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Consistencia interna, estructura factorial y confiabilidad del constructo de la Escala de Yesavage para depresión geriátrica (GDS-15) en Cartagena (Colombia)  [cached]
Adalberto Campo-Arias,Yorjany Urruchurtu Mendoza,Tharim Solano Morales,Alí José Vergara Pino
Revista Salud Uninorte , 2008,
Abstract: Mortality, APACHE II, ventilator-associated pneumonia, central venous catheter-associated sepsis, urinary catheter-associated sepsis.
Comparison of single versus multiple doses of antibiotic prophylaxis in reducing post-elective Caesarean section infectious morbidity  [PDF]
A Shakya,J Sharma
Kathmandu University Medical Journal , 2010, DOI: 10.3126/kumj.v8i2.3554
Abstract: Background: Puerperal sepsis is frequently in Caesarean section. Antibiotic prophylaxis may have significant impact in reduction of infections and thus the need to study its role in sepsis prevention systematically.
Sepse, sepse grave e choque séptico: aspectos clínicos, epidemiológicos e prognóstico em pacientes de Unidade de Terapia Intensiva de um Hospital Universitário
Carvalho, Renan Henrique de;Vieira, Janaína Fernandes;Gontijo Filho, Paulo Pinto;Ribas, Rosineide Marques;
Revista da Sociedade Brasileira de Medicina Tropical , 2010, DOI: 10.1590/S0037-86822010000500025
Abstract: introduction: sepsis is considered to be a severe disease with high mortality. the objective of this study was to determine the incidence and evolution of sepsis among critically ill patients. methods: prospective surveillance of sepsis was performed in the adult intensive care unit, between april and december 2007. results: the patient frequency/day was 442. seventy-five patients (18.6%) had sepsis and 72% of these cases were hospital-acquired. the rates of severe sepsis and septic shock per patient/day were 5.0 and 3.1, respectively. the total mortality was 34.6% and 61% of the cases had microbiological diagnoses. conclusions: sepsis presented with higher frequency than is usually described in the literature.
Fatal Outcome in Bacteremia is Characterized by High Plasma Cell Free DNA Concentration and Apoptotic DNA Fragmentation: A Prospective Cohort Study  [PDF]
Reetta Huttunen,Taru Kuparinen,Juulia Jylh?v?,Janne Aittoniemi,Risto Vuento,Heini Huhtala,Janne Laine,Jaana Syrj?nen,Mikko Hurme
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0021700
Abstract: Recent studies have shown that apoptosis plays a critical role in the pathogenesis of sepsis. High plasma cell free DNA (cf-DNA) concentrations have been shown to be associated with sepsis outcome. The origin of cf-DNA is unclear.
Sepse durante a gesta??o: relato de caso
Laks, Renato;Pedroso, José L.;Pinto, Juliana E. Marques;Gois, Aécio F. T.;
Revista Brasileira de Terapia Intensiva , 2007, DOI: 10.1590/S0103-507X2007000200018
Abstract: background and objectives: sepsis during pregnancy is a rare complication. this potentially fatal disease often occurs due to maternal infectious and can lead to fetal loss. therefore, any attempted treatment must be aimed at the mother?s well being. as a matter of fact, there are few recent medical publications about sepsis in pregnancy. in spite of this, the treatment based on surviving sepsis campaign seems suitable and practical. the aim of this article is making a case report highlighting a very well succeeded treatment of a pregnant woman with urinary sepsis. case report: a 22 year old in her 27th week of pregnancy is hospitalized with pyelonefhritis. one day later, she begins presenting signs of sepsis and unresponsive hypoxemia, resulting in intubation. afterwards, she evolved with persistent low blood pressure that was unresponsive to volume expansion and had to be put on vasopressor medication. she received intensive care support based on surviving sepsis campaign. the patient evolved with an important improvement of her ventilatory stats and was extubated. after completing antibiotic treatment, she was discharged and delivered a healthy baby after 42 weeks pregnancy. conclusions: sepsis in pregnancy is a rare and potentially fatal complication. the main treatment is based on surviving sepsis campaign. the patient had an outstanding improvement and overcame her condition after intensive care support.
Shock séptico en pediatría: un acercamiento a su manejo
Montalván González,Guillermo;
Revista Cubana de Pediatr?-a , 2008,
Abstract: sepsis in the child is an important health problem and it is considered the main cause of death at this age in the world. it also consumes a great deal of health resources. a review of the topic of septic shock in pediatrics and of the possibilities of therapeutic treatment at present was made due to the importance of the diagnosis and early treatment to reduce the mortality from sepsis in childhood.
Hematogenous Panophthalmitis
AK Hamedi,GH.A Mamoori,D Farrokh
Iranian Journal of Pediatrics , 1992,
Abstract: Septicemia is the leading cause of neonatal mortality. Its complications occur following hematogenous spread to other organs. Endophthalmitis is a rare event following sepsis, as infection rarely spreads to the eyes. In this article we report a 13-day-old male infant with hematogenous Panophthalmitis following neonatal sepsis.
Analysis of local and systemic inflammatory responses induced by polymicrobial peritonitis in mice  [PDF]
Tania Silvia Fr de,Silvia Ines Alejandra Cordoba Pires Ferreira,Yara Santos Medeiros
Mediators of Inflammation , 2001, DOI: 10.1080/09629350120093704
Abstract: Background: Abdominal sepsis induces a local production of proinflammatory mediators that may trigger both septic shock and organ-system dysfunction.
Reposi??o de volume na sepse com solu??o salina hipert?nica
Friedman, Gilberto;Soriano, Francisco Garcia;Rios, Ester Correia Sarmento;
Revista Brasileira de Terapia Intensiva , 2008, DOI: 10.1590/S0103-507X2008000300010
Abstract: the present review discusses the hemodynamic and immune-modulatory effects of hypertonic saline in experimental shock and in patients with sepsis. we comment on the mechanisms of action of hypertonic saline, calling upon data in hemorrhagic and septic shock. specific actions of hypertonic saline applicable to severe sepsis and septic shock are highlighted. data available support potential benefits of hypertonic saline infusion in various aspects of the pathophysiology of sepsis, including tissue hypoperfusion, decreased oxygen consumption, endothelial dysfunction, cardiac depression, and the presence of a broad array of pro-inflammatory cytokines and various oxidant species. a therapy that simultaneously blocks the damaging components of sepsis will have an impact on the management of sepsis. proper designed prospective studies may prove a beneficial role for hypertonic saline solution in the future.
TREM-1 expression on neutrophils and monocytes of septic patients: relation to the underlying infection and the implicated pathogen
Thekla Poukoulidou, Aikaterini Spyridaki, Ira Mihailidou, Petros Kopterides, Aikaterini Pistiki, Zoi Alexiou, Michael Chrisofos, Ioanna Dimopoulou, Panagiotis Drimoussis, Evangelos J Giamarellos-Bourboulis, Ioannis Koutelidakis, Androniki Marioli, Anna Mega, Stylianos E Orfanos, Maria Theodorakopoulou, Christos Tsironis, Nina Maggina, Vlassios Polychronopoulos, Iraklis Tsangaris, the Hellenic Sepsis Study Group
BMC Infectious Diseases , 2011, DOI: 10.1186/1471-2334-11-309
Abstract: Peripheral venous blood was sampled from 125 patients with sepsis and 88 with severe sepsis/septic shock. The causative pathogen was isolated in 91 patients. Patients were suffering from acute pyelonephritis, community-acquired pneumonia (CAP), intra-abdominal infections (IAIs), primary bacteremia and ventilator-associated pneumonia or hospital-acquired pneumonia (VAP/HAP). Blood monocytes and neutrophils were isolated. Flow cytometry was used to estimate the TREM-1 expression from septic patients.Within patients bearing intrabdominal infections, expression of TREM-1 was significantly lower on neutrophils and on monocytes at severe sepsis/shock than at sepsis. That was also the case for severe sepsis/shock developed in the field of VAP/HAP. Among patients who suffered infections by Gram-negative community-acquired pathogens or among patients who suffered polymicrobial infections, expression of TREM-1 on monocytes was significantly lower at the stage of severe sepsis/shock than at the stage of sepsis.Decrease of the expression of TREM-1 on the membrane of monocytes and neutrophils upon transition from sepsis to severe sepsis/septic shock depends on the underlying type of infection and the causative pathogen.Septic syndrome is one of the leading causes of death. Its great lethality had led to several randomized trials of the administration of various types of immunotherapy. The concept of all these types of therapeutic approach was to modulate the exaggerated immune response of the host [1]. However most of results were disappointing. Several probable explanations for these failures have been given; among them the heterogeneity of patients is the most likely. This probably has to do with the type of underlying infection, the causative microorganism and the co-morbid conditions. In a recent prospective study of the Hellenic Sepsis Study Group http://www.sepsis.gr webcite 505 patients were enrolled; changes of the innate and adaptive immunity were evaluated with immunop
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