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Prognostic value of copeptin in patients with acute ischemic stroke  [cached]
Tu Wen-Jun,Chen Hui,Cui Li-Hua
Iranian Journal of Neurology , 2011,
Abstract: Stroke is the second leading cause of mortality in the Chinaand one of the leading causes of severe morbidity. An earlyrisk assessment with estimate of the severity of disease andprognosis is pivotal for optimized care and allocation ofhealthcare resources. Reliable prognostic markers availableduring the initial phase after acute stroke may aid clinicaldecision-making.Vasopressin (AVP) is a potent synergistic factor ofcorticotropin-releasing hormone as hypothalamic stimulator ofthe hypothalamo-pituitary-adrenal axis.1 Some studies foundincreased AVP levels in patients with ischemic stroke werecorrelated with stroke severity2 and outcome.3 Copeptin isreleased in an equimolar ratio to AVP, and is more stable inthe circulation and easy to measure.4We designed a preliminary prospective cohort study toevaluate the prognostic value of copeptin in acute strokepatients. Adult patients with a persistent neurological deficitdue to ischemic stroke were eligible. Sixty-ninenonconsecutive patients admitted at 3 hospitals with adiagnosis of acute ischemic stroke confirmed by CT scanningwere evaluated. All patients provided informed consent. Inpatients who died within 24 hours after admission or inpatients who were discharged, data from admission or untildischarge were collected. The National Institute of HealthStroke Scale (NIHSS) score was assessed on admission.Functional outcome was obtained on days 90 according to themodified Rankin Scale (mRS) blinded to copeptin levels. Poorfunctional outcome at 3 months was considered as a mRSscore > 2. Blood samples were collected on admission andimmediately centrifuged and sera stored at –70°C. Copeptinwas measured with a sandwich immunoluminometricassay.1 Discrete variables are summarized as counts(percentage), and continuous variables as medians andinterquartile ranges (IQRs). Two-group comparison of notnormally distributed data was performed using Mann–Whitney U test, and a Kruskal–Wallis one-way analysis ofvariance was used for multi-group comparisons.The median age of the 69 patients was 62 years (IQR,55 to 84), 61% were men and the median NIHSS score onadmission was 7 points (IQR, 3 to 12). In 38 patients(55%) with a poor functional outcome (13 patients died),copeptin levels were higher compared with those inpatients with a favorable outcome (23.5; IQR, 10.6 to 64.3pmol/L vs. 7.5; IQR, 3.8 to 13.6 pmol/L; P < 0.0001).Multivariate logistic regression analysis adjusted for ageand NIHSS score showed that copeptin was anindependent predictor of poor functional outcome (oddsratio = 3.12; 95%CI, 1.54–6.46). The area under the
Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke: A Randomized Controlled, Pilot Study  [PDF]
Kameshwar Prasad,Amit Kumar,Jitendra Kumar Sahu,M. V. P. Srivastava,Sujata Mohanty,Rohit Bhatia,Shailesh B. Gaikwad,Achal Srivastava,Vinay Goyal,Manjari Tripathi,Chandrashekar Bal,Nalini Kant Mishra
Stroke Research and Treatment , 2011, DOI: 10.4061/2011/283473
Abstract: Background. There is emerging evidence to support the use of granulocyte colony-stimulating factor (G-CSF) therapy in patients with acute ischemic stroke. Aims. To explore feasibility, safety, and preliminary efficacy of G-CSF therapy in patients with acute ischemic stroke. Patients and Method. In randomized study, 10 patients with acute ischemic stroke were recruited in 1?:?1 ratio to receive 10?μg/kg G-CSF treatment subcutaneously daily for five days with conventional care or conventional treatment alone. Efficacy outcome measures were assessed at baseline, one month, and after six months of treatment included Barthel Index (BI), National Institute of Health Stroke Scale, and modified Rankin Scale. Results. One patient in G-CSF therapy arm died due to raised intracranial pressure. No severe adverse effects were seen in rest of patients receiving G-CSF therapy arm or control arm. No statistically significant difference between intervention and control was observed in any of the scores though a trend of higher improvement of BI score is seen in the intervention group. Conclusion. Although this study did not have power to examine efficacy, it provides preliminary evidence of potential safety, feasibility, and tolerability of G-CSF therapy. Further studies need to be done on a large sample to confirm the results. 1. Introduction Stroke is an important cause of mortality and morbidity worldwide [1]. Despite recent advances in antithrombotic treatment, poststroke disability has significant economic and social burden. As brain has limited capacity to regenerate, there is the need to develop therapeutic strategies to enhance neuroprotection and repair. Autologous stem-cell transplantation has been tried but has limited due to unproven efficacy and lack of available facility widespread [2]. Currently, few treatments exist for acute stroke, comprising mainly aspirin and thrombolytic drugs which have poor availability in the developing countries and very narrow time window for its intervention. A clear need exists to identify new drugs. Granulocyte colony stimulating-factor (G-CSF) is a cytokine that acts on hematopoietic stem (CD34+) cells and stimulates proliferation, maturation, and survival of the neutrophilic granulocyte lineage. It is widely employed to mobilize bone marrow stem cells in patients with leukaemia treated with bone marrow transplantation and chemotherapy-induced neutropenia for last two decades [3]. Since Sch?bitz et al. [4] observed infarct size-reducing capabilities of G-CSF in animal stroke model, a number of preclinical investigations
The Prognostic Value of Serum Uric Acid Level in Acute Ischemic Stroke
Journal of Neurological Sciences , 2009,
Abstract: Introduction and Objective: Uric acid is a natural anti-oxidant that plays a role in acute oxidative stress reactions like acute ischemic stroke. In this study, we aimed to search the relation between serum uric acid level, length of hospital stay and severity of stroke in acute stroke patients, and consequently, the prognostic value of serum uric acid level.Patients and Methods: We performed a retrospective study on 100 patients who had presented to the emergency department with the findings of acute ischemic stroke. All the laboratory, radiological and clinical investigations were recorded. All the risk factors, National Institute of Health Stroke Scale (NIHSS), laboratory values, clinical findings, length of hospital stay of the patients and the treatment modalities were recorded.Results: The median serum uric acid level was 5.25±2.03 mg/dl. The median level in females was found to be higher than that in males. The length of hospital stay varied from 2 to 57 days and the median value was 13±8.66 days. In the multivariate analysis, increases in the levels of serum uric acid measured were significantly associated with decreased length of hospital stay. We detected a low value correlation between NIHSS and serum uric acid levels, but it was statistically insignificant. According to our results, there was a strong negative correlation between serum uric acid levels and the length of hospital stay, and a weak correlation between the serum uric acid level and the severity of stroke.
Cortisol as a Prognostic Marker of Short-Term Outcome in Chinese Patients with Acute Ischemic Stroke  [PDF]
Wen-Jie Zi, Jie Shuai
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0072758
Abstract: Background Early prediction of outcome is important for allocation of therapeutic strategies. Endocrine alterations of the hypothalamus–pituitary–axis are one of the first stress-induced alterations after cerebral ischemia. We therefore evaluated the prognostic value of serum cortisol in Chinese patients with an acute ischemic stroke. Methods In a prospective observational study, serum cortisol was measured using a solid-phase, competitive chemiluminescent enzyme immunoassay on admission in serum of 226 consecutive Chinese patients with an acute ischemic stroke. The prognostic value of serum cortisol to predict the functional outcome, mortality within 90 days, was compared with clinical variables (e.g., advanced age and the National Institutes of Health Stroke Scale [NHISS] score) and with other known predictors. Results Patients with a poor outcome and nonsurvivors had significantly increased serum cortisol levels on admission (P<0.0001, P<0.0001). There was a positive correlation between levels of cortisol and the NIHSS (r = 0.298, P<0.0001), glucose levels (r = 0.324, P<0.0001) and infarct volume (r = 0.328, P<0.0001). Cortisol was an independent prognostic marker of functional outcome and death [odds ratio 3.44 (2.58–6.23) and 4.21 (1.89–9.24), respectively, P<0.0001 for both, adjusted for age, the NIHSS and other predictors] in patients with ischemic stroke. In receiver operating characteristic curve analysis, cortisol could improve the NIHSS score in predicting short-term functional outcome (Area under the curve [AUC] of the combined model, 0.87; 95% CI, 0.82–0.92; P = 0.01) and mortality (AUC of the combined model, 0.90; 95% CI, 0.84–0.95; P = 0.01). Conclusion Cortisol can be seen as an independent short-term prognostic marker of functional outcome and death in Chinese patients with acute ischemic stroke even after correcting confounding factors. Combined model can add significant additional predictive information to the clinical score of the NIHSS.
A simple slide test to assess erythrocyte aggregation in acute ST-elevated myocardial infarction and acute ischemic stroke: Its prognostic significance  [cached]
Lakshmi Atla,Uma Prasad,Venkatachalam Ch,Nageswar Rao G
Indian Journal of Pathology and Microbiology , 2011,
Abstract: A simple slide test and image analysis were used to reveal the presence of an acute-phase response and to determine its intensity in subjects of acute myocardial infarction and acute ischemic stroke. Erythrocytes tend to aggregate during an inflammatory process. Evaluation of erythrocyte adhesiveness/aggregation is currently available to the clinicians indirectly by erythrocyte sedimentation rate (ESR), but ESR correlates poorly with erythrocyte aggregation, hence a simple slide technique using citrated blood was used to evaluate erythrocyte aggregation microscopically and also by using image analysis. Aims: (1) To study erythrocyte aggregation/adhesiveness by a simple slide test in subjects with acute ST-elevated myocardial infarction (STEMI), acute ischemic stroke and healthy controls. (2) To study the prognostic significance of ESR and erythrocyte aggregation/adhesiveness test (EAAT) in predicting the outcome after 1 week in subjects of acute myocardial infarction and acute ischemic stroke. Patients and Methods: Three groups of subjects were included in the study; 30 patients of acute STEMI, 30 patients of acute ischemic stroke, and 30 subjects with age- and gender-matched healthy controls. Citrated blood was subjected to simple slide test and ESR estimation by Westergren′s method. Stained smears were examined under 400Χ and graded into four grades. Images were taken from nine fields; three each from head, body, and tail of the smear. The degree of erythrocyte aggregation was quantified using a variable called erythrocyte percentage (EP), by using the software MATLAB Version 7.5. A simple program was used to count the number of black and white pixels in the image by selecting a threshold level. Results: The mean ESR of the subjects with acute myocardial infarction (29 + 17.34) was significantly higher (P = 0.001) than the mean ESR of the control group (15.5 + 12.37). The mean EP of the subjects with acute myocardial infarction (69.91 + 13.25) was significantly lower (P < 0.001) than the mean EP of the control group (85.16 + 8.41). The mean ESR of the subjects with acute stroke (40.46 + 33.75) was significantly higher (P = 0.0005) than that of the controls (15.5 + 12.37). The mean EP of the stroke patients (70.59 + 11.30) was significantly lower (P < 0.001) than the mean EP of the controls (85.16 + 8.41). In subjects with acute myocardial infarction there was a significant negative correlation (r = 0.623) between ESR and EP. In acute stroke patients there was a significant negative correlation (r = 0.69) between ESR and EP. On performing standard er
Prognostic Value of Complete Blood Count and Electrolyte Panel during Emergency Department Evaluation for Acute Ischemic Stroke  [PDF]
Latha Ganti,Rachel M. Gilmore,Amy L. Weaver,Robert D. Brown Jr.
ISRN Stroke , 2013, DOI: 10.1155/2013/974236
Abstract: Objective. To determine whether routine laboratory parameters are predictors of early mortality after acute ischemic stroke (AIS). Methods. The cohort consisted of 522 consecutive patients with AIS presenting to the emergency department (ED) at a tertiary referral center during a 27-month period, residing within the surrounding ten counties. Serum laboratory values were obtained for all patients and categorized according to whether the levels were low, normal, or high. These laboratory results were evaluated as potential predictors of 90-day mortality using Cox proportional hazards models. The associations were summarized by calculating risk ratios (RRs) and 95% confidence intervals (CI). Results. The presence of elevated white blood cell count (RR 2.2, 95% CI 1.5–3.4), low bicarbonate (RR 4.2, 95% CI 2.6–6.7), low calcium (RR 2.9, 95% CI 1.4–5.9), and high glucose (RR 1.3, 95% 1.1–1.6) were each univariately associated with significantly higher mortality within the first 90 days. Based on fitting a multivariate Cox regression model, elevated white blood cell count, low bicarbonate, and high glucose were each identified as being jointly associated with early mortality ( ). Conclusion. Early leukocytosis, acidosis, and hyperglycemia and hypocalcemia in AIS appear to be associated with early mortality. Whether addressing these factors will impact survival remains to be investigated. 1. Introduction For patients who present with chief complaint of acute ischemic stroke, the American Stroke Association recommends a set of diagnostic studies [1] to be done at presentation, with the intent of optimizing and expediting the care of these patients. From the Emergency Physicians’ perspective many tests are simply part of a routine battery, often without direct impact on emergency department (ED) management, diagnostic or prognostic value. In this study, we sought to determine whether the routine complete blood count (CBC) and electrolyte panel include any components that are markers of early mortality in acute ischemic stroke. Specifically, the parameters of interest were those obtained as part of routine clinical investigation. 2. Methods 2.1. Study Design This study was an observational study using a consecutive sample of local residents presenting to the ED with acute ischemic stroke (AIS). The primary outcome measure was death at 90 days. This study was approved by the Mayo Clinic Institutional Review Board. 2.2. Study Population and Setting This study was conducted at the Saint Marys Hospital, a tertiary referral academic medical center with an annual ED
Insulin-Like Growth Factor-1 as a Prognostic Marker in Patients with Acute Ischemic Stroke  [PDF]
Jian-Hua Tang, Li-Li Ma, Tian-Xia Yu, Juan Zheng, Hui-Juan Zhang, Hui Liang, Peng Shao
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0099186
Abstract: Objective Insulin-like growth factor-1 (IGF-1) has been associated with cardiovascular risk factors and atherosclerosis. The aim of the present study was to evaluate the prognostic value of IGF-1 levels in patients with acute ischemic stroke (AIS). Methods All patients with first-ever AIS from August 1, 2012 to August 31, 2013 were recruited to participate in the study. Clinical data were collected. The National Institutes of Health Stroke Scale (NIHSS) score was assessed on admission blinded to serum IGF-1 levels. For the assessment of functional outcome at 90 days Modified Rankin Scale (mRS) was used. On admission, serum IGF-1 levels were determined by chemiluminescence immunoassay. The influence of IGF-1 levels on functional outcome and death was assessed by multivariate logistic regression analysis. Results Patients with an unfavorable outcomes and non-survivors had significantly decreased serum IGF-1 levels on admission (P<0.0001 for both). IGF-1 was an independent prognostic marker of functional outcome and death [odds ratio 0.89 (0.84–0.93) and 0.90 (0.84–0.95), respectively, P<0.0001 for both, adjusted for age, NIHSS score and other predictors] in patients with ischemic stroke. Serum IGF-1 levels ≤130 ng/mL was as an value indicator for unfavorable functional outcome (OR 3.31, 95% CI:1.87–5.62; P<0.0001), after adjusting for other significant confounders. Conclusions We reported a significant association between low serum IGF-1 levels and unfavorable functional outcome and death.
Dora Peychinska, Maya Danovska, Dimitar Chakarov, Virginia Simeonova, Christo Lilovski
Journal of IMAB : Annual Proceeding (Scientific Papers) , 2004, DOI: http://dx.doi.org/10.5272/jimab.2004101.19
Abstract: The dynamic follow up of aphasic disorders in patients with acute ischemic stroke is of great importance because of its prognostic value for their future recovery. The purpose of that clinical study is to compare the type of aphasia with the CT data about the infarction localization and to evaluate the prospective aphasia recovery. In the clinical study were included 37 patients with ischemic stroke and aphasia, theated in II-nd Neurology Clinic, Medical University Pleven. The diagnosis ischemic stroke was confirmed by clinical and CT investigations. Partial and full recovery of sensory aphasia was registered in all the patients with total aphasia, while motor aphasia showed little tendency of reduction in acute ischemic stroke. Aphasic disorders were more severe in cases with ischemic infarctions localized in the specific anatomical regions responsible for the speech function. The dynamic follow up of aphasic disorders has prognostic value for the speech recovery. Better prognosis show sensory and amnestic aphasia. Lesion localization also influences the prognosis.
The Etiologic and Prognostic Importance of High Leukocyte and Neutrophil Counts in Acute Ischemic Stroke
Journal of Neurological Sciences , 2010,
Abstract: Objectives: Inflammatory mechanisms play an important role in the pathogenesis of cerebral ischemia and in the risk of stroke. In several studies, elevated leukocyte count has been associated with cardiovascular and cerebrovascular events. The aim of this study is to investigate the relationship between the leukocyte and neutrophil counts and stroke severity, short term prognosis and stroke subtypes of the patients with acute ischemic stroke.Materials/Methods: Leukocyte and neutrophil counts were measured in 166 consecutive acute ischemic stroke patients in the first 24 hour of admission. Clinical findings, stroke risk factors and brain imagings were evaluated. According to their etiology, patients were classified by using the TOAST criteria. Stroke severity was assessed by the modified Rankin Scale(mRS) on admission and discharge, National Institutes of Health Stroke Scale (NIHSS) was used on admission.Results: While 51(%30.72) patients had leukocyte ≥10000/μl and 115(%69.28) patients had leukocyte <10000/ μl, 70(%42.17) patients had neutrophil ≥6100/μl and 96(%57.83) patients had neutrophil<6100/μl. leukocyte and neutrophil counts were significantly higher in severe stroke (p<0.001) hence short term prognosis was significantly poor in these patients. (p<0.001) We found a strong correlation between large vessel disease and high leukocyte count (p<0.05) and also between small vessel disease and normal leukocyte count. (p<0.05) Results were similar for neutrophil levels of patients according to stroke subtypes.Conclus on: According to our study; high leukocyte and neutrophil levels on admission correlate with large vessel disease and therefore could be a predictor of stroke severity and unfavourable outcome.
The Assessment of Early Stage Computed Tomography Findings in Acute Ischemic Stroke  [PDF]
Nebahat Ta?demir,Yusuf Tamam,Veysi Tabak,Anda? Dedeo?lu
Dicle Medical Journal , 2008,
Abstract: The imaging techniques have become important tools during diagnostic stage of acute ischemic stroke during the last 30 years. The improvement in these techniques further increased the clinical areas that these tools could be used. As computerized brain tomography (CT) is a rapid, cheap, non-invasive and highly available imaging tool in most hospitals, it remains to be the primary scanning method for all acute patients.The aim of this study was to evaluate the early stage CT findings in the ischemic stroke patients which have been scanned in the first 8 to 12 hours after the incidence. Sixty four cases (26 male, 38 female) who had clinical symptoms of ischemic stroke have been included in this study. CT scan was performed twice to these patients; first in the first 8 to 12 hours, and second in between 24 hours and 48 hours after the stroke. The middle cerebral artery perfused area was the most common arterial area affected among cases who had CT findings in early scans. Hypodense lesions were most common lesions encountered in CT findings. Hyperdense middle cerebral artery sign in early CT findings could be an indicator of ischemia due to arterial occlusion. We determined that the CT images obtained at the beginning of developing stroke appeared to show the lesions smaller than what they really were. There were significant differences between the emergency room evaluation and detailed clinical evaluation of CT scans. More findings have been observed in late CT scans performed between 24 hours and 48 hours than the ones performed in the first 8 hours and 12 hours. There was no correlation between the presence of CT findings in early scans and severity of clinical features of ischemia. CT appears to be an important tool in diagnosing ischemic strokes even at early stages. Developments in diagnostic precision of CT tools will further increase our understanding of ischemic strokes and their clinical progress.
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