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Caracterización del gen de la citotoxina vacuolizante de Helicobacter pylori a partir de biopsias gástricas de pacientes residentes en Tolima, Colombia
López,A. M.; Delgado,M. P.; Jaramillo,C.; Amézquita,A.; Parra,G.; Echeverry,M. M.;
Revista argentina de microbiolog?-a , 2009,
Abstract: helicobacter pylori successfully colonizes the gastric niche. these bacteria produce a vacuolating cytotoxin known as vaca, which is codified by the vaca gene. this protein represents an important virulence factor. h. pylori strains have different vaca alleles, which show a variety of phenotypes that have been associated with gastrointestinal diseases. the aim of this study was to generate data about the prevalence of h. pylori and the vaca genotype in tolima (colombia) residents, and to evaluate if there exists a relationship between these data and the development of different gastrointestinal pathologies. seventy three patients with different pathologies were included. the dna extracted from biopsy specimens was analyzed and the presence of bacteria was determined by amplifying a fragment of the 16 rdna gene. the vaca genotype was also determined by pcr. fifty-two percent out of the 50 genotyped samples showed vaca s1m1 allele, 42% vaca s2m2, 4% s1m2, and 2% s1,s2,m1,m2. a higher sensitivity for the detection of h. pylori was evidenced by amplifying the vaca gene rather than the 16s rdna gene. no association was found between the vaca genotype and the gastrointestinal diseases included in the study.
Infecciones por helicobacter pylori Helicobacter pylori infections
Liliam Alvarez Gil
Iatreia , 1994,
Abstract: Se revisan los conocimientos sobre el papel de Helicobacter pylori en varias enfermedades gastroduodenales como la gastritis crónica (GC), úlcera gástrica (UG), úlcera duodenal (UD) y dispepsia no ulcerosa (DNU). La revisión abarca aspectos históricos, microbiológicos, clínicos, epidemiológicos, diagnósticos de laboratorio, terapéuticos y de patogénesis. The current knowledge of the role of Helicobacter Pylori in several gastroduodenal diseases is reviewed. It includes chronic gastritis, gastric and duodenal ulcers and nonulcerous dyspepsia. The following aspects are treated in this paper: history, microbiology. Clinical presentation, epidemiology, laboratory diagnosis, therapy and pathogenesis.
The effect of Helicobacter pylori on asthma and allergy  [cached]
Amedeo Amedei,Gaia Codolo,Gianfranco Del Prete,et al
Journal of Asthma and Allergy , 2010,
Abstract: Amedeo Amedei1, Gaia Codolo2, Gianfranco Del Prete1, Marina de Bernard2, Mario M D’Elios11Policlinico AOU Careggi, Department Internal Medicine, University of Florence, Italy; 2Venetian Institute of Molecular Medicine, University of Padua, ItalyAbstract: Current evidence indicates an inverse association between Helicobacter pylori and asthma and allergy. H. pylori is a Gram-negative bacterium which represents the major cause of peptic ulcer and gastric cancer, and preferentially elicits a T helper (Th)-1 response. Many H. pylori factors, such as the neutrophil-activating factor of H. pylori (HP-NAP), are able to drive Th-1 polarization and to display a powerful inhibition of allergic Th-2 response. This article proposes an overview of the actual knowledge about the effects of H. pylori on asthma and allergy. Special attention has been drawn to HP-NAP as a potential novel strategy for the prevention and treatment of asthma and atopy.Keywords: Helicobacter pylori neutrophil-activating factor, protein, Th-1/Th-2, Treg, asthma
Biopatologia do Helicobacter pylori  [cached]
Ladeira Marcelo Sady Plácido,Salvadori Daisy Maria Fávero,Rodrigues Maria Aparecida Marchesan
Jornal Brasileiro de Patologia e Medicina Laboratorial , 2003,
Abstract: A infec o pelo Helicobacter pylori (H. pylori) induz inflama o persistente na mucosa gástrica com diferentes les es organicas em humanos, tais como gastrite cr nica, úlcera péptica e cancer gástrico. Os fatores determinantes desses diferentes resultados incluem a intensidade e a distribui o da inflama o induzida pelo H. pylori na mucosa gástrica. Evidências recentes demonstram que cepas do H. pylori apresentam diversidade genotípica, cujos produtos acionam o processo inflamatório por meio de mediadores e citocinas, que podem levar a diferentes graus de resposta inflamatória do hospedeiro, resultando em diferentes destinos patológicos. Cepas H. pylori com a ilha de patogenicidade cag induzem resposta inflamatória mais grave, através da ativa o da transcri o de genes, aumentando o risco para desenvolvimento de úlcera péptica e cancer gástrico. O estresse oxidativo e nitrosativo induzido pela inflama o desempenha importante papel na carcinogênese gástrica como mediador da forma o ou ativa o de cancerígenos, danos no DNA, bem como de altera es da prolifera o celular e da apoptose.
Helicobacter pylori y enfermedad péptica ulcerosa
Noel Padrón Pérez,Eulalia Fernández Vallín-Cárdenas
Revista Cubana de Medicina General Integral , 1998,
Abstract: Se realizó una revisión dirigida a los médicos de la familia sobre la relación del Helicobacter pylori y la enfermedad péptica ulcerosa. Se incluyen datos epidemiológicos y métodos diagnósticos de la infección. El papel de Helicobacter pylori en la génesis de las recidivas ulcerosas y la significativa disminución de las recurrencias posterior a la erradicación con la terapia antimicrobiana, son aspectos abordados en el presente trabajo. La inmunización como arma de prevención y tratamiento sería un importante logro que se menciona como una futura alternativa para combatir la úlcera asociada a la infección A review on the connection of Helicobacter pylori with peptic ulcer disease was made for the family physicians. Epidemiological data and diagnostic methods were included. The role of Helicobacter pylori in the genesis of ulcer relapses and the significant reduction of recurrences after the erradication with antimicrobial therapy are approached in the present paper. Immunization as an instrument of prevention and treatment would be an important achievement that is mentioned as a future alternative to fight ulcer associated with the infection
Immunity and Helicobacter pylori  [cached]
Paul Harris
Medwave , 2011,
Abstract: The bacteria called Helicobacter pylori arrived to the American continent 12,000 years ago (1), reaching South America roughly 5,400-4,600 years AC according to research by Pelayo Correa, a Colombian pathologist who found Helicobacter in stool next to Chinchorro mummies in the North of Arica close to the Pacific Ocean. In 2005, Barry Marshall was awarded the Nobel Prize for his studies on Helicobacter pylori together with Robin Warren.
The effect of Helicobacter pylori on asthma and allergy
Amedeo Amedei, Gaia Codolo, Gianfranco Del Prete, et al
Journal of Asthma and Allergy , 2010, DOI: http://dx.doi.org/10.2147/JAA.S8971
Abstract: t of Helicobacter pylori on asthma and allergy Review (7081) Total Article Views Authors: Amedeo Amedei, Gaia Codolo, Gianfranco Del Prete, et al Published Date September 2010 Volume 2010:3 Pages 139 - 147 DOI: http://dx.doi.org/10.2147/JAA.S8971 Amedeo Amedei1, Gaia Codolo2, Gianfranco Del Prete1, Marina de Bernard2, Mario M D’Elios1 1Policlinico AOU Careggi, Department Internal Medicine, University of Florence, Italy; 2Venetian Institute of Molecular Medicine, University of Padua, Italy Abstract: Current evidence indicates an inverse association between Helicobacter pylori and asthma and allergy. H. pylori is a Gram-negative bacterium which represents the major cause of peptic ulcer and gastric cancer, and preferentially elicits a T helper (Th)-1 response. Many H. pylori factors, such as the neutrophil-activating factor of H. pylori (HP-NAP), are able to drive Th-1 polarization and to display a powerful inhibition of allergic Th-2 response. This article proposes an overview of the actual knowledge about the effects of H. pylori on asthma and allergy. Special attention has been drawn to HP-NAP as a potential novel strategy for the prevention and treatment of asthma and atopy.
Vacunas en desarrollo: Helicobacter pylori Vaccines under development: Helicobacter pylori  [cached]
Paul Harris D,Carolina Serrano H,Alejandro Venegas E
Revista chilena de infectología , 2006,
Abstract: La infección con Helicobacter pylori es la causa de patologías gastrointestinales como úlcera péptica y cáncer gástrico. Una vacuna contra H. pylori es relevante debido a la alta prevalencia de la infección y a la morbi-mortalidad asociada a ésta en nuestro país. El uso masivo de terapias antimicrobianas actuales no es una estrategia factible, especialmente en países en desarrollo, en parte debido al alto costo, los múltiples efectos adversos, el riesgo de reinfección y la emergencia de resistencia a los antimicrobianos. Numerosos modelos animales han sido utilizados durante a os para determinar el curso de la infección por H. pylori y explorar la factibilidad de una vacuna, ya sea para erradicar o prevenir la infección. Dichos modelos, con la posible excepción de los monos, no son suficientes para responder preguntas fundamentales debido a resultados contradictorios. Un modelo humano de infección por H. pylori debe ser desarrollado con el principal propósito de seleccionar vacunas óptimas. El objetivo final es el desarrollo de estudios de campos de vacunas candidatas, pero el estado actual del conocimiento no proporciona una metódica adecuada para seleccionar tales vacunas candidatas promisorias. Dichos estudios pueden ser dise ados para proporcionar información relevante sobre la inmunidad y patogénesis de la infección por H. pylori Helicobacter pylori causes gastrointestinal disease including peptic ulcer and gastric cancer. An H. pylori vaccine is relevant because of the high prevalence of the infection and its associated complications. Extensive use of traditional antimicrobial therapies to eradicate H. pylori is not feasable, specially in developing countries, in part because of their high cost, associated adverse effects, the risk of reinfection, and the emergence of antimicrobial drug resistance. Numerous animal studies have been performed to determine infection outcomes and to explore the feasibility of a vaccine eradication or prevention of infection. These animal models with the possible exception of monkeys, have not been sufficient to address fundamental issues due to controversial results. A human model of H. pylori infection needs to be developed aimed to select an optimum vaccine candidate. The ultimate scientific goal will be to develop field studies using advanced vaccine candidates, but the current state of knowledge does is insufficient and has provided such candidates. These studies need to be designed in order to provide relevant information on immunity and pathogenesis associated to H. pylori
Behcet’s Disease and Helicobacter Pylori  [PDF]
Ramazan Dan??,Kadim Bayan,?erif Y?lmaz,Abdullah Alt?nta?
Dicle Medical Journal , 2004,
Abstract: The aim of this study is to investigate the relation between Beh et’s disease (BD) and Helicobacter pylori infection. The patients fulfilled the criteria of the International Study Group for Beh et’s disease. Helicobacter pylori infection was diagnosed by the rapid urease test and esophagogastroduodenoscopic examination performed to BD patients. Fourteen of the 22 patients with BD were Helicobacter pylori positive with rapid urease test. All patients with ophthalmic involvement were Helicobacter pylori positive with rapid urease test.
Helicobacter pylori and gastroesophageal reflux disease
Michele Grande, Federica Cadeddu, Massimo Villa, Grazia Attinà, Marco Muzi, Casimiro Nigro, Francesco Rulli, Attilio M Farinon
World Journal of Surgical Oncology , 2008, DOI: 10.1186/1477-7819-6-74
Abstract: Between January 2001 and January 2003 a prospective study was performed in 146 patients with GERD in order to determine the prevalence of Helicobacter pylori infection at gastric mucosa; further the value of the De Meester score endoscopic, manometric and pH-metric parameters, i.e. reflux episodes, pathological reflux episodes and extent of oesophageal acid exposure, of the patients with and without Helicobacter pylori infection were studied and statistically compared. Finally, univariate analysis of the above mentioned data were performed in order to evaluate the statistical correlation with reflux esophagitis.There were no statistically significant differences between the two groups, HP infected and HP negative patients, regarding age, gender and type of symptoms. There was no statistical difference between the two groups regarding severity of symptoms and manometric parameters. The value of the De Meester score and the ph-metric parameters were similar in both groups. On univariate analysis, we observed that hiatal hernia (p = 0,01), LES size (p = 0,05), oesophageal wave length (p = 0,01) and pathological reflux number (p = 0,05) were significantly related to the presence of reflux oesophagitis.Based on these findings, it seems that there is no significant evidence for an important role for H. pylori infection in the development of GERD and erosive esophagitis. Nevertheless, current data do not provide sufficient evidence to define the relationship between HP and GERD. Further assessments in prospective large studies are warranted.Helicobacter pylori (HP) has been demonstrated the causative factor of various gastrointestinal diseases; nevertheless, the relationship between HP infection and gastroesophageal reflux disease (GERD) is still debated [1]. To date, different studies have examined the relationship between atrophic gastritis due to HP infection and reflux oesophagitis with conflicting results.Recent trials suggest that HP infection may be an important cau
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