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A prospective evaluation of the safety and efficacy of the TAXUS Element paclitaxel-eluting coronary stent system for the treatment of de novo coronary artery lesions: Design and statistical methods of the PERSEUS clinical program
Dominic J Allocco, Louis A Cannon, Amy Britt, John E Heil, Andrey Nersesov, Scott Wehrenberg, Keith D Dawkins, Dean J Kereiakes
Trials , 2010, DOI: 10.1186/1745-6215-11-1
Abstract: The PERSEUS trials include two parallel studies of the TAXUS Element stent in single, de novo coronary atherosclerotic lesions. The PERSEUS Workhorse study is a prospective, randomized (3:1), single-blind, non-inferiority trial in subjects with lesion length ≤28 mm and vessel diameter ≥2.75 mm to ≤4.0 mm which compares TAXUS Element to the TAXUS Express2 paclitaxel-eluting stent system. The Workhorse study employs a novel Bayesian statistical approach that uses prior information to limit the number of study subjects exposed to the investigational device and thus provide a safer and more efficient analysis of the TAXUS Element stent. PERSEUS Small Vessel is a prospective, single-arm, superiority trial in subjects with lesion length ≤20 mm and vessel diameter ≥2.25 mm to <2.75 mm that compares TAXUS Element with a matched historical bare metal Express stent control.The TAXUS PERSEUS clinical trial program uses a novel statistical approach to evaluate whether design and metal alloy iterations in the TAXUS Element stent platform provide comparable safety and improved procedural performance compared to the previous generation Express stent. PERSEUS trial enrollment is complete and primary endpoint data are expected in 2010. PERSEUS Workhorse and Small Vessel are registered at http://www.clinicaltrials.gov webcite, identification numbers NCT00484315 and NCT00489541.Drug-eluting stents, including paclitaxel-eluting stents, have been shown to reduce angiographic restenosis and the need for repeat revascularization following coronary angioplasty compared to bare metal stents [1,2]. However, repeat revascularization is still required in approximately 7-10% of patients (versus 20-25% with bare metal stents) [3]. It has been proposed that the thickness of stent struts may impact the ability of the stent to reduce restenosis. Compared to first generation stents with strut thicknesses of approximately 130-150 μm, stents with thinner stent struts (80-100 μm) have been associated w
A Primary Investigation on the Eco-environmental Improvement in the Western China by the Use of in vitro Propagation Techniques of Taxus (Taxus media)  [PDF]
Shao Hongbo,Jiang Shuiyuan,Chu Liye,Zhao Changxing
Pakistan Journal of Biological Sciences , 2006,
Abstract: In this study, a primary investigation on in vitro propagation technique of Taxus (Taxus media) for the sake of improving the eco-environment and increasing economic effect in west China zone was conducted. The better result was obtained and a relatively simple and practical procedure of In vitro propagating of Taxus (Taxus media) was established, which has a broad prospect in improving eco-environment and promotion of economy in west China region. The related results were as followed: The 2 year branches of Taxus media could be selected as explants, obtaining 78% of budding and transplanting survival rate reaching 90%. Use of 0.1% HgCl2 for sterilization for 12 m could reach more than 90% effect of sterilization, which was better than that previous reported. The flowchart for effective in vitro propagation of Taxus media under our experimental condition was below: recover and initiation of explants →bud propagation →subculture →rooting →transplanting in greenhouse →transplanting in fields or going to market.
Please Mind the Gap: How To Podcast Your Brain  [cached]
Karen Spaceinvaders
continent. , 2011,
Abstract: Audio. Please click to listen to the mp3 files of deep brain recordings of individual brain cells, the smallest unit of the brain, in a whole, intact living brain. Each brain region’s cells possess an electrical signature. During recordings electrical signals are transformed into sound to facilitate auditory identification of cells during a process called “mapping.”
Overview of Taxus Resources in China and Strategy for their Sustainable Utilization

Chen Zhenfeng,Zhang Chengwen,Kou Yufeng,Cui Shuyu,

世界科学技术-中医药现代化 , 2002,
Abstract: This paper gives an illustration of the present situation of the distribution of Taxus species, Taxol content and particular status of Taxus resources in China. Meanwhile, it advances the discussion on the sustainable utilization of Taxus resources.
Chiral Enzymatic Activity in Cell Cultures of Taxus Species  [cached]
Carmen Beatriz Alpízar,Eduardo Díaz,Rubén Sánchez-Obregón,Héctor Barrios
Revista de la Sociedad Química de México , 2012,
Abstract: Cultivos de células en suspensión de Taxus brevifolia y Taxus globosa se utilizaron como biocatalizadores para determinar, bajo diferentes condiciones, la actividad catalítica de desracemización configuracional ejercida sobre el racemato y enantiómeros puros de un sustrato exógeno. Taxus brevifolia presentó una relación directamente proporcional entre la relación enantiomérica (er) [1] y el tiempo de reacción, dando una mezcla de 90(S): 10(R) después de 7 días. La biotransformación de los enantiómeros puros demostró que sólo el isómero (R) fue biotransformado por resolución cinética y, una fracción, mediante estereoinversión en su enantiómero opuesto, mientras que el isómero (S) se mantuvo intacto. Las soluciones reguladoras no presentaron ningún efecto, sin embargo la adición de sacarosa y la temperatura sí modificaron los tiempos de reacción y la er. En relación con la edad de los cultivos y la variación del pH el efecto fue crítico. Taxus globosa presentó una baja eficiencia en su actividad catalítica configuracional.
Оleksandr Shynder, Оleksandr Rak, Svitlana Hlukhova
NaUKMA Research Papers. Biology and Ecology , DOI: 10.18523/2617-4529.2018.52-58
Abstract: The article presents the data on the status and structure of the spontaneous heterogeneous population of two species of the genus Taxus (Taxaceae), T. baccata and T. cuspidata, in the Syrets Arboretum of national importance (Kyiv). This population was formed as a result of spontaneous seed reproduction of cultured in the arboretum of adult specimens of two species of yew. The author describes the quantitative composition of individuals of the genus Taxus of seed origin and the conditions of their habitats as part of various types of plantings in Syrets Arboretum. The main morphometric indices of the yew individuals of seed origin were studied, namely their height and diameter of the stem. In general, on the territory of park plantations of the Syrets Arboretum and beyond it, 99 virginile and generative individuals of the genus Taxus (5 or more years) were found. In addition, on several plots more than 100 young individuals (1–4 years) were recorded. The spontaneous population of the yew in the Syrets Arboretum has high density and left-handed age spectrum and relates to young populations of normal type. Most of the generative individuals of the seed origin were identified. It was found that the ratio of individuals T. baccata and T. cuspidata in this population is about 2 : 1. The intensity of the growth and development of the yew trees of the seed origin in the Syrets Arboretum is similar to the characteristics of the populations in natural environment but is less than in the culture. The transition of the young yew individuals on the generative stage of development in the conditions of Syrets Arboretum requires 12–19 years. The best conditions for the sprouting of the yew seed and the development of young individuals were noted in plots with medium sunlight, lack of shrubs, sparse grass (without dense cover), and a thick layer of leaves on the soil surface. In general, preservation of the ex situ rare species of the genus Taxus in the Syrets Arboretum is currently provided in the level of the formation of normal populations.
Bio-ecology of Taxus Baccata l. in Kakheti
Tamar Nadiradze
European Researcher , 2013,
Abstract: The article discusses the bio-ecology of Taxus baccata L. in Kakheti (eastern Georgia), particularly in Tsinandali Park. Yew (Taxus baccata L.) preserved in Tsinandali Park (Telavi region, Georgia) was chosen as an object for long-lasting observation over plant vegetation. Vegetation of 47 new specimens were studied during the period 2001-2010. It was observed the buds opening, the vegetation finishing, the cambium active periods beginning and finishing, the sprout stiffen process, the rate and time of growth. The period between 2001 and 2004 is distinguished by the relatively intensive growth of yew samples. In 2004-2010 growth period was shortened. It is suggested, that shortening often growth period in yew specimen is related to the deficit of water in soil due to frequent drought and snowless winters in Telavi region in the last decade.Observation conducted on the peculiarities of cambial growth confirms that yew has strong ability of frost-resistance. We consider that the bio-ecological studies of yew tree, as an endangered species, and its implementation in decorative gardening will contribute to its conservation
Female gametophyte development and embryogenesis in Taxus baccata L.
Vladimir B. Brukhin,Peter V. Bozhkov
Acta Societatis Botanicorum Poloniae , 1996, DOI: 10.5586/asbp.1996.023
Abstract: Crassinucellate ovules are initiated in Taxus, directly from the shoot apex. The rudimentary pollen chamber is formed in the nucellus. A linear tetrad of megaspores with a functional chalazal megaspore is formed. A free-nuclear stage is charac-teristic at the beginning of megagametophyte development. Archegonia without ventral canal cell are solitary or in complexes. The embryo has a very long suspensor even after maturation. Two types of polyembryony have been revealed: i) embryogenic redifferentiation of suspensor cells and ii) cleavage of embryonic region in the early embryo. In the northern temperate climate of St. Petersburg one month delay in development of reproductive structures has been noted.
In Vitro Antifungal Efficacies of Maize Associated Microorganisms  [PDF]
Esther Aanuoluwa Ekundayo, Bolatito Esther Boboye, Fatusa Clement Adetuyi
Advances in Microbiology (AiM) , 2015, DOI: 10.4236/aim.2015.54024
Abstract: Microorganisms (bacteria and fungi) were isolated from different parts of yellow maize (stem, cob, husk, leaf, root) as well as from rhizosphere and non-rhizosphere soil of maize using conventional microbiological techniques. A total number of twenty-six bacteria and thirteen fungi were isolated. The antagonistic efficacies of these isolates were tested against Sclerotium rolfsii, Aspergillus repens, Penicillium notatum and Pythium sp. using streak bioassay, food poisoning and dual culture techniques. None of the bacteria was antagonistic to the test fungi at 25°C on PDA using streak bioassay. However, there was reduction in the population density of the test fungi using food poisoning technique. The fungal isolates were antagonistic to the test fungi in varying degrees. Generally, S. rolfsii was susceptible to seven out of the eight fungal antagonists while P. notatum was least susceptible. The percentage reduction of S. rolfsii ranged from 40.00 ± 5.78 to 64.07 ± 2.31. Efficacies of chemical fungicides; mancozeb, camazeb and red force at 3 different concentrations— 0.05%, 0.1% and 1.0% (w/v) on the test fungi were also determined. No growth of the test fungi was observed at 1% (w/v) of all the fungicides while at lower concentration (0.05%), red force did not have any inhibitory effect. The growth of S. rolfsii was completely inhibited at 0.05% of mancozeb whereas there was reduction in mycelial growth of A. repens. Effect of inoculation time and nutrients (PDA and MEA) was determined on the antagonistic activities of Trichoderma viride. There were significant differences in inhibitory potentials of the two isolates of Trichoderma viride when pre-inoculated on the culture medium. The antagonistic potentials were more pronounced on malt extract agar than potato dextrose agar.
Isolation of Phenylisoserine Methyl Ester from the Bark of Taxus mairei  [PDF]
Sanro Tachibana,Etsuko Watanabe,Yu Chang Su,Jui Chung Shieh
Pakistan Journal of Biological Sciences , 2004,
Abstract: From the methanolic extracts of bark of Taxus mairei, phenylisoserine methyl ester (2) was isolated along with paclitaxel (taxol) (1). This is the first time that phenylisoserine methyl ester (2) has been isolated from T. mairei. Compound 2 was also isolated from the ethanolic extracts of bark of T. mairei.
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