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Organizational and activational effects of estrogenic endocrine disrupting chemicals
Silbergeld, Ellen K.;Flaws, Jodi A.;Brown, Ken M.;
Cadernos de Saúde Pública , 2002, DOI: 10.1590/S0102-311X2002000200014
Abstract: endocrine disruption is a hypothesis of common mode of action that may define a set of structurally varied chemicals, both natural and synthetic. their common mode of action may suggest that they produce or contribute to similar toxic effects, although this has been difficult to demonstrate. insights from developmental biology suggest that development of hormone sensitive systems, such as the brain and the genitourinary tract, may be particularly sensitive to edcs. because these systems are both organized and later activated by hormones, the brain and vagina may be valuable model systems to study the toxicity of edcs in females and to elucidate mechanisms whereby early exposures appear to affect long term function.
Organizational and activational effects of estrogenic endocrine disrupting chemicals  [cached]
Silbergeld Ellen K.,Flaws Jodi A.,Brown Ken M.
Cadernos de Saúde Pública , 2002,
Abstract: Endocrine disruption is a hypothesis of common mode of action that may define a set of structurally varied chemicals, both natural and synthetic. Their common mode of action may suggest that they produce or contribute to similar toxic effects, although this has been difficult to demonstrate. Insights from developmental biology suggest that development of hormone sensitive systems, such as the brain and the genitourinary tract, may be particularly sensitive to EDCs. Because these systems are both organized and later activated by hormones, the brain and vagina may be valuable model systems to study the toxicity of EDCs in females and to elucidate mechanisms whereby early exposures appear to affect long term function.
Effects of Endocrine Disrupting Chemicals on Sex Differentiation in Fish
环境内分泌干扰物对鱼类性别分化的影响

Gao Lei,Tian Hua,Ru Shaoguo,
高蕾
,田华,汝少国

生态毒理学报 , 2012,
Abstract: Sex differentiation in fish refers to the development of testes or ovaries from undifferentiated gonads and the expression of male or female secondary sex characteristics under the control of sex determination mechanisms, regulated by the endocrine system. Endocrine disrupting chemicals (EDCs) that can interfere with the production, release, transport, metabolism, binding, action of natural hormones, have potential to disrupt the process of sex differentiation in fish. In this review, the patterns, process and endocrine regulation of sex differentiation in fish were introduced, and adverse effects of EDCs on some events related to sex differentiation in fish were reviewed, including sex ratios, gametogenesis, gonadal development and secondary sex characteristics expression. The potential mechanisms of fish sex differentiation were discussed by synthesis of sex steroid and the expression of genes relating sex differentiation. Finally, future prospects of this field were provided in this paper.
Degrading Endocrine Disrupting Chemicals from Wastewater by Photocatalysis: A Review
Jin-Chung Sin,Sze-Mun Lam,Abdul Rahman Mohamed,Keat-Teong Lee
International Journal of Photoenergy , 2012, DOI: 10.1155/2012/185159
Abstract: Widespread concerns continue to be raised about the impacts of exposure to chemical compounds with endocrine disrupting activities. To date, the percolation of endocrine disrupting chemical (EDC) effluent into the aquatic system remains an intricate challenge abroad the nations. With the innovation of advanced oxidation processes (AOPs), there has been a consistent growing interest in this research field. Hence, the aim of this paper is to focus one such method within the AOPs, namely, heterogeneous photocatalysis and how it is used on the abatement of EDCs, phthalates, bisphenol A and chlorophenols in particular, using TiO2-based catalysts. Degradation mechanisms, pathways, and intermediate products of various EDCs for TiO2 photocatalysis are described in detail. The effect of key operational parameters on TiO2 photocatalytic degradation of various EDCs is then specifically covered. Finally, the future prospects together with the challenges for the TiO2 photocatalysis on EDCs degradation are summarized and discussed.
Endocrine disruptors and their effects on puberty  [PDF]
Semra ?etinkaya
Dicle Medical Journal , 2009,
Abstract: Endocrine disruptors and their possible impact on human health have become a topic of discussion. Endocrine disrupting chemicals are found in plastics, detergents, pesticides and industrial chemicals. Some of these persist in the environment and others do not. Some are lipophilic, sequestered in adipose tissue and secreted in milk, and others may only be present for short periods of time but at critical periods of development. Endocrine disruptors are defined as an extrogenous substance or mixture that alters the function of the endocrine system and consequently causes adverse health effects in an intact organism, or its progeny. Endocrine disruptors affect the reproductive system and they may be responsible for oligospermia, abnormality of sperm characteristics, disorders of testicular steroidogenesis, testicular atrophy, uterus weight increases and precocious puberty. In this review, we aimed to assess on exposure to endocrine disruptors and the effects of endocrine disruptors on puberty.
Endocrine disrupting effects on Chinese rare minnow(Gobiocypris rarus) fed with field collected Limnodrilus sp.
MA Tao-wu,WANG Zi-jian,LIU Jian-kang,
MA Tao-wu
,WANG Zi-jian,LIU Jian-kang

环境科学学报(英文版) , 2004,
Abstract: The potential endocrine disrupting effects and other toxicity effects on aquatic biota resulted from food uptake was simulated by feeding the laboratory cultured rare minnow(Gobiocypris rarus) with field collected Limnodrilus sp. The results indicated that the food chain processes affected significantly the growth, slightly reduced gonadosomatic indices, and elevated hepatosomatic indices. There was an obvious vitellogenin(VTG) induction, which generally only occurred in mature female, in the serum of juvenile rare minnow and mature male when fed with Limnodrilus sp. In addition, the rare minnow feeding on Limnodrilus sp. had significantly high renal indices, it meant obvious renal hyperplasia. The present work suggested that Limnodrilus sp. from field water may contain toxic pollutants and could lead to endocrine disruption effects to the predators. It was concluded that endocrine disruptors may not only be assimilated through water, but also be bioconcentrated through food web. The results also suggested the importance of food selection in conducting the study of endocrine disruption effects using sensitive species.
Advances in Effects of Endocrine Disrupting Chemicals on Sex Determination of Fish
环境内分泌干扰物对鱼类性别决定的影响研究进展

尹德玉,汝少国,田华
生态毒理学报 , 2009,
Abstract: There are plenty of aquatic endocrine disrupting chemicals which disrupt the fish sex determination process. In order to afford convenience for the researches of the effects and mechanisms of endocrine disrupting chemicals on disruption of fish sex determination, this paper reviewed the function of sex determination genes including SRY and DMY, and also the sex determination related genes such as Sox, DMRT, CYP, Vasa, Dax1 and Foxl2 in the fish sex determination process. This paper also reviewed the advances in the estrogenic and androgenic effects of endocrine disrupting chemicals on sex determination of fish, discussed the potential mechanisms and future prospects on this field as well.
Review: Endocrine disrupting chemicals (phenol and phthalates) in the South African environment: a need for more monitoring
O.O Olujimi, O.S Fatoki, J.P Odendaal, J.O Okonkwo
Water SA , 2010,
Abstract: There has been increasing concern about the impacts of exposure to chemical compounds with endocrine disrupting activities in the environment, especially aquatic environments, to wildlife and humans. South Africa is known to have used and abused most chemicals listed by developed and developing countries as endocrine-disrupting chemicals. Endocrinedisrupting chemicals have been reported in water, sediment and serum, as well as in fish tissue samples, at a level that could trigger endocrine disruption in humans and wildlife. Although some monitoring has been reported, particularly in water systems within the country, information on EDCs in other environmental matrices is scanty. The water systems monitored so far are very few. The strongest economy in Africa, and an emerging world economy depending on agriculture, mining, manufacturing and industry, needs to focus more on monitoring and to strengthen government organs and institutions to monitor and ensure environmental safety.
Study of Endocrine Disrupting Chemicals in Environment
Zoltán Juvancz,Sarolta Barna,Dániel Gyarmathy,Ferenc Konorót
Acta Polytechnica Hungarica , 2008,
Abstract: Endocrine disrupting chemicals (EDC) cause more and more seriousenvironmental pollutions. The EDCs show only ng-μg/l concentration level in theenvironment, therefore their determinations require multistep sample preparationprocesses and highly sophisticated instrumentation. This paper discuss the EDC effects,and show examples for determination of such compounds.
Review on Bioassay Technology of Endocrine Disrupting Pesticides
内分泌干扰类农药生物检测技术的研究进展

Han Zhihu,Bu Yuanqing,Shan Zhengjun,Cai Daoji,
韩志华
,卜元卿,单正军,蔡道基

生态毒理学报 , 2011,
Abstract: The endocrine disrupting pesticides are severely harmful to the health of human beings and other animals. Bioassay can be used to detect the hormone-like pesticides in the environment rapidly and conveniently. In this study, several common bioassay techniques of endocrine disrupting pesticides were reviewed, which can be generalized as in vivo assay, in vitro assay and non-cellular assay. The advantages and limitations of each method were discussed respectively, as well as their application in the evaluation of endocrine disrupting pesticides in the environment. This study aims to provide useful information for the development and application of bioassay techniques of endocrine disrupting pesticides in China.
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