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Scientific Annals of Alexandru Ioan Cuza University of Iasi. New Series, Section 2. Vegetal Biology , 2006,
Abstract: In this paper the results of the histo-anatomical investigations concerning two semiparasitic species from Romanian flora: Viscum album and Loranthus europaeus, are presented. Authors investigated the structure of the vegetative organs of these two species (the leaf, the stem and the haustoria); some commune or different features of the two species are underlined.
Relationship and genetic diversity of mistletoe (Viscum album L.) subspecies
Leon Mejnartowicz
Acta Societatis Botanicorum Poloniae , 2006, DOI: 10.5586/asbp.2006.007
Abstract: With the help of 21 putative isoenzyme loci, the genetic diversity and variations of Viscum album ssp. album L. from 42 species, subspecies, varieties and hybrids of broadleaf trees, Viscum album ssp. austriacum (Wiesb.) Vollmann, from 4 populations of Scots pine (Pinus sylvestris L.) and Viscum album ssp. abietis (Wiesb.) Abromeit, from 8 populations of European silver fir (Abies alba Mill.) were analyzed. On the dendrogram, the three investigated subspecies form three clusters, each clearly separated from the other, so we suggest a revision of the systematic nomenclature proposed to take into consideration a return to an earlier system of dividing the European mistletoe into three species: Viscum album L., Viscum abietis Beck, and Viscum laxum Boiss. et Reut. From among the 21 tested loci only one locus, SOD-A, was monomorphic. The average number of actual alleles (Na) and effective alleles (Ne) was 2.23 and 1.61 respectively. The observed heterozygosity (Ho) varied from 0.199 in V. album ssp. abietis to 0.345 in the V.a. ssp. album populations. Average FST = 0.277 indicates that about 28% of genetic differentiation is due to an interpopulation diversity of Viscum album populations. There is a small gene flux between Viscum album populations with only one immigrant successfully entering a population per two generations (Nm = 0,653).
Upyr D.V.,Kyslychenco B.S.,Martynov A.V.
Annals of Mechnikov's Institute , 2011,
Abstract: Qualitative and quantitative composition of terpenoids in the Viscum album L. raw material, harvested from different trees of the host (linden and poplar), has been studied by gas chromatography method. The content of terpenoids in grass mistletoe was 0.28% and 0.14% respectively. It was determined 133 compounds are 98 compounds were identified. Among the identified compounds 35 were found in both extrakts, 9 - only in mistletoe harvested from lime (1.8-cineole, camphor, β-evdesmol, etc.), 19 substances - only in mistletoe harvested from poplar (α-isophorone, β-farnesene, β-ionone, farnesol, α-bisabolol etc).
Glucose lowering effect of leaf extracts of Viscum Album in normal  [cached]
Emenike Jacob Nwaegerue,Ifeoma Nneka Nweke,Christian Chinyere Ezeala,Prince C Unekwe
Journal of Research in Medical Sciences , 2007,
Abstract: BACKGROUND: The use of plants in the treatment of diabetes mellitus is a well-established practice in traditional medicine. Viscum album has been recommended for the treatment of several diseases. This study evaluated the glucose lowering effect of leaf extracts of this plant in normal and streptozotocin induced diabetic rats. METHODS: Leaf extracts of Viscum album were prepared with 80 % ethanol and administered to normal and diabetic New Zealand white rats. The LD50 was determined by the Karbar method. The glucose lowering effect was assessed in these animals in comparison to normal saline and glibenclamide. Blood glucose was estimated with the aid of a glucose sensor. RESULTS: The LD50 was 1520 mg/kg. A dose dependent lowering effect of the fasting blood glucose was observed in both the normal and diabetic rats, with maximum lowering occurring 6 hours after extract administration. The patterns of effect were similar to that produced by glibenclamide. CONCLUSIONS: Leaf extracts of Viscum album showed a significant glucose lowering effect in normal and diabetic rats. Extracts from this plant could therefore, be useful in controlling blood glucose level. KEY WORDS: Animal models, diabetes mellitus, Viscum album, hypoglycemic effect, streptozotocin.
The study of geographical distribution, anatomy and mineral elements mistletoe (viscum album l.) In the city of Stavropol.
Uliya Dobrinya
Koncept : Scientific and Methodological e-magazine , 2013,
Abstract: This article presents the results of studying the propagation of mistletoe (Viscum album L.) in the city Ставрополя.Проанализирован species composition of host trees and detailed map of habitats semiparasites in the city. In addition the results of anatomical analysis of leaves and stems of Viscum album L.. Describes the methodology and results of the ash analysis of microscopic elements. Shows photomicrographs of samples.
Mansi Verma
International Journal of Pharmaceutical Research and Development , 2010,
Abstract: In Traditional Indian medicine several plants and herbs been used to treat various disorders. The practices of herbal medicine dates back to the very earliest periods of known human history. Herbal medicines are generally safe gentle and effective in treating various chronic diseases in which modern medicines fails or not reliable. Therefore some species of viscum album has been used medicinally for various activities. The whole plant is used in medicine as a resolvent and laxative, best regarded in cancer, epilepsy, sterlity, vertigo and depression and mensurational disorders. Viscum album contains oleanolic acid, b-amyrin, mesoinositol, asparagnes, praline and fatty acids (oleic acid) and flavonoids. It has many ethnobotanical uses and is medicinally used in the traditional homeopatheic system.
Phytochemical Screening and Antibacterial Activity of Viscum album (Mistletoe) Extracts
S.O. Oguntoye,G.A. Olatunji,O.M. Kolawole,K.I. Enonbun
Plant Sciences Research , 2013,
Abstract: Viscum album is a green parasitic plant belonging to the family of Loranthaceae. It grows as a partial parasite on the branches of many decidous lemon trees especially apple and has various ethnomedical uses. Phytochemical screening has shown the presence of Alkaloids, Carbohydrates, Tannins and Flavonoids. Phytosterols are scanty. Thin-layer chromatography of the ethanolic extract (Petroleum spirit and Diethyl ether, 2:1) showed four spots, while the aqueous extract (Petroleum spirit and Diethyl ether, 2:1) showed the presence of three spots. The ethanolic and aqueous crude extracts inhibited the growth of Klebsiella aerogenes, Proteus sp., Escherichia coli and Pseudomonas aeruginosa. Gentamycin and Cloxacillin did not exhibit any activity against Pseudomonas aeruginosa.
Antioxidant and antimutagenic activities of Viscum album fruit ethanolic extract in human lymphocytes
L Alpsoy, I Uzonur, MS Sakcali, S Karaman
African Journal of Biotechnology , 2010,
Abstract: Polyphenolic compounds are widely distributed in plants and known to be excellent antioxidants in vitro. They have the capacity to reduce free-radical formation by scavenging free-radicals. In this study we have evaluated the antioxidant and antimutagenic potencies of polyphenolic compounds of Viscum album against trichloroethylene (TCE)-induced oxidative and genotoxic damage. V. album extract (VAE 0.5 g/ml) protected human lymphocytes against TCE. In chromosomal aberration (CA) analysis, no significant increase in total aberrations were found after treatment with TCE and all VAE concentrations. The mitotic index (MI) showed significant increase in 0.5 ìg/ml VAE samples when compared with TCE-treated (2 ìM) group. VAE (0.5 ìg/ml) reduced the levels of malondialdehyde (MDA) significantly wherease VAE (1.0 and 2.0 ìg/ml) samples increased MDA concentrations significantly. We have also shown that the various DNA effects of TCE treatment seem to be DNA damages, but not mutations as TCE treated profiles were reverted back to the control like profiles by most probably DNA repair mechanisms in VAE 0.5 g/ml treated group.
T. Oniu,M. Cazacu,V. Muntean,Melania Oniu
Jurnalul de Chirurgie , 2011,
Abstract: Background: Most clinical trials using mistletoe to treat colorectal cancer are out-of-date and have major methodological weaknesses that raise doubts about their findings. Meanwhile, the arsenal of chemotherapy has much evolved over the last decade. Thus, the aim of this study was to determine the effectiveness of the total plant extract Isorel in association with modern chemotherapy in the treatment of colorectal cancer. Methods: After the surgical removal of the primary tumor, a total of 124 patients with advanced colorectal cancer (stage Dukes C and D), were randomly divided into the immunotherapy group (Isorel associated in most of the cases with chemotherapy, n=58) and the control group (most of which received chemotherapy). The chemotherapy regimens were based on 5-fluorouracil, irinotecan and oxaliplatin. Overall survival and adverse events were observed. Results: The addition of immunotherapy with Viscum album extract Isorel to 5FU-based chemotherapy significantly improved overall survival in Dukes stage C (5-year survival: 46% vs. 17%; median survival: 46 vs. 24 months, p=0.004) and D (median survival: 13,5 vs. 9,5 months, p=0.02; longest survival: 26 vs. 12 months). The addition of immunotherapy to oxaliplatin- and irinotecan-based chemotherapy further improved overall survival in Dukes stage C (5-year survival: 64% vs. 38%; median survival: 57,5 vs. 34 months, p=0.04) and D (median survival: 24 vs. 18 months, p=0.02; longest survival: 36 vs. 24 months). Inflammatory local reactions at the s.c. injection site occur frequently (83% of patients) at the beginning of the treatment for 1 to 8 weeks. Conclusions: Immunotherapy with Viscum album extract Isorel, added to chemotherapy, improves the survival of the patients operated for advanced colorectal cancer compared with chemotherapy alone, whatever its type.
The most significant parasitic and saprophytic fungi on common mistletoe (Viscum album L) and their potential application in biocontrol
Karad?i? Dragan,Lazarev Vladimir S.,Milenkovi? Milan
Glasnik ?umarskog Fakulteta , 2004, DOI: 10.2298/gsf0489115k
Abstract: Common mistletoe (Viscum album L) is a semiparasitic angiosperm, which attacks a great number of broadleaf and coniferous tree species. Especially high damage is caused by subspecies V. album subsp. abietis, which infests fir trees. This paper presents the most frequent parasitic and saprophytic fungi occurring on common mistletoe. There are altogether 22 identified species, of which the most significant are Botryosphaeria dothidea Gibberidea visci and Sphaeropsis visci. Further study should be focused on testing their potential use in the biocontrol of common mistletoe.
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