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Hepatoprotective and Antioxidant Activities of Amaranthus viridis Linn  [PDF]
Ashok Kumar BS,Lakshman K,Narayan Swamy VB,Arun Kumar PA
Macedonian Journal of Medical Sciences , 2011,
Abstract: Aim: To study heaptoprotective activity of methanolic extract of whole plant of Amaranthus viridis Linn (MeAv) in paracetamol (PCM) induced hepatotoxicity. Materials and Methods: MeAv was screened for hepatoprotective activity in PCM (3 g/kg) induced hepatotoxicity in Wistar rats for 15 days at dose of 200 and 400 mg/kg by measuring liver marker enzymes (serum glutamate pyruvate transaminase and serum glutamate oxaloacetate transaminase), bilirubin (total bilirubin and direct bilirubin) and albumin (ALB), total protein (TP) levels and histopathological studies. Antioxidant activities were studies by measuring malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT) and total thiols (TT) in liver homegenate of treated animals.Results: MeAv significantly (P<0.001) decreases the elevated liver marker enzymes (serum glutamate pyruvate transaminase and serum glutamate oxaloacetate transaminase), bilirubin (total bilirubin and direct bilirubin) and restores albumin (ALB), total protein (TP) levels. A histopathological study also showed liver protective activity of MeAv. In in vivo antioxidant studies, the MeAv has significantly restored the malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT) and total thiols. Conclusion: In conclusion, administration of MeAv for 15 days showed liver protective activity against paracetamol induced liver damage and the potential antioxidant property of MeAv thought to be the mechanism behind its hepatoprotective activity.
Antinociceptive and Antipyretic Effects of Strychnos potatorum Linn. Seeds on Experimental Rats  [PDF]
E. Sanmugapriya,S. Venkataraman
International Journal of Pharmacology , 2010,
Abstract: In traditional system of medicine, Strychnos potatorum Linn. seeds were used for various ailments like pain, inflammation, anemia, jaundice, bronchitis, diabetes, conjunctivitis, chronic diarrhoea, dysentery etc. To investigate the folkloric use, the present study was carried out to evaluate the antinociceptive and antipyretic activities of seed powder (SPP) and aqueous extract (SPE) of Strychnos potatorum Linn seeds in experimental wistar albino mice and rats, respectively. The antinociceptive activity was studied in both chemical [acetic acid (1 mL/100 g b.wt.) induced writhing] and thermal (hot plate and tail immersion technique) models of inducing nociception. Administration of SPP and SPE at two dose levels (100 and 200 mg kg-1 p.o.) significantly (p<0.001) decreased the abdominal contractions in acetic acid induced writhing model and significantly (p<0.001) increased the reaction time in both hot plate and tail immersion techniques, when compared with the standard drug Aspirin (100 mg kg-1, p.o.). Thus SPP and SPE were found to exhibit antinociceptive activity in both chemical and thermal models indicating their central as well as peripheral mechanisms in inhibiting the nociception, respectively. The antipyretic activity was studied by injecting TAB vaccine at the dose of 1 mL kg-1 b.wt., where the pyresis was induced after 6 h. Both SPP and SPE exhibited dose dependent activity in reducing the pyrexia which is comparable to that of Paracetamol (100 mg kg-1, p.o.).
Espécies de Amaranthus que ocorrem como invasoras no Município de Campinas
Leit?o Filho, Hermógenes de Freitas;
Bragantia , 1968, DOI: 10.1590/S0006-87051968000200018
Abstract: the present paper deals with five species of amaranthus, i. e., amaranthus viridis l, amaranthus deflexus l, amaranthus spinosus linn, amaranthus retroflexus l, amaranthus hybridus l, that occur in campinas as weeds. besides the description of the species, an analytical key for their determinations is also supplied. according to the results, the genus amaranthus is preferentially disseminated in "terra-roxa" type soils. in dry sandy soils the genus does not occur, and in damp soils only the species amaranthus deflexus l was detected.
Evaluation of Antipyretic and Antinociceptive Activities of Plumeria acuminata Leaves  [PDF]
M. Gupta,U.K. Mazumder,P. Gomathi
Journal of Medical Sciences , 2007,
Abstract: The present study was designed to investigate the antipyretic and antinociceptive activity of methanol extract of Plumeria acuminata leaves (MEPA) (Apocynaceae) in several experimental models. A single oral administration of MEPA at different doses (100, 250 and 500 mg kg-1) showed significant reduction in brewer`s yeast induced hyperthermia in rats. MEPA also elicited pronounced inhibitory effect on acetic acid-induced writhing response, hot plate, tail flick and tail immersion responses in mice in the antinociceptive test. These findings suggest that the methanol extract of Plumeria acuminata possessed potent antipyretic and antinociceptive activity. Preliminary phytochemial screening of the extracts showed the presence of alkaloids, flavonoids, tannins, terpenes and steroids which may be responsible for antipyretic and antinociceptive activities.
Antipyretic activity of Vitex negundo Linn Leaves extracts  [cached]
Narayan Miskin1, K.P. Manjunath2, Anant Bhandarkar2, Girish Bolakatti1, Manjunatha S. Katagi1
RGUHS Journal of Pharmaceutical Sciences , 2012,
Abstract: The present study intended to investigate the antipyretic activity of leaf extracts of Vitex negundo linn Plant by using yeast induced pyrexia model in Wistar Albino rats. Acute toxicity study and phytochemical analysis was carried out using well established protocols and methods. The phytochemical analysis of leaves revealed the presence of steroids, triterpenoids, alkaloids, flavonoids, tannins and iridiod glycosides. The data obtained indicate that the Petroleum ether and Methanolic extracts of a leaves of plant Vitex negundo linn, at dose of 300 mg/kg body weight per oral route (P.O) showed the significant reduction in yeast provoked elevated temperature. The antipyretic effects of the extracts were compared with standard drug paracetamol.
Evaluation of the analgesic, antipyretic and anti-inflammatory activities of the extracts from the pericarp of Garcinia mangostana Linn. in experimental animals
Wantana Reanmongkol,Chatchai Wattanapiromsakul
Songklanakarin Journal of Science and Technology , 2008,
Abstract: The effects of the ethanol and dichloromethane extracts from the pericarp of Garcinia mangostana Linn.(G. mangostana) on nociceptive response using writhing and hot plate tests in mice and the antipyretic activity in yeastinduced fever in rats, were examined. Anti-inflammatory activity using carrageenin-induced paw edema in rats was also investigated. The ethanol extract (400, 800 mg/kg, p.o.) significantly suppressed the writhings induced by acetic acid. The dichloromethane extract (200, 400 and 800 mg/kg, p.o.) also decreased acetic acid-induced writhing in mice. Neither theethanol extract nor dichloromethane extract had significant effects on antinociceptive response in the hot plate test. No significanteffects on yeast-induced fever were observed after oral administration of the ethanol and dichloromethane extractsin rats. Either oral administration (800 mg/kg) of the ethanol extract or dichloromethane extract significantly decreased therat paw edema induced by carrageenin. These results suggest that the ethanol and dichloromethane extracts from the fruithull of G. mangostana possess analgesic and anti-inflammatory actions but no antipyretic action and one mechanism of action of the anti-inflammatory activity of the extracts may involve in cyclooxygenase (COX) inhibition.
Screening of anti-inflammatory and antipyretic activity of Vitex leucoxylon Linn  [cached]
Shukla Padmini,Shukla P,Mishra S,Gopalakrishna B
Indian Journal of Pharmacology , 2010,
Abstract: Objective: This study was designed to evaluate the anti-inflammatory and antipyretic activity of ethyl acetate extract of Vitex leucoxylon Linn. in various animal experimental models. Materials and Methods: Ethyl acetate extract of V. leucoxylon Linn. evaluated for anti-inflammatory activity in carrageenan, mediator-induced rat paw edema, and cotton pellet-induced granuloma model. The antipyretic activity was evaluated by yeast-induced pyrexia model. Results: Single administration of the ethyl acetate extract of V. leucoxylon Linn. at dose of 500 mg/kg p.o. showed significant (P < 0.001) inhibition of rat paw edema. The ethyl acetate extract showed significant antipyretic activity in brewer yeast-induced pyrexia in rats throughout the observation period of 4 h. Conclusion: This study shows that ethyl acetate extract of V. leucoxylon Linn. has significant anti-inflammatory and antipyretic activity.
Antiinflammatory, analgesic and antipyretic activities of Mimusops elengi Linn  [cached]
Purnima A,Koti B,Thippeswamy A. H. M.,Jaji M
Indian Journal of Pharmaceutical Sciences , 2010,
Abstract: In the present study, 70% ethanol extract of Mimusops elengi Linn. bark was assessed for antiinflammatory, analgesic and antipyretic activities in animals. The antiinflammatory activity of ethanol extract of Mimusops elengi (200 mg/kg, p.o) was evaluated using carrageenan-induced paw edema and cotton pellet-induced granuloma models. Analgesic effect was evaluated using acetic acid-induced writhing and Eddy′s hot plate models and antipyretic activity was assessed by Brewer′s yeast-induced pyrexia in rats. The ethanol extract of Mimusops elengi (200 mg/kg, p.o) significantly inhibited the carrageenan-induced paw oedema at 3rd and 4th h and in cotton pellet model it reduced the transudative weight and little extent of granuloma weight. In analgesic models the ethanol extract of Mimusops elengi decreases the acetic acid-induced writhing and it also reduces the rectal temperature in Brewer′s yeast induced pyrexia. However, Mimusops elengi did not increase the latency time in the hot plate test. These results show that ethanol extract of Mimusops elengi has an antiinflammatory, analgesic and antipyretic activity.
A Study On Antipyretic Activity Of Capparis zeylanica Linn. Plant Methanolic Extract  [PDF]
Amiya Ranjan Padhan,,Anuj kumar Agrahari,Ashutosh Meher
International Journal of Pharma Sciences and Research , 2010,
Abstract: Objective - The objective of the present work was to study the antipyretic activity of plant Capparis zeylanica Linn. belonging to family Capparaceae, known as “Karambha” in Sanskrit & “Asadhua” in Oriya. Materials & Methods - The Methanolic extract was taken for the study and evaluated for antipyretic activity using Brewer’s yeast induced pyrexia in Wister strain albino rats. The methanolic extract at a dose of 100mg/kg & 200mg/kg were evaluated for antipyretic activity. Result - The extract of C. zeylanica plant showed a significant (P < 0.01) dose dependent antipyretic effect in yeast induced elevation of body temperature in experimental rats. Conclusion - The Methanolic extract of Capparis. zeylanica Linn. plant have significant antipyretic activity when compared with the standard drug. So. It can be recommended for further studies.
Interferência interespecífica entre Amaranthus hybridus L. e Amaranthus viridis L.
Maluf, Angela Maria;
Pesquisa Agropecuária Brasileira , 1999, DOI: 10.1590/S0100-204X1999000500001
Abstract: the objective of this paper was to study the interspecific interference between two amaranthus species ? a. viridis and a. hybridus ?, the latter with two distinct biotypes (green and purple); both species ocurred in two localities. in the populations of each of the locations, some independent substitution trials were made in pots, and it could be concluded that the populations that germinate more readily are those which are superior in competition i.e., those that establish themselves and produce the largest number of seeds. there was a tendency for a. hybridus (green biotype) to dominate both a. hybridus (purple biotype) and a. viridis, and for a. hybridus (purple biotype) to dominate a. viridis. in mixed stands, there were cases where the species were competing for the same resources, cases where they were exploiting different environmental resources, and even cases of mutual antagonism.
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