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A case of iatrogenic myositis in piglest
ALONSO-SPILSBURY,M.; RAMíREZ-NECOECHEA,R.; MOTA,D.; AGUILAR,P.;
Archivos de medicina veterinaria , 2003, DOI: 10.4067/S0301-732X2003000100013
Abstract: a case of infectious myositis due to yatrogenia was observed in weaning piglets. six piglets from four litters were affected showing unilateral and bilateral hind limb, knuckling of the metatarsalphalangeal joint, inability to move, dog sitting position, and hyperflexion of the posterior digits.necropsy findings showed: osteochondrosis, osteomyelitis, bubos increased more than 30 times the normal size and, abscesses between phalanges. other conditions seen were: iron spots in semitendinous and semimembranous muscles, aqueous blood, paleness and splenomegaly. it was concluded that the skeletal disorders and the lameness with buboalgia seen in these pigs were caused by inadequate iron injections performed by unskilled workers at the farm
Miositis osificante de los aductores de la cadera Ossifying myositis of hip adductors  [cached]
Feliberto Blanco Trujillo,Juan Carlos Hernández González,Antonio Guardia Parra,Antonio Pascual Rodríguez
MEDISAN , 2011,
Abstract: Se presenta el caso clínico de un paciente de 24 a os de edad, asistido en la Escuela de Trabajadores Sociales de Santiago de Cuba por aumento de volumen en la cadera izquierda y limitación funcional total, no dolorosa, de esa parte del cuerpo. Se comprobó clínica y radiográficamente que se trataba de una miositis osificante de los aductores de la cadera, pero no pudo ser operado en esta provincia porque regresó a su país natal. The clinical case of a 24-year-old patient attended at Social Workers School in Santiago de Cuba due to increased left hip size and total functional limitation without pain of that body area was presented. It was clinically and radiographically documented that the diagnosis was ossifying myositis of hip adductors. However, surgery could not be done in that province because the patient travelled back to his country.
Miositis osificante postraumática
Pereda Cardoso,Osvaldo; Echevarria Castillo,Rafael; Blanco Placencia,Hector; González Reinaldo,Omar; Padrón Valdés,Froilán;
Revista Cubana de Ortopedia y Traumatolog?-a , 2007,
Abstract: postraumatic circumscriptus myositis ossificans is a proliferative benign process in which metaplastic formation occurs in non-osseous tissue. a case diagnosed with myositis ossificans in the hip as a complication of a muscular tear was presented. an updated literature review on this topic and the corresponding diagnosing methods was made.
Morphoea with Myositis: A Rare Association
Mary Sommerlad,Richard Bull,Claire Gorman
Case Reports in Rheumatology , 2011, DOI: 10.1155/2011/134705
Abstract: In this case, we describe an unusual presentation of a young woman with a rash typical of morphoea (confirmed on biopsy), who went on to develop myositis in an atypical distribution. Although the association of myositis with diffuse systemic sclerosis is well described, the link with localised scleroderma (morphoea) and myositis has not been described.
Type 1 interferons and myositis
Steven A Greenberg
Arthritis Research & Therapy , 2010, DOI: 10.1186/ar2885
Abstract: The inflammatory myopathies - including dermatomyositis (DM), inclusion body myositis, and polymyositis (PM) - are poorly understood autoimmune diseases affecting skeletal muscle. Evidence regarding the significance of type 1 interferons to these diseases, especially DM, is reviewed in the present article, with much of this material recently discussed elsewhere [1,2].The type 1 interferons are a class of molecules that include IFNα and IFNβ. After binding to the type 1 interferon receptor (IFNAR) on target cells, these cytokines can stimulate the transcription of a set of genes, the type 1 interferon-inducible genes. Proteins abundantly produced from these genes' transcripts - such as myxovirus resistance protein A, interferon-stimulated gene 15 (ISG15), and 2',5'-oligoadenylate synthetase 1 - remain inside cells. They normally function as defenses against viral infections through a variety of means, such as inhibiting viral transcription, translation, or assembly of viral nucleocapsids. It is possible that the chronic intracellular overproduction of these transcripts and proteins might be directly harmful to cells, such as muscle fibers in myositis [3].The varied forms of myositis have distinct clinical and pathological features (Figure 1), and probably involve distinct mechanisms of tissue injury. DM, in addition to clinical skin involvement, has two unique pathological features (perifascicular atrophy and endothelial cell tubuloreticular inclusions) that distinguish it from other muscle diseases. Inclusion body myositis has a unique clinical distribution of involvement, with substantial weakness of the quadriceps and wrist and finger flexors, as well as specific suggestive pathological features including rimmed vacuoles. The broad category of PM is mainly distinguished by a collection of otherwise individually nonspecific features. Although frequently lumped together, DM and PM probably involve entirely different mechanisms of tissue injury.Because type 1 interfe
Myositis Ossificans Progressiva
J Jannati,M Samadi
Iranian Journal of Pediatrics , 1995,
Abstract: Myositis Ossificans Progressiva (MOP) is a rare heritable disorder characterized by congenital skeletal abnormalities and progressive ectopic ossification of connective tissue. The cause of MOP is unknown and there is no known effective treatment. The course is inevitable slow progression in the extent of involvement and increasing loss of motor function until the patient is practically handicapped. In this article an 11-year old boy is presented in whom the signs and symptoms of MOP started since he was 5 months old. He showed bands of ossification in neck, over the vertebral column, shoulder, ankle and hip joints with restriction of movement in the involved joints as well as hypoplasia of the big toes and bilateral hallux valgus.
Acute orbital myositis: case report
Bittar, Mirian S.;Garcia, Maria L.;Marchiori, Paulo E.;
Arquivos de Neuro-Psiquiatria , 1997, DOI: 10.1590/S0004-282X1997000100022
Abstract: the case of 22-year old, white woman with bilateral orbital myositis following an acute upper respiratory tract infection is reported. the most important clinical findings were ocular pain, proptosis, restricted eye motility and swelling of the eyelids. the enlarged eye muscles were seen on orbital computerized tomography scan. the clinical findings of inflammatory orbital myositis and clinical response to corticotherapy are emphasized.
Dermatomyositis Sine Myositis with Membranoproliferative Glomerulonephritis
Mohammad Bagher Owlia,Roya Hemayati,Shokouh Taghipour Zahir,Mohammad Moeini Nodeh
Case Reports in Rheumatology , 2012, DOI: 10.1155/2012/751683
Abstract: Dermatomyositis (DM) is an autoimmune disease that is characterized by involvement of proximal musculature and skin. We report a 52-year-old woman with a 6-year history of dermatomyositis sine myositis, who developed lower extremity edema and proteinuria. Pathological examination of renal biopsy showed membranoproliferative glomerulonephritis. She received steroid, cyclophosphamide, and mycophenolate mofetil. Over the 9 to 10 months after the beginning of treatment, the proteinuria was improved.
Dermatomyositis Sine Myositis with Membranoproliferative Glomerulonephritis  [PDF]
Mohammad Bagher Owlia,Roya Hemayati,Shokouh Taghipour Zahir,Mohammad Moeini Nodeh
Case Reports in Rheumatology , 2012, DOI: 10.1155/2012/751683
Abstract: Dermatomyositis (DM) is an autoimmune disease that is characterized by involvement of proximal musculature and skin. We report a 52-year-old woman with a 6-year history of dermatomyositis sine myositis, who developed lower extremity edema and proteinuria. Pathological examination of renal biopsy showed membranoproliferative glomerulonephritis. She received steroid, cyclophosphamide, and mycophenolate mofetil. Over the 9 to 10 months after the beginning of treatment, the proteinuria was improved. 1. Introduction Dermatomyositis (DM) is an autoimmune disease that characterized by involvement of proximal musculature and skin. Rarely DM presents with characteristic cutaneous manifestations without muscle involvement, the so called dermatomyositis sine myositis [1]. Renal involvement is uncommon in dermatomyositis especially in sine myositis variant of DM compared to other autoimmune disorders such as SLE, systemic scleroderma, and microscopic polyarteritis nodosa [2]. We report a patient who developed membranoproliferative glomerulonephritis (MPGN) 6 years after the diagnosis of dermatomyositrs sine myositis. 2. Case Report A 52-year-old woman was admitted to our hospital with chronic cough, exertional dyspnea, and edema of lower extremities in November 2010. Dermatomyositis sine myositis was diagnosed for her with typical Gottron’s sign, heliotrope rash, episodes of mechanic’s hand, and nail fold capillary changes without muscle weakness about 6 years ago. At that time, serologic tests such as ANA and anti-dsDNA were negative, and C3, C4, and CH50 levels were normal. Her ischemic ulcers on hand knuckles showed infiltrations of lymphoplasma cells without evidence of overt vasculitis on biopsy specimens in favor of nonspecific connective tissue diseases. In April 2004, She developed fever, cough, diarrhea, and vomiting, while she had been treated with prednisolone and azathioprine. After a course of antibiotic therapy and due to cytopenia, azathioprine switched to cyclosporine. Six years later, the patient had several hospital admissions because of dry cough, exertional dyspnea, and fever. Initially, computed tomography (CT) of the chest and echocardiography were normal. However, later pulmonary function tests revealed restrictive pattern and high-resolution CT scan of the lungs showed fibrosis of anterior segment of the right upper lobe. She developed diabetes mellitus and hypertension 3 years ago. The patient was taking prednisolone, cyclosporine, hy droxychloroquine, amlodipine, triamterene, hydrochlorothiazide, aspirin, and glybenclamide, without kidney
Genomic signatures characterize leukocyte infiltration in myositis muscles  [cached]
Zhu Wei,Streicher Katie,Shen Nan,Higgs Brandon W
BMC Medical Genomics , 2012, DOI: 10.1186/1755-8794-5-53
Abstract: Background Leukocyte infiltration plays an important role in the pathogenesis and progression of myositis, and is highly associated with disease severity. Currently, there is a lack of: efficacious therapies for myositis; understanding of the molecular features important for disease pathogenesis; and potential molecular biomarkers for characterizing inflammatory myopathies to aid in clinical development. Methods In this study, we developed a simple model and predicted that 1) leukocyte-specific transcripts (including both protein-coding transcripts and microRNAs) should be coherently overexpressed in myositis muscle and 2) the level of over-expression of these transcripts should be correlated with leukocyte infiltration. We applied this model to assess immune cell infiltration in myositis by examining mRNA and microRNA (miRNA) expression profiles in muscle biopsies from 31 myositis patients and 5 normal controls. Results Several gene signatures, including a leukocyte index, type 1 interferon (IFN), MHC class I, and immunoglobulin signature, were developed to characterize myositis patients at the molecular level. The leukocyte index, consisting of genes predominantly associated with immune function, displayed strong concordance with pathological assessment of immune cell infiltration. This leukocyte index was subsequently utilized to differentiate transcriptional changes due to leukocyte infiltration from other alterations in myositis muscle. Results from this differentiation revealed biologically relevant differences in the relationship between the type 1 IFN pathway, miR-146a, and leukocyte infiltration within various myositis subtypes. Conclusions Results indicate that a likely interaction between miR-146a expression and the type 1 IFN pathway is confounded by the level of leukocyte infiltration into muscle tissue. Although the role of miR-146a in myositis remains uncertain, our results highlight the potential benefit of deconvoluting the source of transcriptional changes in myositis muscle or other heterogeneous tissue samples. Taken together, the leukocyte index and other gene signatures developed in this study may be potential molecular biomarkers to help to further characterize inflammatory myopathies and aid in clinical development. These hypotheses need to be confirmed in separate and sufficiently powered clinical trials.
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