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Prevalencia del asma en escolares chilenos: Estudio descriptivo de 24.470 ni?os. ISAAC-Chile
Mallol V,Javier; Cortez Q,Eliana; Amarales O,Lidia; Sánchez D,Ignacio; Calvo G,Mario; Soto L,Susana; Strickler P,Alexis; Kyling M,Adriana; Sanhueza B,Ines; Albornoz V,Carmen;
Revista médica de Chile , 2000, DOI: 10.4067/S0034-98872000000300005
Abstract: background: there is little information about the prevalence of asthma in latin american children. aim: to determine the prevalence of asthma among chilean school age children. subjects and methods: the prevalence of respiratory symptoms related to asthma in schoolchildren aged 7 and 13 years, coming from south santiago, central santiago, valdivia and punta arenas, was determined using the methodology of the international study on asthma and allergies in childhood (ismc). a random sample of school children aged 6-7 and 13-14 years from each locality was selected. this resulted in 24)470 surveyed children (11,723 aged 6-7 years and 12,747 aged 13-14 years). results: the current prevalence of wheezing ("wheezing in the last 12 months") ranged from 16.5% to 20.ó% in children aged 67 years, and from 6.8% to 11.7% in children aged 13-14 years. the cumulative prevalence of asthma ("asthma ever"), ranged from 9.7% and 16.5% in the 6-7 years group and from 7.3% to 12.4% in those aged 13-14 years. conclusions: this study found much higher figures for prevalence of respiratory symptoms related to asthma in school children than those previously reported in this country, with a significant variability between centers (p<0.05). the prevalence of asthma in chilean schoolchildren is as high and variable as that reported in industrialized countries
Cambios en la prevalencia de asma en escolares chilenos entre 1994 y 2002: International Study of Asthma and Allergies in Childhood (ISAAC) - Chile phases I and III Changes in the prevalence of asthma in Chilean school age children between 1994 and 2002
Javier Mallol,Viviana Aguirre,Pedro Aguilar,Mario Calvo
Revista médica de Chile , 2007,
Abstract: Background: In developed countries, the prevalence of asthma in children has significantly increased in the last decades. However, there is no information about the trends of asthma in Latin America. Aim: To determine changes in asthma prevalence between 1994 and 2002 in Chilean schoolchildren. Material and methods: The prevalence of asthma symptoms in schoolchildren aged 7 (n =18.697) and 13 years (n =18.939), from South Santiago, Valdivia and Punta Arenas, obtained during phases I and III of the ISAAC, carried out in 1994 and 2002, was compared. Results: From 1994 to 2002, the mean national prevalence of "wheezing in the last 12 months" in the group aged 6-7years, changed from 18.2% to 17.9% (p =NS); "asthma ever" from 12.5% to 10.7% (p =NS), and "severe episode" from 3.2% to 2.8% (p =NS). There was a significant increase of the prevalence of "wheezing in the last 12 months", in children aged 13-14years, from 9.8% to 15.5% (p =0.01); in "asthma ever" from 10.2% to 14.9% (p =0.01), and for "severe episode" from 2.8% to 3.8% (p =0.01). Conclusions: There was a significant increase in the prevalence of respiratory symptoms related to asthma in children aged 13-14 years that was consistent in all the 3 participating centres of the ISAAC. However, the prevalence of asthma symptoms in children aged 6-7 years remained without significant changes between 1994 and 2002
Prevalencia de síntomas de dermatitis atópica en ni os y adolescentes en La Habana (2002-2003) Prevalence of symptoms of atopic dermatitis in children and adolescents in La Habana (2002-2003)
Patricia Varona Pérez,Dania Fabré Ortiz,Roberto águila,Beatriz Corona
Revista Cubana de Medicina General Integral , 2012,
Abstract: Objetivos: determinar la prevalencia de eczema atópico y describir sus características en ni os y adolescentes de La Habana, así como su relación con el asma y la rinitis. Métodos: estudio transversal que aplicó la metodología ISAAC (International Study of Asthma and Allergies in the Childhood) adaptada al contexto nacional. Incluyó 1 803 ni os (6-7 a os) y 3 023 adolescentes (13-14 a os) de población escolar urbana en los municipios Playa y Marianao, durante los a os 2002-2003. La información se obtuvo a partir de entrevistas a los padres de los ni os y a los adolescentes. En el análisis se utilizaron estadígrafos de frecuencia absoluta y relativa en porcentajes, odds ratio y sus intervalos de confianza al 95 %. Resultados: la prevalencia acumulada de síntomas de eczema, fue referida en aproximadamente 4 de cada 10 ni os: 38,3 % (IC 33,8-42,7) y en 2 de cada 10 adolescentes: 22,5 % (IC 20,1-25,0); la prevalencia actual en los ni os y adolescentes fue 22,2 % (IC 19,0-25,5) y 14,1 % (IC 12,4-16,1) respectivamente. En los primeros 2 a os de vida, el 50 % de los ni os inició los síntomas, que fueron más severos en 2 de cada 10 escolares. Los ni os con síntomas de eczema, tuvieron hasta 4 veces más riesgo de padecer rinitis (OR 1,9 IC 95 % 1,1-3,5) o asma (OR 2,4 IC 95 % 1,6-3,6); en los adolescentes el riesgo de padecer rinitis se elevó hasta 5 (OR 2,6 IC 95 % 1,4-4,9). Conclusiones: se evidenció una alta prevalencia de dermatitis atópica y su relevancia como problema de salud. Los resultados constituyeron una línea de base para la comparación con los de otras ciudades del país y con los de otras latitudes; permitieron documentar tendencias a escala poblacional y evaluar el impacto de futuras intervenciones. Objectives: to determine the prevalence of atopic eczema and to describe its features in children and adolescents of La Habana, as well as its relation to asthma and rhinitis. Methods: a cross-sectional study was conducted applying the ISAAC methodology (International Study of Asthma and Allergies in the Childhood) adapted to national context. Included are 1 803 children (6-7 years) and 3 023 adolescents (13-14 years) from the urban students of Playa and Marianao municipalities during 2002-2003. Information was obtained from interviews with parents of children and adolescents. In analysis authors used the absolute and relative frequency in percentages, odds ratio and its 95 % confidence intervals. Results: prevalence accumulated of eczema symptoms was referred in approximately 4 of each 10 children: 38.3 % (CI 33.8-42.7) and in 2 of each 10 adolescents
Validation of epidemiological tools for eczema diagnosis in brazilian children: the isaac's and uk working party's criteria
Agostino Strina, Mauricio L Barreto, Sergio Cunha, Maria de Fátima SP de Oliveira, Shirlei C Moreira, Hywel C Williams, Laura C Rodrigues
BMC Dermatology , 2010, DOI: 10.1186/1471-5945-10-11
Abstract: We performed a cohort study in urban Brazil. Parents/guardians of 1,419 children answered ISAAC phase II questionnaire. Children were examined for skin lesions (UKWP protocol). Two dermatologists examined most cases of eczema (according to ISAAC or UKWP), and a sample without eczema.Agreement between repeat questionnaires on the filter question was poor (kappa = 0.4). Agreement between the 2 dermatologists was fair (kappa = 0.6). False positive reports included scabies in 39% of ISAAC cases and 33% of UKWP cases. Sensitivity and PPV were low (ISAAC: 37.1% and 16.1%; UKWP: 28.6% and 23.8%). Specificity and NPV were high (ISAAC: 90.0% and 96.6%; UKWP: 95.3% and 96.2%). One-year prevalence of eczema was 11.3% (ISAAC), 5.9% (UKWP) and 4.9% (adjusted dermatologist diagnosis). Point prevalence of scabies (alone or not) was 43%, 33% and 18%, in eczemas according to ISAAC, to UKWP and to dermatologists. The reasons why children with eczema were not identified by ISAAC or UKWP were wrongly denying dry skin, itchy rash or personal history of atopic diseases. A limitation is that questionnaire was already validated in Brazil, but not field tested in this specific setting.Studies using UKWP or ISAAC criteria should include a validation arm, to contribute to the understanding of potential limitations of their use in different contexts and to explore solutions. We list specific recommendations.Eczema has recently been proposed by the World Allergy Organization [1] to replace terms such as atopic dermatitis, atopic eczema, atopic eczema/dermatitis syndrome, previously used interchangeably in the literature [2]. Its individual diagnosis is a relatively undisputed matter: a chronic, or chronically relapsing, inflammatory skin disease, characterized by itchy papules, which become excoriated and lichenified, whose distribution pattern changes during lifetime from more generalized eruptions with oozing and crusted lesions in early childhood, to the childhood pattern of typical flexural
Evaluation of Agreement Between Video and Written Questionnaires for Asthma Symptoms Among Children of Tehran: ISAAC Study
L Fadaizadeh,K Saeedfar,K Najafizadeh,MR Masjedi
Journal of Shahid Sadoughi University of Medical Sciences , 2008,
Abstract: Introduction: International study on asthma was conducted to study the prevalence of Asthma symptoms among 13-14 year old children using written and video questionnaires during the early 90's. The aim of the present study (ISAAC) was to evaluate the agreement between the two questionnaires which were self-completed by the children. Methods: This study, which was a part of the third phase of International Study of Asthma and Allergy in Childhood (ISAAC) and performed exactly similar to phase1, was performed by National Research Institute of Tuberculosis and Lung Diseases (NRITLD) in two cities of Iran; Rasht and Tehran. All stages of the study were performed in accordance with ISAAC protocol. The present study discusses data related to children of Tehran. A total of 3100 school children aged 13-14 years were questioned about asthma symptoms using written and video questionnaires of ISAAC study. For statistical analysis, initially a descriptive study of the available data was performed. Thereafter, chance corrected agreement between the two questionnaires was evaluated using Cohen’s Kappa co-efficiency. Results: Of the total of 3100 children, 52.4% were male and 47.6% female, with a mean age of 13.6 years. Although the questions discussed in the two questionnaires were not exactly similar, the results of the video questionnaires showed a statistically significant lower positive response to asthma symptoms as compared to the written version. Kappa co-efficiency ranged between 0.06- 0.21 (mean=0.12), which is considered poor for all variables. Conclusion: Positive responses to having asthma symptoms were significantly higher using the written questionnaire compared to the video questionnaire. Similar to previous studies, agreement between the two was considered poor for all variables. Although factors such as language, culture, dwelling area, e.t.c. have special effects on results of these questionnaires, results indicate that the two questionnaires should be further studied and validated for this special group of patients in order to reach a better interpretation of prevalence of asthma symptoms.
Prevalence and Severity of Asthma Symptoms in Children of Tehran- International Study of Asthma and Allergies in Childhood (ISAAC)
Mohammad Reza Masjedi,Lida Fadaizadeh,Katayoon Najafizadeh,Pouneh Dokouhaki
Iranian Journal Of Allergy, Asthma and Immunology , 2004,
Abstract: This descriptive study was conducted to determine the prevalence of asthma and related symptoms among 6-7 and 13-14 year old school children in Tehran as a part of International study of Asthma and Allergies in childhood (ISAAC) phase III. The ISAAC written questionnaire was given to a total of 6127 students of 72 schools in urban area of Tehran. Simple random sampling was performed with a uniform distribution throughout 12 clusters of 2 divisions of the municipality. All 6-7 and 13-14 year old students were enrolled in this study. Results showed that 15% of the 6-7 year olds and 17% of the 13-14 year olds had positive history of wheezing among which 8.6% and 10.6% respectively had had recent attacks. Physician confirmed asthma was reported in 2.1% of the 6-7 year olds and 2.6% of the 13-14 age group. Severity of asthma assessed by frequency of speech limitation due to wheeze was positive in 1.5% of 6-7 aged group and 3% of 13-14 year olds. Exercise induced wheeze was detected in 2.3% of the 6-7year old group compared to 15.3% of the 13-14 year olds. Nocturnal cough was more prevalent among 13-14 year olds (18.4%) compared to only 7.2% in the 6-7 year olds. Overall, no significant change in prevalence of asthma symptoms has occurred since 1997 (the last phase of ISAAC) among children of Tehran. The results of our study suggest higher rates of confirmed asthma among 6-7 years old girls compared to boys. However, more extensive and precisely designed studies are needed to further confirm these findings.
Prevalence, Risk Factors and Severity of Asthma Symptoms in Children of Kermanshah, IRAN: ISAAC Phase I, II  [PDF]
Mehdi Zobeiri
Acta Medica Iranica , 2011,
Abstract: Asthma is the most common chronic disorder of school-age children and youth, with rising prevalence in all over the world. By attention to the geographic area there is considerable difference in the prevalence of asthma. The International Study of Asthma and Allergies in Childhood (ISAAC), was founded to maximize the value of epidemiological research into asthma and allergic disease by establishing a standardized methodology and facilitating international collaboration. To determine the prevalence of asthma and related symptoms in Kermanshah (a city in west of IRAN) schoolchildren and also identifying the related variables that increased asthma risk using the ISAAC protocols. This descriptive analytic study was done by the ISAAC written questionnaire and additional questions about family number, demographic and socio-economic characteristics of two groups of first and second grade of primary and guidance schools (6-7 y, 13-14 y). Suggested sample size were applied and selected randomly. Results were analyzed by SPSS soft ware by 95% confidence interval. The ISAAC-written questionnaire was completed by a total of 6236 (48.7% were 6-7 and 51/3% were 13-14 years old) schoolchildren. 50.4% of students were girls and 49/6% were boys. The prevalence of diseases and symptoms were as follows: 20.6% had ever wheezing (27.4% in 13-14 years old and 13.4% in 6-7 years old children and it was 21.6% in girls and 19.5% in boys). Among which the estimated mean national 12-month prevalence of wheeze (current wheeze), speech limiting wheeze , exercise wheeze, night cough and physician diagnosed asthma (ever asthma) were respectively 30.1%, 5.4%, 9.4%, 7.3% and 3.3% for the 6-7 year age group and 44.2%, 13.5%, 28.9% , 17.4% and 2.1% for the 13-14 year age group. Current wheeze was higher in Childs and adolescents with family history of smoking and in higher family number. Comparing with regional study the results of this epidemiological survey of asthma in Kermanshah indicate that asthma is more common here, more prevalent in girls than boys and is higher in 13-14 years old than 6-7 years old but sever asthma is much less common. The results may be due to better diagnosis and better control of disease.
Cambios en la prevalencia de asma en escolares chilenos entre 1994 y 2002: International Study of Asthma and Allergies in Childhood (ISAAC) - Chile phases I and III
Mallol,Javier; Aguirre,Viviana; Aguilar,Pedro; Calvo,Mario; Amarales,Lidia; Arellano,Pamela; Palma,Rodrigo;
Revista médica de Chile , 2007, DOI: 10.4067/S0034-98872007000500005
Abstract: background: in developed countries, the prevalence of asthma in children has significantly increased in the last decades. however, there is no information about the trends of asthma in latin america. aim: to determine changes in asthma prevalence between 1994 and 2002 in chilean schoolchildren. material and methods: the prevalence of asthma symptoms in schoolchildren aged 7 (n =18.697) and 13 years (n =18.939), from south santiago, valdivia and punta arenas, obtained during phases i and iii of the isaac, carried out in 1994 and 2002, was compared. results: from 1994 to 2002, the mean national prevalence of "wheezing in the last 12 months" in the group aged 6-7years, changed from 18.2% to 17.9% (p =ns); "asthma ever" from 12.5% to 10.7% (p =ns), and "severe episode" from 3.2% to 2.8% (p =ns). there was a significant increase of the prevalence of "wheezing in the last 12 months", in children aged 13-14years, from 9.8% to 15.5% (p =0.01); in "asthma ever" from 10.2% to 14.9% (p =0.01), and for "severe episode" from 2.8% to 3.8% (p =0.01). conclusions: there was a significant increase in the prevalence of respiratory symptoms related to asthma in children aged 13-14 years that was consistent in all the 3 participating centres of the isaac. however, the prevalence of asthma symptoms in children aged 6-7 years remained without significant changes between 1994 and 2002
Prevalence of Symptoms of Severe Asthma and Allergies in Irish School Children: An ISAAC Protocol Study, 1995–2007  [PDF]
Zubair Kabir,Patrick J. Manning,Jean Holohan,Patrick G. Goodman,Luke Clancy
International Journal of Environmental Research and Public Health , 2011, DOI: 10.3390/ijerph8083192
Abstract: Childhood asthma is a recurring health burden and symptoms of severe asthma in children are also emerging as a health and economic issue. This study examined changing patterns in symptoms of severe asthma and allergies (ever eczema and hay fever), using the Irish International Study of Asthma and Allergies in Childhood (ISAAC) protocol. ISAAC is a cross-sectional self-administered questionnaire survey of randomly selected representative post-primary schools. Children aged 13–14 years were studied: 2,670 (in 1995), 2,273 (in 1998), 2,892 (in 2002–2003), and 2,805 (in 2007). Generalized linear modelling using Poisson distribution was employed to compute adjusted prevalence ratios (PR). A 39% significant increase in symptoms of severe asthma was estimated in 2007 relative to the baseline year 1995 (adjusted PR: 1.39 [95% CI: 1.14–1.69]) increasing from 12% in 1995 to 15.3% in 2007. Opposite trends were observed for allergies, showing a decline in 2007, with an initial rise. The potential explanations for such a complex disease pattern whose aetiological hypothesis is still evolving are speculative. Changing environmental factors may be a factor, for instance, an improvement in both outdoor and indoor air quality further reinforcing the hygiene hypothesis but obesity as a disease modifier must also be considered.
Birth weight and obesity risk at first grade in a cohort of Chilean children Peso al nacer y riesgo de obesidad en primer grado en una cohorte de ni os chilenos  [cached]
S. Loaiza,A. Coustasse,X. Urrutia-Rojas,E. Atalah
Nutrición Hospitalaria , 2011,
Abstract: The purpose of the study was to determine the association of birth weight as a risk factor for obesity at first grade in a cohort of elementary school Chilean children. Height and weight at birth and follow up measurements at first grade were analyzed from a national cohort of 119,070 new borns. Subjects were classified by anthropometric characteristics: new born weight in kilograms, Ponderal Index, (birth weight/height3 x 100), and gestational age (physical maturity) categories at birth. The study tested the hypothesis that a macrocosomic newborn (> 4,000 g or > 8.8 pounds) or Large for Gestational Age , would be at higher risk to be obese at first grade. A positive relationship between birth weight > 4,000 g, (O.R. =1.55), (p < 0.001), high Ponderal Index (O.R. = 1.39), (p < 0.001), large for gestational age (O.R. = 1.51), (p < 0.001), and obesity at first grade was found. Macrosomic children were more likely to be obese at first grade after controlling for the effects of confounding prenatal variables (O.R. = 1.67, (p < 0.001). When weight gain between birth and first grade was > 120% of reference value, the obesity risk was 20 times higher (p < 0.001). A direct and statistically significant relationship between high birth weight and obesity at first grade in this group of Chilean children were observed. These results highlight the significance of birth weight as an important tool for healthcare providers that can be used as an indicator of obesity risk for children. Objetivo: determinar la asociación entre el peso al nacer y el riesgo de obesidad en escolares de primer a o de ense anza Metodología: se analizó el peso y talla al nacer y las mismas variables al ingresar a la escuela en una cohorte de 119.070 recién nacidos chilenos. El peso al nacer fue categorizado: en Kg (< 2.500 g, >; 4.000 g), según edad gestacional (peque o, adecuado y grande) y según el índice ponderal (peso al nacer g/ talla al nacer cm3) * 100: bajo < 2,49 normal, 2,50 to 3,16 y alto > 3,17. El estado nutricional en los escolares fue clasificado según IMC (peso/talla2) de acuerdo a la referencia del CDC. Se consideró obesidad un valor > percentilo 95. Resultados: Un incremento de peso entre el nacimiento y el ingreso a la escuela > 120% de la referencia determinó un alto riesgo de obesidad: OR 20,5 95% IC 19,7-21,4. Se observó también una relación directa y estadísticamente significativa entre un peso al nacer > 4.000 g (OR 1,55 95% IC 1,48-1,61), grande para la edad gestacional (OR 1,51 95% IC 1,45-1,57) y alto índice ponderal (OR 1,39 95% IC 1,31-1,47) con la obesidad en pri
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