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Biomedical Application of Beach Morning Glory Ipomoea pes-caprae
S. Bragadeeswaran,K. Prabhu,S. Sophia Rani,S. Priyadharsini,N. Vembu
International Journal of Tropical Medicine , 2012, DOI: 10.3923/ijtmed.2010.81.85
Abstract: Ipomoea pes-caprae is a medicinal plant used in many countries for the treatment of several ailments including inflammatory and algesic processes. The present study describes the antimicrobial, hemolytic, analgesic and anti-inflammatory effects of the methanolic extract obtained from flower parts of this plant. The results indicated that the methanolic extract) exhibited considerable antinociceptive activity against two classical models of pain in mice. Methanolic extract presented a calculated the value of 5 and 2 mg kg-1 of body weight, i.p. against tail flick test and also inhibited both phases of pain (tail flick and hot plate). The maximum for paw licking Aanalgesic Rresponse (AR) was recorded 4 in crude extract of Ipomoea pes-caprae flower extract after 45 min of administration and minimum of 1 AR showed 30 and 45 min after administration whereas minimum of 3 AR was recorded in 60 min, respectively. The methanolic extracts exhibited the considerable antimicrobial activity against human bacterial and fungal pathogens. Preliminary phytochemical analysis suggested the presence of steroids, terpenoids, alkaloids and flavonoids. These findings support, at least in part, the popular use of I. pes-caprae to treat dolorous processes.
Phytochemical and Antibacterial Properties of Leaf Extracts of Ipomoea asarifolia
MS Aliyu, U Lawal, MB Tijjani, MHI Doko, I Garba, HA Kokya, SA Ado, UA Hanwa, MM Ibrahim
Nigerian Journal of Basic and Applied Sciences , 2011,
Abstract: The antibacterial potency of aqueous and methanol extracts of Ipomoea asarifolia leaves; a plant widely used by traditional medical practitioners in Nigeria was determined in vitro against three bacterial pathogens (Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa) by agar well diffusion method. The pattern of inhibition varied with the extracts and the organisms tested. Both the aqueous and methanol extracts were potent on E. coli and S. aureus with maximum zone of growth inhibition of 21mm and 20mm at 200mg/ml respectively Pseudomonas aeruginosa was resistant to both extracts at all the concentrations tested. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) against E. coli for aqueous extract were 50mg/ml and 100mg/ml respectively; and 100mg/ml and 200mg/ml for methanol extract respectively. Similarly, The MIC and MBC against S. aureus for aqueous extract were 100mg/ml and 200mg/ml; 200mg/ml for the methanol extract. Preliminary phytochemical screening reveal the presence of anthraquinones, saponins and tannins in both aqueous and methanol extracts; triterpenes, flavonoids and glycosides were found only in the aqueous extract while alkaloids were found only in the methanol extract. However, carbohydrate and steroids were absent in both extracts. The spectra of activities shown by the extracts could be attributed to the presence of these phytochemicals which signifies the potential of I. asarifolia as a source of therapeutic agents. These findings therefore, justify the traditional medicinal use of the plant.
Chromatographic estimation of maturity based phytochemical profiling of Ipomoea mauritiana  [cached]
M. Sajjad Khan,Nitin Nema,M. D. Kharya,Salma Khanam
International Journal of Phytomedicine , 2011,
Abstract: Collection of herbs at right maturity is one of such parameter which affect afficacy of medicinal plants. Standard reference markers used in quality control of herbal drugs mostly authenticate identity and not efficacy. In order to derive bioactive markers, knowledge regarding appropriate collection time for each herb is essential. Traditional medical knowledge is bioactivity-oriented and informs about best time of collection for certain medicinal species, as observed in case of Ipomoea mauritiana Jacq. (Vidari–Sanskrit). Only mature (bigger size) tubers of Ipomoea mauritiana are used by Traditional Medical Practitioners (TMP) for preparing galactagogues and immunomodulatory herbal medicines (Rasayan).Microscopy of transverse sections revealed structural variation between mature and immature tubers and girth of tubers determine the maturity of plant, the difference in phytochemical profiles of mature and immature tubers was observed.Variation in phytoconstituents of mature and immature tubers was confirmed through proximate analysis, phytochemical screening, qualitative HPLC and HPTLC analysis revealed the variation in phytoconstituents in mature and immature tubers. Keywords: Microscopy, HPLC, HPTLC, proximate analysis, phytochemical screening.
ANTI INFLAMMATORY, ANALGESIC AND PHYTOCHEMICAL STUDIES OF CLITORIA TERNATEA LINN FLOWER EXTRACT  [PDF]
Shyamkumar,Bhat Ishwar
International Research Journal of Pharmacy , 2012,
Abstract: Clitoria ternatea Linn is a well known bio active plant in the Ayurvedic medicine. The present study evaluates the analgesic and anti-inflammatory activity of Clitoria ternatea Linn flower extract. The petroleum ether (60-80 C) extract poses significant anti inflammatory, analgesic properties. The extract is found to be safe even at the dose of 2000 mg/kg body weight by acute toxicity studies. Phytochemical investigation carried out on Petroleum ether(60-80 C) extract reveals the presence of Taraxerol, a pentacyclic triterpenoid which may impart the pharmacological activity of the extract.
PHARMACOGNOSTICAL AND PHYTOCHEMICAL INVESTIGATION OF IPOMOEA SEPIARIA KOENIG EX. ROXB. LEAF  [PDF]
Sayani Majumder,Nishteshwar K
International Research Journal of Pharmacy , 2013,
Abstract: Ipomoea sepiaria Koenig ex. Roxb. of the family Convolvulaceae is a perennial climber growing on the bank of streams, rivers, specially over hedges. Traditionally the whole herb is to possess number of therapeutic properties like, aphrodisiac, a good antidote to arsenic, rejuvenating, diuretic, aphrodisiac, laxative and also used in sterility in women and in diabetes. As the plant is not explored scientifically as yet, it was thought worth to evaluate each and every part of the plant thoroughly and the leaves being first selected for this. Present study deals with detailed macroscopy, qualitative & quantitative microscopy also includes its powder microscopy and its Chromatographic evaluations of leaf. Important diagnostic characters like, cluster crystals, starch grains, pitted vessels, laticiferous cells etc were observed. Physicochemical studies revealed loss on drying, total ash, etc. Preliminary analysis revealed the presence of various functional groups like alkaloids, saponins, phenols and resin. TLC & HPTLC study of the alcoholic, pet. ether and chloroform extract showed the presence of spots in short & long UV and after spraying developing reagent, respectively. The information generated by this particular study will provide relevant pharmacognostical and physicochemical data needed for proper identification and authentication of leaves of this particular species.
Review of the genus Ipomoea: traditional uses, chemistry and biological activities
Meira, Marilena;Silva, Eliezer Pereira da;David, Jorge M;David, Juceni P.;
Revista Brasileira de Farmacognosia , 2012, DOI: 10.1590/S0102-695X2012005000025
Abstract: approximately 600-700 species of ipomoea, convolvulaceae, are found throughout tropical and subtropical regions of the world. several of those species have been used as ornamental plants, food, medicines or in religious ritual. the present work reviews the traditional uses, chemistry and biological activities of ipomoea species and illustrates the potential of the genus as a source of therapeutic agents. these species are used in different parts of the world for the treatment of several diseases, such as, diabetes, hypertension, dysentery, constipation, fatigue, arthritis, rheumatism, hydrocephaly, meningitis, kidney ailments and inflammations. some of these species showed antimicrobial, analgesic, spasmolitic, spasmogenic, hypoglycemic, hypotensive, anticoagulant, anti-inflammatory, psychotomimetic and anticancer activities. alkaloids, phenolics compounds and glycolipids are the most common biologically active constituents from these plant extracts.
Review of the genus Ipomoea: traditional uses, chemistry and biological activities  [cached]
Marilena Meira,Eliezer Pereira da Silva,Jorge M David,Juceni P. David
Revista Brasileira de Farmacognosia , 2012,
Abstract: Approximately 600-700 species of Ipomoea, Convolvulaceae, are found throughout tropical and subtropical regions of the world. Several of those species have been used as ornamental plants, food, medicines or in religious ritual. The present work reviews the traditional uses, chemistry and biological activities of Ipomoea species and illustrates the potential of the genus as a source of therapeutic agents. These species are used in different parts of the world for the treatment of several diseases, such as, diabetes, hypertension, dysentery, constipation, fatigue, arthritis, rheumatism, hydrocephaly, meningitis, kidney ailments and inflammations. Some of these species showed antimicrobial, analgesic, spasmolitic, spasmogenic, hypoglycemic, hypotensive, anticoagulant, anti-inflammatory, psychotomimetic and anticancer activities. Alkaloids, phenolics compounds and glycolipids are the most common biologically active constituents from these plant extracts.
PHYTOCHEMICAL SCREENING AND THE EVALUATION OF THE ANTIOXIDANT, TOTAL PHONELIC CONTENT AND ANALGESIC PROPERTIES OF THE PLANT PANDANUS FOETIDUS (FAMILY: PANDANACEAE)  [PDF]
Hossain Md. Lokman,Monjur-Al-Hossain A.S.M.,Sarkar Kishore Kumar,Hossin Arif
International Research Journal of Pharmacy , 2013,
Abstract: Pandanus foetidus is an important medicinal plant having widespread application in a variety of disorders. The aim of this study was the phytochemical investigation and evaluation of the anti-oxidant, total phenolic content and analgesic activities of the whole plant Pandanus foetidus. Phytochemical screening of the ethanolic extract of Pandanus foetidus ensured the presence of carbohydrates, glycosides, alkaloids, tannins, flavonoids and steroids. The anti-oxidant activity was measured by DPPH free radical scavenging activity (IC50=48 μg/ml). The plant Pandanus foetidus shows total phenolic content test due to the presence of reducing sugar, tannins and flavonoids.The crude ethanolic extract of the tubers of Pandanus foetidus exhibited significant analgesic activity at a dose of 250 mg/kg and 500 mg/kg with 71.15% and 80.77 % inhibition of writhing respectively.
Ethnobotanical, pharmacognostical, pharmacological and phytochemical studies on Smilax domingensis in Guatemala
Cáceres, Armando;Cruz, Sully M.;Martínez, Vicente;Gaitán, Isabel;Santizo, Aylin;Gattuso, Susana;Gattuso, Martha;
Revista Brasileira de Farmacognosia , 2012, DOI: 10.1590/S0102-695X2011005000211
Abstract: smilax domingensis willd., smilacaceae, known as zarzaparrilla, is a climbing shrub from tropical america. the rhizome is popularly used in medicine as anti-inflammatory, antiseptic, and tonic. since 1983 studies are being conducted in guatemala for validation of the ethnobotanical uses, particularly in vitro demonstration of antimicrobial activity, using wild material, with high variability and some taxonomic problems. this article reports the taxonomic determination, cultivation of drug material, evaluation of use by in vitro and in vivo pharmacological assays, and phytochemical characterization. extracts from cultivated material was evaluated by antimicrobial, anti-inflammatory, analgesic and immunomodulatory models, confirming the antimicrobial and immunomodulatory activities. phytochemistry was done in the crude drug and extracts. quality control parameters are described (micrographic drawings and phytochemical characteristics). evidence is presented that cultivated rhizome has antimicrobial and immunomodulatory activities, validating the popular use and helping the industrial development of phytopharmaceutical products.
Ethnobotanical, pharmacognostical, pharmacological and phytochemical studies on Smilax domingensis in Guatemala  [cached]
Armando Cáceres,Sully M. Cruz,Vicente Martínez,Isabel Gaitán
Revista Brasileira de Farmacognosia , 2012,
Abstract: Smilax domingensis Willd., Smilacaceae, known as zarzaparrilla, is a climbing shrub from Tropical America. The rhizome is popularly used in medicine as anti-inflammatory, antiseptic, and tonic. Since 1983 studies are being conducted in Guatemala for validation of the ethnobotanical uses, particularly in vitro demonstration of antimicrobial activity, using wild material, with high variability and some taxonomic problems. This article reports the taxonomic determination, cultivation of drug material, evaluation of use by in vitro and in vivo pharmacological assays, and phytochemical characterization. Extracts from cultivated material was evaluated by antimicrobial, anti-inflammatory, analgesic and immunomodulatory models, confirming the antimicrobial and immunomodulatory activities. Phytochemistry was done in the crude drug and extracts. Quality control parameters are described (micrographic drawings and phytochemical characteristics). Evidence is presented that cultivated rhizome has antimicrobial and immunomodulatory activities, validating the popular use and helping the industrial development of phytopharmaceutical products.
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