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An Inflammatory Fibroid Polyp (Vanek’s Tumor) of the Ileum that Presented as Intussusception  [PDF]
Jung-Hee Yoon
Advances in Computed Tomography (ACT) , 2013, DOI: 10.4236/act.2013.24024

Ileoileal intussusceptions caused by inflammatory fibroid polyps are uncommon. Inflammatory fibroid polyps (Vanek’s tumor) are rare benign lesions that originate in the submucosa of the gastrointestinal tract. Here, we report the case of a 54-year-old woman who was admitted with an acute onset of abdominal pain and signs of intestinal obstruction. The ileal segment was resected, and single-layer end-to-end anastomosis was performed. A submucosal polypoid mass measuring approximately 4.5 × 4.0 cm was found. The histopathological analysis revealed an ulcerated mucosal lesion with variable cellularity that was formed by spindle cells with slight mitosis and abundant inflammatory infiltrate that was mainly composed of eosinophils. Immunohistochemistry confirmed the diagnosis of ileal inflammatory fibroid polyps. Cross-sectional imaging (multidetector computed tomography) plays a significant role in diagnosing this condition and guiding its management.

Inflammatory fibroid polyp of the oesophagus
Shashi Godey, Robert T Diggory
World Journal of Surgical Oncology , 2005, DOI: 10.1186/1477-7819-3-30
Abstract: We present the case of a patient with a rapidly growing inflammatory fibroid polyp (IFP) of the oesophagus, which showed up within five months after a normal endoscopy.The treatment of IFP is by surgical excision, either open or endoscopic. Laser or other form of ablative treatment like thermo cautery can also be tried.Inflammatory fibroid polyp (IFP) is a benign, nonmetastasing tumour of the digestive tract. It has been described to occur commonly in the stomach and intestines. Cases have been reported in rectum [1], duodenum [2] and oesophagus, though rare. It is a slowly growing tumour unlike this case which had rapidly grown in a period of five months. The usual presentation is either with dyspeptic or obstructive symptoms. The treatment is usually confined to local excision of the lesion either endoscopically or by an open procedure. The details of the clinical presentation, histopathological findings and therapeutic choices are discussed.A 76-year-old man presented with epigastric pain and dysphagia. Endoscopy revealed grade 1 oesophagitis with a normal stomach and duodenum. Five months later he was readmitted with anorexia, weight loss, dysphagia and anaemia. Endoscopy on this occasion revealed a large pedunculated polypoidal lesion arising from the gastro-oesophageal junction within a hiatus hernia. Pathological examination of biopsies taken from the polyp showed inflammatory changes in squamous mucosa with no evidence of malignancy. As the lesion was pedunculated it was decided to attempt endoscopic snare excision which proved unsuccessful, as the lesion was too large for the snare. At laparotomy a large polypoidal mass was found arising from the distal oesophagus. Through a gastrostomy the lesion was delivered into the abdomen, a linear stapler was applied to the base of the stalk and the lesion was excised. The patient made an uneventful recovery.The resected specimen (figure 1) measured 9 cm × 4 cm × 4 cm and consisted of soft and slimy tissue. Histology
Inflammatory fibroid polyp: an immunohistochemical study
Santos, Gilda da Cunha;Alves, Venancio A.F.;Wakamatsu, Alda;Zucoloto, Sérgio;
Arquivos de Gastroenterologia , 2004, DOI: 10.1590/S0004-28032004000200007
Abstract: background: inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. aim: to study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. material and methods: nine cases were studied by immunohistochemistry using a panel of antibodies against smooth-muscle actin, vimentin, s-100 protein, factor viii- r.ag and macrophage (ham-56). results: there was a strong diffuse positive staining pattern in the spindle cells with vimentin antibody. a patchy staining for smooth-muscle actin was observed in these cells. immunophenotyping revealed a heterogeneous reaction with ham-56. in edematous areas, ham-56-positive cells show voluminous cytoplasm and reniform nuclei. in cell-rich areas, the ham-56-positive cells had fusiform cytoplasm. stains for s-100 and factor viii rag were negative in the proliferating elements. conclusions: the present immunohistochemical study refutes the suggested neural or vascular nature of the lesion. the strong positivity for vimentin in all cases suggests a major component of spindle cells best recognizable as fibroblasts. these results would favor the existence of a span of morphological and immunohistochemical patterns possibly indicating evolutive phases of an inflammatory reaction.
Inflammatory Fibroid Polyp: A Case Report
Ay?egül ?LG?L?,Ufuk USTA,Fulya ?Z PUYAN,?mer YAL?IN
Trakya Universitesi Tip Fakultesi Dergisi , 2008,
Abstract: Inflammatory fibroid polyp is a rare benign lesion that most frequently originates from the gastric antrum, but can also be seen in any part of the gastrointestinal tract. Differential diagnosis includes gastrointestinal polyps and polypoid stromal tumors due to their polypoid appearance on gross examination, and microscopically, various malignant and benign stromal tumors, primarily gastrointestinal stromal tumors. We presented a 51-year-old female patient who was referred to our center with a diagnosis of adenocarcinoma made after an endoscopic biopsy, but found to have an inflammatory fibroid polyp located in the antrum after distal subtotal gastrectomy.
Endoscopic resection of inflammatory gastric fibroid polyp: A case report
Grgov Sa?a,Kati? Vuka,Hattori Takanori
Srpski Arhiv za Celokupno Lekarstvo , 2009, DOI: 10.2298/sarh0910545g
Abstract: Introduction An inflammatory fibroid polyp is a rare condition with frequent localization in the antrum of the stomach. Because of the localization in the bottom parts of the mucosa and submucosa, a histological diagnosis is difficult to establish at endoscopic biopsies. So, a correct diagnosis is histologically possible after surgical excision which is a common manner of treatment. Many authors have shown that endoscopic removal of an inflammatory fibroid polyp is possible. Case outline We are presenting a case of complete endoscopic resection of an inflammatory fibroid polyp of the stomach antrum in a 72-year-old patient. He complained of nausea, vomiting and loss of appetite. The polyp endoscopically looked like flat elevation with central umbilication, 16 mm in diameter and it was localized praepylorically. Pathohistologically, areas of severe epithelial dysplasia were verified at endoscopic biopsies which suggested early gastric cancer. Helicobacter pylori (H. pylori) infection was verified histologically and with rapid urease test. The patient was treated with triple eradication H. pylori therapy. Two months after the therapy, we decided to perform endoscopic resection of the polyp. We applied a suction technique of mucosal resection by which the polyp was completely resected. After complete endoscopic removal, the final diagnosis of an inflammatory fibroid polyp localised in the submucosa and mucosa of the antrum of the stomach was histologically made. On follow-ups, after 3, 6 and 12 months, there were no endoscopic and histological signs of either inflammatory fibroid polyp relapse, or recurrence of H. pylori infection. The patient had no dyspeptic symptoms. Conclusion We recommend an endoscopic method of resection as a therapy of choice for an inflammatory fibroid polyp of the stomach.
Giant ileal inflammatory fibroid polyp: a rare cause of intestinal intussusception
Ogata, Daniel Cury;Pereira Neto, Elisiário;Sezerino, Daniel Oséias;Bernhardt, Joel Ant?nio;
Journal of Coloproctology (Rio de Janeiro) , 2012, DOI: 10.1590/S2237-93632012000300019
Abstract: ileal inflammatory fibroid polyp is a rare non-neoplastic lesion of the gastrointestinal tract. intussusception caused by an inflammatory fibroid polyps is uncommon. the authors report a case of a 75 year-old female patient presenting with ileal obstruction due to intussusception of a polypoid lesion. the patient underwent surgical treatment and histopathology confirmed the diagnosis.
Giant ileal inflammatory fibroid polyp: a rare cause of intestinal intussusception  [cached]
Daniel Cury Ogata,Elisiário Pereira Neto,Daniel Oséias Sezerino,Joel Ant?nio Bernhardt
Journal of Coloproctology (Rio de Janeiro) , 2012,
Abstract: Ileal inflammatory fibroid polyp is a rare non-neoplastic lesion of the gastrointestinal tract. Intussusception caused by an inflammatory fibroid polyps is uncommon. The authors report a case of a 75 year-old female patient presenting with ileal obstruction due to intussusception of a polypoid lesion. The patient underwent surgical treatment and histopathology confirmed the diagnosis. Os pólipos fibroides inflamatórios s o raras les es n o neoplásicas do trato gastrointestinal e a intussuscep o devido a essa entidade é incomum. Os autores relatam um caso de paciente do sexo feminino, 75 anos, que apresentou obstru o ileal devido a uma intussuscep o por les o polipoide. A paciente foi submetida a tratamento cirúrgico, sendo diagnosticado pólipo fibroide inflamatório do íleo.
A Rare Combination of Gastric Inflammatory Fibroid Polyp and Hiatal Hernia  [PDF]
Coskun Polat, Murat Burc Yazicioglu, Serkan Turel, Mehmet Nuri Kosar, Yuksel Arikan
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.27080
Abstract: Inflammatory fibroid polyp (IFP) is a rare solitary gastrointestinal lesion of unknown etiology. It generally presents as polypoid mass in the gastric antrum. Mostly affects adults at average age of 60 years. IFP can cause different symptoms such as abdominal pain, gastrointestinal bleeding, intestinal obstruction or intussusception. IFP is a bening lesion and it may rarely mimic the submucosal tumor. The diagnosis can be possible after removal of the detected lession either by laparoscopic or open approach. In the present paper, we report a patient with gastric IFP and hiatal hernia. IFP was excised throughout the gastrotomy and following hiatal hernia was repaired. According to our best knowledge, this may be the first case report of gastric IFP concomitance with a hiatal hernia.
Ileal inflammatory fibroid polyp causing chronic ileocolic intussusception and mimicking cecal carcinoma  [cached]
Naveen Gara, John S Falzarano, Whitney ML Limm, Thomas S Namiki, Laurie KS Tom
World Journal of Gastrointestinal Oncology , 2009,
Abstract: Inflammatory fibroid polyp (IFP) is a rare, idiopathic pseudotumorous lesion of the gastrointestinal tract. While mostly reported as solitary gastric lesions, multiple cases of small bowel IFPs are also reported. It is a documented cause of intussusception in adults. In the case reports of ileal inflammatory fibroid polyps with intussusception, an emergent presentation with small bowel obstruction has been most often described. Here we depict a case of ileal inflammatory fibroid polyp presenting with chronic intermittent ileocolic intussusception, anemia and weight loss with an endoscopic appearance mimicking necrotic cecal carcinoma.
Intussusception due to inflammatory fibroid polyp: A case report and comprehensive literature review  [cached]
Sami Akbulut
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i40.5745
Abstract: AIM: To give an overview of the literature on intussusception due to inflammatory fibroid polyp (IFP). METHODS: We present a new case of ileal intussusception due to IFP and a literature review of studies published in English language on intussusception due to IFP, accessed via PubMed and Google Scholar databases. For the search, the keywords used were: intussusception, IFP, intussusception and IFP, intussusception due to IFP, and IFP presenting as intussusception. The search covered all articles from 1976 to November 2011. RESULTS: We present a 38-year-old woman who was admitted 10 d after experiencing abdominal pain, vomiting, and nausea. Ultrasonography demonstrated small bowel intussusception. An ileal intussusception due to a mass lesion 50 cm proximal to the ileocecal junction was found during laparotomy. Partial ileal resection and anastomosis were performed. A diagnosis of ileal IFP was made based on the immunohistochemical findings. In addition, a total of 56 reports concerning 85 cases of intussusception due to IFP meeting the aforementioned criteria was included in the literature review. The patients were aged 4 to 81 years (mean, 49 ± 16.2 years); 44 were women (mean, 51.8 ± 14.3 years) and 41 were men (mean, 46 ± 17.5 years). According to the location of the IFP, ileal intussusception was found in 63 patients, while 17 had jejunal, three had colonic, and two had ileojejunal intussusception. CONCLUSION: Although IFPs are rare and benign, surgery is the only solution in case of intestinal obstruction. Differential diagnosis should be made via immunohistochemical examination.
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