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Diversity of Secondary Metabolites from Marine Bacillus Species: Chemistry and Biological Activity  [PDF]
Muhammad Abdul Mojid Mondol,Hee Jae Shin,Mohammad Tofazzal Islam
Marine Drugs , 2013, DOI: 10.3390/md11082846
Abstract: Marine Bacillus species produce versatile secondary metabolites including lipopeptides, polypeptides, macrolactones, fatty acids, polyketides, and isocoumarins. These structurally diverse compounds exhibit a wide range of biological activities, such as antimicrobial, anticancer, and antialgal activities. Some marine Bacillus strains can detoxify heavy metals through reduction processes and have the ability to produce carotenoids. The present article reviews the chemistry and biological activities of secondary metabolites from marine isolates. Side by side, the potential for application of these novel natural products from marine Bacillus strains as drugs, pesticides, carotenoids, and tools for the bioremediation of heavy metal toxicity are also discussed.
SECONDARY METABOLITES FROM MARINE PENICILLIUM BREVICOMPACTUM
ROVIROSA,JUANA; DIAZ-MARRERO,ANA; DARIAS,JOSE; PAINEMAL,KARIN; SAN MARTIN,AURELIO;
Journal of the Chilean Chemical Society , 2006, DOI: 10.4067/S0717-97072006000100004
Abstract: in a screening of basidiomycete cultures isolated from marine invertebrates collected along the chilean coastline for the production of antibiotics we identified a penicillium brevicompactum strain as a producer of metabolites inhibiting the growth of bacteria and fungi. bioactivity guided purification resulted in the isolation of four known metabolites. their structures were elucidated by spectroscopic methods
SECONDARY METABOLITES FROM MARINE PENICILLIUM BREVICOMPACTUM  [cached]
JUANA ROVIROSA,ANA DIAZ-MARRERO,JOSE DARIAS,KARIN PAINEMAL
Journal of the Chilean Chemical Society , 2006,
Abstract: In a screening of Basidiomycete cultures isolated from marine invertebrates collected along the Chilean coastline for the production of antibiotics we identified a Penicillium brevicompactum strain as a producer of metabolites inhibiting the growth of bacteria and fungi. Bioactivity guided purification resulted in the isolation of four known metabolites. Their structures were elucidated by spectroscopic methods
A review on studies of secondary metabolites from marine fungi
海洋真菌生物活性物质研究之管见

ZHU Wei-Ming,WANG Jun-Feng,
朱伟明
,王俊锋

菌物学报 , 2011,
Abstract: Marine fungi are a kind of important source for active marine natural products. Up to now, 1,117 new compounds have been isolated and identified from the fermentation broth of marine fungi. In this paper, the history, status quo, methods and issues in studying secondary metabolites from marine fungi are presented. The compounds originated from marine fungi and their perspective in drug discovery were also discussed.
PREDICTION OF BIOLOGICAL ACTIVITY SPECTRA FOR SECONDARY METABOLITES FROM MARINE MACROALGAE CAULERPA SPP (CHLOROPHYTA – CAULERPALS)  [PDF]
R. Azhaguraj,M.C. John Milton,J. Ganesh,G. Justin Zenith kumar
International Research Journal of Pharmacy , 2012,
Abstract: This study aims to evaluate the biological activity of Caulerpin β-Sitosterol, Taraxerol and Palmtic acid isolated from the marine macro algae Caulerpa spp. The PASS computer program was used in this study to predict the biological activity profile of the four Phenazine derivates. The results were analyzed to show various biological activities like pharmacological (Kinase inhibitor, Neuroprotector and Antiviral), Effects (Oxidoreductase inhibitor, Acid Phosphatase inhibitor) and toxicological activity (Teratogen) of these compounds. The PASS software is useful for the study of biological activity of secondary metabolites.
Assessment of Secondary Metabolites from Marine-Derived Fungi as Antioxidant  [PDF]
Nihad Abdel-Monem, Ahmed M. Abdel-Azeem, E. S. H. El Ashry, Doaa A. Ghareeb, Asmaa Nabil-Adam
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.33009
Abstract:

Marine derived fungi are considered as a promising source of novel drugs due to their biodiversity and consequent chemo-diversity. Although marine microorganisms especially fungi are not well defined taxonomically, making this a promising frontier for the discovery of new medicines. This study focused on marine derived fungi as a model for bioactive exploration for new entities with anti-inflammatory and antioxidant capacity. Three in-vitro assays were used to investigate the bioactive antioxidant potentiality of fungal extracts. Thiobarbituric acid (TBARS),α,α-Diphenyl-β- picrylhydrazyl (DPPH) and NO assay are based on their total phenolic and flavonoid content of each extract group. Ch. globosum recorded the highest antioxidant activity (92.82%) in TBARS assay, while G. dankaliensis came first by recording 59.28% in DPPH assay in comparison with ascorbic acid (61.83%). In NO inhibition assay, N. oryzae showed 49.3% comparing with ascorbic acid (73.12%). From the preliminary result of our extracts, we can consider the marine derived fungi extracts as

Synthesis and Bioactivity of Secondary Metabolites from Marine Sponges Containing Dibrominated Indolic Systems  [PDF]
Adriano Mollica,Marcello Locatelli,Azzurra Stefanucci,Francesco Pinnen
Molecules , 2012, DOI: 10.3390/molecules17056083
Abstract: Marine sponges. (e.g., Hyrtios sp., Dragmacidin sp., Aglophenia pleuma, Aplidium cyaneum, Aplidium meridianum.) produce bioactive secondary metabolites involved in their defence mechanisms. Recently it was demonstrated that several of those compounds show a large variety of biological activities against different human diseases with possible applications in medicinal chemistry and in pharmaceutical fields, especially related to the new drug development process. Researchers have focused their attention principally on secondary metabolites with anti-cancer and cytotoxic activities. A common target for these molecules is the cytoskeleton, which has a central role in cellular proliferation, motility, and profusion involved in the metastatic process associate with tumors. In particular, many substances containing brominated indolic rings such as 5,6-dibromotryptamine, 5,6-dibromo-N-methyltryptamine, 5,6-dibromo-N-methyltryptophan (dibromoabrine), 5,6-dibromo-N,N-dimethyltryptamine and 5,6-dibromo-L-hypaphorine isolated from different marine sources, have shown anti-cancer activity, as well as antibiotic and anti-inflammatory properties. Considering the structural correlation between endogenous monoamine serotonin with marine indolic alkaloids 5,6-dibromoabrine and 5,6-dibromotryptamine, a potential use of some dibrominated indolic metabolites in the treatment of depression-related pathologies has also been hypothesized. Due to the potential applications in the treatment of various diseases and the increasing demand of these compounds for biological assays and the difficult of their isolation from marine sources, we report in this review a series of recent syntheses of marine dibrominated indole-containing products.
Field experimental evaluation of secondary metabolites from marine invertebrates as antifoulants
PEREIRA, R. C;CARVALHO, A. G. V.;GAMA, B. A. P.;COUTINHO, R.;
Brazilian Journal of Biology , 2002, DOI: 10.1590/S1519-69842002000200015
Abstract: the crude organic extracts of the endemic gorgonian phyllogorgia dilatata and two sponge species aplysina fulva and mycale microsigmatosa were evaluated for anti-fouling properties through field experiments. to investigate this property in ecologically meaningful conditions, crude extracts from these invertebrates were incorporated at concentrations naturally found in these marine organisms into a stable gel used as a substratum for fouling settlement. crude extract from a. fulva showed no significant anti-fouling property at the natural concentrations used in the field experiments. in fact, fouling organisms settled significantly more on gels treated with a. fulva extract than on the control gel. on the other hand, both m. microsigmatosa and p. dilatata yielded crude extracts that exhibited a selective action inhibiting only the settlement of barnacles. the evidences obtained here by means of field experiments can provide a basis for future development of one kind of natural antifoulant technology to prevent marine biofouling.
Field experimental evaluation of secondary metabolites from marine invertebrates as antifoulants  [cached]
PEREIRA R. C,CARVALHO A. G. V.,GAMA B. A. P.,COUTINHO R.
Brazilian Journal of Biology , 2002,
Abstract: The crude organic extracts of the endemic gorgonian Phyllogorgia dilatata and two sponge species Aplysina fulva and Mycale microsigmatosa were evaluated for anti-fouling properties through field experiments. To investigate this property in ecologically meaningful conditions, crude extracts from these invertebrates were incorporated at concentrations naturally found in these marine organisms into a stable gel used as a substratum for fouling settlement. Crude extract from A. fulva showed no significant anti-fouling property at the natural concentrations used in the field experiments. In fact, fouling organisms settled significantly more on gels treated with A. fulva extract than on the control gel. On the other hand, both M. microsigmatosa and P. dilatata yielded crude extracts that exhibited a selective action inhibiting only the settlement of barnacles. The evidences obtained here by means of field experiments can provide a basis for future development of one kind of natural antifoulant technology to prevent marine biofouling.
Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus  [PDF]
Ming-Hui Wang,Xiao-Ming Li,Chun-Shun Li,Nai-Yun Ji,Bin-Gui Wang
Marine Drugs , 2013, DOI: 10.3390/md11062230
Abstract: Two new secondary metabolites, namely, pinodiketopiperazine A ( 1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide ( 2), along with alternariol 2,4-dimethyl ether ( 3) and l-5-oxoproline methyl ester ( 4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites ( 5– 10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp ( Artemia salina) lethality with LD 50 11.2 μM.
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