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The Inhibitory Action of the Extracts of Adathoda vasica, Eclipta alba, and Centella asiatica on the Corrosion of Mild Steel in Hydrochloric Acid Medium: A Comparative Study  [PDF]
M. Shyamala,P. K. Kasthuri
International Journal of Corrosion , 2012, DOI: 10.1155/2012/852827
Abstract: The Inhibitive action of the extracts of Adathoda vasica, Eclipta alba, and Centella asiatica on the corrosion of mild steel in 1N HCl has been studied using weight loss method, electrochemical methods, and hydrogen permeation method. Polarization method indicates that the plant extracts are under mixed control, that is, promoting retardation of both anodic and cathodic reactions. The impedance method reveals that charge-transfer process controls the corrosion of mild steel. The plant extracts obey Langmuir adsorption isotherm. Theoretical fitting of the corrosion data to the kinetic-thermodynamic model was tested to show the nature of adsorption. Physisorption mechanism has been proposed for the inhibition action of these plant extracts. The protective film formed on the surface was confirmed by SEM. From hydrogen permeation method, all the plant extracts were able to reduce the permeation current. Results obtained in all three methods were very much in good agreement in the order Eclipta alba > Adathoda vasica > Centella asiatica, and, among the three plant extracts studied, the maximum inhibition efficiency was found in Eclipta alba which showed 99.6% inhibition efficiency at 8.0% v/v concentration of the extract. 1. Introduction Mild steel was the material of choice due to its characteristics of wide application in motor car bodies, machines, gears, pipes, tanks, and so forth and in most of the chemical industries. Hydrochloric acid and sulphuric acids are the medium generally being used for pickling mild steel. About 90% of pickling problems can be solved by introducing appropriate pickling inhibitor to the medium. The recent and growing trend is using plant extracts as corrosion inhibitor. Owing to strict environmental legislation, emphasis is being focused on development of naturally occurring substances as corrosion inhibitors [1]. Recently, many plant extracts have been reported to be very effective corrosion inhibitors for the protection of mild steel in acidic media [2–19]. In this study, the inhibition effect of the leaf extracts of Adathoda vasica (Adathodai), Eclipta alba (Karisalankanni), and Centella asiatica (Vallarai) on the corrosion of mild steel in 1N hydrochloric acid was investigated using weight loss method, electrochemical methods, and hydrogen permeation method. There was no literature report on the studies of corrosion inhibition effect of the above plant extracts on mild steel in hydrochloric acid medium previously. From literature survey, it were found that the six plants selected for investigation was found to contain some
PHYTOCEUTICAL EVALUATION AND ANTIMICROBIAL PROPERTIES OF Eclipta alba AND Tylophora indica  [cached]
Sangeeta Raut, Smita Raut and Alekha Ghadai
International Journal of Microbiology Research , 2012,
Abstract: Since plants are used as therapeutic agents, the present study was conducted to evaluate the phytochemical profile and antibacterial activities of extracts of. Eclipta alba and Tylophora indica .Studies on the antibacterial activity of methanol, petroleum ether and aqueous extracts of dry leaf, stem and root of Eclipta alba and Tylophora indica was evaluated using zone of inhibition studies and minimum inhibitory concentration. The microorganisms used include Escherichia coli, Micrococcus roseus and Pseudomonas flavescens . The extract exhibited antibacterial activity against these experimental strains. Methanol extracts shows higher degree of antibacterial activity than aqueous and petroleum ether extracts. The minimum inhibitory concentration ranged between 12.5mg/mL and 75mg/mL depending on microorganism and various extract. Screening of the phytochemical extracts revealed the presence of compounds like alkaloids, glycosides, tannins and flavonoids. Escherichia coli and Pseudomonas flavescens are more sensitive where as Micrococcus roseus is less sensitive to extracts of Eclipta alba and Tylophora indica. The experimental observation shows that Eclipta alba and Tylophora indica have antibacterial activity and can be used for therapeutic purposes.
Protective role of Eclipta alba L. extract against ethinylestradiol induced genotoxic damage in cultured human lymphocytes  [cached]
Yasir Hasan Siddique,Gulshan Ara,Tanveer Beg,Mohammad Faisal
Alternative Medicine Studies , 2011, DOI: 10.4081/ams.2011.e4
Abstract: In India, natural preparations derived from plants are widely used for the treatment of various diseases. Hence it becomes necessary to assess the modulating action of the plant extracts when associated with other substances. Ethinylestradiol is not only a genotoxic agent but also a tumor initiating agent. It is widely used in oral contraceptive formulations and also for the treatment of various sexual and metabolic disorders. In the present study, the antigenotoxic effect of Eclipta alba was evaluated against the genotoxic effect induced by 10 μM of ethinylestradiol in the presence of metabolic activation using mitotic index (MI), chromosomal aberrations, sister chromatid exchanges and replication index (RI) as parameters. The treatment of 10 μM of ethinylestradiol along with 1.02x10–4, 2.125x10–4, 3.15x10–4 and 4.17x10–4 g/mL of Eclipta alba (E. alba) extract in culture medium results in a significant dose dependent decrease in the genotoxic effects induced by the treatment of 10 μM of ethinylestradiol. The results of the present study suggest that the plant extract per se does not have genotoxic potential, but can modulate the genotoxicity of ethinylestradiol in cultured human lymphocytes.
Compounds Identification Using HPLC and FTIR In Eclipta alba And Emilia sonchifolia
M.Thenmozhi,P.K.Bhavya,Rajeshwari Sivaraj
International Journal of Engineering Science and Technology , 2011,
Abstract: Engineering modern techniques are used in various fields like drug and medicine. Many plants synthesize substances that are useful to the maintenance of health in humans and other animals. The use ofplants as medicines predates written human history. Medicinal plants are in all way having its own immense importance in current era. All plants produce chemical compounds as part of their normal metabolic activities. These metabolic activities can be measured using HPLC, FTIR etc., The present study reports the phytochemicals present in methanolic extract of Eclipta alba and Emilia sonchifolia, the dentification of these compounds using HPLC and FTIR. The results revealed the presence of a well number of phytochemicals in them responsible for antimicrobial, antioxidant and curing activities against several diseases.
ANTIMUTAGENIC EFFECTS OF COMPOUNDS OBTAINED FROM ECLIPTA ALBA LINN AGAINST STRAINS OF SALMONELLA TYPHIMURIUM  [cached]
Prabhu Nagarajan1*, Vigneshwari Ramakrishnan Sundaramoorthy1, Joseph Pushpa Innocent Danialas2
International Journal of Bioassays , 2012,
Abstract: In this experimental study, antimutagenic activity of compounds obtained from Eclipta alba Linn was screened by using Ames assay for detecting direct mutagenic activity and those requiring the metabolic activation. The crude compound extracted from Eclipta alba was considered as antimutagen and analyzed in this experiment. Two strains of Salmonella typhimurium, TA163 and TA96 were used to analyze the test. These two strains are confirmed as histidine requiring mutant strains. When the mutagen is added to the culture, the strain is mutated back, thereby loosing the histidine dependence for its growth. By this study, the crude compound of Eclipta alba prevents the strain to be mutated back to the non dependence for the genotyping of the Salmonella strains were performed by histidine requirement, rfa mutation analysis, UVrB mutation, R-factor analysis toxicity tests and antimutagenicity assay. The antimutagens obtained from the plant extract were determined for antimutagenic activity against direct acting mutagens and mutagen needing activation. For direct acting mutagens, NPD (N- nitro-o-phenyl diamine), MNNG (N- methyl-N-nitro-N-nitro soguanidine) and NaNa3 (sodium azide) with 1mg of the plant extract gives 98%, 95.2% and 90.7% inhibition the reverted colonies were observed whereas the mutagen needing activation 2-AAf (2-acetyl aminofluorine) gives 96.6% inhibition was observed. These above results indicated that the extract could inhibit the mutagenicity induced by direct acting mutagens as well as mutagens needing activation. Thus the extracts isolated from the test plant have possibility of antimutagenic activity of compound and further biochemicals extracted from the test plant will be analyzed.
In vitro evaluation of Eclipta alba against serogroups of Leptospira interrogans  [cached]
Prabhu N,Innocent Joseph,Chinnaswamy P,Natarajaseenivasan K
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: Leptospirosis is now acknowledged as the most widespread zoonoses in the world. Hundreds of cases occur in India every year accounting for considerable morbidity and sizable mortality. Several studies have delineated the epidemiology, pathology and variable clinical features of this condition. The present study comprises the importance and utilization of traditional based medicines to overcome the adverse reaction by conventional drugs and standardize the technology. The antileptospiral activity of Eclipta alba L. was well studied by both tube dilution and micro dilution techniques and the result showed better inhibitory action against various serogroups of Leptospira interrogans. L. australis, L. autumnalis and L. grippotyphosa are inhibited by both water and ethanol extract by tube dilution technique. The MIC level observed are 50 μg and 100 μg respectively. Similarly acetone extract, Icterohaemorrhagiae was responded to 200 μg/ml as MIC whereas in petroleum ether extract, no inhibition was observed. In the case of micro dilution technique, the entire inhibition rates are supported to the tube dilution technique. It showed that the micro dilution technique is the best method where we obtained the results within 30 minutes; at the same time tube dilution technique takes minimum of 7 days to provide the result.
Potential of AM fungi (Glomus mosseae and Acaulospora laevis) and Trichoderma viride in enhancing growth and development of Eclipta alba (L.) Hassk  [cached]
CHHAVI MANGLA, ADITYA KUMAR and ASHOK AGGARWAL*
Indian Phytopathology , 2011,
Abstract: An attempt was made to study the effect of selected arbuscular mycorrhizal (AM) fungal species (Glomus mosseae & Acaulospora laevis) in different combinations with Trichoderma viride on growth and biomass of Eclipta alba in green house conditions. The study revealed improved growth of all the seedlings inoculated with AM fungi. A prominent improvement in growth parameters was observed after 60 and 90 days. A. laevis alone showed best increment in leaf area while its combination with T. viride was found to be most effective in enhancement of shoot and root length. Chlorophyll content increased significantly in seedlings treated with dual combination of G. mosseae and T. viride. The total shoot and root (fresh and dry) weight and AM association (% root colonization and spore number) also increased in all the inoculated seedlings after 60 and 90 days.
Biologically estimation of heavy / toxic metals present in traditional medicinal plant – Eclipta alba  [PDF]
Prakash. MMS. Kinthada,P.V.S. Naidu,P. Muralidhar
International Journal of Pharmacy and Biomedical Sciences , 2011,
Abstract: Traditional medicinal plants are used for the treatment of various ailments. The plant materials (leaves) were found to contain all heavy metals with the different concentration in the soil, it was grown among all the heavy metals Fe, Mn, Zn, while the rest of the metals were at low concentration. The present estimation showed that Eclipta alba L is suitable for the control of environmental pollutants, such as heavy metals, however for medicinal purposes. It should be collected from those areas, which are not contaminated with heavy metals. The purpose of the current study was to standardize various indigenous medicinal plant for heavy metals contamination and to make awareness among the public regarding its safer use and collection areas, containing high level of heave metals and their adverse health effects.
Hepatoprotective Effect of Enicostemma littorale blume and Eclipta alba During Ethanol Induced Oxidative Stress in Albino Rats  [PDF]
P. Baranisrinivasan,E.K. Elumalai,C. Sivakumar,S. Viviyan Therasa
International Journal of Pharmacology , 2009,
Abstract: The leaves of Enicostemma littorale blume (Ens) and Eclipta alba (Ecl) have been used for skin infection, antiviral and antibacterial activity in traditional medicine. The present study is aimed at to evaluate the hepato-protective effect of the aqueous leaf extracts of the above two plants during ethanol induced oxidative stress in albino rats. The aqueous leaf extracts of Enicostemma littorale and Eclipta alba combine (1:1) at dose level of 250 mg kg-1 b.wt. were tested for hepato-protective and antioxidant effects during ethanol induced oxidative stress in liver tissue of wistar male albino rats. The degree of hepatoprotection was assessed by measuring the activity levels of the marker enzymes such as serum aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP). Free radicals generated lipid peroxidation was assessed by measuring the tissue levels of thiobarbituric acid reacting substances (TBARS) and the activity levels of the tissue antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD). The ethanol supplemented rats recorded elevated activity levels of serum AST, ALT and ALP revealing ethanol induced hepatotoxicity. The increased levels of TBARS in liver and decreased activity levels of SOD and CAT in ethanol fed animal’s revealed oxidative stress. The aqueous leaf extracts supplementation of Ens+Ecl in 1:1 produced significant hepatoprotection and antioxidative effect during ethanol induced hepatotoxicity. The study can be concluded that the therapeutic effect of aqueous leaf extracts of Ens+Ecl in 1:1 is not only hepatoprotective but also possess significant antioxidant property.
PHYTOCHEMICAL CONSTITUENTS AND PHARMACOLOGICAL ACTIVITIES OF ECLIPTA ALBA LINN (ASTERACEAE): A REVIEW  [PDF]
Manik Sharma,Muhammad Yusuf,Showkat Hussain,Abrar Hussain
International Research Journal of Pharmacy , 2012,
Abstract: Eclipta alba (L.) Hassk commonly known as bhringraj. It is mainly found spreading easily in moist grounds and is widely used for its nutritional values all over the world. The plant is used to treat different diseases in human in traditional medicine. The important pharmacological activities are hepatoprotection, antibacterial, analgesic, antidiabetic hair growth, etc. This paper explains the evidence- based information regarding the photochemistry and pharmacological activity of this plant.
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