05). The Z-scores of pre (-3.44 ± -0.96) and post (-2.47 ± -0.60) pamidronate treatments of whole 12 patients were significantly different (p<0.001). Conclusion: Pamidronate was significantly more effective in reducing pain, annual fracture rate, and increasing bone mineral density and mobility than calcitonin without any severe adverse effects even in the neonatal period and severe forms of osteogenesis imperfecta. [Cukurova Med J 2013; 38(4.000): 667-674]
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