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Protective Effects of Methanolic Fruit Extract of Solena amplexicaulis in Carbon Tetrachloride Induced Hepatotoxicity on Rat  [cached]
Parameshwar Hanwathe,Ravi Kumar Bobbala,Krishna Mohan Gottumukhala,Narsimha Reddy Yellu
Stamford Journal of Pharmaceutical Sciences , 2010,
Abstract: Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. In the present study, the hepatoprotective activity of methanolic extract of the fruits of Solena amplexicaulis (Family, Cucurbitaceae) at doses of 250 mg/kg and 500 mg/kg body weight per oral were evaluated by carbon tetrachloride intoxication in rats. The toxic group which received Carbon tetrachloride (1ml/kg body weight per oral.) dissolved in 1:1 ratio in olive oil alone exhibited significant increase in serum alanine amino transferase, aspartate amino transferase, alkaline phosphatase and total bilirubin levels compared to the groups received pretreatment of Solena amplexicaulis per oral. The extract treated group remarkably controlled the aspartate amino transferase, serum alanine amino transferase, alkaline phosphatase and total bilirubin levels in serum and the effects were comparable with standard drug (silymarin 100 mg/kg body weight per oral). The histological examinations of the liver showed propound steatosis degeneration and nodule formation in the hepatic architecture of carbon tetrachloride treated rats. But the animals received pretreatment of the extract shown decreased necrotic zone and hepatocellular degeneration when compared to the liver exposed to carbon tetrachloride intoxication alone. This study suggests that methanolic extract of the fruit of Solena amplexicaulis has a liver protective effect against carbon tetrachloride-induced hepatotoxicity.
HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF ALTHAEA OFFICINALIS LINN AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY ON ALBINO WISTAR RATS
Jabbar Zoobi,Ali Mohd
International Research Journal of Pharmacy , 2011,
Abstract: In Indian traditional system of medicine, herbal remedies are prescribed for the treatment of various diseases including liver diseases. The present study was aimed to investigate the hepatoprotective activity of the ethanolic extract of Althaea officinalis against Carbon tetrachloride induced hepatotoxicity in rats. Liver function were assessed by the determination of SGPT and SGOT studies. The serum biochemical analysis results suggested that the use of ethanolic extract of Althaea officinalis exhibited significant protective effect from hepatic damage in CCl4 induced hepatotoxicity model.
Hepatoprotective Activity of Ethanolic Extract of the Stems of Anisochilus Carnosus against Carbon Tetrachloride-induced Hepatotoxicity in Rats
P Venkatesh, A Dinakar, N Senthilkumar
International Journal of Health Research , 2010,
Abstract: Purpose: To evaluate the hepatoprotective activity of ethanolic extract of the stems of Anisochilus Carnosus (EEAC) against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Methods: Hepatotoxicity was induced in albino Wistar rats of either sex by intraperitoneal injection of CCl4 in olive oil (1:1). Two doses of ethanolic extract of Anisochilus Carnosus (200 and 400 mg/kg body weight) were administered to the experimental rats. The hepatoprotective effect of the extract was evaluated by the assay of liver function biochemical parameters like serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, alkaline phosphatase, total bilirubin and total protein. Results: In ethanolic extract treated animals, the toxic effect of CCl4 was significantly controlled by the plant extract as compared to the normal and the standard drug silymarin treated group. Conclusion: Ethanolic extract of stems of Anisochilus Carnosus possesses significant hepatoprotective activity.
Observation of the hepatoprotective and antioxidant activities of Trianthema decandra Linn. (Vallai sharunnai) roots on carbon tetrachloride-treated rats
G. Balamurugan,P. Muthusamy
Bangladesh Journal of Pharmacology , 2008,
Abstract: The present study was carried out to observe the hepatoprotective effect and antioxidant activity of the ethanol extract of the roots of Trianthema decandra Linn. (200 and 400 mg/kg) in rats treated with carbon tetrachloride for 8 weeks. Extract at the tested doses restored the levels of all serum (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin and total protein) and liver homogenate enzymes (glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase) significantly. Histology demonstrated profound steatosis degeneration and nodule formation were observed in the hepatic architecture of carbon tetrachloride treated rats which were found to acquire near-normalcy in extract plus carbon tetrachloride administrated rats, and supported the biochemical observations. This study suggests that ethanol extract of T. decandra has a liver protective effect against carbon tetrachloride- induced hepatotoxicity and possess antioxidant activities.
Studies on hepatoprotective activity of traditional ayurvedic formulation ‘Vidakana Choornam’ against carbon tetrachloride induced hepatotoxicity in albino rat
Jayarama Reddy, Gnanasekaran D, Ranganathan TV and Vijay D
International Journal of Pharmaceuticals Analysis , 2010,
Abstract: The study was carried out to ascertain the hepatoprotective activity of traditional ayurvedicformulation ‘Vidakana Choornam’ against carbon tetrachloride induced hepatotoxicity in albino rat. Effect ofcarbon tetrachloride and herbal products on liver weights was studied. Bilirubin level in serum, SerumGlutamate Pyruvate Transaminase (GPT) level in serum, Serum Glutamate Oxaloacetate Transaminase(GOT) level in serum and ALP level in serum were estimated in both control treatment. Histopathologicalstudies were also carried out. It was found that there was an increase in liver weight during carbontetrachloride treatment which may be due to accumulation of fat. The results of Vidakana Choornam’treatment against carbon tetrachloride induced hepatotoxicity revealed that there was considerablereduction in Bilirubin level in serum, Serum Glutamate Pyruvate Transaminase (GPT) level in serum, SerumGlutamate Oxaloacetate Transaminase (GOT) level in serum and ALP level in serum. The hepatoprotectiveactivity of this simple formulation was found to be as effective as Liv – 52, infact the activity on decreasingthe serum bilirubin level was much higher when compared to Liv – 52
Hepatoprotective effects of Quercus infectoria gall extract against carbon tetrachloride treated liver injury in rats
Gaurav Lodhi,Hemant K Singh,Kamlesh K Pant,Ch V Rao
International Journal of Applied Research in Natural Products , 2012,
Abstract: Summary. In the present study, galls of Quercus infectoria possessing potent antioxidant and antiinflammatory properties were evaluated for their hepatoprotective effect against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Subcutaneous injection of CCl4, administered twice a week, produced a marked elevation in the serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and tumor necrosis factor alpha (TNF-α). Histological analysis of the liver of these rats revealed marked necro-inflammatory changes that were associated with increase in the levels of TBARS, PGE2 and catalase and decrease in the levels of glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GPx). Daily oral administration of aqueous ethanolic extract of Quercus infectoria galls at 200, 400 and 600 mg/kg doses produced a dose dependent reduction in the serum levels of liver enzymes and inflammatory mediators and attenuated the necroinflammatory changes in the liver. The QIE treatment also normalized various biochemical parameters of oxidative stress. Our study shows that the hepatoprotective effects of QIE and silymarin were comparable and suggests that QIE could be used as a hepatoprotective agent. Industrial relevance. Research in traditional medicine has lead to the development of many modern medicines. In recent times, focus on plants research has increased all over the world and a large body of evidence has been collected to show immense potential of medicinal plants used in various traditional systems. It is very interesting to note that there is no drug available in the modern system of medicine for treating hepatic disorders; only certain herbal preparations are available to treat this quite vulnerable disease. The situation/background thus explained above warrants for developing a safe, effective and scientifically validated hepatoprotective agent taking lead from traditional medicine, which is affordable for the rural poor population.The results of the present study clearly demonstrate the hepatoprotective potential of natural products. The scientific information generated would certainly help the industry in developing new, potent hepatoprotective drugs with no or least adverse effects. Keywords. Quercus infectoria; galls; Carbon tetrachloride; Hepatoprotective
Hepatoprotective Effect of the Aqueous Root-Bark Extract of Ficus sycomorus (Linn) on Carbon Tetrachloride Induced Hepatotoxicity in Rats
S.H. Garba,J. Prasad,U.K. Sandabe
Journal of Biological Sciences , 2007,
Abstract: The aqueous root-bark extract of Ficus sycomorus (Linn) was tested for its chemical constituents, acute toxicity and hepatoprotective effect against Carbon tetrachloride (CCl4) induced hepatotoxicity in rats. A total of 78 adult albino rats weighing between 150-320 g were used. The animals were each weighed at the start of the experiment and divided into two segments consisting of 42 rats for the acute toxicity and 36 rats for the hepatoprotective study segments, respectively. In the acute toxicity study the aqueous extract of the root-bark of Ficus sycomorus was administered intraperitoneally (ip) in a dose range of 0.2-12 g kg-1 and the rats were observed for the physical signs of toxicity for 24 h. The hepatoprotective segment involved dosing the negative control rats intraperitonealy with carbon tetrachloride (CCl4) 3 mL kg-1 that was dissolved in corn oil to induce liver damage while the treatments groups were pretreated with 640 mg kg-1 of the extract orally an hour before CCl4 (3 mL kg-1) was administered to observe if the extract has any hepatoprotective effect against CCl4 induced hepatotoxicity At the end of each treatment period, the animals were weighed and blood was obtained from animals administered CCl4 and pre-treated with 640 mg kg-1 of the extract for biochemical analysis with the liver extracted, weighed and processed for histological assessment. Phytochemical analysis of the extract revealed the presence of saponins, flavonoids, alkaloids, tannins and reducing sugar and LD50 was calculated as 3.20 0.6031 g kg-1. Pre-treatment of the rats with the extract was able to reduce though not significantly, changes in the biochemical parameters (decrease in albumin but increase in Aspartate Transaminase (AST), Alanine-Transaminase (ALT), Alkaline Phosphatase (ALP) and bilirubin) and preserved the liver parenchymal architecture against CCl4 induced degenerative changes, fibroplasia and cirrhosis. The results of this study showed that the plant extract had hepatoprotective effect on the parenchymal architecture of the liver against CCL4 induced hepatotoxicity in rats. But further studies to observe its hepatocurative potentials would be useful and is recommended.
Hepatoprotective and in vivo Antioxidant Effects of Careya arborea against Carbon tetrachloride Induced Liver Damage in Rats
R. Sambath Kumar,T. Sivakumar,P. Sivakumar,R. Nethaji,M. Vijayabasker,P.Perumal,Malaya Gupta,Upal Kanti Mazumder
International Journal of Molecular Medicine and Advance Sciences , 2011,
Abstract: The present study was carried out to evaluate the hepatoprotective and antioxidant effect of the Methanol Extract of Careya arborea Roxb (MECA) (Family- Myrtaceae) stem bark in Wistar albino rats. The different groups of animals were administered with carbon tetrachloride (CCl4) (30 % CCl4, 1 mL Kg 1 b. wt. in liquid paraffin 3 doses (i.p.) at 72 h interval). The MECA at the doses of 50, 100 and 200 mg Kg 1 and silymarin 25 mg Kg 1were administered to the CCl4 treated rats. The effect of MECA and silymarin on serum transaminase (GOT, GPT), Alkaline Phosphates (ALP), bilirubin, uric acid and total protein were measured in the rats induced hepatotoxicity by CCl4. Further, the effects of the extract on Lipid Peroxidation (LPO), enzymatic antioxidant (Superoxide Dismutase (SOD) and Catalase (CAT)), and nonenzymatic antioxidant (Glutathione (GSH), vitamin C and vitamin E) were estimated. The MECA and silymarin produced significant (p < 0.05) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, uric acid, and lipid peroxidation and significantly (p < 0.05) increased the levels of SOD, CAT, GSH, vitamin C, vitamin E and protein in a dose dependent manner. From these results, it was suggested that MECA possess potent hepatoprotective and antioxidant properties.
Evaluation of hepatoprotective activity of Cleome viscosa Linn. extract  [cached]
Gupta Nishant,Dixit Vinod
Indian Journal of Pharmacology , 2009,
Abstract: Objectives: To evaluate the hepatoprotective activity of ethanolic extract of Cleome viscosa Linn. (Capparidaceae) against carbon tetrachloride (CCI 4 ) induced hepatotoxicity in experimental animal models. Materials and Methods: Leaf powder of Cleome viscosa was extracted with ethanol. The hepatoprotective activity of the extract was assessed in CCI 4 induced hepatotoxicity in rats. Various biochemical parameters were estimated and histopathological studies were also performed on rat liver. The hepatoprotective activity was also supported by determining a functional parameter, i.e. thiopental-induced sleep of mice poisoned with CCl 4 . Results: The test material was found effective as hepatoprotective, through in vivo and histopathological studies. The extract was found to be effective in shortening the thiopental induced sleep in mice poisoned with CCl 4 . The hepatoprotective effect of ethanolic extract was comparable to that of silymarin, a standard hepatoprotective agent. Conclusion: The results of the present study show that ethanolic extract of Cleome viscosa has significant hepatoprotective activity.
Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats
Yibin Feng, Ka-Yu Siu, Xingshen Ye, Ning Wang, Man-Fung Yuen, Chung-Hang Leung, Yao Tong, Seiichi Kobayashi
Chinese Medicine , 2010, DOI: 10.1186/1749-8546-5-33
Abstract: Sprague-Dawley rats aged seven weeks were injected intraperitoneally with 50% CCl4 in olive oil. Berberine was orally administered before or after CCl4 treatment in various groups. Twenty-four hours after CCl4 injection, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, serum and liver superoxide dismutase (SOD) activities were measured. Histological changes of liver were examined with microscopy.Serum ALT and AST activities significantly decreased in a dose-dependent manner in both pre-treatment and post-treatment groups with berberine. Berberine increased the SOD activity in liver. Histological examination showed lowered liver damage in berberine-treated groups.The present study demonstrates that berberine possesses hepatoprotective effects against CCl4-induced hepatotoxicity and that the effects are both preventive and curative. Berberine should have potential for developing a new drug to treat liver toxicity.Liver damage induced by carbon tetrachloride (CCl4) involves biotransformation of free radical derivatives, increased lipid peroxidation and excessive cell death in liver tissue [1,2]. This model of CCl4-induced liver injury has been widely used in new drug development for liver diseases.Berberine is a plant alkaloid present in many medicinal herbs, such as Hydrastis canadensis, Coptidis Rhizoma, Berberis aquifolium, Berberis aristata and Berberis vulgaris [3]. Coptidis Rhizoma (Huanglian), which is rich in berberine, exhibited hepatoprotective effects on CCl4-induced liver injury via scavenging the peroxidative products [4]. Antioxidative effects of Coptidis Rhizoma and its major active ingredient berberine against peroxynitrite-induced kidney damage were demonstrated in vitro and in vivo [5]. Previous studies reported that berberine inhibited inflammation [6] and low-density lipoprotein (LDL) oxidation [7]. Other studies found that berberine was a candidate drug for Alzheimer's disease [8] and cancer [9]. Berberine exhib
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