oalib
Search Results: 1 - 10 of 100 matches for " "
All listed articles are free for downloading (OA Articles)
Page 1 /100
Display every page Item
Aktuelles: Rechtzeitige Insulintherapie  [PDF]
Abrahamian H
Journal für Klinische Endokrinologie und Stoffwechsel , 2010,
Abstract:
Beginn und Dosisanpassung einer intensivierten konventionellen Insulintherapie (ICT) beim Erwachsenen  [PDF]
Lohr R,Hauke D,Lechner A
Journal für Klinische Endokrinologie und Stoffwechsel , 2012,
Abstract: Eine intensivierte Insulintherapie (ICT) ist die Behandlung der Wahl bei Diabetes mellitus Typ 1 und auch bei vielen Menschen mit insulinpflichtigem Typ-2-Diabetes. Bei Therapiebeginn müssen individuell Insuline ausgew hlt und die richtige Dosierung festgelegt werden. Im weiteren Verlauf ist dann die Anpassung der Insulintherapie an besondere Alltagssituationen wie Sport oder akute Erkrankungen vorrangig. Eine gute Patientenschulung und eine gute Zusammenarbeit zwischen Betroffenem und Behandlerteam sind entscheidend, um diese komplizierte Therapie erfolgreich umzusetzen.
Biphasisches Insulinaspart 70 (BIAsp 70, NovoMix(R) 70) in der intensivierten konventionellen Insulintherapie bei Typ-2-Diabetes: Eine sterreichische Anwendungsbeobachtung  [PDF]
Francesconi C,Ebenbichler C,Benesch M,Prager R
Journal für Klinische Endokrinologie und Stoffwechsel , 2009,
Abstract: Insulin NovoMix 70 ist ein modernes biphasisches Insulin. Durch eine neue Zusammensetzung des kurz- und langwirksamen Anteils (70 % schnellwirksames Insulin und 30 % langwirkende Insulinaspart-Protamin-Kristalle) ist es nun m glich, eine bereits existierende Insulin-Therapie zu intensivieren oder eine moderne Mischinsulin-Therapie patientengerecht anzupassen. Die Ergebnisse zahlreicher klinischer Studien und bisherige klinische Erfahrungen stellen folgende therapeutische Vorteile von NovoMix 70 in den Vordergrund: ● Einfache Intensivierung der Insulintherapie. ● Vergleichbare Wirksamkeit wie unter Basis- Bolus-Therapie beim Typ-2-Diabetes [1, 2]. ● Individuelle Therapie (Monotherapie oder in Kombination mit NovoMix 30 [2] bzw. in Kombination mit Metformin). ● Physiologische Zusammensetzung der schnellwirkenden und langsamen Insulinkomponenten (Bolus- und Basis-Insulin in einem Insulinprodukt). ● Gute Wirksamkeit bezogen auf postprandiale Blutzuckeranstiege [1]. ● Mahlzeitbezogene Injektion (unmittelbar davor, w hrend oder nach der Hauptmahlzeit). ● Kein Bedarf für Zwischenmahlzeiten bessere Gewichtskontrolle m glich. ● Verabreichung mit NovoPen 4. ● Kostengünstige und effiziente Insulintherapie. Die NovoMix 70-Anwendungsbeobachtung ist eine Beobachtungsstudie (Anwendungsbeobachtung nach § 2 des sterreichischen Arzneimittelgesetzes) mit dem Ziel, das Konzept der modernen konventionellen Insulintherapie mit NovoMix 70 Penfill (mit NovoPen 4) bei Typ-2-Diabetikern im klinischen Alltag zu untersuchen. Neben den Wirksamkeits- und Vertr glichkeitsparametern wurde der Therapieerfolg, beurteilt durch Arzt und Patient, untersucht. Insgesamt nahmen w hrend einer durchschnittlichen Beobachtungsdauer von 91 Tagen 619 Patienten mit Diabetes mellitus Typ 2 teil. 48,1 % der Teilnehmer waren m nnlich und 51,1 % weiblich (0,8% ohne Geschlechtsangabe). Die Teilnehmer hatten ein Durchschnittsalter von 63,4 Jahren, eine Diabetesdauer von 12,8 Jahren und einen mittleren HbA1c von 9,3 %.
Proinsulin: from hormonal precursor to neuroprotective factor  [PDF]
Enrique J. de la Rosa,Flora de Pablo
Frontiers in Molecular Neuroscience , 2011, DOI: 10.3389/fnmol.2011.00020
Abstract: In the last decade, non-canonical functions have been described for several molecules with hormone-like activities in different stages of vertebrate development. Since its purification in the 1960s, proinsulin has been one of the best described hormonal precursors, though it has been overwhelmingly studied in the context of insulin, the mature protein secreted by the pancreas. Beginning with our discovery of the presence and precise regulation of proinsulin mRNA in early neurulation and neurogenesis, we uncovered a role for proinsulin in cell survival in the developing nervous system. We subsequently demonstrated the ability of proinsulin to prevent pathological cell death and delay photoreceptor degeneration in a mouse model of retinitis pigmentosa. In this review, we focus on the evolution of proinsulin/insulin, beginning with insulin-like peptides expressed in mainly the neurosecretory cells of some invertebrates. We summarize findings related to the regulation of proinsulin expression during development and discuss the possible effects of proinsulin in neural cells or tissue, and its potential as a neuroprotective molecule.
Association between proinsulin, insulin, proinsulin/insulin ratio, and insulin resistance status with the metabolic syndrome
Pivatto, Ivana;Bustos, Patricia;Amigo, Hugo;Acosta, Ana Maria;Arteaga, Antonio;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2007, DOI: 10.1590/S0004-27302007000700016
Abstract: the metabolic syndrome (ms) constitutes an independent risk factor of cardiovascular disease. there is evidence that proinsulin blood levels and the proinsulin/insulin ratio are associated to the ms. the purpose of this study was to compare proinsulin and insulin, insulin resistance index, and the proinsulin/insulin ratio as predictors of ms. this is a cross-sectional study involving 440 men and 556 women with a mean age of 24 years. diagnosis of ms was made according to the national cholesterol education program adult treatment panel iii. blood levels of insulin and proinsulin were measured, and the insulin resistance status was estimated using the homeostatic model assessment (homa-ir). the prevalence of ms was 10.1%. homa-ir was the best ms risk factor for both women and men (or = 2.04; 95% ci: 1.68-2.48 and 1.09; 95% ci: 1.05-1.13, respectively). homa-ir presented the best positive predictive value for ms: 22% and 36% for men and women, respectively, and was the best ms indicator. the proinsulin/insulin ratio did not show significant association with ms. homa-ir, proinsulin, and insulin presented good negative predictive values for both genders that could be used to identify an at-risk population.
Aktuelles: Humalog(R) Mix25: Der leichte Einstieg in die Insulintherapie  [PDF]
Woisetschl?ger C
Journal für Klinische Endokrinologie und Stoffwechsel , 2010,
Abstract:
The Proinsulin C-peptide—A Multirole Model  [PDF]
Donald F. Steiner
Experimental Diabetes Research , 2004, DOI: 10.1080/15438600490424389
Abstract: The C-peptide links the insulin A and B chains in proinsulin, providing thereby a means to promote their efficient folding and assembly in the endoplasmic reticulum during insulin biosynthesis. It then facilitates the intracellular transport, sorting, and proteolytic processing of proinsulin into biologically active insulin in the maturing secretory granules of the β cells. These manifold functions impose significant constraints on the C-peptide structure that are conserved in evolution. After cleavage of proinsulin, the intact C-peptide is stored with insulin in the soluble phase of the secretory granules and is subsequently released in equimolar amounts with insulin, providing a useful independent indicator of insulin secretion. This brief review highlights many aspects of its roles in biosynthesis, as a prelude to consideration of its possible additional role(s) as a physiologically active peptide after its release with insulin into the circulation in vivo.
Associations of age with serum insulin, proinsulin and the proinsulin-to-insulin ratio: a cross-sectional study
Bente Bryhni, Egil Arnesen, Trond G Jenssen
BMC Endocrine Disorders , 2010, DOI: 10.1186/1472-6823-10-21
Abstract: In the Troms? Study 1994-95 we measured insulin and proinsulin concentrations in random blood samples from 6212 persons without self-reported diabetes mellitus and plotted the levels as percentiles according to age. In regression analyses we assessed the relationships between age and insulin, proinsulin, and proinsulin/insulin, while adjusting for the concomitant measurements of glucose and other metabolic variables, and the time since the last meal.Median insulin concentrations declined significantly with advancing age group in men, but not in women. Proinsulin levels and proinsulin/insulin increased across age groups in both genders. After adjustment, greater age was associated with lower log10(insulin) and higher log10(proinsulin) and log10(proinsulin/insulin) (p = 0.0001 for all).Negative associations of age with random insulin levels, together with positive associations of age with proinsulin and proinsulin/insulin, point towards a loss of beta cell function inherent in the ageing process.The prevalence of abnormal glucose tolerance and diabetes mellitus increases with age [1-3]. For example, the age-specific prevalences of diabetes in Europe were less than 10% in subjects younger than 60 years, but between 10 and 20% in subjects 60-79 years of age [3]. A prerequisite for the development of impaired glucose tolerance (IGT) and type 2 diabetes is a decline in the capacity of the islet cells to secrete insulin. This deterioration of beta cell function prevents an adequate up-regulation of insulin secretion to compensate for insulin resistance [4].Insulin release is reported to diminish with increasing age [5]. This decrease could involve a reduction in islet mass, but could also be caused by a functional impairment of the beta cells with ageing. A decline in post-challenge insulin levels with advancing age has been observed in population studies [6,7]. Although this finding could reflect beta cell failure in ageing, it might also be due to alterations in diet or
Ladungssicherung – ein aktuelles Thema
Ralf Wunderlich,Gerrit Hasselmann
Logistics Journal : Nicht-referierte Ver?ffentlichungen , 2004,
Abstract: Ladungssicherung ist derzeit ein aktuelles Thema mit einer hohen Brisanz. Schon kleine Fehler in diesem Bereich k nnen gro e Sch den ausl sen. Verst rkte Forschungsaktivit ten führen zu neuen Erkenntnissen, die in zukünftigen Ma nahmen Berücksichtigung finden sollten. Dies trifft auch für die Ladungssicherung von Betonfertigteilen zu.Load securing presently is a very important issue. Small acts of negligence may lead to great damage. Recent research activities revealed new facts which should be considered when future measures are taken. This also concerns the securing of precast concrete elements.
Specific insulin and proinsulin secretion in glucokinase-deficient individuals
Pardini, V.C.;Velho, G.;Reis, R.;Purisch, S.;Blanché, H.;Vieira, J.G.H.;Moisés, R.C.S.;
Brazilian Journal of Medical and Biological Research , 1999, DOI: 10.1590/S0100-879X1999000400008
Abstract: glucokinase (gck) is an enzyme that regulates insulin secretion, keeping glucose levels within a narrow range. mutations in the glucokinase gene cause a rare form of diabetes called maturity-onset diabetes of the young (mody). an early onset (less than 25 years), autosomal dominant inheritance and low insulin secretion stimulated by glucose characterize mody patients. specific insulin and proinsulin were measured in serum by immunofluorimetric assays (ifma) during a 75-g oral glucose tolerance test (ogtt). two kindreds (sa and lz) were studied and compared to non-diabetic unrelated individuals (control group 1) matched for age and body mass index (bmi). in one kindred, some of these subjects were also obese (bmi >26 kg/m2), and other family members also presented with obesity and/or late-onset niddm. the mody patients were also compared to a group of five of their first-degree relatives with obesity and/or late-onset niddm. the proinsulin profile was different in members of the two mody kindreds. fasting proinsulin and the proinsulin/insulin ratio were similar in mody members of kindred lz and subjects from control group 1, but were significantly lower than in mody members of kindred sa (p<0.02 and p<0.01, for proinsulin and proinsulin/insulin ratio, respectively). moreover, mody members of family sa had higher levels of proinsulin and proinsulin/insulin ratio, although not significantly different, when compared to their first-degree relatives and to subjects from control group 2. in conclusion, we observed variable degrees of proinsulin levels and proinsulin/insulin ratio in mody members of two different kindreds. the higher values of these parameters found in mody and non-mody members of kindred sa is probably related to the obesity and late-onset niddm background present in this family.
Page 1 /100
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.