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Primary localized amyloidosis of urinary bladder: Case report  [PDF]
Basri ?ak?ro?lu,Lora Ate?,Ramazan G?zükü?ük,Mustafa Gü?lü
Dicle Medical Journal , 2012,
Abstract: Primary amyloidosis of the bladder is a rare pathologicalcondition which the etiology is unknown. The signsand symptoms suggests bladder tumor. In some patients,lower urinary tract symptoms such as lower abdominalpain, frequent urination, dysuria and complaints of grosspainless hematuria occur. In this study a case of primarylocalized amyloidosis of the bladder in a 66 years oldfemale who had gross painless hematuria as the initialsymptom is described.Key words: Amyloidosis, bladder, hematuria.
Localized amyloidosis of urinary bladder: A diagnostic dilemma  [cached]
Jain Manoj,Kumari Niraj,Chhabra Poonam,Gupta Ramesh
Indian Journal of Pathology and Microbiology , 2008,
Abstract: Amyloidosis is a heterogeneous group of disorders affecting a single-or multiple-organ system and presents as generalized or localized disease. Both generalized amyloidosis and localized amyloidosis can be primary or secondary. Localized amyloidosis affects organs like urinary bladder, lung, larynx, skin, tongue and the region around the eye, producing detectable nodular masses which are clinically suspected as malignancy. We present six cases of localized urinary bladder amyloidosis that were clinically and cystoscopically suspected as bladder tumor or cystitis, which occurred over a period of last 10 years. Histology in all cases revealed diagnosis of primary amyloidosis. None of them had any stigmata of secondary disease. The cases were treated by simple transurethral resection of bladder. Two out of the six cases recurred after 3 to 5 years of initial presentation and were asymptomatic thereafter. Amyloidosis of the bladder is a rare condition which often mimics bladder neoplasm clinically and cystoscopically and histological examination is a must for definite diagnosis and proper management.
Localized amyloidosis of the urinary bladder, clinically masquerading as bladder cancer  [cached]
DeSouza Maria,Rekhi Bharat,Thyavihally Yuvaraja,Tongaonkar Hemant
Indian Journal of Pathology and Microbiology , 2008,
Abstract: Amyloidosis is characterized by extracellular deposition of a proteinaceous, hyaline material. Localized deposition of amyloid in individual organs is uncommon. It can occur in the absence of systemic involvement. Herein, we describe two cases of localized amyloidosis of the urinary bladder, which clinically, radiologically, and on cystoscopy masqueraded as bladder cancer. A diagnosis of amyloidosis in both these cases was ascertained on biopsy, supplemented with special stains.
Primary Malignant Melanoma of the Urinary Bladder
Jalal Eddine El Ammari,Youness Ahallal,Mohammed Jamal El Fassi,Moulay Hassan Farih
Case Reports in Urology , 2011, DOI: 10.1155/2011/932973
Abstract: Introduction. Primary melanoma of the urinary bladder is very rare. As far as we know, 19 cases have been reported worldwide, usually as case reports. Case Presentation. We present a 71-year-old male patient presented with a 2-month history of hematuria. Ultrasonography revealed a 5-cm-size mass located in the bladder trigone. A transurethral resection of the bladder tumor (TURBT) revealed a malignant melanoma. Evaluation for metastatic disease was negative. The patient deceased five months later before radical treatment could be performed. Conclusion. This is one more reported case of primary melanoma of the urinary bladder. The previously reported cases of bladder melanoma are reviewed. Therapy and prognosis are discussed.
Primary localised amyloidosis of urinary bladder (a case report).  [cached]
Goswami A,Vaidyanathan S,Rao M,Malik A
Journal of Postgraduate Medicine , 1984,
Primary mucinous adenocarcinoma in a defunctionalized urinary bladder: a case report
Mary Taneous, Preetha Ramalingam, Donald G Mode, Jared G Heiner, Martha K Terris, Jeffrey R Lee
Journal of Medical Case Reports , 2009, DOI: 10.1186/1752-1947-3-9306
Abstract: We report a 57-year-old Caucasian man presenting with penile discharge for 30 years following ileal conduit surgery for neurogenic bladder, and who was found to have primary mucinous adenocarcinoma of his defunctionalized bladder.Although urinary diversion without cystectomy is less common in current urologic practice, there are many patients with longstanding defunctionalized bladders. While there are no established surveillance protocols, defunctionalized bladder patients with urethral discharge should be evaluated.Primary adenocarcinoma of the urinary bladder accounts for approximately 0.5-2% of all bladder cancers [1]. Patients generally present with hematuria, dysuria, suprapubic pain, and, less commonly, mucusuria. The histologic appearance of bladder adenocarcinoma can be enteric, signet ring, mucinous, clear cell, hepatoid and mixed types. The differential diagnosis includes glandular differentiation of transitional cell carcinoma and direct extension or metastatic spread of adenocarcinoma arising primarily from the colon, prostate, appendix or endometrium.Predisposing factors for the development of primary adenocarcinoma of the bladder include schistosomiasis, exstrophy, persistent urachal remnants, and bladder augmentation by intestinal segments [1,2]. Concomitant cystitis glandularis occurs in the majority of cases, but is not considered a definitive precursor lesion since adenocarcinoma can develop in the absence of cystitis glandularis and only a small number of bladders with cystitis glandularis actually develop malignancies [2].The potential for adenocarcinoma to develop in the defunctionalized bladder that is left in-situ at the time of urinary diversion is rare [3-5]. We describe the fifth case of primary mucinous adenocarcinoma arising in a longstanding defunctionalized bladder.A 57-year-old Caucasian man presented with profuse blood-streaked mucous drainage from his penis. Past medical history was significant for T12 spinal cord injury secondary t
Primary primitive neuroectodermal tumor of the urinary bladder: a case report  [cached]
Yasuyuki Kobayashi,Kenji Nishimura,Taigo Kato,Hidefumi Kishikawa
Journal of Solid Tumors , 2012, DOI: 10.5430/jst.v2n4p53
Abstract: We report a rare case of primary primitive neuroectodermal tumor (PNET) of the urinary bladder. An 85-year-old man with hormone refractory prostate cancer was presented with gross hematuria. Abdominal computed tomography showed a tumor occupying the right lateral portion and neck of the bladder wall, while a cystoscopic examination revealed a bleeding, sessile globular tumor with no papillary features. Transurethral resection of the bladder tumor was performed. Histopathological results showed a small round cell tumor forming rosettes, further positive immunoreactivities for some neural markers and MIC gene product (CD99), which indicated PNET of the bladder. Four months after surgery, PNET of the bladder recurred with rapid growth and the patient died of tumor. To our knowledge, there have been only 8 such cases reported.
Primary Squamous Cell Carcinoma of the Urinary Bladder Presenting as Peritoneal Carcinomatosis  [PDF]
Himisha Beltran,Brian D. Robinson,Scott T. Tagawa
Advances in Urology , 2010, DOI: 10.1155/2010/179250
Abstract: We report an unusual case of a 78-year-old Caucasian female, who presented with peritoneal carcinomatosis and hypercalcemia, and was found to have a rapidly progressive primary squamous cell carcinoma of the urinary bladder. Squamous cell bladder carcinoma is a rare malignancy in the United States, accounting for just 1–3% of bladder tumors. Interestingly our patient lacked the established risk factors, including exposure to the parasite Schistosoma haematobium, recurrent urinary tract infections, bladder calculi, radiation exposure, chronic indwelling catheter, neurogenic bladder, or tobacco abuse. Although hypercalcemia has been rarely described, an initial presentation of peritioneal carcinomatosis has not been previously reported. 1. Case Report A 78-year-old Caucasian woman presented with a subacute onset of diffuse abdominal pain, associated with progressive abdominal distention, nausea, and anorexia. Her initial labs were notable for hyponatremia (Sodium level of 127?mEq/L), and hypercalcemia (corrected calcium level of 14?mg/dL), and acute prerenal failure (Blood Urea Nitrogen 55?mg/dL, creatinine 4.8?mg/dL), which were new compared to two weeks prior. Her hemoglobin, liver enzymes, coagulation panel, and lactate dehydrogenase (LDH) were within normal limits. Urinalysis revealed pyuria, microscopic hematuria, mild proteinuria, and culture grew Escherichia coli. She was treated with intravenous fluids, zoledronic acid, and antibiotics, and her renal function and electrolytes improved. A Computed Tomography (CT) scan of the chest/abdomen/pelvis with oral contrast (Figure 1) revealed a thickened peritoneum and omentum (arrowheads) and ascites (arrows), consistent with peritoneal carcinomatosis. Visualization of her pelvis was limited due to streak artifact from bilateral hip prostheses. She had no evidence of obstruction, mass lesions, or lymphadenopathy, and her visualized organs were normal in appearance. Figure 1 Her past medical history was remarkable for hypertension, diabetes mellitus, osteoarthritis, and coronary artery disease. She denied any use, past or present, of alcohol, tobacco, or illicit drugs. She was of Jewish descent and lived in the US her entire life as a homemaker, with no history of foreign travel. She lived alone and was very functional at baseline. Menses began at age thirteen, and menopause at age fifty. She had two children who were alive and well. She was up to date with her health maintenance and cancer screening, and she had no history of abnormal pap smear, mammogram, or colonoscopy. She had no family history of
Primary signet-ring cell adenocarcinoma of the urinary bladder: a case report
Cobo-Dols,M.; Alcaide,J.; Gutiérrez,V.; Gil,S.; Alés,I.; Villar,E.; Montesa,A.; Carabantes,F.; Bretón,J. J.; Benavides,M.;
Oncología (Barcelona) , 2006, DOI: 10.4321/S0378-48352006000400007
Abstract: primary signet-ring cell adenocarcinoma of the urinary bladder is a rare tumor. we report in this study the case of a 53 year old man consulting for gross hematuria. computed tomography imaging demonstrated right hydronephrosis and an invasive bladder tumor. the bladder biopsy showed a signet-ring cell carcinoma; the exploration of the gastrointestinal tract did nor reveal any other tumor localization. a total cystoprostatectomy was performed followed by adjuvant chemotherapy with cisplatin and gemcitabine. the aim of this study is to determine the anatomoclinical, therapeutic and evolutionary characteristics of this rare tumor.
Primary small cell neuroendocrine carcinoma of the urinary bladder with coexisting high-grade urothelial carcinoma: a case report and a review of the literature
Bui Marilyn,Khalbuss Walid
CytoJournal , 2005,
Abstract: Primary neuroendocrine carcinomas of the urinary bladder are rare. Here, we report a case of an 82-year-old man who presented with hematuria and was found to have an ulcerated lesion in the bladder. A diagnosis of small neuroendocrine cell carcinoma with coexisting minor high-grade urothelial components was rendered. In this report, the clinical, cytological, histological, and immunohistochemical features of this case are described, and a review of the literature about this neoplasm is presented. The differential diagnoses of small cell tumor in urinary bladder washing specimens are discussed.
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