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Zinc, oxidative stress, genetic background and immunosenescence: implications for healthy ageing
Eugenio Mocchegiani, Marco Malavolta, Fiorella Marcellini, Graham Pawelec
Immunity & Ageing , 2006, DOI: 10.1186/1742-4933-3-6
Abstract: ZincAge [1] is a specific targeted research project (STREP) funded by the European Union in the 6th Framework Program (FP6). It involves epidemiological studies on the influence of diet and lifestyle on healthy ageing, aimed at preventing adult degenerative disease, particularly focusing on cardiovascular diseases and also addressing malnutrition of the elderly. The 3rd ZincAge meeting brought together biochemical, genetic and lifestyle implications for healthy ageing in the context of nutritional impact of zinc.It is quite clear that antioxidant and micronutrients in the diet, such as zinc, influence the development and function of immune cells, the activity of stress-related proteins and antioxidant enzymes and help to maintain genomic integrity and stability. All these functions occur through the action of proteins involved in the regulation of zinc homeostasis, such as metallothioneins (MT), which bind zinc with high affinity but, at the same time, release free zinc ions in response to oxidative/nitrosative stress to modulate the expression of zinc-dependent genes and to activate antioxidant enzymes and impact immune response. Thus, the role of zinc is mainly to transduce oxidative stress and other signals converging at the production of nitric oxide into an specific intracellular response, suggesting an intriguing task of "signal transducer", similar to that found for calcium in the past. However, many aspects of this model are still unexplored, because the intracellular mechanisms involved in the regulation zinc homeostasis have been poorly studied in ageing.It is known is that during ageing, the intake of zinc decreases, thus contributing to cause frailty, general disability and increased incidence of age-related degenerative diseases (cancer, infections and atherosclerosis). This situation may be better or worse in different European countries, taking into account the large differences in dietary habits between southern and northern areas. One of the aim of
Ageing of the Varistors Containing Oxide of Zinc
N.R. Debbache Adjabi,A. Omeiri
Asian Journal of Information Technology , 2012,
Abstract: The varistors are materials which belong to the class of ceramics and which in the beginning was primarily made up of Silicon carbide (Sic), but for a few years one has advantageously used the varistors Containing Zinc Oxides (ZnO); these last are used more and more for the protection of the electric components against overpressures.The varistors used as element of lightning protector on the lines of distribution of energy are subjected in a permanent way to the various types of constraints. We thus propose a study of the ageing of the varistors under the thermal stresses and electric. However, we examined, during the operation of ageing revolution according to the time of three sizes characterizing a varistor: the leakage current, the tension of threshold and the coefficient of linearity.
Third world conference against racism  [PDF]
Damian-Laki?evi? Ana
Medjunarodni Problemi , 2002, DOI: 10.2298/medjp0201007d
Abstract: The author analyses the Third World Conference against Racism which took place in Durban from 31 August - 8 September 2001. Considering the work of the Conference and the adopted documents - the Declaration and Program of Action - she focuses her attention on the following three dominant topics the Middle East conflict, reparations for the period of slavery and colonialism, and human rights and rights of minorities.
Proceedings of the Third Conference on Uncertainty in Artificial Intelligence (1987)  [PDF]
Laveen Kanal,John Lemmer,Tod Levitt
Computer Science , 2013,
Abstract: This is the Proceedings of the Third Conference on Uncertainty in Artificial Intelligence, which was held in Seattle, WA, July 10-12, 1987
Galaxies: The Third Dimension -- Conference Summary  [PDF]
Eric Emsellem,Joss Bland-Hawthorn
Physics , 2002,
Abstract: ``Galaxies: the Third Dimension'' continues a tradition which started in Marseilles 1994 with the ``Tridimensional Optical Spectroscopic Methods in Astrophysics'' meeting, followed by ``Imaging the Universe in Three Dimensions'' at Walnut Creek in 1999. Since then, there have been developments both in instrumentation and in the way astronomy is conducted, and these need to be seen against a broad canvas. As we emphasize below, one of the main reasons for satisfaction is the trend towards talks focused on scientific results rather than on `yet another 3D spectroscopic technology.'
Proceedings of the Twenty-Third Conference on Uncertainty in Artificial Intelligence (2007)  [PDF]
Ronald Parr,Linda S. van der Gaag
Computer Science , 2012,
Abstract: This is the Proceedings of the Twenty-Third Conference on Uncertainty in Artificial Intelligence, which was held in Vancouver, British Columbia, July 19 - 22 2007.
The Third Conference on Baltic and Nordic Studies in Romania, May 2012  [cached]
Silviu Miloiu
Revista Romana de Studii Baltice si Nordice , 2012,
Abstract: The Romanian Association for Baltic and Nordic Studies continued to organize in 2012 a series of events, one of the most meaningful of which was the third international conference on Baltic and Nordic Studies entitled European networks: the Balkans, Scandinavia and the Baltic world in a time of economic and ideological crisis opened on 25 May at Valahia University of Targovi te and sponsored by the Romanian National Research Council, Niro Investment Group and other partners (http://www.arsbn.ro/conference-2012.htm). The main goal of the conference was to foster debate and academic discussion with regard to the challenges the Balkan and Baltic regions face today, within a time of severe global economic instability. The participants discussed and advanced solutions to problems such as the accession of Balkan states to the EU and/or NATO, with particular reference to the experiences of the relatively new EU and/or NATO Member States from South-Eastern Europe and the Eastern Baltic region; the economic, security or cultural threats posed by Balkan and/or Eastern European states or non-state actors to the Western or Nordic Europe as perceived there; the development of extremist movements and the Balkan organized crime in the Scandinavian countries; the Balkan Roma peoples as a “threat” for Western and Nordic Europe; strategies for integrating minorities in the Baltic Sea rim countries and the Black Sea areas.
Are zinc-bound metallothionein isoforms (I+II and III) involved in impaired thymulin production and thymic involution during ageing?
Eugenio Mocchegiani, Robertina Giacconi, Catia Cipriano, Elisa Muti, Nazzarena Gasparini, Marco Malavolta
Immunity & Ageing , 2004, DOI: 10.1186/1742-4933-1-5
Abstract: MTmRNA and IL-6mRNA (RT-PCR) in the thymus from different donors were tested. Concomitantly, TECs proliferation, zinc ion bioavailability (ratio total thymulin/active thymulin), thymulin activity and corticosterone were tested from different donors.Both isoforms of MTmRNA and IL-6mRNA increase in old thymus coupled with low zinc ion bioavailability, reduced TECs proliferation, impaired thymulin activity and enhanced plasma corticosterone in comparison with young. Conversely, although the thymus is involuted in very old mice because of no changes in thymus weight in comparison to old mice, reduced MTmRNA, especially MT-I+II isoforms, and low IL6mRNA occur. Concomitantly, good zinc ion bioavailability, maintained TECs proliferation, satisfactory thymulin activity and reduced corticosterone are observed in very old mice.The concomitant increments by high IL-6 of both MT isoforms in the thymus from old mice may be involved in thymic involution because provoking low zinc ion bioavailability, which is relevant for thymic efficiency. By contrast, the limited increments of MTs by low IL-6 induce good zinc ion bioavailability and satisfactory thymic efficiency in very old mice. Therefore, abnormal increased MTs may provoke complete thymic involution during ageing and the possible appearance of age-related diseases. If their increments are instead limited by low inflammation, healthy ageing and longevity may be reached.The thymus gland is a central lymphoid organ in which bone marrow-derived T cell precursors undergo a complex process of maturation and differentiation leading to migration of positively selected thymocytes to the T cell-dependent peripheral areas [1]. Although thymocytes proliferation and differentiation persist throughout life, they diminish with ageing. Older thymuses are significantly atrophied and have fewer thymocytes than younger ones. Therefore, the thymus undergoes an age-dependent degenerative process, which allows a progressive loss of thymocytes as
Problems and Conjectures presented at the Third International Conference on Permutation Patterns, University of Florida, March 7-11, 2005  [PDF]
Murray Elder,Vince Vatter
Mathematics , 2005,
Abstract: We recount problems, questions and conjectures that arose during a problem session of the Third International Conference on Permutation Patterns, University of Florida, March 7-11, 2005.
“Looking Back: The Past, History and History Writing in Early America and the Atlantic World”, Third EEASA Biannual Conference
Yohanna Alimi
Transatlantica : Revue d'études Américaines , 2012,
Abstract: The third biannual conference of the European Early American Studies Association (EEASA) was held in Paris at the Institut Charles V (Université Paris-Diderot) on Thursday December 9, Friday December 10 and Saturday December 11, 2010. It was co-hosted by Université Paris-Diderot and Université Versailles-St Quentin, and locally organized by REDEHJA (Réseau pour le Développement Européen de l’Histoire de la Jeune Amérique). After holding its previous conference in Venice in December 2008 on “A...
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