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Phytochemical Screening and Evaluation of Anesthetic Effects of Qurs saffron (A Herbal Medicine)  [cached]
Naveed Ullah
Asian Journal of Medical Sciences , 2011,
Abstract: Qurs saffron (herbal tablets) is used so widely as an analgesic for the treatment of gout through the Asia. And it is believed to be so safe because of its herbal properties. Therefore its effects on all the body functions are the need of hour to confirm the safety of this product for human health. In the current study the qualitative phytochemical screening of the product revealed that, it have excess quantity of alkaloids, moderate amount of saponin and carbohydrates. The alkaloids present in the product may be responsible of anti- gout effect. The anesthetic effect of the product were also checked, which were found to be negative. No comparable anesthetic effect was noted to that of xylocaine. From the current study it can be concluded that the product is effective for the use as anti-gout, and safe from the anesthetic effect.
Design, Development and Phytochemical Evaluation of a Poly Herbal Formulation Linkus Syrup  [PDF]
Zeeshan Ahmed Sheikh, Aqib Zahoor, Saleha Suleman Khan, Khan Usmanghani
Chinese Medicine (CM) , 2014, DOI: 10.4236/cm.2014.52012
The present work has been carried out on polyherbal formulation named as Linkus Syrup. The herbal formulation consists of Glycyrrhiza glabra, Hyssopus officinalis, Piper longum and Alpinia galangal. The Linkus syrup physico-chemical evaluation such as pH, density, identification of polysaccharide, tanning agents, ascorbic acid and shelf life was complied. The TLC and quantitative determination of alkaloid were quantified. Determination of biomarker has been validated for the analysis of vasicine. The study result revealed that Linkus syrup formulation was well standardized at different levels such as physic-chemical consistency and assay of bio marker compound.
Acute Toxicity Study and Phytochemical Screening of Selected Herbal Aqueous Extract in Broiler Chickens  [PDF]
S.R. Hashemi,I. Zulkifli,M. Hair Bejo,A. Farida
International Journal of Pharmacology , 2008,
Abstract: In order to collect ethnobotanical information about growth and health promoter plants as feed additive in broiler chickens, five medicinal plants Euphorbia hirta, Solanum torvum, Zingiber officinale, Curcuma longa and Zingiber zerumbet used by traditional medical practitioners for the treatment of several ailments of microbial and non-microbial origins were investigated for phytochemical screening and acute toxicity study. A total of 30 female broiler chicks were obtained. At 21 days of age, the chicks were allocated at random into six groups. Five chickens were assigned at random to each treatment in five replicates and kept in 30 cages (one chickens per cage) till five weeks of age. Five groups were administered a single oral dose of 2,000 mg kg-1 b.wt. while 5 mL distilled water was given to the control group of birds as placebo. Phytochemical screening study showed that plant contained volatile oils, tannins, alkaloids, saponins, flavonoids. Alkaloids and steroids were only found in the aqueous extract of Euphorbia hirta. Tissues were harvested and processed for photomicrographic examinations. Macro and microscopic observations indicated no alteration in liver and kidneys of the treated birds with 2000 mg kg-1 of selected herbal plants extract. In the hematological study, a highly significant decrease was observed in AST, ALT, ALP level of broiler group receiving the aqueous extract of E. hirta 14 after of administration. Acute toxicity study indicated that water suspensions of selected herbal aqueous extract are not toxic when administered by the oral route to experimental birds at 2000 mg kg-1 b.wt. In conclusion, the results obtained in the present study are in agreement to a certain degree with the traditional uses of the plants estimated as prophylaxis against various diseases and promote of health.
Compartmentalization of Mammalian Pantothenate Kinases  [PDF]
Adolfo Alfonso-Pecchio, Matthew Garcia, Roberta Leonardi, Suzanne Jackowski
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049509
Abstract: The pantothenate kinases (PanK) catalyze the first and the rate-limiting step in coenzyme A (CoA) biosynthesis and regulate the amount of CoA in tissues by differential isoform expression and allosteric interaction with metabolic ligands. The four human and mouse PanK proteins share a homologous carboxy-terminal catalytic domain, but differ in their amino-termini. These unique termini direct the isoforms to different subcellular compartments. PanK1α isoforms were exclusively nuclear, with preferential association with the granular component of the nucleolus during interphase. PanK1α also associated with the perichromosomal region in condensing chromosomes during mitosis. The PanK1β and PanK3 isoforms were cytosolic, with a portion of PanK1β associated with clathrin-associated vesicles and recycling endosomes. Human PanK2, known to associate with mitochondria, was specifically localized to the intermembrane space. Human PanK2 was also detected in the nucleus, and functional nuclear localization and export signals were identified and experimentally confirmed. Nuclear PanK2 trafficked from the nucleus to the mitochondria, but not in the other direction, and was absent from the nucleus during G2 phase of the cell cycle. The localization of human PanK2 in these two compartments was in sharp contrast to mouse PanK2, which was exclusively cytosolic. These data demonstrate that PanK isoforms are differentially compartmentalized allowing them to sense CoA homeostasis in different cellular compartments and enable interaction with regulatory ligands produced in these same locations.
Pantothenate Kinase Associated Neurodegeneration: A Case Report  [PDF]
S Rahar,A Chaudhary
Journal of Nepal Paediatric Society , 2012, DOI: 10.3126/jnps.v32i1.5333
Abstract: Pantothenate kinase-associated neurodegeneration (PKAN) is a form of neurodegeneration with brain iron accumulation (NBIA), formerly called Hallervorden-Spatz syndrome. PKAN is the first described inborn error of coenzyme A metabolism. PKAN encompasses two clinical subtypes, classic and atypical. We here report an eight year girl diagnosed as classic PKAN. We also review the literature about PKAN.
Cardioprotective effects of tea and its catechins  [PDF]
Nana Li, Yue Zhao, Yuerong Liang
Health (Health) , 2013, DOI: 10.4236/health.2013.54A004

Tea is rich in polyphenolic catechins which are beneficial to health. There have been evidences suggesting that habitual tea consumption may reduce the risk of cardiovascular disease (CVD). Intake of tea or catechins isolated from tea was shown to inhibit the development of CVD in population studies and in animal models. Many possible pathways and mechanisms were investigated. There have been evidences showing that tea and tea catechins reduced the risk of CVD by enhancing antioxidant activity, attenuating metabolic syndrome, inhibiting angiotensin converting enzyme, improving endothelial dys-function, preventing cardiac hypertrophy and protecting mitochondria from damage.

Nainwal Pankaj,Nanda Deepak,Batsa Ranveer
International Journal of Research in Ayurveda and Pharmacy , 2011,
Abstract: Herbal medicine has become a popular form of healthcare. Even though several differences exist between herbal and conventional pharmacological treatments, herbal medicine can be tested for efficacy using conventional trial methodology. Several specific herbal extracts have been demonstrated to be efficacious for specific conditions. Even though the public is often misled to believe that all natural treatments are inherently safe, herbal medicines do carry risks. Ultimately, we need to know which herbal remedies do more harm than good for which condition. Because of the current popularity of herbal medicine, research in this area should be intensified Caesalpinia pulcherrima, a plant widely used in the traditional medicinal systems of India has been reported to possess antibacterial, anti-inflammatory, antioxidant, anticancer and immunosuppressive activities. This review highlights some of the phytochemical and pharmacological aspects of the plant which has been searched during their detailed study.
Extraction of catechins and caffeine from different tealeaves and comparison with micellar electrokinetic chromatography
Guanqun Song,Jinming Lin,Feng Qu,C. W. Huie
Chinese Science Bulletin , 2003, DOI: 10.1360/03wb0105
Abstract: This work describes the simultaneous determination of catechins and caffeine in green, black tealeaves and canned tea-drink using micellar electrokinetic chromatography. The catechins analyzed include (+)-catechin, (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epigallocatechin gallate. Using UV absorption method at 280 nm, the limits of detections of catechins and caffeine are 10 6 mol/L, which is suitable for the real sample determination. Using this analytical method, the extraction of these compounds from the tealeaves with hot water is compared under different temperatures. The effects of temperature on the amount of catechins and caffeine extracted are evident, showing that (-)-epigallocatechin gallate is the most easiest to be extracted at 100°C. The stability of catechins and caffeine in stocking solution of tea-drink at 4°C is also compared on five consecutive days. The contents of catechins and caffeine in green and black teas are discussed and the difference of the content between different tealeaves can provide a reference for the assessment of tea quality.
Atypical Pantothenate-Kinase Associated Neurodegeneration (PKAN) in Two Iranian Patients
H. Hashem,H. Rokni Yazdi,A. Adibi
Iranian Journal of Radiology , 2008,
Abstract: Pantothenate kinase- associated neurodegeneration (PKAN) or Hallervorden-Spatz syndrome is a rare autosomal recessive disorder characterized by dystonia, Parkinsonism, and iron accumulation in the brain. There are two types of this disease: the classic disease which is characterized by an early onset and rapid progression, and the atypical disease which is characterized by later onset and slow progression. Clinical diagnosis is based on clinical and characteristic magnetic resonance imaging findings. We report two Iranian cases of atypical PKAN, the diagnosis of which was missed till MRI showed classic imaging findings.
Biotechnological production of citric acid
Max, Belén;Salgado, José Manuel;Rodríguez, Noelia;Cortés, Sandra;Converti, Attilio;Domínguez, José Manuel;
Brazilian Journal of Microbiology , 2010, DOI: 10.1590/S1517-83822010000400005
Abstract: this work provides a review about the biotechnological production of citric acid starting from the physicochemical properties and industrial applications, mainly in the food and pharmaceutical sectors. several factors affecting citric acid fermentation are discussed, including carbon source, nitrogen and phosphate limitations, ph of culture medium, aeration, trace elements and morphology of the fungus. special attention is paid to the fundamentals of biochemistry and accumulation of citric acid. technologies employed at industrial scale such as surface or submerged cultures, mainly employing aspergillus niger, and processes carried out with yarrowia lipolytica, as well as the technology for recovering the product are also described. finally, this review summarizes the use of orange peels and other by-products as feedstocks for the bioproduction of citric acid.
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