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Pyoderma Gangrenosum  [cached]
Krishnan S G S,Yesudian Devakar P,Jayaraman M,Janaki V R
Indian Journal of Dermatology , 1997,
Abstract: An 18 year old girl presented with multiple, painful, non- healing ulcers over the lower extremities of 2 month duration. The lesions had started as hemorrhagic bullae which broke down leaving ulcers. The features were consistent with those of pyoderma gangrenosum. Patients did not have any associated disease including myeloproliferative disorder. Ulcer healed with systemic steroids.
Minocycline in pyoderma gangrenosum  [cached]
Koshy Thomas,Binitha M
Indian Journal of Dermatology, Venereology and Leprology , 1992,
Abstract: A case of pyoderma gangrenosum resistant to the usual modes of treatment was successfully treated with minocycline. The drug was well tolerated without any side effects.
Pyoderma gangrenosum and anticardiolipin antibody  [cached]
de Godoy Jose Maria,Batigalia Fernando,Braile Domingo
Indian Journal of Dermatology , 2006,
Abstract: Pyoderma gangrenosum (PG) is a rare ulceronecrotic inflammatory cutaneous disorder and is frequently associated with systemic diseases. The authors report a 22-year-old male patient with pyoderma gangrenosum, thrombosis of both popliteal arteries, ischemic stroke and seropositivity for anticardiolipin antibody. Despite intravenous treatment with antibiotics, corticosteroid and heparin, pyoderma gangrenosum caused necrosis of his right lower limb which resulted in amputation. It was concluded that the anticardiolipin antibody may have contributed to the gravity of this case.
Pyoderma gangrenosum in a patient with Crohn’s disease: Case report and a review of the literature  [PDF]
Oktay Bulur,Ayse Serap Karada?,Yasar Nazl?gül,Servet Güre?ci
Dicle Medical Journal , 2010,
Abstract: Pyoderma gangrenosum is a rare neutrophilic noninfectious dermatose. Etiopathogenesis remains unclear, but in half of cases, there is an associated underlying disease. Inflammatory bowel disease is the most common underlying disorder. Systemic immunosuppressive or immunomodulator drugs and some topical agents are used in treatment of pyoderma gangrenosum. Systemic corticosteroids are the first-choice of treatment. We reported a case with Crohn’s disease associated with pyoderma gangrenosum. She was successfully treated with oral methyl prednisolon. The case was a 54-year-old woman who admitted to hospital because of erythematous, painful plaques on the right and left pretibial surfaces. She had a history of Crohn’s disease, diabetes mellitus, and hypertension. An elevated white blood cell count (13500/μL) and high erythrocyte sedimentation rate (120 mm/h) were detected. A regime of broad-spectrum antibiotics was started, but response was poor. Histopathological assessment of biopsy specimens showed necrosis, severe edema and erythrocyte extravasations in superficial dermis, regenerative changes in adjacent epithelium, and mixed inflammatory reaction surrounding necrosis in the inner part of the dermis. Based on these clinical and laboratory findings, poor response to antibiotics and underlying disease; her skin lesions were considered as pyoderma gangrenosum. Oral methylprednisolone was started and her skin lesions improved. The steroid dose was tapered and finally stopped under outpatient follow-up. In conclusion, our patient also showed that corticosteroids continue to be the first-choice therapy in pyoderma gangrenosum.
Pyoderma Gangrenosum - Variants And Associations  [cached]
Sentamilselvi G,Manoharan K,Saraswath Devesh,Janaki V.R
Indian Journal of Dermatology , 2002,
Abstract: Six cases of pyoderma gangrenosum encountered with in a period of 2 years are described here with their clinical presentations and associations. Three patients were cases of superficial granulomatous pyoderma and three were of ulcerative type. Rheumatoid arthritis was found to be the associated disease in one of the cases of ulcerative type. Response to therapy was satisfactory in all of them expect in one case of ulcerative pyoderma gangrenosum who was resistant to most of the available therapeutic modalities.
Management of pyoderma gangrenosum - An update
Bhat Ramesh
Indian Journal of Dermatology, Venereology and Leprology , 2004,
Abstract: Pyoderma gangrenosum is a neutrophilic dermatosis with distinctive clinical manifestations. It is frequently associated with systemic diseases like inflammatory bowel disease, rheumatoid arthritis and myeloproliferative diseases. The etiopathogenesis of pyoderma gangrenosum is still not well understood. Clinically it is classified into ulcerative, pustular, bullous and vegetative types. The diagnosis mainly depends on the recognition of evolving clinical features as there are no specific investigations for the diagnosis. It is essential to exclude other infectious diseases before therapy is initiated as corticosteroids and immunosuppressant therapy are the mainstays in the treatment of this disease. Recently, drugs like tacrolimus, mycophenolate mofetil and infliximab have shown promising results in this condition. Recent concepts regarding the various types of pyoderma gangrenosum and its management are reviewed.
Pyoderma gangrenosum affecting the mouth  [PDF]
Marcos Martins Curi, Camila Lopes Cardoso, Daniel Henrique Koga, Cristina Zardetto, Sérgio Rocha Araújo
Open Journal of Stomatology (OJST) , 2013, DOI: 10.4236/ojst.2013.32026
Abstract:

Pyoderma gangrenosum is a rare ulcerative cutaneous disorder commonly associated with systemic diseases such as inflammatory bowel diseases. This paper reports a case of pyoderma gangrenosum affecting the mouth and the skin associated with ulcerative colitis. A Medline search in English literature from 1961 to 2012 revealed only 11 documented cases of pyoderma gangrenosum with oral involvement. Previous reported cases of oral cavity involvement have shown that the most common sites of manifestation are the tongue, palate, and tonsillar fauces. This case emphasizes the importance of including inflammatory bowel diseases and their manifestations in the differential diagnosis of ulcerative lesions in the oral cavity.

Pyoderma gangrenosum in HIV patient  [cached]
Sayal S,Malik A,Banerjee S
Indian Journal of Dermatology, Venereology and Leprology , 1997,
Abstract: Pyoderma gangrenosum (PG) has previously been reported in very few patients with HIV infection. We describe here a 30-year-old housewife with HIV infection having multiple ulcerations over lower limbs characteristic of PG.
Pyoderma gangrenosum and ulcerative colitis in the tropics
Alese, Olatunji B.;Irabor, David O.;
Revista da Sociedade Brasileira de Medicina Tropical , 2008, DOI: 10.1590/S0037-86822008000600020
Abstract: pyoderma gangrenosum is a rare inflammatory skin condition, characterized by progressive and recurrent skin ulceration. there may be rapidly enlarging, painful ulcers with undermined edges and a necrotic, hemorrhagic base. disorders classically associated with pyoderma gangrenosum include rheumatoid arthritis, inflammatory bowel disease, paraproteinemia and myeloproliferative disorders. there have been some reports of the occurrence of pyoderma gangrenosum in africa, and in nigeria, but only one specifically reported pyoderma gangrenosum in association with ulcerative colitis. we report on a 45-year-old man who presented with pyoderma gangrenosum associated with ulcerative colitis; the second report in nigeria. the skin lesions were managed with daily honey wound dressings. oral dapsone and prednisolone were started. the frequency of the bloody diarrhea decreased, and was completely resolved by the second week after admission. the ulcers also showed accelerated healing. the goal of therapy is directed towards the associated systemic disorder, if present.
Herpes misdiagnosed as pyoderma gangrenosum  [cached]
Kumar L,Shanmugasekar C,Lakshmi C,Srinivas C
Indian Journal of Sexually Transmitted Diseases , 2009,
Abstract: Retroviral infection is known to cause varied manifestation of any disease. We report a 27-year-old female who presented with non-healing painful ulcer in the left hand of 6 months′ duration. The patient was diagnosed as pyoderma gangrenosum and treated with immunosuppressant drugs. One month later, she developed perianal vesicles and Tzanck smear from the vesicles showed multinucleated giant cells. A workup for sexually transmitted disease revealed HIV 1 Elisa to be positive. Diagnosis of herpetic ulcer was made and treated with famciclovir and hand ulcer gradually healed in 25 days. We report this case to highlight the occurrence of herpetic ulcer in an unusual site in a HIV patient and may lead to misdiagnosis of pyoderma gangrenosum
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