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Anti-arthritic potential of the plant Justicia gendarussa Burm F
Paval, Jaijesh;Kaitheri, Srinivasan Keloth;Potu, Bhagath Kumar;Govindan, Sreejith;Kumar, Raju Suresh;Narayanan, Sareesh Naduvil;Moorkoth, Sudheer;
Clinics , 2009, DOI: 10.1590/S1807-59322009000400015
Abstract: objective: to evaluate the anti-arthritic potential of the plant justicia gendarussa using two different rat models. materials and method: the anti-arthritic potential of the alcoholic extract of the plant justicia gendarussa was evaluated using the freund's adjuvant-induced and collagen-induced arthritic rat models. the rats were treated with the ethanolic extract of justicia gendarussa and with standard aspirin. results: the ethanolic extract of justicia gendarussa showed significant anti-arthritic activity that was statistically similar to that of aspirin. our results suggest that the alcoholic extract of justicia gendarussa exhibits significant anti-arthritic potential.
Antioxidant and Hepatoprotective Potential of Stem Methanolic Extract of Justicia gendarussa Burm
K.L. Krishna,K. Mruthunjaya,Jagruti A. Patel
International Journal of Pharmacology , 2010,
Abstract: In vitro antioxidant activity of stem extracts of Justicia gendarussa Burm along with in vivo hepatoprotective activity of methanolic fraction was carried out to ascertain the folkloric claim of its hepatoprotective activity. The crude methanolic extract was prepared by soxhlet extraction and fractionated into pet ether, chloroform and methanol fractions. The marc remained was further extracted with doubled distilled water by refluxation in waterbath. Preliminary phytochemical tests, total phenolic and flavonoid content present in each fraction/extract was determined. All fractions and aqueous extract were evaluated for their antioxidant activity using DPPH free radical scavenging activity, hydrogen peroxide scavenging activity, reduction of ferric ion in presence and absence of EDTA. The methanolic fraction was further studied for its in vivo hepatoprotective activity using CCl4 induced hepatotoxicity in albino rats. The various biochemical parameters were evaluated to asses its hepatoprotective activity. Methanolic fraction has more phenolic/flavonoid content and shows good antioxidant activity. The methanolic fraction has a good hepatoprotective activity at dose of 300 mg kg-1 b.wt. in albino rats. Interestingly its hepatoprotective activity decreases as the dose increases. Stem extract of JG has moderate hepatoprotective activity; it may be due to its total phenolic and flavonoid contents. These findings substantiate the ancient literature about its reports as hepatoprotective herb and inspires for further extensive study regarding its exact hepatoprotective activity.
Comparing the anti-arthritic activities of the plants Justicia gendarussa Burm F. and Withania somnifera Linn  [cached]
Paval Jaijesh,Kaitheri Srinivasan,Potu Bhagath,Govindan Sreejith
International Journal of Green Pharmacy , 2009,
Abstract: The aim of this study was to compare the anti-arthritic activities of the plants Justicia gendarussa and Withania somnifera. Arthritis is induced in male albino rats using Freund′s complete adjuvant and bovine type II collagen. Leaves of J. gendarussa and roots of W. somnifera were powdered and extracted with ethanol (95%) using the soxhlet method. The effect of these plant extracts on arthritic rats were assessed by various blood parameters and also by taking the change in paw volume. The plants J. gendarussa and W. somnifera suppressed the anti-arthritic changes induced in rats and the results were statistically significant.
Biomass production and antibacterial activity of Justicia gendarussa Burm. f. – A valuable Medicinal plant  [cached]
P Sugumaran,N Kowsalya,Raju Karthic,S Seshadri
Journal of Tropical Life Science , 2013,
Abstract: Rooting and biomass production of Justicia gendarussa has been achieved through a hydroponic system of cultivation. The obtained biomass of leaves, stem and root were examined for antibacterial activity against various human pathogenic organisms such as Staphylococcus aureus, Escherichia coli, Shigella sp., Pseudomonas sp. and Klebsiella pneumoniae. Methanolic extract of J. gendarussa root responded against E. coli. The growth of Shigella sp., Pseudomonas sp. and K. pneumonia were inhibited by leaf extract. The maximum inhibition zone against S. aureus was observed in stem extract treatment.
ACTIVITY OF ETHANOLIC EXTRACT FROM Justicia gendarussa Burm. LEAVES ON DECREASING THE URIC ACID PLASMA  [cached]
Katrin Basah,Berna Elya,Department of Pharmacy, Faculty Mathematics and Sciences, University of Indonesia, Depok 16424, Indonesia,Muhamad Iqbal Julian
Makara Seri Sains , 2011,
Abstract: The effect of Justicia gendarussa leaves extract has been investigated using oxonate-induced hyperuricemic malealbino rats. In this experiment thirty five male albino rats were divided randomly into seven groups. There were threegroup doses variations of J. gendarussa extract that were 1.3 g/kg bw, 2.6 g/kg bw and 5.2 g/kg bw; two comparisongroups that were allopurinol 0.68 g/kg bw and herbal “X” 0.85 g/kg bw; and two control groups that were inducedcontrol potassium oxonate 0.25 mg/kg bw and normal control CMC 0,5 %. Intraperitoneal administration of potassiumoxonate 0.25 mg/kg bw was given one hour before administration of test drugs in eight day and plasma uric acid wasmeasured in rats after two hours. Plasma uric acid was measured by spectrophotometric on 520 nm with enzymaticmethod. The results showed that all extracts could reduced uric acid level of rats. The decreasing potency of uric acidlevel was equal to doses increase, so the best result that can reduce uric acid level was J. gandarussa extract at a dose5.2 g/ kg bw. This results indicated that J. gendarussa leaves extract may be effective for the prevention and thetreatment of hyperuricemia.
Anti-Inflammatory and Analgesic Activities of Ethanol Extract of Aerial Parts of Justicia gendarussa Burm.  [PDF]
C. Jothimanivannan,R.S. Kumar,N. Subramanian
International Journal of Pharmacology , 2010,
Abstract: The aim of the present study was to evaluate the anti-inflammatory and analgesic activities of the ethanol extract of aerial parts of Justicia gendarussa (EJG) in animal models. The anti-inflammatory activity of the extract was evaluated by using carrageenan-induced rat paw edema and cotton pellet granuloma method. The analgesic activity of the extract was evaluated for its central and peripheral pharmacological actions by using Eddy’s hot plate method and acetic acid-induced writhing, respectively. The study was carried out in two different dose levels of 250 and 500 mg kg-1 orally. The EJG did not produce any mortality up to 2000 mg kg-1. EJG at the dose of 500 mg kg-1 showed maximum inhibition of 52% in carrageenan-induced paw edema and 45% inhibition in dry weight cotton pellet granuloma formation. Dose dependent increase in latency of response in the hot plate method and 33% inhibition in acetic acid induced writhings in mice were observed with EJG at the dose of 500 mg kg-1. The pharmacological screening of the extract showed significant (p<0.001-0.01) dose-dependent anti-inflammatory activity with good analgesic profile when compared with reference standard. The presence of flavonoids might be responsible for these activities and which are probably mediated via inhibition of various autocoids formation and release.
Memecylon edule leaf extract mediated green synthesis of silver and gold nanoparticles
Elavazhagan T, Arunachalam KD
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S18347
Abstract: ylon edule leaf extract mediated green synthesis of silver and gold nanoparticles Original Research (7595) Total Article Views Authors: Elavazhagan T, Arunachalam KD Published Date June 2011 Volume 2011:6 Pages 1265 - 1278 DOI: http://dx.doi.org/10.2147/IJN.S18347 Tamizhamudu Elavazhagan, Kantha D Arunachalam Centre for Interdisciplinary Research, Directorate of Research, SRM University, Kattankulathur-603203, Tamilnadu, India Abstract: We used an aqueous leaf extract of Memecylon edule (Melastomataceae) to synthesize silver and gold nanoparticles. To our knowledge, this is the first report where M. edule leaf broth was found to be a suitable plant source for the green synthesis of silver and gold nanoparticles. On treatment of aqueous solutions of silver nitrate and chloroauric acid with M. edule leaf extract, stable silver and gold nanoparticles were rapidly formed. The gold nanoparticles were characterized by UV-visible spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray analysis (EDAX) and Fourier transform infra-red spectroscopy (FTIR). The kinetics of reduction of aqueous silver and gold ions during reaction with the M. edule leaf broth were easily analyzed by UV-visible spectroscopy. SEM analysis showed that aqueous gold ions, when exposed to M. edule leaf broth, were reduced and resulted in the biosynthesis of gold nanoparticles in the size range 20–50 nm. TEM analysis of gold nanoparticles showed formation of triangular, circular, and hexagonal shapes in the size range 10–45 nm. The resulting silver nanoparticles were predominantly square with uniform size range 50–90 nm. EDAX results confirmed the presence of triangular nanoparticles in the adsorption peak of 2.30 keV. Further FTIR analysis was also done to identify the functional groups in silver and gold nanoparticles. The characterized nanoparticles of M. edule have potential for various medical and industrial applications. Saponin presence in aqueous extract of M. edule is responsible for the mass production of silver and gold nanoparticles.
Memecylon edule leaf extract mediated green synthesis of silver and gold nanoparticles  [cached]
Elavazhagan T,Arunachalam KD
International Journal of Nanomedicine , 2011,
Abstract: Tamizhamudu Elavazhagan, Kantha D ArunachalamCentre for Interdisciplinary Research, Directorate of Research, SRM University, Kattankulathur-603203, Tamilnadu, IndiaAbstract: We used an aqueous leaf extract of Memecylon edule (Melastomataceae) to synthesize silver and gold nanoparticles. To our knowledge, this is the first report where M. edule leaf broth was found to be a suitable plant source for the green synthesis of silver and gold nanoparticles. On treatment of aqueous solutions of silver nitrate and chloroauric acid with M. edule leaf extract, stable silver and gold nanoparticles were rapidly formed. The gold nanoparticles were characterized by UV-visible spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray analysis (EDAX) and Fourier transform infra-red spectroscopy (FTIR). The kinetics of reduction of aqueous silver and gold ions during reaction with the M. edule leaf broth were easily analyzed by UV-visible spectroscopy. SEM analysis showed that aqueous gold ions, when exposed to M. edule leaf broth, were reduced and resulted in the biosynthesis of gold nanoparticles in the size range 20–50 nm. TEM analysis of gold nanoparticles showed formation of triangular, circular, and hexagonal shapes in the size range 10–45 nm. The resulting silver nanoparticles were predominantly square with uniform size range 50–90 nm. EDAX results confirmed the presence of triangular nanoparticles in the adsorption peak of 2.30 keV. Further FTIR analysis was also done to identify the functional groups in silver and gold nanoparticles. The characterized nanoparticles of M. edule have potential for various medical and industrial applications. Saponin presence in aqueous extract of M. edule is responsible for the mass production of silver and gold nanoparticles.Keywords: Memecylon edule, nanoparticles, bioreduction, electron microscopy, FTIR
One-step green synthesis and characterization of leaf extract-mediated biocompatible silver and gold nanoparticles from Memecylon umbellatum  [cached]
Arunachalam KD,Annamalai SK,Hari S
International Journal of Nanomedicine , 2013,
Abstract: Kantha D Arunachalam, Sathesh Kumar Annamalai, Shanmugasundaram HariCenter for Environmental Nuclear Research, Directorate of Research, SRM University, Chennai, Tamil Nadu, IndiaAbstract: In this experiment, green-synthesized silver and gold nanoparticles were produced rapidly by treating silver and gold ions with an extract of Memecylon umbellatum leaf. The reaction process was simple and easy to handle, and was monitored using ultraviolet-visible spectroscopy. The effect of the phytochemicals present in M. umbellatum, including saponins, phenolic compounds, phytosterols, and quinones, on formation of stable silver and gold nanoparticles was investigated by Fourier-transform infrared spectroscopy. The morphology and crystalline phase of the nanoparticles were determined by transmission electron microscopy and energy-dispersive x-ray spectroscopy. The results indicate that the saponins, phytosterols, and phenolic compounds present in the plant extract play a major role in formation of silver and gold nanoparticles in their respective ions in solution. The characteristics of the nanoparticles formed suggest application of silver and gold nanoparticles as chemical sensors in the future. Given the simple and eco-friendly approach for synthesis, these nanoparticles could easily be commercialized for large-scale production.Keywords: green synthesis, phytochemicals, saponins, nanoparticles, transmission electron microscopy
One-step green synthesis and characterization of leaf extract-mediated biocompatible silver and gold nanoparticles from Memecylon umbellatum
Arunachalam KD, Annamalai SK, Hari S
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S36670
Abstract: e-step green synthesis and characterization of leaf extract-mediated biocompatible silver and gold nanoparticles from Memecylon umbellatum Original Research (170) Total Article Views Authors: Arunachalam KD, Annamalai SK, Hari S Published Date March 2013 Volume 2013:8 Pages 1307 - 1315 DOI: http://dx.doi.org/10.2147/IJN.S36670 Received: 03 August 2012 Accepted: 24 November 2012 Published: 26 March 2013 Kantha D Arunachalam, Sathesh Kumar Annamalai, Shanmugasundaram Hari Center for Environmental Nuclear Research, Directorate of Research, SRM University, Chennai, Tamil Nadu, India Abstract: In this experiment, green-synthesized silver and gold nanoparticles were produced rapidly by treating silver and gold ions with an extract of Memecylon umbellatum leaf. The reaction process was simple and easy to handle, and was monitored using ultraviolet-visible spectroscopy. The effect of the phytochemicals present in M. umbellatum, including saponins, phenolic compounds, phytosterols, and quinones, on formation of stable silver and gold nanoparticles was investigated by Fourier-transform infrared spectroscopy. The morphology and crystalline phase of the nanoparticles were determined by transmission electron microscopy and energy-dispersive x-ray spectroscopy. The results indicate that the saponins, phytosterols, and phenolic compounds present in the plant extract play a major role in formation of silver and gold nanoparticles in their respective ions in solution. The characteristics of the nanoparticles formed suggest application of silver and gold nanoparticles as chemical sensors in the future. Given the simple and eco-friendly approach for synthesis, these nanoparticles could easily be commercialized for large-scale production.
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