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Perceptions on physiopathology and preferred treatment of epilepsy and asthma in the Limpopo Province, South Africa
Supa Promtussananon
Health SA Gesondheid , 2003, DOI: 10.4102/hsag.v8i1.117
Abstract: The objectives of this study were to analyse perceptions of epilepsy and asthma, due to attribution of cause, suggested means of risk reduction and preferred treatment. Opsomming Die doelwitte van hierdie studie was om persepsies van epilepsie en asma te analiseer na aanleiding van die toeskrywing van oorsaak, voorgestelde metodes van risikovermindering en verkose behandeling. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.
Association Between Asthma Severity and Obesity in Two Asthma Clinics in Tehran
Sanaz Tavasoli,Hassan Heidarnazhad,Anooshirvan Kazemnejad,Sara Miri
Iranian Journal Of Allergy, Asthma and Immunology , 2005,
Abstract: The prevalence of both obesity and asthma has increased in recent years. Thus we decided to investigate the relation between obesity and asthma severity. We undertook a cross-sectional study in outpatient asthma clinics of 2 tertiary hospitals in Tehran. Obesity was defined as a body mass index greater than 30. Asthma severity was defined by using the Guide for Asthma Management and Prevention 2004 guidelines, according to patients’ clinical and/or spirometerical parameters. Active cigarette smoking patients and patients with a history of other lung diseases were excluded. A total of 116 individuals, aged 16-83 years with a mean age of 46.57±15.05 years, met the entry criteria. There were 73 females and 43 males. The prevalence of obesity in our study population was 29.3%. The Spearman correlation coefficient between asthma severity and body mass index was r= 0.275 (p= 0.001). Mean body mass index of females and males were 28.95±5.41 and 25.17±4.17, respectively. Mean body mass index of females with asthma was significantly higher than males (p< 0.0001). The odds ratios for obesity were 8.650, 8.746, and 22.491 for mild, moderate and severe persistent asthma, respectively, compared to patients with mild intermittent asthma. With increasing asthma severity, we observed higher occurrence of obesity in adults. The association of asthma severity with obesity suggests that obesity may be a potentially modifiable risk factor for asthma or asthma exacerbation.
From expression pattern to genetic association in asthma and asthma-related phenotypes
Vanessa T Vaillancourt, Martine Bordeleau, Michel Laviolette, Catherine Laprise
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-630
Abstract: Before correction, 31 of the 85 genes selected were associated with at least one asthma-related phenotype. We found four genes that survived the correction for multiple testing. The rs11630178 in aggrecan gene (AGC1) is associated with atopy (p=0.0003) and atopic asthma (p=0.0001), the rs1247653 in the interferon alpha-inducible protein 6 (IFI6), the rs1119529 in adrenergic, alpha-2A-, receptor (ADRA2A) and the rs13103321 in the alcohol dehydrogenase 1B (class I), beta polypeptide (ADH1B), are associated with asthma (p=0.019; 0.01 and 0.002 respectively).To our knowledge, this is the first time those genes are associated with asthma and related traits. Consequently, our study confirms that genetic and expression studies are complementary to identify new candidate genes and to investigate their role to improve the comprehension of the complexity of asthma pathophysiology.Asthma is a complex disease which is characterized by hyperresponsiveness, obstruction and inflammation of the airways and is modulated by the interaction of genetic and environmental factors [1]. The appearance of an immune response and of a remodeling process, which implicates structural and inflammatory cells, dictates the development, the severity and the chronicity of asthma [2]. Atopy, which also shows a genetic component, is characterized by the excessive production of immunoglobulin E in response to environmental allergens and is an important risk factor of asthma [3]. Using candidate genes approach, genome wide association studies, linkage analysis or genomic expression, studies of the last decades revealed that the pathophysiology of asthma is related with more than 300 genes [4,5]. Indeed, several studies showed that microarrays are a relevant tool to highlight genes that are implicated in the different processes occurring during asthma. [6,7] This study aims firstly to demonstrate that expression and genetic association studies complement each other and secondly to test the hypothesis tha
Association between Asthma and Periodontal Disease
S. Yaghobee,M. Paknejad,A. Khorsand
Journal of Dentistry of Tehran University of Medical Sciences , 2008,
Abstract: Objective: An association between poor oral health and chronic lung disease has recently been reported. The purpose of this study was to explore this potential association between asthma and periodontal disease.Materials and Methods: This is a descriptive case controlled study. The samples were selected from patients referred to respiratory disease clinic in a hospital in Tehran, Iran. The study population comprised of one hundred individuals: fifty asthmatics and fifty asthmatic controls evaluated for Plaque index (PI), Gingival index (GI), Papillary Bleed-ing index (PBI), Periodontal Disease index (PDI) and Calculus index (CI). The data were analyzed by SPSS software.Results: There were significant differences between asthmatics and non-asthmatic sam-ples in PI, GI, BOP, and PDI (P<0.01). However, there was no such differences in CI be-tween the two groups (P=0.084).Conclusion: The results of the present study support recent published reports advocating a relationship between respiratory disease and periodontal health status.
Association Between Asthma and Body Mass Index in Children
Babak Amra,Alireza Rahmani,Sohrab Salimi,Zahra Mohammadzadeh
Iranian Journal Of Allergy, Asthma and Immunology , 2005,
Abstract: Obesity has been reported to be associated with an increase in asthma in children. If there is any association, it could be attributed to an effect of obesity on lung volume and thus airway’s obstruction. Data from 2413 children aged 7–12 years in Isfahan were analyzed. The subjects were included in this study if data were available for: height, weight, age, lung volume, and any measure of asthma, including history of diagnosed asthma, wheeze, chronic cough, and medication as obtained by questionnaire. Body mass index (BMI) percentiles, divided into quintiles per year age, were used as a measure of standardized weight.After adjusting for, sex, age, smoking and family history, BMI was a significant risk factor for wheeze ever (p = 0.000) and asthma ever (p = 0.000), diagnosed asthma (P=0.000) and current asthma (p = 0.000). There was no significant correlation between BMI and obstructive spirometry. Increased BMI was significantly associated with an increased airway resistance.Despite the fact that higher BMI is a risk factor for, wheeze ever, wheeze and dyspnea in the last 12 months, and diagnosed asthma, higher BMI is not a risk factor for obstructive pattern in pulmonary function test.
Association Between C Reactive Protein and Asthma
Amina Hamed Ahmad Al Obaidi,Abdul Ghani Mohamed Al Samarai,Abdul Karem Yahya Jawad,Jasim Mohamed Al Janabi
Turk Toraks Dergisi , 2010,
Abstract: Objective: Reported studies have found an inverse relationship between lung function and markers of systemic inflammation. The aim of this study was to clarify the relationship between C-reactive protein (CRP) serum levels, body mass index and asthma. Material and Method: In the present study, CRP was determined in 178 patients with asthma and 50 healthy control subjects. Of all asthmatics, 126 had stable asthma and 52 had asthma during exacerbation. Results: CRP was significantly higher (p<0.05) in asthmatic patients as compared to the control group. In asthmatics with exacerbation, serum CRP was significantly higher than in stable asthmatic patients and control subjects. FEV1 was significantly inversely correlated with serum CRP in asthmatic patients. In asthmatic patients there was a significant (p<0.0001) association between serum level of CRP and body mass index. Furthermore, the mean BMI was significantly higher in asthmatic patients than that in control subjects. Conclusion: Serum CRP may be a non specific marker of asthma and its exacerbation. In addition, obesity could be a risk factor for asthma.
Association between obesity and asthma among teenagers
Bertolace, Maria do Pilar Carneiro;Toledo, Eliana;Jorge, Patrícia Polis de Oliveira;Liberatore Junior, Raphael Del Roio;
Sao Paulo Medical Journal , 2008, DOI: 10.1590/S1516-31802008000500008
Abstract: context and objective: obesity and asthma are serious and growing problems. since adipose tissue produces inflammatory substances, the aim of this study was to estimate the prevalence of asthma among students at schools in s?o josé do rio preto (phase 1), and to corroborate the hypothesis for an association between obesity and asthma among these students (phase 2). design and setting: cross-sectional study at faculdade de medicina de s?o josé do rio preto (famerp). methods: the study consisted of two successive and dependent stages. phase i was a cross-sectional study on 4103 randomly selected students (13-14 years old), to determine the prevalence and severity of asthma. phase ii was an analytical cross-sectional study on 431 students (190 asthmatics and 231 non-asthmatics) from phase i, to evaluate the hypothesis of an association between obesity measured by the body mass index (bmi) and asthma. to diagnose asthma and obesity, the criteria of the international study of asthma and allergies in childhood (isaac) and the chart from the centers for disease control (cdc; 2000) were used. the data were analyzed using student's t test. results: we found that 5.6% of the students analyzed in phase i were asthmatic. the bmi among the asthmatic students (21.84 kg/m2) was higher than the bmi among the non-asthmatics (21.73 kg/m2), although the p value was 0.766. conclusion: in our study group, we did not find any association between increased bmi and the prevalence of asthma.
Asthma Control Test and Asthma Quality of Life Questionnaire Association in Adult Asthmatics
Aylin Ozgen Alpaydin,Mine Bora,Arzu Yorgancioglu,Aysin Sakar Coskun
Iranian Journal Of Allergy, Asthma and Immunology , 2012,
Abstract: Asthma control and quality of life are expected to be correlated. We aimed to evaluate the association of asthma control test (ACT) with asthma quality of life questionnaire (AQLQ) and guideline based control assessment. We also aimed to investigate the impact of therapy adjustment according to ACT score on AQLQA total of 101 asthmatic patients were included. ACT, AQLQ and Global Initiative for Asthma (GINA) based control assessments were performed. Based on ACT, treatment was adjusted by stepping down in controlled and stepping up in uncontrolled/partly controlled patients. In some controlled/partly controlled patients, no therapy adjustment was done. After 3-months the same parameters were reevaluated.We found a statistically significant association between ACT and AQLQ, a one point increase in ACT was associated with a 0.129 point increase in AQLQ. ACT scores increased significantly in the step-up group; however AQLQ total scores were not affected after therapy adjustment. We found that ACT was concordant with GINA recommended control classification in the first (kappa=0.511, 7.718) and third months (kappa=0.599, 7.912) (p<0.001 for both).We determined an association between ACT and AQLQ. ACT was also found fairly concordant with GINA. However, treatment adjustment according to ACT was not found satisfactory in terms of quality of life.
Association of GST Genes Polymorphisms with Asthma in Tunisian Children  [PDF]
Chelbi Hanene,Lachheb Jihene,Ammar Jamel,Hamzaoui Kamel,Hamzaoui Agnès
Mediators of Inflammation , 2007, DOI: 10.1155/2007/19564
Abstract: Background. A positive association between genetic polymorphism and asthma may not be extrapolated from one ethnic group to another based on intra- and interethnic allelic and genotype frequencies differences. Objective. We assessed whether polymorphisms of GST genes (GSTM1, GSTT1, and GSTP1) are associated with asthma and atopy among Tunisian children. Methods. 112 unrelated healthy individuals and 105 asthmatic (73 atopic and 32 nonatopic) children were studied. Genotyping the polymorphisms in the GSTT1 and GSTM1 genes was performed using the multiplex PCR. The GSTP1 ILe105Val polymorphism was determined using PCR-RFLP. Results. GSTM1 null genotype was significantly associated with the increased risk of asthma (P=.002). Asthmatic children had a higher prevalence of the GSTP1Ile105 allele than the control group (43.8% and 33.5%, respectively; P=.002). Also, the presence of the GSTP1 homozygote Val/Val was less common in subjects with asthma than in control group. We have found that GSTT1 null genotype (GSTT10∗/0∗) was significantly associated with atopy (P=.008). Conclusion. Polymorphisms within genes of the GST superfamily were associated with risk of asthma and atopy in Tunisia.
The Association between Cold Spells and Pediatric Outpatient Visits for Asthma in Shanghai, China  [PDF]
Yuming Guo, Fan Jiang, Li Peng, Jun Zhang, Fuhai Geng, Jianming Xu, Canming Zhen, Xiaoming Shen, Shilu Tong
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042232
Abstract: Background Asthma is a serious global health problem. However, few studies have investigated the relationship between cold spells and pediatric outpatient visits for asthma. Objective To examine the association between cold spells and pediatric outpatient visits for asthma in Shanghai, China. Methods We collected daily data on pediatric outpatient visits for asthma, mean temperature, relative humidity, and ozone from Shanghai between 1 January 2007 and 31 December 2009. We defined cold spells as four or more consecutive days with temperature below the 5th percentile of temperature during 2007–2009. We used a Poisson regression model to examine the impact of temperature on pediatric outpatient visits for asthma in cold seasons during 2007 and 2009. We examined the effect of cold spells on asthma compared with non-cold spell days. Results There was a significant relationship between cold temperatures and pediatric outpatient visits for asthma. The cold effects on children's asthma were observed at different lags. The lower the temperatures, the higher the risk for asthma attacks among children. Conclusion Cold temperatures, particularly cold spells, significantly increase the risk of pediatric outpatient visits for asthma. The findings suggest that asthma children need to be better protected from cold effects in winter.
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