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Enfermedad inflamatoria intestinal en pacientes celíacos Inflammatory bowel disease in celiac patients  [cached]
M. Masachs,F. Casellas,J. R. Malagelada
Revista Espa?ola de Enfermedades Digestivas , 2007,
Abstract: Introducción: se ha sugerido una potencial asociación entre la enfermedad celíaca y la enfermedad inflamatoria intestinal, que puede justificar que ambas enfermedades puedan presentarse en un mismo enfermo o en sus familiares de primer orden con mayor frecuencia de lo esperado. Objetivo: determinar la prevalencia de la enfermedad de Crohn y la colitis ulcerosa en los enfermos celíacos y en sus familiares. Método: estudio epidemiológico prospectivo transversal en un grupo de pacientes celíacos, sus familiares de primer grado y un grupo control de características epidemiológicas similares, constituido por familiares de pacientes que acuden al Servicio de Urgencias por un problema agudo. Para detectar la existencia de colitis ulcerosa y enfermedad de Crohn en los celíacos y sus familiares, se realizó una entrevista semiestructurada. Resultados: se han incluido 86 celíacos y 432 familiares, que se han comparado con 809 controles (129 pacientes con una enfermedad aguda y 680 familiares de primer grado suyos). Se han detectado 3 casos de enfermedad de Crohn en el grupo de los enfermos celíacos y 4 casos de enfermedad de Crohn en sus familiares. Sólo se ha detectado 1 caso de enfermedad de Crohn en el grupo control (p < 0,01). No se ha identificado ningún caso de colitis ulcerosa en ninguno de los tres grupos de estudio. Conclusión: los pacientes con enfermedad celíaca y sus familiares tienen mayor predisposición a presentar una enfermedad de Crohn, que la población control. Introduction: a potential association between celic disease and inflammatory bowel disease hs been suggested, which may explain the fact that both disorders occasionally present in one patient or in his/her first-degree relatives more frequently than expected. Objective: to establish the prevalence of Crohn's disease and ulcerative colitis in celiac patients and their relatives. Method: a cross-sectional, prospective epidemiological study in a group of celiac patients, their first-degree relatives, and a control group with similar epidemiological characteristics including the relatives of patients presenting at the ER for acute conditions. A semistructured interview was used to identify the presence of Crohn's disease and ulcerative colitis in celiac patients and their relatives. Results: in all, 86 celiac patients and 432 relatives were included, who were compared to 809 control subjects (129 patients with acute conditions and 680 first-degree relatives). Three cases of Crohn's disease were identified among celiac patients, and 4 cases among their relatives. Only 1 case of Crohn's disease
The happy celiac: An oxymoron or a possibility?  [PDF]
Maurizio Esposito
Health (Health) , 2012, DOI: 10.4236/health.2012.45041
Abstract: Background: Several international studies, confirmed in Italy too, show a hard presence of socio-relational problems inside the celiac population. Methods: Qualitative study involving persons with celiac disease and their families. 25 individual semi-structured interviews were conducted in three Italian regions. Results: Problems of management of social life for celiac persons are experienced, specially in the fields of: school, work, travels and life outside the home. Conclusion: Chronic illness is a “biographical disruption” [1] and the whole society has to be invested to fight the burden of celiac persons in their possibility of access to public life.
The Shutdown of Celiac Disease-Related Gliadin Epitopes in Bread Wheat by RNAi Provides Flours with Increased Stability and Better Tolerance to Over-Mixing  [PDF]
Javier Gil-Humanes, Fernando Pistón, Francisco Barro, Cristina M. Rosell
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091931
Abstract: Celiac disease is a food-sensitive enteropathy triggered by the ingestion of wheat gluten proteins and related proteins from barley, rye, and some varieties of oat. There are no interventional therapies and the only solution is a lifelong gluten-free diet. The down-regulation of gliadins by RNAi provides wheat lines with all the gliadin fractions strongly down-regulated (low-gliadin). The technological properties of doughs prepared from the low-gliadin lines indicated a general weakening effect, although some of the lines displayed similar properties to that of the wild-type lines. In contrast, the stability was increased significantly in some of the transgenic lines, indicating better tolerance to over-mixing. Results reported here are the first analyses of the mixing and bread-making quality of the wheat lines with all gliadin fractions strongly down-regulated. Flour from these lines may be an important breakthrough in the development of new products for the celiac community. These lines might be used directly or blended with other non-toxic cereals, as raw material for developing food products that can be safely tolerated by CD patients and others with gluten intolerance or gluten sensitivity, incrementing the range of available food products and enhancing their diet.
Endoscopic ultrasound-guided celiac plexus neurolysis  [cached]
Assaad M Soweid,Cecilio Azar
World Journal of Gastrointestinal Endoscopy , 2010,
Abstract: Endoscopic celiac plexus neurolysis (CPN) has become the procedure of choice for the management of patients with pancreatic cancer and abdominal pain unresponsive to medical treatment. It is necessary to differentiate between CPN and endoscopic celiac plexus block performed in patients with benign disease. In this review we describe the technique of this procedure with special emphasis on technical details.
The Prevalence of Celiac Autoantibodies in Hepatitis Patients
Hamidreza Sima,Azita Hekmatdoost,Tahereh Ghaziani,Seyed Moayyed Alavian
Iranian Journal Of Allergy, Asthma and Immunology , 2010,
Abstract: Celiac disease has been associated with other autoimmune disorders such as autoimmune hepatitis, moreover it is known that T cell mediated immune response to dietary gluten and released cytokines are important for the entheropathy seen in celiac disease. We investigated celiac autoantibodies in patients with autoimmune hepatitis (AIH), and chronic hepatitis B (CHB).Sera from 84 patients with Autoimmune Hepatitis (AIH) type 1 and 88 patients with Chronic Hepatitis B (CHB) were tested for Immunoglobulin A and G antibodies to Gliadin, Immunoglobulin A antibodies to tissue transglutaminase using enzyme immunoassay, and Immunoglobulin A anti-endomysial antibodies by both indirect immunofluorescence, and enzyme immunoassay. The patients positive for anti-endomysial antibodies and/or anti tissue transglutaminase antibodies were considered for deuodenal biopsy. The study was approved by Research Center for Gastroenterology and Liver Disease Ethics Committee and all patients gave their written informed consent to participate.Immunoglobulin A anti-endomysial and Immunoglobulin A anti-gliadin antibodies were positive in two out of 84 patients with AIH. Moreover, Immunoglobulin A anti-gliadin antibodies were positive in another patient who was also positive for anti tissue transglutaminase antibodies. Tissue transglutaminase antibodies were positive in eight (9.1%) of 88 patients with CHB, two of which were also positive for anti-endomysial antibodies. One of the patients with CHB was only positive for anti-endomysial antibodies.Compared with the general population, the prevalence of celiac autoantibodies in CHB and AIH patients is relatively high, and it is noteworthy that most positive patients were asymptomatic for celiac disease. We suggest screening for celiac disease before and during treatment in patients with viral and autoimmune hepatitis.
Removing celiac disease-related gluten proteins from bread wheat while retaining technological properties: a study with Chinese Spring deletion lines
Hetty C van den Broeck, Teun WJM van Herpen, Cees Schuit, Elma MJ Salentijn, Liesbeth Dekking, Dirk Bosch, Rob J Hamer, Marinus JM Smulders, Ludovicus JWJ Gilissen, Ingrid M van der Meer
BMC Plant Biology , 2009, DOI: 10.1186/1471-2229-9-41
Abstract: The effects of deleting individual gluten loci on both the level of T-cell stimulatory epitopes in the gluten proteome and the technological properties of the flour were analyzed using a set of deletion lines of Triticum aestivum cv. Chinese Spring. The reduction of T-cell stimulatory epitopes was analyzed using monoclonal antibodies that recognize T-cell epitopes present in gluten proteins. The deletion lines were technologically tested with respect to dough mixing properties and dough rheology. The results show that removing the α-gliadin locus from the short arm of chromosome 6 of the D-genome (6DS) resulted in a significant decrease in the presence of T-cell stimulatory epitopes but also in a significant loss of technological properties. However, removing the ω-gliadin, γ-gliadin, and LMW-GS loci from the short arm of chromosome 1 of the D-genome (1DS) removed T-cell stimulatory epitopes from the proteome while maintaining technological properties.The consequences of these data are discussed with regard to reducing the load of T-cell stimulatory epitopes in wheat, and to contributing to the design of CD-safe wheat varieties.Celiac disease (CD) is a disorder that is characterized by a permanent intolerance to gluten proteins from wheat, rye, and barley. Over 0.5% of the Western population suffers from CD, which presents itself by chronic diarrhea, fatigue, osteoporosis, lymphoma, and several other clinical symptoms after prolonged gluten consumption. Until now, the only treatment is a complete and life long elimination of gluten from the daily diet [1]. In the small intestine, several native gluten peptides can bind directly to specific human leukocyte antigen (HLA)-DQ2 or DQ8 receptors on antigen presenting cells (APCs). However, after deamidation by tissue transglutaminase (tTG), the affinity of the peptides for these HLA-receptors is strongly increased. The gluten peptides can be presented by APCs to gluten-sensitive T-cell lymphocytes leading to the release o
The Canadian celiac health survey – the Ottawa chapter pilot
Ann Cranney, Marion Zarkadas, Ian D Graham, Connie Switzer
BMC Gastroenterology , 2003, DOI: 10.1186/1471-230x-3-8
Abstract: The Professional Advisory Board of the CCA in collaboration with the University of Ottawa developed a comprehensive questionnaire on celiac disease. The questionnaire was pre-tested and then a pilot survey was conducted on members of the Ottawa Chapter of the CCA using a Modified Dillmans' Total Design method for mail surveys.We had a 76% response to the first mailout of the questionnaire. The mean age of participants was 55.5 years and the mean age at diagnosis was 45 years. The majority of respondents presented with abdominal pain, diarrhea, fatigue or weight loss. Prior to diagnosis, 30% of respondents consulted four or more family doctors. Thirty seven percent of individuals were told they had either osteoporosis or osteopenia. Regarding the impact of the gluten-free diet (GFD), 45% of individuals reported that they found following a GFD was very or moderately difficult. The quality of life of individuals with celiac disease was comparable to the mean quality of life of Canadians.On the basis of our results, we concluded that a nationwide survey is feasible and this is in progress. Important concerns included delays in the diagnosis of celiac disease and the awareness of associated medical conditions. Other issues include awareness of celiac disease by health professionals and the impact of the GFD on quality of life. These issues will be addressed further in the national survey.Celiac disease or gluten sensitive enteropathy (GSE) is a genetically based immune-mediated disease characterized by a life-long intolerance to gluten. In celiac disease the small intestinal mucosa is damaged by the gluten proteins contained in wheat, barley and rye. The damage to the small mucosa results in impaired absorption of iron, calcium, folate and the fat-soluble vitamins A, D, E, and K. Elimination of gluten from the diet usually results in full mucosal recovery.Celiac disease may manifest with varying symptoms and severity [1]. The variety of clinical presentations can make th
Plasma ghrelin concentration in celiac patients
Rados?aw Kempiński,Marek Demissie,Maria Jasińska,Leszek Paradowski
Polish Gastroenterology , 2008,
Abstract: Introduction: Ghrelin isthe endogenousgut hormone, first isolated from stomach, and laterfound in varioustissues as: small bowel, kidney, pancreas. It has been recently found to act as growth hormone (GH) releaser, playing significant role in food intake and energy metabolism regulation. The role of the hormone in malabsorption syndromes is still not clear. Aim of the study was the evaluate the ghrelin plasma concentrations in adults suffering from celiac disease (CD) and comparing it to controls. Material and methods: Fasting ghrelin plasma concentrations were measured using enzyme immunoassay in 20 consecutive patients with active celiac disease and 18 healthy controls. Results: Fasting ghrelin concentrations were high in patients with active CD compared to controls (53.78 ng/mL vs. 10.25 ng/mL; p〈0.05).
Safe Foods for Celiac People  [PDF]
Carlos Osella, Maria de La Torre, Hugo Sánchez
Food and Nutrition Sciences (FNS) , 2014, DOI: 10.4236/fns.2014.59089
Abstract:

Celiac Disease is a chronic entheropathy produced by gluten intolerance, more precisely to certain proteins called prolamines, which causes atrophy of intestinal villi, malabsorption and clinical symptoms that can appear in both childhood and adulthood. This pathogeny, results from the interaction of genetic, immunologic and environmental factors, which produce the lesions on the mucosa of the proximal small intestine. It is important to estimate the maximum gluten content that could be present in supposedly “gluten-free” foods, a limit of 20 mg/Kg is admitted. Rice flour, sorghum flour, starches, hydrocolloids, soy flour and dairy products are analyzed for carrying out the manufacture of gluten-free products, such as bread, noodles and others.

A Retrospective Study on Standard Regimen for Vaccination in Celiac Children  [PDF]
Salvatore Leonardi, Giovanna Vitaliti, Andrea Pratico’, Rossella Pecoraro, Mario La Rosa
World Journal of Vaccines (WJV) , 2011, DOI: 10.4236/wjv.2011.12006
Abstract: Background: HLA system plays an essential role in the human immune system activity and the expression of some spe-cific HLA antigens could modify the immune response to vaccinations. Celiac Disease is included among the diseases associated to specific HLA profiles, principally characterized by the expression of the HLA DQ2 antigen. Object: Our study was a retrospective study, leaded on a group of celiac children, with the object to evaluate their immunological response to both obligatory and recommended vaccinations in childhood. Materials and methods: It was a retrospec-tive study, including 66 patients affected by celiac disease, between 3 and 15 years of age, and a control group of 50 children of the same age. All patients performed both obligatory and recommended vaccinations as indicated in the Italian standard regimen for vaccinations. The immunologic response to each vaccine was analysed and compared in the two groups. Moreover, authors also studied the immunologic response to vaccines in celiac children comparing patients whose diagnosis was made before 18 months of age with those whose disease was diagnosed after 18 months of age. Results: Our results showed that in celiac patients the immunological response to vaccine is similar to that one found in general population, except for HBV vaccine. Conclusions: the valuation of immunological response to HBV vaccine should be regularly effectuated in celiac children and revaccination should be recommended.
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