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Interaction of active compounds from Aegle marmelos CORREA with histamine-1 receptor  [cached]
Agung Endro Nugroho,Dany Dwi Agistia,Maulana Tegar,Hari Purnomo
Bioinformation , 2013,
Abstract: The aim of this study is to determine the affinity of six active compounds of Aegle Marmelos Correa, they are (E, R)-Marmin, skimmianine, (S)-aegeline, aurapten, zeorin, and dustanin as antihistamines in histamine H1 receptor in comparison to cetirizin, diphenhydramine and chlorpheniramine as ligands comparison. Previously, in the in vitro study marmin obviously antagonized the histamine H1 receptor in a competitive manner. Methods: molecular docking to determine the interaction of ligand binding to its receptor. Lower docking score indicates more stable binding to that protein. Results: Marmin, skimmianine, aegeline, aurapten, zeorin, and dustanin were potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists by interacting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor. Conclusions: Based on molecular docking, Amino acid residues involved in ligand protein interactions were Asp107, Lys179, Lys191, Asn198, and Trp428.
Hepatoprotective effect of the pulp/seed of Aegle marmelos correa ex Roxb against carbon tetrachloride induced liver damage in rats  [cached]
Singh Ramnik,Rao Harwinder
International Journal of Green Pharmacy , 2008,
Abstract: A number of herbal preparations are widely used in traditional system of medicine for the management of hepatic disorders. However, many of them have not been investigated for their described effects. Aegle marmelos Roxb is one such drug used in the treatment of hepatitis in folk medicine. Therefore, an attempt has been made to investigate for hepatoprotective effect of fruits of Aegle marmelos against carbon tetrachloride (CCl 4 ) induced hepatotoxicity in rats. Sixty Albino Wistar rats were divided into six equal groups of 10. Four groups received extracts of pulp/seeds of Aegle marmelos and intraperitoneal (i.p.) CCl 4 (0.2 ml/100 g) either before or after administration of pulp/seeds. Two groups were controls, one treated with CCl 4 and one with normal saline. Liver damage was assessed by plasma concentration of bilirubin and enzyme activities of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase. Treatment with aqueous extract of fruit pulp/seeds significantly reduced CCl 4 -induced elevation in plasma enzyme and bilirubin concentration in rats. This study suggests that CCl 4 -induced liver damage in rats can be ameliorated by treatment of extracts from fruits pulp/seeds.
Comparative Effect of Crude and Commercial Enzyme on the Juice Recovery from Bael Fruit (Aegle marmelos Correa) Using Principal Component Analysis  [PDF]
Anurag Singh,H. K. Sharma,Sanjay Kumar,Ashutosh Upadhyay,K. P. Mishra
International Journal of Food Science , 2013, DOI: 10.1155/2013/239839
Abstract: The effect of incubation time, incubation temperature, and crude enzyme concentration was observed on the yield, viscosity, and clarity of the juice obtained from bael fruit pulp. The recommended enzymatic treatment conditions from the study were incubation time 475?min, incubation temperature 45°C, and crude enzyme concentration 0.20?mL/25?g bael fruit pulp. The recovery, viscosity, and clarity of the juice under these conditions were 82.9%, 1.41?cps, and 21.32%T, respectively. The variables, clarity, and yield were found as principal components for comparing different samples of the juice treated with enzyme. 1. Introduction The bael fruit (Aegle Marmelos Correa) has been attributed with various nutritional and therapeutic properties. The fruit has excellent aroma which is not destroyed even during processing [1]. The bael fruit pulp contains many functional and bioactive compounds such as carotenoids, phenolics, alkaloids, coumarins, flavonoids, terpenoids, and other antioxidants which may protect against chronic diseases [2]. It has been surmised that the psoralen in the pulp increases tolerance of sunlight and aids in the maintaining of normal skin color and is considered fruitful in the treatment of leucoderma. The marmelosin (C13H12O3) content, found in the bael fruit, is considered as panacea of various stomach ailments [3]. Bael fruit, because of its hard shell, mucilaginous texture, and numerous seeds, is not popular as fresh fruit. However, the excellent flavor and nutritive and therapeutic value of bael fruits show potential for processing into values added products. Bael is commercially considered as an important fruit, but the potential of the fruit is not fully tapped. The edible pulp, 100?g of bael fruit contains 61.5?g water, 1.8?g protein, 0.39?g fat, 1.7?g minerals, 31.8?g carbohydrate, 55?mg carotene, 0.13?mg thiamine, 1.19?mg riboflavin, 1.1?mg niacin, and 7 to 21?mg ascorbic acid [4]. Generally, three methods of juice extraction are employed, namely, cold, hot, and enzymatic methods. The use of fungal enzyme in fruit juice extraction had shown significant increase in juice recovery as compared to cold and hot extraction methods. The enzymes, mainly pectinases, and cellulases assist in pectin and cellulolytic hydrolysis, respectively, which cause a reduction in pulp viscosity and a significant increase in juice yield [5]. The extraction of bael juice on large scale has not been explored for its commercial scale viability and exploitation but conventionally, the extraction includes addition of water to pulp, boiling and pressing of
Antigenotoxic Activity of Polyphenolic Rich Extracts from Aegle marmelos (L.) Correa in Human Blood Lymphocytes and E.coli PQ 37  [PDF]
Prabhjit Kaur,Amandeep Walia,Subodh Kumar,Satwinderjeet Kaur
Records of Natural Products , 2009,
Abstract: The present paper deals with the antigenotoxic activity of Aegle marmelos fruit extracts employing short term assays i.e. the SOS chromotest using Escherichia coli PQ37 and the Comet assay in peripheral human blood lymphocytes. Methanol extract and Acetone extract were quite effective in decreasing the SOS response induced by hydrogen peroxide and aflatoxin B1 in the SOS chromotest. Methanol extract inhibited the genotoxicity of H 2O 2 by 70.48% and that of AFB1 by 84.65%. The extracts showed significant decrease in the tail moment induced by hydrogen peroxide (9 m M) in the Single Cell Gel Electrophoresis (SCGE) assay. The antigenotoxic activity exhibited by the extracts may be attributed the various polyphenolic constituents present in these extracts.
Chemical constituents from Aegle marmelos
Laphookhieo, Surat;Phungpanya, Chalita;Tantapakul, Cholpisut;Techa, Somsak;Tha-in, Suphara;Narmdorkmai, Wanwasan;
Journal of the Brazilian Chemical Society , 2011, DOI: 10.1590/S0103-50532011000100024
Abstract: a new natural product oxazoline derivative named aeglemarmelosine (1) along with eight known compounds (2-9) were isolated from roots and twigs of aegle marmelos. compounds 1-6 were isolated from the roots whereas compounds 7-9 were obtained from twigs. compounds 5 and 6 were also detected from the twigs. all structures were characterized by extensive 1d and 2d nmr spectroscopic methods.
Antioxidant activity of Aegle marmelos and Psidium guajava leaves  [PDF]
International Journal of Medicinal and Aromatic Plants , 2012,
Abstract: Aegle marmelos, Bilwa (AM) and Psidium guajava, Guava, (PG) leaves were screened for phytochemicals by sequential extraction using a series of solvents. The antioxidant components such as -carotene, α-Tocopherol, glutathione, ascorbic acid, total polyphenols and flavonoids were also analyzed. In addition, the leaves were extracted with methanol (ME), ethanol (EE) and water (WE) and the polyphenol content, antioxidant activities by 2, 2; - diphenyl 1-picryl hydrazyl (DPPH) radical scavenging method and reducing power was determined. Majority of phytochemicals were found in methanol and water extracts of Aegle marmelos, methanol and water extracts and in Psidium guajava, terpenoids and steroids were found in all the sequential extracts. Aegle marmelos was rich in tocopherols, glutathione, ascorbic acid and flavonoids, whereas Psidium guajava, was rich in -carotene and total polyphenols. The three extracts showed varying degree of antioxidant efficacy in each assay. Water extract (WE) of both the samples showed maximum radical scavenging activity and reducing power. In Psidium guajava extracts with high polyphenol content showed maximum antioxidant activity. Results indicate that the Aegle marmelos and Psidium guajava has the potential to be utilized as sources of natural antioxidants especially the polyphenols.
P. Sandhya et al.
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Plant products served as an alternative to synthetic products because of local accessibility, eco friendly nature and lower prices. Natural gums and mucilages are widely explored as pharmaceutical excipients. The present study was undertaken to separate mucilage from unripe fruits of Aegle marmelos (L) Corr. and explore its use as binder in tablets. The binding properties at different concentrations of mucilage were evaluated using Paracetamol as model drug. Mucilage at 3%w/w was found to be comparable with 10%w/w of starch paste. The drug release studies indicated that Aegle marmelos mucilage could be considered as a potential binding agent.
Aegle marmelos:A Review on its Medicinal Properties  [PDF]
Pushpendra K. Patel,Jyoti Sahu,Lokesh Sahu,Narendra K.
International Journal of Pharmaceutical and Phytopharmacological Research , 2012,
Abstract: Present generation is a fast moving generation and no doubt about the potency of allopathic medicine, they provide fast result, but the darkest side of this medicine is their several side effects and contraindications. On the other hand the plants are good substitution for those medicines because of their less or no side effect and their ability to cure the problem from their root. The present study is based on the pharmacological activity of Aegle marmelos, commonly known as a bael in India. This plant is having great potential to cure the disease like diabetes, cholesterol, peptic ulcer, inflammation, diarrhoea, and dysentery, anticancer, cardio protective, anti bacterial, anti fungal, radio protective, anti pyretic, analgesic, constipation, respiratory infection, antioxidant, hepatoprotective, wound healing and many more. The present review summarizes the scientific information of various aspects of Aegle marmelos plant used in traditional system of medicine for variety of purpose.
Indian Streams Research Journal , 2013,
Abstract: In this study, we report biosynthesis of copper nanoparticles was done using Aegle Marmelos leaf extract. First we prepared leaf extract of Aegle Marmelos in deionised water. This extract added to 1mMol of copper chloride solution and we observed the change in color of the solution from colorless to colored solution, this indicates that there is a formation of Cu nanoparticles. These biosynthesized Cu nanoparticles were characterized with the help of X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR). It was observed that the Aegle Marmelos leaf extract can reduce copper ions into copper nanoparticles within 8 to 10 min of reaction time.
Fruit Gum of Aegle marmelos as Pharmaceutical Aid
D.N. Patil,A.R. Kulkarni,B.S. Patil
International Journal of Pharmacology , 2010,
Abstract: In the present study have formulated the oral tablets of paracetamol by using Aegle marmelos fruit gum as a binder. The four different tablet formulations were prepared by wet granulation method. The binder concentrations used in the formulation were 2, 4, 6 and 8% w/v of A. marmelos fruit gum, tablets were subjected for evaluation of hardness, friability, drug content uniformity. Preliminary evaluation of granules showed that, 0.71 to 0.77 mm granule size, 29.20 to 30.10° angles of repose and 22.1 to 12.7% fines. Hardness was found in the range of 7.1 to 7.4 kg cm-2, the percent friability was in the range of 1.50 to 0.75%. The tablet showed 97.46 to 98.96% of labeled amount of paracetamol indicating uniformity in drug content, 8 to 18 min disintegration time and more than 90% dissolution in 75 min. Tablets at 6% w/w binder concentration showed more optimum results as tablet binder. The Aegle marmelos gum was found to be useful for the preparation of uncoated tablet dosage form.
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