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Agreement Evaluation of a Newly Proposed System for Malocclusion Classification
Miguel-Neto,Antonio Borges; Nishio,Clarice; Mucha,José Nelson;
International journal of odontostomatology , 2010, DOI: 10.4067/S0718-381X2010000100006
Abstract: the current malocclusion classification systems, routinely used in orthodontic practice, still yield different disagreement values among examiners who evaluate one and the same clinical case. objectives: the purpose of this study was to evaluate the agreement effectiveness of a newly proposed system for malocclusion classification - in the anteroposterior orientation -, conceived by the present authors.thirty-four examiners evaluated 15 malocclusion cases using angle's, katz’s and the newly proposed system classifications to determine which system shows the highest degree of agreement and accuracy when results were communicated among examiners. a comparison of the classifications attributed to each individual case and the mean figures found for the total data in each classification showed that the methods advanced by the newly proposed system yielded a higher degree of agreement (73.33%) than angle’s (26.66%) and katz’s (26.66%). the newly proposed system proved to be an outstanding malocclusion classification system with a high degree of agreement among examiners. on the other hand, however, further studies involving a wider sample of malocclusions and a greater number of examiners are strongly recommended if more conclusive results are to be achieved.
Proposed Nomenclature for Surface Features on Pluto and Its Satellites and Names for Newly Discovered Satellites  [PDF]
Eric E. Mamajek,Valerie A. Rapson,David A. Cameron,Manuel Olmedo,Shane Fogerty,Eric Franklin,Erini Lambrides,Imran Hasan,Richard E. Sarkis,Stephen Thorndike,Jason Nordhaus
Physics , 2015,
Abstract: In anticipation of the July 2015 flyby of the Pluto system by NASA's New Horizons mission, we propose naming conventions and example names for surface features on Pluto and its satellites (Charon, Nix, Hydra, Kerberos, Styx) and names for newly discovered satellites.
Comparison of existing syncope rules and newly proposed anatolian syncope rule to predict short-term serious outcomes after syncope in the Turkish population
Kamil Kayayurt, Haldun Akoglu, Onder Limon, As?m Ergene, Ozcan Yavasi, Serdar Bayata, Nergiz Berk, Erden Unluer
International Journal of Emergency Medicine , 2012, DOI: 10.1186/1865-1380-5-17
Abstract: This prospective, cohort study was conducted at the emergency department of a tertiary care centre. Between December 1 2009 and December 31 2010, we prospectively collected data on patients of ages 18 and over who presented to the emergency department with syncope.We enrolled 231 patients to the study. A univariate analysis found 23 variables that predicted syncope with adverse events. Dyspnoea, orthostatic hypotension, precipitating cause of syncope, age over 58 years, congestive heart failure, and electrocardiogram abnormality (termed DO-PACE) were found to predict short-term serious outcomes by logistic regression analysis and these were used to compose the ASR. The sensitivity of ASR, OESIL, EGSYS and SFSR for mortality were 100% (0.66 to 1.00); 90% (0.54 to 0.99), 80% (0.44 to 0.97) and 100% (0.66 to 1.00), respectively. The specificity of ASR, OESIL, EGSYS and SFSR for mortality were 78% (0.72 to 0.83); 76% (0.70 to 0.82); 80% (0.74 to 0.85) and 70% (0.63 to 0.76). The sensitivity of ASR, OESIL, EGSYS and SFSR for any adverse event were 97% (0.85 to 1.00); 70% (0.52 to 0.82); 56% (0.40 to 0.72) and 87% (0.72 to 0.95). The specificity of ASR, OESIL, EGSYS and SFSR for any adverse event were 72% (0.64 to 0.78); 82% (0.76 to 0.87); 84% (0.78 to 0.89); 78% (0.71 to 0.83), respectively.The newly proposed ASR appears to be highly sensitive for identifying patients at risk for short-term serious outcomes, with scores at least as good as those provided by existing diagnostic rules, and it is easier to perform at the bedside within the Turkish population. If prospectively validated, it may offer a tool to aid physicians' decision-making.Syncope is a symptom of cerebral hypoperfusion and is defined as a short, sudden, self-terminating episode of transient loss of consciousness with a failure to maintain postural tone and with a variety of aetiologies. More than two million people are evaluated for syncope each year in the US, with the cost running into the billions of d
Universality in survivor distributions: Characterising the winners of competitive dynamics  [PDF]
J. M. Luck,A. Mehta
Physics , 2015, DOI: 10.1103/PhysRevE.92.052810
Abstract: We investigate the survivor distributions of a spatially extended model of competitive dynamics in different geometries. The model consists of a deterministic dynamical system of individual agents at specified nodes, which might or might not survive the predatory dynamics: all stochasticity is brought in by the initial state. Every such initial state leads to a unique and extended pattern of survivors and non-survivors, which is known as an attractor of the dynamics. We show that the number of such attractors grows exponentially with system size, so that their exact characterisation is limited to only very small systems. Given this, we construct an analytical approach based on inhomogeneous mean-field theory to calculate survival probabilities for arbitrary networks. This powerful (albeit approximate) approach shows how universality arises in survivor distributions via a key concept -- the {\it dynamical fugacity}. Remarkably, in the large-mass limit, the survival probability of a node becomes independent of network geometry, and assumes a simple form which depends only on its mass and degree.
Deployment of VoIP Technology: QoS Concerns  [PDF]
Amor Lazzez,Thabet Slimani
Computer Science , 2013,
Abstract: Voice over IP (VoIP) is an emerging communication service allowing voice transmission over a private or a public IP network. VoIP allows significant benefits for customers and service providers including cost savings, phone and service portability, mobility, and the integration with other applications. Nevertheless, the deployment of the VoIP technology encounters many challenges such as interoperability issues, security issues, and QoS concerns. Among these disadvantages, QoS issues are considered the most serious due to the QoS problems that may arise on IP networks, and the stringent QoS requirements of voice traffic. The aim of this paper is carry out a deep analysis of the QoS concerns of the VoIP technology. Firstly, we present a brief overview about the VoIP technology. Then, we discuss the QoS issues related to the use of the IP networking technology for voice traffic transmission. After that, we present the QoS concerns related voice clarity. Finally, we present the QoS mechanisms proposed to make the IP technology able to support voice traffic QoS requirements in terms of voice clarity, voice packet delay, packet delay variation, and packet loss.
Formalizing typical crosscutting concerns  [PDF]
Marius Marin
Computer Science , 2006,
Abstract: We present a consistent system for referring crosscutting functionality, relating crosscutting concerns to specific implementation idioms, and formalizing their underlying relations through queries. The system is based on generic crosscutting concerns that we organize and describe in a catalog. We have designed and implemented a tool support for querying source code for instances of the proposed generic concerns and organizing them in composite concern models. The composite concern model adds a new dimension to the dominant decomposition of the system for describing and making explicit source code relations specific to crosscutting concerns implementations. We use the proposed approach to describe crosscutting concerns in design patterns and apply the tool to an opensource system (JHotDraw).
Telomerase-Null Survivor Screening Identifies Novel Telomere Recombination Regulators  [PDF]
Yan Hu equal contributor,Hong-Bo Tang equal contributor,Ning-Ning Liu equal contributor,Xia-Jing Tong,Wei Dang,Yi-Min Duan,Xiao-Hong Fu,Yang Zhang,Jing Peng,Fei-Long Meng,Jin-Qiu Zhou
PLOS Genetics , 2013, DOI: 10.1371/journal.pgen.1003208
Abstract: Telomeres are protein–DNA structures found at the ends of linear chromosomes and are crucial for genome integrity. Telomeric DNA length is primarily maintained by the enzyme telomerase. Cells lacking telomerase will undergo senescence when telomeres become critically short. In Saccharomyces cerevisiae, a very small percentage of cells lacking telomerase can remain viable by lengthening telomeres via two distinct homologous recombination pathways. These “survivor” cells are classified as either Type I or Type II, with each class of survivor possessing distinct telomeric DNA structures and genetic requirements. To elucidate the regulatory pathways contributing to survivor generation, we knocked out the telomerase RNA gene TLC1 in 280 telomere-length-maintenance (TLM) gene mutants and examined telomere structures in post-senescent survivors. We uncovered new functional roles for 10 genes that affect the emerging ratio of Type I versus Type II survivors and 22 genes that are required for Type II survivor generation. We further verified that Pif1 helicase was required for Type I recombination and that the INO80 chromatin remodeling complex greatly affected the emerging frequency of Type I survivors. Finally, we found the Rad6-mediated ubiquitination pathway and the KEOPS complex were required for Type II recombination. Our data provide an independent line of evidence supporting the idea that these genes play important roles in telomere dynamics.
A Splice Variant of ASC Regulates IL-1 Release and Aggregates Differently from Intact ASC  [PDF]
Kazuhiko Matsushita,Michiko Takeoka,Junji Sagara,Naoki Itano,Yuka Kurose,Akihiro Nakamura,Shun'ichiro Taniguchi
Mediators of Inflammation , 2009, DOI: 10.1155/2009/287387
Abstract: The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recruit domain (CARD), respectively, and exon 2 encodes a proline and glycine-rich (PGR) domain. Here, we identified a variant ASC protein (vASC) lacking the PGR domain that was smaller than full length ASC (fASC) derived from fully transcribed mRNA and searched for differences in biochemical and biological nature. Both fASC and vASC were found to activate procaspase-1 to a similar degree, but the efficiency of IL-1 excretion was significantly higher for vASC. There was also a marked structural difference observed in the fibrous aggregates formed by fASC and vASC. These results suggest that although the PGR domain is dispensable for procaspase-1 activation, it plays an important role in the regulation of the molecular structure and activity of ASC.
Cancer survivor after the end of treatment - The role of the nurse
Maria Lavdaniti,Maria Avramika
To Vima tou Asklipiou , 2011,
Abstract: As the main interest of health professionals is for the well-being of patients/clients, ethical decision making is one of the prominent elements of his/her professionalism. Aim: The present study aims to illustrate the role of ethical judgment and the so-called "moral imagination" in health professions. Method and material: Review of theoretical and research literature, including both classic and recent sources about ethical dilemmas that health professionals may anticipate, as well as the suggested ways to manage these dilemmas. Results: Health professionals often have to act in complicated situations. Review of relevant literature indicates that the professionals' ethical decisions are structured not only through the codes of ethics, but also through other collective practices, such as organizational culture and cultural schemas about the role of health professional. Resorting to schematic thinking may temporarily release the professional from his/her concerns, but in the long run, it may devoid him/her of the sense of satisfaction from work and of the ability to offer clients the optimal care. The development of the so-called "moral imagination" permits the professional to advance from the typical application of the rules to actual ethical judgment. Conclusions: Ethical decision making presupposes not only a thorough knowledge of ethical guidelines, but also the development of the ability to openly reflect upon the ethical dimensions of an issue (moral imagination) that allows health professionals to overcome schematic thinking and investigate comprehensive solutions to ethical dilemmas.
Indian Streams Research Journal , 2013,
Abstract: Prior to the emergence of Sikhism, in Medieval Indian society religious traditions did not take much care of humanistic concerns. The religions were confined to mere performance of empty rituals and outward religiosity. Under the tyrannical foreign rule, there was no scope for modern notion of liberty, equality and justice. Sikhism in 15th century had emerged as the youngest liberal and humanistic religion to protect the human dignity, individual freedom and human rights of masses. Sikh history have ample proofs which clearly show that how the Sikh Gurus raised strong voice against socioeconomic and political exploitation, transgression of human rights, infringement of individual liberties and disregard for human dignity. The institution of the Khalsa was created as vanguard and supporter of humanistic concerns of an individual. Sikh Gurus call for free, fair, equitable and democratic socio-political order which ensure the social equality, individual liberty and self-esteem of an individual.
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