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Histiocitose de células de Langerhans com envolvimento ungueal em crian?a: relato de caso
Mendes, Wellington Luiz;Melotti, Claudia Zavaloni;Bezerra, Alanna Mara;Soares, Fernando Augusto;Camargo, Beatriz de;
Anais Brasileiros de Dermatologia , 2006, DOI: 10.1590/S0365-05962006000600007
Abstract: langerhans cell histiocytosis may appear in a variety of ways. the authors present the case report of a 3-year-old white boy with a main complaint about chronic media otitis and a tumor lesion in right mastoid bone. pathology revealed histiocytosis. the patient had severe dermatitis on the scalp and dystrophic changes with onycholysis, pustules, and nail plate deformity underneath all fingernails and toenails. these lesions responded to antineoplastic therapy. development of nail dystrophics in langerhans cell histiocytosis is unusual in children. this case suggests that treatment with antineoplastic therapy might be effective.
Histiocitose das células de Langerhans na regi o anogenital
S. Neto M.,Carvalho C. H.,Fadul Jr. R.,Ambrogini C.
Revista da Associa??o Médica Brasileira , 1998,
Abstract: A Histiocitose das células de Langerhans (HCL) acometendo o trato genital tem uma incidência rara com apenas 48 casos relatados na literatura1-5 . Considerando somente as les es da regi o anogenital, esse número cai para dois casos descritos1,2. Reportamos o 3o caso de HCL anogenital em uma paciente de 31 anos, branca, cuja comprova o diagnóstica foi feita através de microscopia eletr nica. O tratamento realizado foi quimioterapia sistêmica e excis o cirúrgica local.
Histiocitose de células de Langerhans em margem anal: relato de caso e revis?o da literatura
Magno, Jaime Coelho Carlos;D'Almeida, Dianice Gallo;Magalh?es, José Pinheiro;Pires, Vilmar José;Araújo, M?nica Leite de;Miranda, Cláudia Barreto de;Nagel, Janaina;
Revista Brasileira de Coloproctologia , 2007, DOI: 10.1590/S0101-98802007000100012
Abstract: a rare case of langerhans cell histiocytosis with perianal involvement in a 34 year old white man is presented. during nineteen months this patient had a complaint of anal pain with bleeding, due to a large perianal ulcer. the initial diagnosis was crohn's disease, anal tuberculosis, syphilis, pyoderma gangrenosum or donovanosis. after the third biopsy, the surgical specimens showed microscopic changes suggestives of langerhans cell histiocytosis. the imunohistochemical study was positive to s100 protein and cd1a. the patient was treated with six doses of intralesional triancinolona and oral thalidomide for three months. treatment was well tolerated and complete resolutions of peri-anal ulcer occurred.
Histiocitose de células de Langerhans: doen?a de Letterer-Siwe - importancia do diagnóstico dermatológico em dois casos
Ferreira, Leonardo Mello;Emerich, Paulo Sergio;Diniz, Lucia Martins;Lage, Luciene;Redighieri, Isabella;
Anais Brasileiros de Dermatologia , 2009, DOI: 10.1590/S0365-05962009000400013
Abstract: langerhans cell histiocytosis is defined as a clonal proliferation of langerhans phenotypic-like cells. letterer-siwe disease is the most common and serious of these entities, affecting mainly infants up to two years of age. we present two cases of this rare disease, diagnosed after dermatological examination, highligthing its typical aspects.
Histiocitose das células de Langerhans na regi?o anogenital
S. Neto, M.;Carvalho, C. H.;Fadul Jr., R.;Ambrogini, C.;Ferreira, L. M.;
Revista da Associa??o Médica Brasileira , 1998, DOI: 10.1590/S0104-42301998000400016
Abstract: the langerhans cell histiocytosis (lch) of the genital tract is rare, with only 48 cases related in the literature1-5. there were reported only 2 cases in the anogenital region1,2. we reported the third case of lch in the anogenital region; patient was female, 31 years-old, caucasian and the diagnosis was confirmed by electron microscopic magnification. the treatment was local surgical excision and systemic chemotherapy.
Histiocitose das células de Langerhans: experiência de 16 anos
Campos, Márcia Kanadani;Viana, Marcos Borato;Oliveira, Benigna Maria de;Ribeiro, Daniel Dias;Silva, Cláudia Márcia de Resende;
Jornal de Pediatria , 2007, DOI: 10.1590/S0021-75572007000100014
Abstract: objectives: to describe the clinical course of langerhans cell histiocytosis and to compare its outcome according to age, staging of the disease and treatment response. methods: retrospective analysis of data on 33 children with langerhans cell histiocytosis followed at hospital das clínicas, universidade federal de minas gerais, brazil, between 1988 and 2004. results: age at diagnosis ranged from 2 months to 16 years (median: 2.5 years). seventeen children were male. the follow-up period varied from 21 days to 16.2 years (median: 3.4 years). the most common clinical manifestations at diagnosis were osteolytic lesions, enlarged lymph nodes and skin lesions. the overall survival rate for the whole group was 86.1% at 16 years (95%ci 66.6-94.6%). deaths occurred in patients with multisystem disease and organ dysfunction at diagnosis. those patients who had a "better" response to treatment in the sixth week were likely to have a significantly higher overall survival rate than those who showed disease progression. overall survival rate was significantly higher for patients with single-system disease. the disease-free survival rate for the whole group was 30.9% at 16 years (95%ci 15.6-47.5%), and was significantly higher for those with single-system disease. age groups were not associated with different disease-free survival rates. diabetes insipidus was the most common sequela. no cases of secondary neoplasms were observed. conclusion: the clinical manifestations of langerhans cell histiocytosis vary widely, with a high relapse rate and low mortality rate.
Histiocitose de células de Langerhans: relato de caso e revis?o da literatura
Quattrino, Ada Lobato;Silveira, Júlio César Gomes;Diniz, Cíntia;Briggs, Maria do Carmo;Vilar, En?i;
Anais Brasileiros de Dermatologia , 2007, DOI: 10.1590/S0365-05962007000400006
Abstract: the authors describe the case of a two-year-old boy who presented vesico-papular lesions all over the trunk which became crusted, in addition to tumorations with necrosis in the cervical region. in the course of his hospitalization, he had sudden onset of convergent strabismus on the right side. histopathological and immunohistochemical examination of cutaneous lesions revealed typical aspects of langerhans' cell histiocytosis, thus confirming diagnosis. the patient underwent chemotherapy, with a significant improvement in his clinical picture.
Achados da tomografia computadorizada de alta resolu??o na histiocitose de células de Langerhans pulmonar
Rodrigues, Rosana Souza;Capone, Domenico;Ferreira Neto, Armando Le?o;
Radiologia Brasileira , 2011, DOI: 10.1590/S0100-39842011000400007
Abstract: objective: the present study was aimed at characterizing main lung changes observed in pulmonary langerhans cell histiocytosis by means of high-resolution computed tomography. materials and methods: high-resolution computed tomography findings in eight patients with proven disease diagnosed by open lung biopsy, immunohistochemistry studies and/or extrapulmonary manifestations were retrospectively evaluated. results: small rounded, thin-walled cystic lesions were observed in the lung of all the patients. nodules with predominantly peripheral distribution over the lung parenchyma were observed in 75% of the patients. the lesions were diffusely distributed, predominantly in the upper and middle lung fields in all of the cases, but involvement of costophrenic angles was observed in 25% of the patients. conclusion: comparative analysis of high-resolution computed tomography and chest radiography findings demonstrated that thin-walled cysts and small nodules cannot be satisfactorily evaluated by conventional radiography. because of its capacity to detect and characterize lung cysts and nodules, high-resolution computed tomography increases the probability of diagnosing pulmonary langerhans cell histiocytosis.
Histiocitose de células de Langerhans: rápida resolu??o após cessa??o do tabagismo
Chatkin, José Miguel;Silva, Vinicius D.;Fritscher, Carlos C.;Fiterman, Jussara;Reck, Cláudia;
Jornal Brasileiro de Pneumologia , 2005, DOI: 10.1590/S1806-37132005000200014
Abstract: we describe a case of pulmonary langerhans cell histiocytosis with a close temporal relationship between smoking cessation and radiological improvement. high-resolution computed tomography revealed multiple small nodules located in the upper and middle lobes of both lungs. microscopy of these lesions showed histiocytic infiltration that reacted strongly to staining for s100 protein. the histiocytes resembling langerhans cells showed strong reactivity for s100 protein. smoking cessation was recommended and the patient complied. chest x-ray and computed tomography performed 6 and 24 months later revealed almost complete resolution of the radiographic abnormalities. despite the possibility that this evolution was attributable to spontaneous remission, in this case, the lesions did, in fact, disappear rapidly after smoking cessation.
Corpos estranhos em otorrinolaringologia: um estudo de 128 casos
Silva, Breno Sim?es Ribeiro da,Souza, Leandro Oliveira,Camera, Marcela Gon?alves,Tamiso, Arnaldo G. Braga
Arquivos Internacionais de Otorrinolaringologia , 2009,
Abstract: Introdu o: A ocorrência de corpos estranhos em otorrinolaringologia é motivo de frequentes consultas no servi o de urgência. Objetivo: O objetivo deste trabalho é descrever uma série de pacientes com corpos estranhos, bem com avaliar o quadro clínico e o tratamento nestes casos. Método: Foi realizado estudo prospectivo de 128 pacientes com diagnóstico de corpo estranho de nariz, orelha e orofaringe, atendidos no pronto-socorro do Hospital Paulista de Otorrinolaringologia, S o Paulo, no período de agosto de 2005 a agosto de 2007. Resultados: Foram 67,18% casos de corpo estranho de orelha; 18,75% casos de cavidade nasal e 14,07% de orofaringe. Destes pacientes 55,47% foram do sexo masculino e 44,53% do sexo feminino. A idade mediana foi de 17 anos. A média do tempo de evolu o foi de 12,2 dias, sendo que 57,03% dos casos foram atendidos com menos de 24 horas de evolu o. Do total de pacientes, 64,85% receberam atendimento inicial no PS do Hospital, e 35,15% vieram encaminhados de outro servi o após alguma tentativa de remo o prévia. O sintoma mais comum dos casos de corpo estranho de orofaringe foi a odinofagia, presente em 88,88% dos casos; dos corpos estranhos de nariz, a rinorreia unilateral esteve presente em 37,5% dos casos e cacosmia em 25% dos casos; e nos corpos estranhos de orelha 39,53% evoluíram com hipoacusia. Conclus o: A maioria dos casos com manipula o prévia para remo o dos corpos estranhos por profissional n o habilitado ou por leigos evoluiu com complica es.
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