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Quality of life in patients with gastric cancer: translation and psychometric evaluation of the Iranian version of EORTC QLQ-STO22
Sanamber Sadighi, Ali Montazeri, Zahra Sedighi, Mohammad Mohagheghi, Hossein Froutan
BMC Cancer , 2009, DOI: 10.1186/1471-2407-9-305
Abstract: Forward-backward procedure was applied to translate the English language version of the EORTC QLQ-STO22 into Persian (Iranian language). Then, the questionnaire and the EORTC core quality of life instrument (QLQ-C30) were administered to a sample of patients with confirmed diagnosis of gastric cancer. All patients filled in questionnaires before and after one month of treatment. Patients were divided into two groups based on intension of treatment (curative vs. palliative). Reliability and validity of the module was tested by internal consistency and known group comparisons, respectively.In all, 105 patients were entered into the study. Cronbach's alpha for multi-item scales (to test reliability) ranged from 0.54 to 0.87. The questionnaire discriminated well between clinically distinct subgroups of patients both before and after treatment lending support to its convergent and clinical validity.Overall, the Iranian version of the EORTC QLQ-STO22 demonstrated a good reliability and clinical validity to support its use in combination with core questionnaire in outcome studies of gastric cancer in Iran. However, using the QLQ-STO22 in a wide range of Iranian patients with gastric cancer should allow further confirmation for its psychometric properties.Although mortality rates due to gastric cancer had been declining for several decades, on a worldwide scale its incidence is still high, and it is the second leading cause of cancer death, behind lung cancer [1,2]. Recent efforts to improve survival include pre and post-operative chemotherapy and chemo-radiotherapy. However, improvements in survival with multi-modal treatment may also be associated with increased toxic side effects. Therefore full evaluation of new treatments of gastric cancer should be included patient-reported outcome measures such as health related quality of life (HRQOL) as well as assessment of biomarkers, pathologic responses or survival outcomes.Although quality of life in patients with gastric canc
Validation of the Japanese version of the EORTC hepatocellular carcinoma-specific quality of life questionnaire module (QLQ-HCC18)
Naoko Mikoshiba, Ryosuke Tateishi, Makoto Tanaka, Tomoko Sakai, Jane M Blazeby, Norihiro Kokudo, Kazuhiko Koike, Keiko Kazuma
Health and Quality of Life Outcomes , 2012, DOI: 10.1186/1477-7525-10-58
Abstract: EORTC quality of life (QOL) translation guidelines were followed to create a Japanese version of the EORTC QLQ-HCC18. This was then administered to 192 patients with hepatocellular carcinoma along with the EORTC QLQ-C30 and FACT-Hep questionnaires. Tests for reliability and validity were conducted including comparison of scores between the EORTC and FACT questionnaire and detailed assessment of the new scales and items in clinically distinct groups of patients.Multi-trait scaling analysis confirmed three putative scales in the QLQ-HCC18, fatigue, fever and nutrition. Cronbach’s alpha for these scales were between 0.68 and 0.78. The QLQ-HCC18 scales correlated with scales measuring similar items in the FACT-Hep and the questionnaire was stable over time with an intra-class correlation score of 0.70 for almost all scales. The questionnaire had the ability to distinguish between patients with different Karnofsky Performance Status, and Child-Pugh liver function class.The Japanese version of EORTC QLQ-HCC18 is a reliable supplementary measure to use with EORTC QLQ-C30 to measure QOL in Japanese patients with hepatocellular carcinoma.
Patient information in radiation oncology: a cross-sectional pilot study using the EORTC QLQ-INFO26 module
Johannes Adler, Yvonne Paelecke-Habermann, Patrick Jahn, Margarete Landenberger, Bernd Leplow, Dirk Vordermark
Radiation Oncology , 2009, DOI: 10.1186/1748-717x-4-40
Abstract: In a cross-sectional, single-centre study 94 patients currently undergoing radiotherapy were asked to complete two questionnaires. The EORTC QLQ-INFO26 module was used to assess the quality and quantity of information received by patients in the areas disease, medical tests, treatment, other services, different places of care and how to help themselves, as well as qualitative aspects as helpfulness of and satisfaction with this information. The importance of different media, in particular the internet, was investigated by a nine-item questionnaire.The response rate was n = 72 patients (77%). Patients felt best informed concerning medical tests (mean ± SD score 79 ± 22, scale 0-100) followed by disease (68 ± 21). Treatment (52 ± 24) and different places of care and other services (30 ± 36 and 30 ± 30, respectively) ranked last. 37% of patients were very satisfied and 37% moderately satisfied with the amount of information received, 61% wished more information. Among eight media, brochures, television and internet were ranked as most important. 41% used the internet themselves or via friends or family, mostly for research of classic and alternative treatment options. Unavailability and the necessity of computer skills were most mentioned obstacles.In a single-center pilot study, radiotherapy patients indicated having received most information about medical tests and their disease. Patients very satisfied with their information had received the largest amount of information. Brochures, television and internet were the most important media. Individual patient needs should be considered in the development of novel information strategies.Patient information in oncology has recently received increasing attention. Providing adequate information to the cancer patient can reduce anxiety and improve compliance of the patient [1]. Information disclosure adapted to the individual needs of each patient can facilitate patient-physician communication to enable informed decisions [2
Translation and pilot validation of Hindi translation of assessing quality of life in patients with primary brain tumours using EORTC brain module (BN-20)  [cached]
Budrukkar Ashwini,Jalali Rakesh,Kamble Rashmi,Parab Sachin
Journal of Cancer Research and Therapeutics , 2006,
Abstract: Aim: To translate and validate the European Organisation for Research and Treatment for Cancer (EORTC) brain cancer module (BN-20) into Hindi to make it available for patients and scientific community. Methods and Results: The EORTC BN-20 was translated into Hindi using standard guidelines by EORTC. The process included forward translation by two translators, discussion with the translators in case of discrepancies and formation of first intermediate questionnaire. This questionnaire was then given to two more translators who translated this questionnaire back into English. These 2 questionnaires were then compared with the original EORTC questionnaire and the second intermediate questionnaire was formed. The second intermediate questionnaire was subsequently administered in 10 patients with brain tumors who had never seen the questionnaire before, for pilot-testing. Each of these 10 patients after filling up the questionnaire themselves was then interviewed for any difficulty encountered during the filling up of the questionnaire. These were in the form of specific modules including difficulty in answering, confusion while answering and difficulty to understand, whether the questions were upsetting and if patients would have asked the question in any different way. There were major suggestions in three questions, which were incorporated into the second intermediate questionnaire to form the final Hindi BN-20 questionnaire. Conclusion: The final Hindi BN-20 has been approved by EORTC and can be used in clinical practice and studies for patients with brain tumors.
Validation of the Danish version of the disease specific instrument EORTC QLQ-CR38 to assess Health-related quality of life in patients with colorectal cancer  [cached]
Thaysen Henriette,Jess P,Laurberg S?ren,Groenvold M
Health and Quality of Life Outcomes , 2012, DOI: 10.1186/1477-7525-10-150
Abstract: Background The European Organisation for Research and Treatment of Cancer (EORTC) quality of life colorectal questionnaire module (QLQ-CR38) was developed in 1999, and an update, the QLQ CR29 was published recently. To date the Danish version of the questionnaire has not been validated. The aim of this study was to examine the psychometric properties of the Danish version of EORTC QLQ-CR38. Methods EORTC QLQ-CR38 was administered to 190 patients with colorectal cancer in two Danish hospitals, one month after their operation. A psychometric evaluation of the questionnaire’s structure, reliability, convergent, divergent and known-groups validity was performed. Results Data from 164 (86.3%) patients were available for analysis. The Danish version of EORTC QLQ-CR38 showed satisfactory psychometric properties for the scales: body image, sexual functioning, male sexual problems and defecations problems. Suboptimal psychometric performances were found for the scales: micturition problems, symptoms of the gastrointestinal tract and weight loss. Evaluation of the psychometric properties of the scale chemotherapy side effects was limited by the low number of patients receiving chemotherapy. It was not possible to assess the psychometric properties of the scale female sexual problems and the single item sexual enjoyment due to a high number of missing values. The homogeneity of the study population made the evaluation of known-group validity difficult. Conclusions The results of this study suggest that the validity of the Danish version of EORTC QLQ-CR38 is acceptable. Furthermore, the results support the appropriateness of the updated version, the EORTC QLQ-CR29.
Responsiveness of EORTC QLQ-C30, QLQ-CR38 and FACT-C quality of life questionnaires in patients with colorectal cancer
Lionel Uwer, Christine Rotonda, Francis Guillemin, Jo?lle Miny, Marie-Christine Kaminsky, Mariette Mercier, Laetitia Tournier-Rangeard, Isabelle Leonard, Philippe Montcuquet, Philippe Rauch, Thierry Conroy
Health and Quality of Life Outcomes , 2011, DOI: 10.1186/1477-7525-9-70
Abstract: This prospective study included 127 patients with colorectal cancer: 71 undergoing chemotherapy and 56 radiation therapy. Responsiveness statistics included the Standardized Response Mean (SRM) and the Effect Size (ES). The patient's overall assessment of his/her change in state of health status was the reference criterion to evaluate the responsiveness of the QoL questionnaires.34 patients perceived their health as stable and 17 as improved between the first and the fourth courses of chemotherapy. 21 patients perceived their health as stable and 22 as improved between before and the last week of radiotherapy.The responsiveness of the 3 questionnaires differed according to treatments. The EORTC QLQ-C30 questionnaire was more responsive in patients receiving chemotherapy, particulary functional scales (SRM > 0.55). The QLQ-CR38 and the FACT-C questionnaires provided little clinically relevant information during chemotherapy or radiotherapy.The EORTC QLQ-C30 questionnaire appears to be more responsive in patients receiving chemotherapy.Colorectal cancer (CRC) is common in Western societies. The management of locally advanced rectal cancer includes preoperative chemoradiotherapy and surgery. Surgery followed by adjuvant or palliative chemotherapy is the standard of care of localized or advanced stages of CRC. These treatments may affect the patient's quality of life (QoL) and may be responsible for late side-effects or sequelae. QoL assessment is essential to better inform clinical decisions by providing insights into the patient's experiences of disease and treatment [1].Many questionnaires assess the QoL of patients with CRC. The more frequently used are [2]: the European Organization for Research and Treatment of Cancer (EORTC) QoL QLQ-C30 [3], validated in all European languages [4], the colorectal module QLQ-CR38 [5], and the Functional Assessment of Cancer Therapy-General version FACT-G [6] named FACT-C [7] when specific concerns of patients with CRC are added to
Early results of quality of life for curatively treated rectal cancers in Chinese patients with EORTC QLQ-CR29
Junjie Peng, Debing Shi, Karyn A Goodman, David Goldstein, Changchun Xiao, Zuqing Guan, Sanjun Cai
Radiation Oncology , 2011, DOI: 10.1186/1748-717x-6-93
Abstract: Patients with stage I-III rectal cancer who were treated curatively in a single institution were accrued prospectively. Quality of life was assessed by use of the European Organization for Research and Treatment of Cancer questionnaire module for all cancer patients (QLQ-C30) and for colorectal cancer patients (QLQ-CR29). Quality of life among different treatment modalities and between stoma and nonstoma patients was evaluated in all patients.A total of 154 patients were assessed. The median time of completion for the questionnaires was 10 months after all the treatments. For patients with different treatment modalities, faecal incontinence and diarrhea were significantly higher in radiation group (p = 0.002 and p = 0.001, respectively), and no difference in male or female sexual function was found between radiation group and non-radiation group. For stoma and nonstoma patients, the QLQ-CR29 module found the symptoms of Defaecation and Embarrassment with Bowel Movement were more prominent in stoma patients, while no difference was detected in scales QLQ-C30 module.Our study provided additional information in evaluating QoL of Chinese rectal cancer patients with currently widely used QoL questionnaires. As a supplement to the QLQ-C30, EORTC QLQ-CR29 is a useful questionnaire in evaluating curatively treated patients with rectal cancer. Bowel dysfunction (diarrhea and faecal incontinence) was still the major problem compromising QoL in patients with either pre- or postoperative chemoradiotherapy.Colorectal cancer is the second most common cause of cancer death in developed countries and has become an increasingly important health problem in China. Today, multidisciplinary treatment has become the standard strategy in the management of colorectal cancer. In particular, rectal cancer requires a multidisciplinary approach. Patients with transmural disease or node-positive disease may need to receive adjuvant treatment including radiotherapy and/or chemotherapy[1,2]. Alth
Quality of life of patients after retropubic prostatectomy - Pre- and postoperative scores of the EORTC QLQ-C30 and QLQ-PR25
Peter Bach, Tanja D?ring, Andreas Gesenberg, Cornelia M?hring, Mark Goepel
Health and Quality of Life Outcomes , 2011, DOI: 10.1186/1477-7525-9-93
Abstract: This study investigated pre perative QoL of 185 patients who consecutively underwent open radical retropubic prostatectomy for organ-confined PCa to postoperative QoL of another 185 patients. The EORTC QLQ-C30, EORTC QLQPR25 module and 24 h ICS pad test were used (mean follow-up 28.6 months).The examined symptom scores of the EORTC QLQ-PR25 were on lowest level. In the dyspnoea symptom score differences of age emerged: the amount of patients who are short of breath rose significantly in older patients after surgery (p < 0.05 paired, two-tailed student's t-test).. Lastly, the urinary symptom score was found postal-therapeutically low; this fact was age independent. The results of sexual symptom score need to be taken into consideration, since prostatectomy resulted in a significant reduction of sexual activity independent of age. All functioning scales postoperatively reached high values without significant changes (p > 0.05 student's t-test ), which implies a high QoL after surgery. A reliable and satisfying status of continence was found in our patients after retropubic prostatectomy. A high rate of patients (89.2%) would choose retropubic prostatectomy again.Retropubic prostatectomy represents a reliable and accepted procedure in the treatment of organ-confined PCa. For the first time it could be shown that patients` QoL remained on a high level after retropubic prostatectomy. Nevertheless, the primary avoidance or postoperative therapy of erectile dysfunction should be in the focus of surgeons.Prostate cancer (PCa) is the most common malignancy in men worldwide and is actually detected as localized disease in most patients. Diagnosis and therapy of PCa has long-ranging consequences for patient's further life. Patients with newly diagnosed early stage prostate cancer face a difficult choice of different treatment options with curative intention, and they must consider both goals of optimising quantity and quality of life. Radical prostatectomy is regarded as a sta
Health-related Quality of life in 640 head and neck cancer survivors after radiotherapy using EORTC QLQ-C30 and QLQ-H&N35 questionnaires
Stephen Wan Leung, Tsair-Fwu Lee, Chih-Yen Chien, Pei-Ju Chao, Wen-Ling Tsai, Fu-Min Fang
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-128
Abstract: A cross-sectional investigation was conducted to assess the HR-QoL of 640 HNC patients with cancer-free survival of more than 2 years. Among them, 371 patients were treated by two-dimensional RT (2DRT), 127 by three-dimensional conformal RT (3DCRT), and 142 by intensity-modulated RT (IMRT). The EORTC QLQ-C30 questionnaire and QLQ-H&N35 module were used. A general linear model multivariate analysis of variance was used to analyze the prognosticators of HR-QoL.By multivariate analysis, the variables of gender, annual family income, tumor site, AJCC stage, treatment methods, and RT technique were prognosticators for QLQ-C30 results, so were tumor site and RT technique for H&N35. Significant difference (p < 0.05) of HR-QoL outcome by different RT techniques was observed at 2 of the 15 scales in QLQ-C30 and 10 of the 13 scales in H&N35. Compared with 2DRT, IMRT had significant better outcome in the scales of global QoL, physical functioning, swallowing, senses (taste/smell), speech, social eating, social contact, teeth, opening mouth, dry mouth, sticky saliva, and feeling ill.The technological advance of RT substantially improves the head-and-neck related symptoms and broad aspects of HR-QoL for HNC survivors.Health-related quality of life (HR-QoL) and its assessment have become increasingly important in health care, especially in the field of chronic diseases. Conventionally, the endpoints of medical care for cancer patients usually focused on the so-called survival rate, local control rate, or complication rate. These endpoints were usually assessed from the physician's points of view. These assessments lacked knowledge and understanding of the patients' mental and emotional well being. HR-QoL generally refers to the patient's perception of the effects of the disease and the impact on the patient's daily functioning, and has two fundamental premises. First, it is a multi-dimensional survey incorporating physical, psychological, social, and emotional functional domains.
Psychometric evaluation of the Taiwan Chinese version of the EORTC QLQ-PR25 for HRQOL assessment in prostate cancer patients  [cached]
Chang Yu-Jun,Liang Wen-Miin,Wu Hsi-Chin,Lin Hsueh-Chun
Health and Quality of Life Outcomes , 2012, DOI: 10.1186/1477-7525-10-96
Abstract: Objective To evaluate the psychometric properties of the Taiwan Chinese Version of the EORTC QLQ-PR25 health-related quality of life (HRQOL) questionnaire for patients with prostate cancer. Methods 135 prostate cancer patients were recruited in the urology outpatient clinic of a university teaching hospital. Each patient completed the EORTC QLQ-PR25 at every clinic visit between 2004 and 2008, totaling 633 assessments. Confirmatory factor analysis and Rasch analysis were used to evaluate the domain- and item-level psychometric properties. Results The results supported the unidimensionality of each of the four EORTC QLQ-PR25 domains (urinary, bowel, and hormonal-treatment-related symptoms, and sexual functioning). Item calibrations for each domain were found invariant across the three assessment time periods. The item-person maps showed 71.3% of item coverage for the urinary symptoms domain and 13–42.7% for the other three domains. Conclusions The Taiwan Chinese Version of the EORTC QLQ-PR25 questionnaire is reliable and can be used to measure HRQOL over time. Adding new items to each domain may improve its clinical content coverage and measurement precision.
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