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Daniela Luminita Ichim,Gogu Gheorghita,Mirela Campeanu,Cristian Campeanu
Analele ?tiin?ifice Ale Universit??ii Alexandru Ioan Cuza din Ia?i,Sectiunea II A : Genetica si Biologie Moleculara , 2005,
Abstract: The gamma radiations determined to the species of Echinacea purpurea (L) Moench on increase of the quantity of DNA, comparatively to control and to the species of Hypericum perforatum (L.), the decrease of the quantity of DNA (excepting the30 Gy dose witch hand a stimulative effect).
Vlad Artenie,Daniela Luminita Ichim,Gogu Gheorghita,Mihaela Pintilei
Analele ?tiin?ifice Ale Universit??ii Alexandru Ioan Cuza din Ia?i,Sectiunea II A : Genetica si Biologie Moleculara , 2006,
Abstract: In this paper we were focused on the activity of superoxide dismutase (SOD) in Hypericum perforatum L and Echinacea purpurea L., Moench plantlets, obtained from seeds irradiated with gamma rays before germination.Total activity as well as specific activity of SOD in Hypericum perforatum L. plantlets shows an inhibition, which becames higher at higher irradiation doses. For Echinacea purpurea L. species, gamma radiation shows a slowly stimulative effect of total activity of SOD for some of the higher doses, but the specific enzyme activity is inhibated for all irradiation doses applyed on non-germinated irradiated seeds.
Discussion on clinical efficacy of Hypericum perforatum for depression abroad  [cached]
Zhong Xi Yi Jie He Xue Bao , 2004,
Abstract: The development of molecular pharmacology and neuropharmacology accelerated the studies on molecular mechanism of Hypericum perforatum for depression. The clinical trials indicated that this galenical was superior to the traditional synthetic drugs for antidepression. This preparation had good tolerability and safety. Clinical pharmacokinetics and pharmacodynamics provided further evidence for clinical application of Hypericum. The clinical efficacy of Hypericum for depression was notable and credible.
Research on the biology of Echinacea angustifolia (Dc.) Moench and Echinacea purpurea (L.) Moench  [cached]
Leon Sorin MUNTEAN,Alexandru SALONTAI,Mircea TAMAS,Constantin BOTEZ
Notulae Botanicae Horti Agrobotanici Cluj-Napoca , 1989,
Abstract: Echinacea angustifolia (Dc.) Moench and Echinacea purpurea (L.) Moench species have been highly appreciated for their therapeutic qualities, both of them belong to the few plants of immunostimulative and antiviral properties. The adaptation and cultivation process of these plants has been initiated for medical purposes at the Cluj-Napoca Agronomy Institute. The biological researches evidenced the two species, multiplied by nursery transplant, formed a rosette of leaves during their first year of plantation. The first floral offshoots in Echinacea purpurea were seen during the months September and October (in approximately 40 percent of plants). Flowering Echinacea angustifolia appeared only sporadically the first year of cultivation. Leaves number and plant mass in both species increased markedly the first year of vegetation starting from August. Herba and radix ratio represented 74 percent and 26 percent respectively of the whole plant mass in Echinacea angustifolia and 87 percent and 13 percent respectively in Echinacea purpurea.
Research on the biology of Echinacea pallida Nutt. and Echinacea purpurea (L.) Moench (II)  [cached]
Leon Sorin MUNTEAN,Alexandru SALONTAI,Constantin BOTEZ,Mircea TAMAS
Notulae Botanicae Horti Agrobotanici Cluj-Napoca , 1991,
Abstract: In the second year of vegetation, after emergence, Echinacea pallida Nutt. and Echinacea purpurea (L.) Moench, form a leaf rosette and the first floral shoots appear in June. Plant vigour is significantly higher in Echinacea purpurea than in E. pallida, saved for roots. E. pallida is tetraploid, 2n=4x=44 chromosomes, of small size, between 5,87 and 3,04 microns, relatively easy to individualize by their shape and size.
The Efficacy of Hypericum perforatum Extract on Recurrent Aphthous Ulcers
M. Motallebnejad,A. Moghadamnia,M. Talei
Journal of Medical Sciences , 2008,
Abstract: According to anti-inflammatory and anti-nociceptive effects of Hypericum perforatum (St. John's wort), the aim of this study was to evaluate the efficacy of Hypericum perforatum extract on the management of Recurrent Aphthous Ulcers (RAU). Thirty patients with RAU participated in a randomly, placebo controlled double blind trial during three episodes of RAU to evaluate the efficacy of the topical hypericum containing mouthwash (0.5%). After a no-treatment run-in phase, patients were asked to use placebo mouthwash or hypericum mouthwash randomly. The diameters of ulcer and inflammatory halo (with 0.1 mm precision) and ulcer duration (day) were recorded and associated pain (Visual Analog Scale) were recorded by patients during each episode. Hypericum mouthwash resulted in a significant reduction of pain of RAU (p<0.05). Healing time was reduced in hypericum mouthwash group in comparison to other episodes (p = 0.052). Other indices did not show any significant differences. Hypericum perforatum extract in form of mouthwash (0.5%), may be of benefit in reduction of pain of RAU and has relative effect on reduction of healing time.
The morphology and yield of Hypericum perforatum L. in different regions of Western Siberia  [PDF]
Iryna I. Bayandina,Yulia V. Zagurskaya,Elena V. Dimina,O.O. Vronskaya
Modern Phytomorphology , 2012,
Abstract: It is established that linear characters of Hypericum perforatum don’t correlate with weight parameters of yield. The most important parameters of yield are the number of shoots of the first and second order, reproductive effort and a fructification index of plants.
Enhancement of Hypericin Production and Cell Growth of Hypericum perforatum L. Suspension Cultures by Nitric Oxide

Mao-Jun Xu,Ju-Fang Dong,Gang Zhang,

生物工程学报 , 2005,
Abstract: Nitric oxide has emerged as a key signaling molecule in plants recently. The role of nitric oxide in elicitor induced defense responses of plants has been extensively investigated. In this work, sodium nitroprusside was utilized as the donor of nitric oxide to investigate the effects of exogenous nitric oxide on hypericin production and cell growth of suspension cell cultures of Hypericum perforatum L.. Compared with the untreated Hypericum perforatum L. suspension cells, external application of 0 5 and 15 0 mmol/L sodium nitroprusside induced 1 4 and 0 5 fold dry cell weight, and 0 9 and 2 1 fold hypericin content respectively. The results showed that low concentration of sodium nitroprusside promoted the growth of Hypericum perforatum L. suspension cells, while high concentration of sodium nitroprusside enhanced hypericin biosynthesis in Hypericum perforatum L. suspension cells. The maximum hypericin production was achieved by adding 0 5 mmol/L and 15 0 mmol/L sodium nitroprusside to the culture at day 0 and day 14 respectively, increasing the total hypericin yield by nearly 3 2 fold. The effects of sodium nitroprusside on hypericin content and growth of Hypericum perforatum L. suspension cells were abolished by nitric oxide specific scavenger 2 4 carboxyphenyl 4,4,5,5 tetramethylimidazoline 1 oxyl 3 oxide, which indicated that the effects of the application of sodium nitroprusside were caused by nitric oxide released from sodium nitroprusside rather than sodium nitroprusside itself. The results also showed that 15 0 mmol/L sodium nitroprusside stimulated the activities of phenylalanine ammonia lyase (PAL), one of the key enzymes of phenylpropanoid pathway, in suspension cells of Hypericum perforatum L., which suggested that the synthetic pathway of hypericin might be activated by NO through triggering the defense responses of Hypericum perforatum L. suspension cells.
Cadmium, Mercury and Lead in Hypericum perforatum L. collected in Western Serbia  [cached]
?urovi? D.,Bulat Z.,Buha A.,Matovic V.
E3S Web of Conferences , 2013, DOI: 10.1051/e3sconf/20130115009
Abstract: Wild population of Hypericum perforatum growing in Western Serbia was analyzed for the content of important environmental pollutants cadmium, mercury and lead. Metal contents were determined by inductively coupled plasma optical emission spectrometry. Obtained results showed that levels of mercury and lead were under while cadmium concentrations exceeded limits recommended for medicinal plants. High levels of cadmium in investigated plants can be the result of soil enriched with cadmium as well as the ability of Hypericum perforatum to accumulate cadmium.
Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female Rats  [PDF]
Maria Vittoria Micioni Di Bonaventura,Giovanni Vitale,Maurizio Massi,Carlo Cifani
Journal of Obesity , 2012, DOI: 10.1155/2012/956137
Abstract: Purpose. The present study evaluated the effect of Hypericum perforatum dry extract in an experimental model of binge eating (BE). Methods. BE for highly palatable food (HPF) was evoked in female rats by three 8-day cycles of food restriction/re-feeding and acute stress on the test day (day 25). Stress was induced by preventing access to HPF for 15 min, while rats were able to see and smell it. Hypericum perforatum dry extract was given by gavage. Results. Only rats exposed to both food restrictions and stress exhibited BE. The doses of 250 and 500 mg/kg of Hypericum perforatum extract significantly reduced the BE episode, while 125 mg/kg was ineffective. The same doses did not affect HPF intake in the absence of BE. The dose of 250 mg/kg did not significantly modify stress-induced increase in serum corticosterone levels, suggesting that the effect on BE is not due to suppression of the stress response The combined administration of 125 mg/kg of Hypericum perforatum together with Salidroside, active principle of Rhodiola rosea, produced a synergic effect on BE. Conclusions. The present results indicate for the first time that Hypericum perforatum extracts may have therapeutic properties in bingeing-related eating disorders.

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