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HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACTS OF NARINGI CRENULATA (ROXB) NICOLSON AGAINST CCl4 INDUCED HEPATOTOXICITY IN RATS
V. R. Mohan et al.
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: The present study was designed to screen and evaluate the hepatoprotective and antioxidant activity of ethanol extracts of leaf and bark of Naringi crenulata (Roxb) Nicolson (NCL, NCB) against CCl4 induced hepatotoxicity in rats. Liver functions were assessed by the activities of liver marker enzymes, SGOT, SGPT, ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubins. It also exhibited antioxidant activity by showing the increased activity of SOD, CAT, GPx and GRD and decreased in TBARS compared to CCl4 treated groups. Silymarin, a known hepatoprotective drug is used for comparison. The plant extracts were effective in protecting liver against injury induced by CCl4 in rats.
HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF CANSCORA PERFOLIATA LAM (GENTIANACEAE) AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS  [PDF]
Thangakrishnakumari S,Nishanthini A,Muthukumarasamy S,Mohan V.R.
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: The aim of the study was to investigate the hepatoprotective activity of ethanol extract of whole plant of Canscora perfoliata in CCl4 induced hepatotoxic rats. Administration of hepatotoxins (CCl4) showed significant elevation of serum SGOT, SGPT, ALP, bilirubin, conjugated, unconjugated bilirubin and lipid peroxidation. Treatment with Canscora perfoliata (150 and 300mg/kg) significantly reduced the above mentioned parameters. The plant extract also enhanced the antioxidant activity. The ethanol extract of Canscora perfoliata have significant effect on the CCl4 induced hepatotoxicity animal models.
EVALUATION OF HEPATOPROTECTIVE EFFECT OF ADIANTUM INCISUM FORSK LEAF EXTRACT AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS  [PDF]
P Royal Frank,V Suresh,G Arunachalam,SK Kanthlal
International Research Journal of Pharmacy , 2012,
Abstract: Oxidative damage is involved in the pathogenesis of various hepatic injuries. In the present study, the protectivity of methanolic extract of leaves of Adiantum incisum forsk (MEAI), as an antioxidant to protect against CCl4-induced oxidative stress and hepatotoxicity in Albino Wistar rats was investigated. Intraperitoneal injection of CCl4, produced a marked elevation in the serum levels of serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin, and decrease in the total protein. Histopathological analysis of the liver of CCl4-induced rats revealed marked liver cell necrosis with inflammatory collections that were conformed to increase in the levels of SOD, GPx, LPO and CAT. Daily oral administration of methanolic extract of A.incisum forsk at 100 and 200 mg/kg doses for 10 days produced a dose-dependent reduction in the serum levels of liver enzymes. Treatment with A.incisum forsk normalized various biochemical parameters of oxidative stress and was compared with standard Silymarin. Therefore, the results of this study show that A.incisum forsk can be proposed to protect the liver against CCl4-induced liver damage in rats, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenger effects.
HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF SPERMACOCE HISPIDA.LINN AGAINST CARBON TETRACHLORIDE (CCl4) INDUCED HEPATOTOXICITY ON ALBINO WISTAR RATS.  [cached]
M.Karthikeyan
International Journal of Pharmaceutical Research and Development , 2011,
Abstract: In Indian traditional system of medicine, herbal remedies are prescribed for the treatment of various diseases including liver diseases. The present study was aimed to investigate the hapatoprotective activity of the Ethanolic Extract of Spermacoce hispida.Linn (SHE) against carbon tetra chloride (CCl4) inducd hepatotoxicity in rats. Liver functions were assessed by the determination of SGOT, SGPT, ALP and bilirubin. Histopathological studies were carried out.The serum biochemical analysis results suggest that the use of Ethanolic extract of Spermacoce hispida.Linn exhibited significant protective effect from hepatic damage in CCl4 induced hepatotoxicity model. Histopathological studies revealed that concurrent administration of the extract with CCl4 exhibited protective effect on the liver, which further evidenced its hepatoprotective activity.
Hepatoprotective potential of Cordia subcordata Lam. against carbon tetra chloride (CCl4)-induced hepatotoxicity in Wistar albino rats  [PDF]
Saravana Kumar.A,Gandhimathi.R,Senthil Kumar.K.K,Kusuma Praveen Kumar
Journal of Biomedical Sciences and Research , 2009,
Abstract: Aim: To investigate the phytoconstituents, acute oral toxicity and hepatoprotective activity of ethanol (90%) extract of Cordia subcordata Lam. (EECS) using CCl4 induced hepatotoxicity in male Wistar albino rats.Methods: The EECS at doses of 100, 200 and 400mg/kg, p.o and the standard drug Liv.52 (40mg/kg, p.o) were administered for 7 days in CCl4 intoxicated rats. The hepatoprotective activity was assessed by using various biochemical parameters like SGOT, SGPT, alkaline phosphatase (ALP) and acid phosphatase (ACP), also total bilirubin and urea along with histopathological studies of liver tissue. The biochemical changes and histopathological studies were observed on 4th and 8th day. Results: EECS at tested doses significantly decrease (P<0.001) the elevated levels of the hepatic enzymes, total bilirubin and urea in a dose dependent manner after 3days whereas it’s subsequent return towards near normal after 7days indicating the recovery of hepatic cells. In the liver sections of the rats treated with EECS extracts for 7 days, the normal cellular architecture was retained as compared to Liv.52, thereby furtherly confirming the potent hepatoprotective effect of EECS.Conclusion: The EECS afforded significant protection against CCl4 induced hepatocellular injury.
Hepatoprotective and Antioxidant effect of Polygala rosmarinifolia Wight & Arn against CCl4 induced hepatotoxicity in rats.  [PDF]
M. Alagammal,M. Packia Lincy,V.R. Mohan
Journal of Pharmacognosy and Phytochemistry , 2013,
Abstract: Carbon tetrachloride (CCl4) intoxicated rats showed significant elevation in serum enzymes, bilirubin and lipid peroxidation of the liver tissues and reduction in serum total protein, superoxide dismutase, catalase, reduced glutathione peroxide activity. Treatment with ethanol extract of Polygala rosmarinifolia whole plant altered the above parameters to the levels of near normal. All the above results were comparable with the standard drug silymarin (100mg/kg) treated group. Thus the present study ascertains that the ethanol extract of Polygala rosmarinifolia whole plant possesses significant hepatoprotective activity.
HEPATOPROTECTIVE ACTIVITY OF ENHYDRA FLUCTUANS LOUR. AERIAL PARTS AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS  [PDF]
Swain Pramod Kumar,Patro V. Jagannath,Dinda Subas Chandra,Nayak Durga Prasan
International Journal of Research in Ayurveda and Pharmacy , 2012,
Abstract: Enhydra fluctuans Lour. an edible herbaceous vegetable plant and widely used in torpidity of liver and in nervous diseases. The different extracts (Pet-Ether extract, Chloroform extract and Ethanol extract) of Enhydra fluctuans aerial parts were studied for its hepatoprotective effect on CCl4-induced hepatotoxic rats. The extracts were referred as PEEF, CEF and EEF respectively. In the toxicity study, all the extracts did not produce any mortality even at the highest dose (2000mg/kg) so 200mg/kg dose was taken as the tested dose. The extracts were found to decrease significantly CCl4-induced elevation of SGOT, SGPT, bilirubin and total cholesterol at the dose of 200mg/kg body weight. But it increased HDL-cholesterol level and liver weight with respect to CCl4 toxic rats. Histopathological profiles of CCl4-induced hepatotoxic liver revealed extensive centrilobular necrosis extending to other necrotic areas, ballooning degeneration with steatosis. The protective effect of PEEF, CEF and EEF (200 mg/kg, p.o.) were confirmed by histopathological examination of liver section of control, CCl4-induced and extracts treated groups of rats. Though all the extracts showed remarkable effect. EEF (200mg/kg, p.o.) treated rats exhibited a significant improvement of hepatocellular architecture over CCl4-induced group as evident from considerable reduction in necrosis and steatosis which is comparable with the standard drug Silymarin (25mg/kg, p.o.).
Protective Effect of a Herbal Formula Against Carbontetrachloride Induced Hepatotoxicity  [PDF]
O. Prakash,G.N. Singh,R.M. Singh,S.C. Mathur
International Journal of Pharmacology , 2008,
Abstract: This study investigated the protective effects of a polyherbal formula BCEZ, containing extracts of Bacopa monneiri Linn. Penn., Curcuma longa Linn., Emblica officinalis Gaertn. and Zingiber officinale Rosc., on the carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Hepatic injury was achieved by injecting 0.5 mL kg-1, i.p. of CCl4. The BCEZ at the doses 50, 100 and 250 mg kg-1, p.o. offered significant hepatoprotective action by reducing the serum marker enzymes like Serum Glutamate Oxaloacetate Transaminase (SGOT) and Serum Glutamate Pyruvate Transaminase (SGPT). They also reduced the elevated levels of alkaline phosphatase (ALP). Histopathological studies further confirmed the hepatoprotective activity of BCEZ when compared with the CCl4 treated control groups. The results obtained were compared with silymarin (100 mg kg-1, p.o.), the standard drug. Thus it can be concluded, BCEZ might be a potential herbal agent for its hepatoprotective activity.
Development and evaluation of hepatoprotective polyherbal formulation containing some indigenous medicinal plants  [cached]
Dandagi P,Patil M,Mastiholimath V,Gadad A
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: The present study explores the hepatoprotective activity of various extracts of Ferula asafoetida , Momordica charantia Linn and Nardostachys jatamansi against experimental hepatotoxicity. Polyherbal suspensions were formulated using extracts showing significant activity and evaluated for both physicochemical and hepatoprotective activity in comparison with LIV-52 as standard. Petroleum ether (60-80°), chloroform, benzene, ethanol and aqueous extracts of Ferula asafetida , Momordica charantia Linn and Nardostachys jatamansi were evaluated for hepatoprotective activity against carbon tetrachloride-induced liver toxicity in Wistar rats. Polyherbal suspensions were prepared by the trituration method using a suspending agent and other excipients. Formulation F3 has shown significant hepatoprotective effect by reducing the elevated serum enzyme levels such as glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and alkaline phosphatase. These biochemical observations were supplemented by histopathological examination of liver sections. Various parameters evaluated for all formulations were within the official specifications. Experimental data suggested that treatment with formulation F3 enhances the recovery from carbon tetra chloride-induced hepatotoxicity. From these results it may be concluded that the F3 formulation (containing chloroform, petroleum ether and aqueous extracts of Ferula asafetida , petroleum ether and ethanol extracts of Momordica charantia Linn. and petroleum ether and ethanol extracts of Nardostachys jatamansi ) demonstrated significant hepatoprotective activity, that might be due to combined effect of all these extracts.
Hepatoprotective Activity of Ethanolic Extract of the Stems of Anisochilus Carnosus against Carbon Tetrachloride-induced Hepatotoxicity in Rats
P Venkatesh, A Dinakar, N Senthilkumar
International Journal of Health Research , 2010,
Abstract: Purpose: To evaluate the hepatoprotective activity of ethanolic extract of the stems of Anisochilus Carnosus (EEAC) against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Methods: Hepatotoxicity was induced in albino Wistar rats of either sex by intraperitoneal injection of CCl4 in olive oil (1:1). Two doses of ethanolic extract of Anisochilus Carnosus (200 and 400 mg/kg body weight) were administered to the experimental rats. The hepatoprotective effect of the extract was evaluated by the assay of liver function biochemical parameters like serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, alkaline phosphatase, total bilirubin and total protein. Results: In ethanolic extract treated animals, the toxic effect of CCl4 was significantly controlled by the plant extract as compared to the normal and the standard drug silymarin treated group. Conclusion: Ethanolic extract of stems of Anisochilus Carnosus possesses significant hepatoprotective activity.
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