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Antidiabetic activity of the ethanol extract of Capparis sepiaria L leaves  [cached]
Selvamani P,Latha S,Elayaraja K,Babu P
Indian Journal of Pharmaceutical Sciences , 2008,
Abstract: Capparis sepiaria L, a profusely branched hedge plant, is used in Indian traditional medicine. Capparis sepiaria leaves were extracted with ethanol and concentrated to dryness. The LD 50 value was determined as 894.43 mg/kg body weight by acute toxicity study. The ethanol extract was investigated for possible hypoglycemic effect produced by single oral administration at various dose levels 100, 200 and 300 mg/kg in the streptozotocin induced diabetic rats and compared against normal saline control and the standard glibenclamide. A maximum fall of plasma glucose level 9.40%; 13.57%; 15.25% and 18.80% was observed after 12 h of treatment when administered with ethanol extract of Capparis sepiaria at 100, 200 and 300 mg/kg, and glibenclamide 10 mg/kg dose, respectively. The findings from the study suggest that the Capparis sepiaria leaves may be prescribed as an adjunct to traditional formulation and drug treatment for controlling diabetes mellitus.
Phytochemical Screening and Toxicity Studies on the Leaves of Capparis sepiaria Linn. (Capparidaceae)  [cached]
P. Rajesh,,S. Latha,,P. Selvamani,,V. Rajesh Kannan
Journal of Basic and Clinical Pharmacy , 2010,
Abstract: Capparis sepiaria Linn. (Family: Capparidaceae) is a rare indigenous in South India but has widespread distribution in many tropical and sub-tropical countries. The present study intended with various phytochemical screening and toxicity studies were carried out on the leaves of the Capparis sepiaria. Preliminary phytochemical evaluation of the ethanolic extract of revealed that the presence of reducing sugar, flavonoids, steroids, tannins, glycosides, alkaloids, gums, resins, amino acids, proteins and anthraquinones. The toxicity studies were performed as acute, sub-acute and chronic toxicity determined the LD50 value of 300-5000 mg/kg body weight 4-6 weeks. The results of the various phytochemical tests indicated that the plant to be rich in various biologically active compounds which could serve as potential source of the crude drugs and in addition the plant is not toxic to the experimental model
ANTITUMOR ACTIVITY OF CAPPARIS SEPIARIA ON EHRLICH ASCITES CARCINOMA IN MICE  [cached]
Y VenuGopal,Ravindranath A,Kalpana G,Prabhaker Reddy.V
International Journal of Biomedical Research , 2013, DOI: 10.7439/ijbr.v2i4.103
Abstract: The methanol extract of Capparis Sepiaria (Capparaceae) bark (MECS) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The extract was administered at the doses of 200, and 400 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MECS on the growth of transplantable murine tumor, life span of EAC-bearing hosts and hematological profile MECS caused significant (P < 0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The results indicate that MECS exhibited significant antitumor activity in EAC-bearing mice.
ANTITUMOR ACTIVITY OF CAPPARIS SEPIARIA ON EHRLICH ASCITES CARCINOMA IN MICE  [cached]
Y VenuGopal,Ravindranath A,Kalpana G,Prabhaker Reddy.V
International Journal of Biomedical Research , 2011, DOI: 10.7439/ijbr.v2i4.103
Abstract: The methanol extract of Capparis Sepiaria (Capparaceae) bark (MECS) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The extract was administered at the doses of 200, and 400 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MECS on the growth of transplantable murine tumor, life span of EAC-bearing hosts and hematological profile MECS caused significant (P < 0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. The results indicate that MECS exhibited significant antitumor activity in EAC-bearing mice.
6. Hepatoprotective activity of Coccinia indica leaves extract  [PDF]
B. Shyam Kumar,D. Gnanasekaran,V. Jaishree,K.P. Channabasavaraj
International Journal of Pharmaceutical and Biomedical Research (IJPBR) , 2010,
Abstract: The leaves of Coccinia indica (Family: Cucurbitaceae) are sweet, acrid, cooling, and astringent to the bowels, cures kapha and pitta. It is cultivated in Africa and Asia particularly in India used as a vegetable. A diethyl ether extract of the leaves was studied for hepatoprotective activity against carbon tetrachloride induced liver toxicity in rats. The results shownhepatoprotective activity of Coccinia indica leave extract at dose 400 mg/kg body weight was comparable with standard treatment 125 mg/kg body weight of silymarin, a known hepatoprotective drug. These data also supplement for histopathological study of rat liver section.
Hepatoprotective Activity of Capparis spinosa Root Bark Against CCl4 Induced Hepatic Damage in Mice
Nasrin Aghel,Iran Rashidi,Amir Mombeini
Iranian Journal of Pharmaceutical Research , 2007,
Abstract: Many hepatoprotective herbal preparations have been recommended in alternative systems of medicine for the treatment of hepatic disorders. No systematic study has been done on protective efficacy of Capparis spinosa (Capparidaceae) to treat hepatic diseases. Protective action of C. spinosa ethanolic root bark extract was evaluated in this study in an animal model of hepatotoxicity, which was induced by carbon tetrachloride.Healthy male mice (30-35 g body weight, 6-8 week old) were divided into 7 groups. Group 1 was normal control group; Group 2, the hepatotoxic group was given CCl4; Group 3 was administered olive oil (vehicle); Groups 4-6 received different doses of ethanolic root bark extract (100, 200 & 400 mg/kg) with CCl4; Group 7 was administered overdose of the extract (800 mg/kg). The parameters studied were alanine transaminase and aspartate transaminase activities and duration of sleep. The hepatoprotective activity was also supported by histopathological studies of liver tissue.Results of the biochemical studies of blood samples of CCl4 treated animals showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by CCl4. Whereas blood samples from the animals treated with ethanolic root bark extracts showed significant decrease in the levels of serum markers, indicating the protection of hepatic cells. The results revealed that ethanolic root bark extract of C. spinosa could afford significant dose-dependent protection against CCl4 induced hepatocellular injury.
Capparis sepiaria Linn - Pharmacognostical standardization and toxicity profile with chemical compounds identification (GC-MS)  [cached]
P. Rajesh,S. Latha,P. Selvamani,V. Rajesh Kannan
International Journal of Phytomedicine , 2011,
Abstract: The present study was intended to evaluate the various pharmacognostical procedures in the leaves of Capparis sepiaria Linn., (Capparidaceae). The various pharmacognostical parameters were carried out as per WHO guidelines procedure i.e., bitterness, fineness, microscopical sections, loss on drying, water and alcoholic extractive values, water insoluble ash, acid soluble ash, total ash, swelling index, foaming index, heavy metal analysis, phytochemical analysis and toxicity studies (acute, subacute and chronic toxicity). The study was extended with analyzing the chemical compounds identification in the EECS (ethanolic extract of Capparis sepiaria by using GC-MS. The presence of various phytoconstituents such as glycosides, reducing sugars, flavonoids, saponins, starch and terpenoids is evidenced in EECS & AECS. The results showed that acid insoluble ash (1.70%), total ash (8.68%), water soluble ash (3.42%), water extractive (31.55%), alcohol extractive (5.06%), foaming index (105.26 Unit), loss on drying (9.84%), swelling index (4.16%), acute toxicity (nil), sub-acute toxicity (nil), chronic toxicity (nil). The study was concluded with the plant has standardized as per the World Health Organization procedures. The result of the pharmacognostical standardization of this plant serves as a reference piece and helps in future identification and authentication of this plant specimen. Might be the plant C. sepiaria has potential property by the standardization and it can be included in the normal flora of the plant kingdom. Keywords: C. sepiaria; Microscopical; Macroscopical standardization.
Hepatoprotective activity of the leaves of Nyctanthes arbor-tristis linn.  [cached]
Hukkeri V,Akki Kusum,Sureban R,Gopalakrishna B
Indian Journal of Pharmaceutical Sciences , 2006,
Abstract: The decoction of the leaves of Nyctanthes arbor-tristis Linn. of Oleaceae widely used in Ayurvedic system of medicine for the treatment of sciatica, arthritis, fevers, various painful conditions and diuretics, liver disorders and as laxative. The aim of the present study was to evaluate the alcoholic and aqueous extracts of the leaves of Nyctanthes arbor-tristis for hepatoprotective effect against carbontetrachloride-induced liver damage in rats.Administration of alcoholic and aqueous extracts of the leaves of Nyctanthes arbor-tristis protect the liver from toxic effects of carbontetrachloride by reducing the elevated levels of Serum glutamate pyruvate transaminase, Serum glutamate oxaloacetate transaminase and serum bilirubin (total and direct). Results revealed that both the alcoholic and aqueous extracts showed significant hepatoprotective activity by reducing the elevated levels of biochemical parameters at a dose of 500 mg/kg body weight. The results were supported by histopathological studies of liver samples which showed regeneration of hepatocytes by the extracts.
SCREENING OF ETHANOLIC EXTRACT OF STACHYTARPHETA INDICA L. (VAHL) LEAVES FOR HEPATOPROTECTIVE ACTIVITY  [PDF]
Joshi VG,Sutar P S,Karigar A A,Patil S A
International Journal of Research in Ayurveda and Pharmacy , 2010,
Abstract: Petroleum ether, Chloroform, Ethanol and Aqueous extract of shade dried leaves of Stachytarpheta indica L. (Vahl) were subjected for phytochemical studies. Ethanolic extract showed the presence of Carbohydrates, Glycosides and Flavanoids. Most of the active constituents were present in Ethanolic extract and hence extract was further evaluated for hepatoprotective activity. Hepatoprotective activity of Ethanolic extract of Stachytarpheta indica L. (Vahl) was evaluated by carbon tetrachloride induced toxicity with standard hepatoprotective drug as Liv-52. Ethanolic extract of Stachytarpheta indica L. (Vahl) produced reduction in CCl4 induced elevated levels of SGPT, SGOT, SALP and Serum bilirubin and reversed total protein in rats indicating hepatoprotective activity at the dose of 200mg/kg body weight and was comparable to that of standard drug Liv-52(1ml/kg body weight).Further histopathological studies indicated that the animals pretreated with ethanolic extract of Stachytarpheta indica L. (Vahl) was minimal with distinct preservation of structures and architectural frame of the hepatic cells, and is comparable to standard Liv-52.
Hepatoprotective activity of the methanolic extract of Tylophora indica (Burm. f.) Merill. leaves  [cached]
Mujeeb M,Aeri V,Bagri P,Khan S
International Journal of Green Pharmacy , 2009,
Abstract: The methanolic extract of Tylophora indica leaves was screened for hepatoprotective activity in carbon tetrachloride induced hepatotoxicity in albino rats. The degree of protection was measured by estimating biochemical parameters like Serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, total protein and level of serum bilirubin (both total and direct). Hepatoprotective activity of methanolic extract at a dose of 200 mg/kg and 300 mg/kg body weight, i.p., was compared with Silymarin (25 mg/kg, i.p.) treated animals. Tylophora indica leaves (200 and 300 mg/kg) exhibited significant reduction in serum hepatic enzymes when compared to rats treated with carbon tetrachloride alone. Furthermore, histopathological studies were also done to support the study.
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