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Pilomatricoma: epitelioma calcificado de Malherbe Pilomatricoma: calcifying epithelioma of Malherbe  [cached]
Rebeca Paohwa Liu da Fonseca,José de Souza Andrade Filho,Izabella Costa Araujo,Aloísio Ferreira da Silva Filho
Revista Brasileira de Cirurgia Plástica , 2012,
Abstract: INTRODU O: Pilomatricoma (epitelioma calcificante de Malherbe) representa cerca de 1% dos tumores benignos de pele. O objetivo deste estudo retrospectivo é rever as características clínicas e histopatológicas dessa les o em pacientes tratados nos Departamentos de Cirurgia Plástica e Anatomia Patológica de um hospital geral. MéTODO: Dados relacionados a 68 les es, presentes em 56 pacientes, foram revisados. Todos os pacientes foram submetidos a excis o cirúrgica dos tumores. Os seguintes aspectos foram estudados: gênero, idade, localiza o e tamanho das les es, diagnóstico pré-operatório, recorrência e características peculiares à histopatologia. RESULTADOS: Trinta e um pacientes eram do sexo masculino (55,4%) e 25, do feminino (44,6%). As les es estavam localizadas na face (42,4%), membros superiores (19,7%), tronco (13,6%), membros inferiores (12,1%), pesco o (9,1%) e couro cabeludo (3,1%). Em um paciente, foi observada recorrência após o primeiro tratamento cirúrgico. Outra paciente apresentou les es em vários locais, em cinco ocasi es diferentes. Um terceiro paciente teve o diagnóstico de pilomatricoma proliferante. Todos os tumores eram benignos. O diagnóstico clínico de pilomatricoma foi realizado pelo cirurgi o em apenas 19,7% dos casos. CONCLUS ES: Pilomatricomas devem ser considerados no diagnóstico diferencial, especialmente dos nódulos de cabe a e pesco o. Exame clínico cuidadoso e conhecimento da les o favorecem o diagnóstico preciso e, portanto, o tratamento adequado. BACKGROUND: Pilomatricoma (calcifying epithelioma of Malherbe) represents approximately 1% of all benign skin tumors. The aim of this retrospective study was to review the clinical and histopathological characteristics of this lesion in patients presenting to the Departments of Plastic Surgery and Pathology of a general hospital. METHODS: Data regarding 68 lesions in 56 patients were reviewed. All patients underwent surgical excision of the tumors. The medical records were reviewed for gender, age, lesion location and size, preoperative diagnosis, recurrence, and particular histopathological characteristics. RESULTS: Thirty-one patients (55.4%) were male and 25 (44.6) female. The lesions were distributed in the face (42.4%), upper limbs (19.7%), trunk (13.6%), lower limbs (12.1%), neck (9.1%), and scalp (3.1%). In one patient, the condition recurred following the first surgical treatment. Another patient had multiple presentation of her lesions, that appeared in several locations and five different occasions. A third patient was diagnosed with proliferating pilomatricoma. All
A Case Report of Calcifying Epithelioma of Malherbe (Pilomatrixoma) Mimicking Breast Carcinoma in Male Patient  [PDF]
Maria Marta Martins, Adrienne Pratti Lucarelli, José Mendes Aldrighi, Aline Forattini
Case Reports in Clinical Medicine (CRCM) , 2014, DOI: 10.4236/crcm.2014.35063

Pilomatricoma or calcifying epithelioma of Malherbe is a rare benign tumor of the skin and/or the subcutaneous tissue originating from the hair matrix. It is usually seen in children and adolescents, however a smaller second peak of onset is seen in the elderly. The head, neck, or upper extremities are the most common anatomical sites of pilomatricomas, being less frequently seen on the trunk and lower extremities, and very rarely have they been diagnosed in the breast. Its malignant counterpart, pilomatrix carcinoma, is rare and found more often in men. Due to its incapacity of regression, treatment consists of surgical excision. We present the case of a man with a pilomatrixoma of the breast, presenting as ACR BI-RADS 4, and we review the literature regarding pilomatrixomas.

Pilomatricoma: A dermal analog of calcifying odontogenic cyst  [cached]
Kaveri H,Punnya A
Indian Journal of Dental Research , 2008,
Abstract: Pilomatricoma, also known as "Calcifying Epithelioma of Malherbe" is an uncommon, benign, cutaneous tumor originating from the hair matrix. Most often, its precise preoperative diagnosis is not possible. Rarity of this lesion and its histological resemblance to the calcifying odontogenic cyst (the Gorlin′s cyst) make it relevant, both to the maxillofacial surgeons and the pathologists. Here, we describe a case of pilomatricoma of the periorbital region in a young Indian female patient. We believe that its inclusion is essential in the differential diagnosis of hard masses of the maxillofacial and paraoral regions.
Multiple Calcifying Epitheliomas of Malherbe’s of Axilla: A Case Report of Rare Variety  [PDF]
Mushtaq Chalkoo, Shahnawaz Ahangar, Naseer Awan, Mujahid Ahmad Mir, Aarif Bashir, Nida Shafiq
Surgical Science (SS) , 2014, DOI: 10.4236/ss.2014.56042

Pilomatrixoma, a rare benign tumour of sebaceous gland is commonly known as calcifying epithelioma of Malherbe or Tricholemmal cyst. We came across even the rarest form of this benign tumour of skin. Our case report was interestingly detected at a higher age group, unusual site of the body, multiple in nature following postoperative incision drainage of abscess in left axilla.

Calcifying Epithelioma of Malherbe-A Diagnostic Challenge on FNAC  [PDF]
Kuldeep Singh, Satish Sharma,M.Barbotra,V.K Dubey
JK Science : Journal of Medical Education & Research , 2002,
Abstract: Pilomatrixoma or calcifYing epithelioma ofMalherbe is one ofbenign adenexal tumors ofthe skin.!toccurs in all the age groups with common locations in the head and neck region. Fine needle aspirationcytolog) has a challenge in the diagnosis of these tumors.We report a similar case of calcifyingepithelioma.
Intraosseous calcifying cystic odontogenic tumor  [cached]
Kler Shikha,Palaskar Sangeeta,Shetty Vishwa,Bhushan Anju
Journal of Oral and Maxillofacial Pathology , 2009,
Abstract: The calcifying odontogenic cyst was first reported by Gorlin et al . in 1962. It had been classified as a neoplasm related to the odontogenic apparatus because of its histological complexity and morphological diversity until it was renamed as a calcifying cystic odontogenic tumor by the WHO, in 2005. Here we describe a case of mandibular calcifying cystic odontogenic tumor in a 75-year-old male, which was present since five years, with a history of occurrence after the extraction of teeth in the involved region. The lesion was surgically removed and a histopathological examination revealed a cystic tumor with predominance of ghost cells and some amount of dentinoid tissue.
Calcifying Epithelial Odontogenic Tumor  [PDF]
Olavo Hoston Gon?alves Pereira,Laura Priscila Barboza de Carvalho,Vilson Lacerda Brasileiro Junior,Cláudia Roberta Leite Vieira de Figueiredo
Case Reports in Pathology , 2013, DOI: 10.1155/2013/725380
Abstract: The calcifying epithelial odontogenic tumor (CEOT) is a rare benign epithelial odontogenic neoplasm of slow growth that is locally aggressive and tends to invade bone and adjacent soft tissue. Here is reported the case of a 21-year-old female patient with a CEOT in the left mandibular posterior region. The computerized tomography in coronal plane revealed a hypodense lesion in the posterior region of the left mandibular body with hyperdense areas inside and was associated with element 37. An incisional biopsy of the lesion was performed and the histopathological analysis revealed the presence of layers of epithelial odontogenic cells that formed prominent intercellular bridges. A large quantity of extracellular, eosinophilic, and amyloid-like material and an occasional formation of concentric calcifications (Liesegang rings) were also found. The histopathological diagnosis was a Pindborg tumor. Resection of the tumor with a safety margin was performed and after 6 months of follow-up there has been no sign of recurrence of the lesion. 1. Introduction The calcifying epithelial odontogenic tumor (CEOT) or Pindborg tumor is a rare benign epithelial odontogenic neoplasm [1, 2], with approximately 200 reported cases in the literature [3]. In general it occurs as a slow-growing tumor [4], associated with an impacted tooth in the posterior mandibular region [5, 6]. This occurs predominantly between the fourth and fifth decades of life, with no preference of gender [2–4]. Radiographically, CEOT is characterized by a uni- or multilocular lesion that often shows a mixed radiolucent-radiopaque pattern [6]. Treatment consists in the surgical removal of the lesion, with recurrence in 14% of cases [5]. The prognosis is considered good [6]. 2. Case Report A 21-year-old black female patient sought treatment at the Oral and Maxillofacial Trauma Surgery Unit, with swelling in the mandibular left posterior region. While performing the intraoral physical exam an asymptomatic hardened exophytic nodule was found in region 37 (Figure 1). Figure 1: Intraoral aspect of the lesion, characterized by a hardened nodular and exophytic mass in the mandibular body, on the left side. The patient reported a clinical evolution of only five months of the lesion. A radiographic exam revealed a diffuse radiolucent, unilocular lesion, associated with region 37, yet including the distal root of region 36 up to the crown of region 38 (Figure 2). Using a computerized tomography in coronal section, it was possible to observe that it was a question of a local hypodense lesion in the mandibular
A pigmented calcifying cystic odontogenic tumor  [cached]
Yasemin ?ZLüK,Yersu KAPRAN,Ahmet Bülent KAT?BO?LU,Cem TANYEL
Türk Patoloji Dergisi , 2007,
Abstract: A case of a pigmented calcifying cystic odontogenic tumor (CCOT) localized in the mandible occuring in a 16-year-old white female - is reported, and the characteristic histomorphologic features of CCOT and the pathogenesis of melanin and melanocytes present in the pigmented type is discussed under the light of histochemical and immunohistochemical data.
Peripheral calcifying cystic odontogenic tumour of the maxillary gingiva
Ana Lima, Dárcio Kitakawa, Janete Almeida, Adriana Aigotti Brand?o, Ana Anbinder
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-455
Abstract: Authors report a rare case of a peripheral calcifying cystic odontogenic tumor of the maxillary gingiva. A 39-year-old male patient presented with a fibrous mass on the attached buccal gingiva of the upper left cuspid teeth. It was 0.7-cm-diameter, painless and it was clinically diagnosed as a peripheral ossifying fibroma. After an excisional biopsy, the diagnosis was peripheric calcifying cystic odontogenic tumor. The patient was monitored for five years following the excision, and no recurrence was detected.All biopsy material must be sent for histological examination. If the histological examination of gingival lesions with innocuous appearance is not performed, the frequency of peripheral calcifying cystic odontogenic tumor and other peripheral odontogenic tumors may be underestimated.A calcifying cystic odontogenic tumor (CCOT) is an extremely rare benign cystic neoplasm that is characterized by an ameloblastoma-like epithelium and ghost cells that have the potential to undergo calcification [1]. Originally, CCOTs were referred to as calcifying odontogenic cysts (COC). The structure was first described by Gorlin in 1962 as a distinct entity and was therefore called Gorlin cyst [2]. COC was considered as a developmental odontogenic cyst in the jaw. In their first report, Gorlin et al. [2] considered this lesion to be a possible analogue of the cutaneous calcifying epithelioma of Malherbe (the pilomatrixoma). COC accounted for approximately 1% of jaw cysts. In 1981, Praetorius et al. [3] studied and reevaluated 16 cases of COC and proposed that the group actually contained two entities, a cyst and a neoplasm. Since then, neoplastic potential has been investigated.In 2005, the World Health Organization (WHO) designated Gorlin’s cyst as a tumor and described it as belonging to a group of related neoplasms, including the benign cystic-type (CCOT), the benign solid-type dentinogenic ghost cell tumor, and the malignant ghost cell odontogenic carcinoma [1]. The dentino
Different manifestations of calcifying cystic odontogenic tumor  [PDF]
Estevam Rubens Utumi,Irineu Gregnanin Pedron,Leopoldo Penteado Nucci da Silva,Gustavo Grothe Machado
Einstein (S?o Paulo) , 2012,
Abstract: The calcifying cystic odontogenic tumor normally presents as apainless, slow-growing mass, involving both maxilla and mandible,primarily the anterior segment (incisor/canine area). It generallyaffects young adults in the third to fourth decades, with no genderpredilection. Computerized tomography images revealed importantcharacteristics that were not detected by panoramic radiography,such as fenestration, calcification and tooth-like structures. Thetypical microscopic feature of this lesion is the presence of variableamounts of aberrant epithelial cells, without nuclei, which arenamed “ghost cells”. In addition, dysplastic dentine can be foundand occasionally the cyst can be associated with an area of dentalhard tissue formation resembling an odontoma. The treatment forcalcifying cystic odontogenic tumor involves simple enucleationand curettage. The purpose of this article is to present two differentmanifestation of calcifying cystic odontogenic tumor in whichcomputerized tomography, associated to clinical features, servedas an important tool for diagnosis, adequate surgical planning andfollow-up of patients.
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