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Extramedullary nasal plasmacytoma: Literature review and a rare case report
Corvo, Marco Antonio dos Anjos;Granato, Lídio;Ikeda, Felipe;Próspero, José Donato de;
International Archives of Otorhinolaryngology , 2013, DOI: 10.7162/S1809-97772013000200016
Abstract: introduction: extramedullary plasmacytoma is a plasma cell tumor that grows within any of the soft tissues of the organism. similar to all plasmacytic dyscrasia, the disease is extremely rare. aim: this study reports a case of an extramedullary plasmacytoma of the nasal cavity and provides a literature review on the topic. case report: a 51-year-old woman presented at our tertiary university hospital with a 6-month history of progressive nasal obstruction, predominantly to the right side, and self-limiting epistaxis. examination revealed a large pale-reddish tumor within the right nasal cavity. anatomopathological analysis showed features consistent with a plasmacytoma diagnosis, which was subsequently confirmed by immunohistochemical techniques. further assessment revealed the solitary nature of the condition, consistent with extramedullary plasmacytoma. radiotherapy was initiated, which led to partial regression of the symptoms. the tumor was surgically removed by using a mid-facial degloving approach. the patient evolved with a naso-oral fistula and underwent 3 corrective surgeries. no evidence of associated systemic disease was found after 5 years of follow-up. conclusions: this case report, which describes a rare tumor of the nasal cavity, is expected to improve the recognition and referral of this condition by ear, nose, and throat (ent) specialists for multidisciplinary management and long-term follow-up.
Extramedullary Plasmacytoma of Maxillary Antrum
Aniece Chowdhary, Des Raj Bhagat, Shazia Hamid, Rajni Malhotra, S S. Bhau
JK Science : Journal of Medical Education & Research , 2009,
Abstract: Extramedullary plasmacytoma (EMP) represents approximately 3% of all plasma cell neoplasms.With anidea to heighlight its diagnosis,treatment modalties, we report a case of extramedullary plasmacytoma in a52 years old male patient.
Extramedullary Plasmacytoma of Soft Tissues and Gingiva  [cached]
Amrit Kaur Kaler,Shankar A,Madhusmitha Jena
Online Journal of Health & Allied Sciences , 2012,
Abstract: Extramedullary plasmacytoma (EMP) is a rare plasma cell neoplasm of soft tissue without bone marrow involvement or other systemic characteristics of multiple myeloma. It accounts for 3% of all plasma cell tumors. Multiple extramedullary plasmacytoma is defined when there is more than one extramedullary tumor of clonal plasma cells and such presentation has not been described earlier. We report such rare case of multiple extramedullary plasmacytoma involving multiple soft tissues in chest, abdomen, mandible, maxilla, and gingiva.
Soft Tissue Extramedullary Plasmacytoma
Fernando Ruiz Santiago,Manuel Tello Moreno,Aurelio Martín Castro,Luis Guzmán álvarez,Pedro Navarrete González
Case Reports in Medicine , 2010, DOI: 10.1155/2010/307902
Abstract: We present the uncommon case of a subcutaneous fascia-based extramedullary plasmacytoma in the leg, which was confirmed by the pathology report and followed up until its remission. We report the differential diagnosis with other more common soft tissue masses. Imaging findings are nonspecific but are important to determine the tumour extension and to plan the biopsy.
Testicular extramedullary plasmacytoma
M Abbasi,B Nemat-Gorgani,M Samet
Journal of Shahid Sadoughi University of Medical Sciences , 2006,
Abstract: Extramedullary plasmacytomas are plasma cell tumors that arise outside the bone marrow. They are most often located in the head and neck. Extramedullary plasmacytomas account for approximately 3 percent of plasma cell malignancies. The diagnosis of an extramedullary plasmacytoma depends upon the demonstration of a monoclonal plasma cell tumor at an extramedullary site with no evidence of multiple myeloma based upon bone marrow examination and roentgenographic studies, absence of an M-protein in serum and/ or urine, and no related organ or tissue impairment. These tumors are highly responsive to local radiation therapy and rarely progress or recur. A 77 year old man referred for gradual enlargement of scrotum in April, 2004. He had no fever, weight loss or loss of appetite during the period. No tenderness, warmth or erythem of scrotum was observed on physical examination. No lymphadenopathy was detected. Later he had temporary relief because of antibiotic therapy . 7 months later, he referred again following the aggravation of his symptom. Ultrasonography of his scrotum was done and enlargement in the left testis was reported. Lab data including CBC,diff,ESR,AFP were normal but βHCG titer was reported higher than normal . He underwent radical orchiectomy and the specimen was sent for pathological study. Spermatocytic seminoma and plasmacytoma were suspected, but plasmacytoma was reported after the IHC . In order to rule out multiple myeloma, whole body bone scanning with sestamibi and urine Bence Jones protein were examined, all of which were negative. In bone marrow aspiration, the cellularity was normal and no pathologic lesion was reported. Considering clinical and paraclinical evidences, the diagnosis was extramedullary plasmacytoma.
Extramedullary Plasmacytoma of the Tonsil
Kevin C. Huoh,Annemieke Van Zante,David W. Eisele
Case Reports in Otolaryngology , 2011, DOI: 10.1155/2011/430809
Abstract: Plasma cell tumors are a diverse group of neoplasms characterized by monoclonal proliferation of plasma cells. Extramedullary plasmacytoma (EMP) is a rare form of localized plasma cell tumor that arises most often in the head and neck region. We present an unusual case of EMP of the palatine tonsil from a tertiary care university hospital. We discuss the histopathologic and radiologic evaluation as well as treatment of EMP.
Solitary Extramedullary Plasmacytoma of the Thyroid Gland
M. Ridal,N. Ouattassi,T. Harmouch,A. Amarti,M. N. Alami
Case Reports in Otolaryngology , 2012, DOI: 10.1155/2012/282784
Abstract: Solitary extramedullary plasmacytoma of the thyroid gland is an uncommon condition. Up to date, its clinical pathological features are not fully understood. We present a case of an extramedullary nonmucosal plasmacytoma of the thyroid gland which is the first case with regional metastatic lymph nodes. This condition requires a scrupulous survey to rule out a metastatic multiple myeloma. Although localized forms management is still controversial, authors require combined approach for regional metastatic forms. The prognosis is favorable compared to solitary bone plasmacytomas or multiple myeloma.
Primary isolated extramedullary plasmacytoma of colon
Vishal Gupta, Brindaban Nahak, Puja Sakhuja, Anil K Agarwal, Nirmal Kumar, Pramod K Mishra
World Journal of Surgical Oncology , 2007, DOI: 10.1186/1477-7819-5-47
Abstract: We present a case of 42 year male who presented with diarrhea. Multiple colonic strictures were found on investigation. Colonoscopic biopsy was not helpful in making any specific diagnosis. Patient underwent subtotal colectomy. Isolated primary colonic plasmacytoma was found on histopathological examination.Plasmacytoma is known to occur in extra osseous sites. Primary colonic plasmacytoma, however, is a rare clinical entity. Primary colonic plasmacytoma may have varying clinical presentations including multiple colonic strictures that may mimic colonic tuberculosis or inflammatory bowel disease. Although these cases are rare, treating physician as well as radiologist, and pathologist should be aware of this entity.According to World Heath Organization [1] plasma cell tumors have been classified in to two main groups: multiple myeloma and plasmacytoma. Plasmacytoma includes solitary plasmacytoma of bone and solitary extramedullary plasmacytoma.Solitary extramedullary plasmacytoma represents a rare disease and diagnostic criteria and natural history are not very well defined at present. They are most commonly found in the oral cavity and upper respiratory tract [2]. About 10% of these tumors have been reported in gastrointestinal tract [3,4]. Involvement of colon and rectum is extremely rare and so far only 20 cases of extramedullary plasmacytoma of colon and rectum have been reported in the literature. However, only 7 of these cases have adequate clinical and other details.A 42 year old male presented in July 2004 with 8 months history of diarrhea, progressive weight loss and malaise. Diarrhea was intermittent, watery with a frequency of 3–4 times/day, without fresh or altered blood. It was associated with crampy lower abdominal pain. There was history of weight loss of 5 kg in last 8 months. There was no history of anorexia, fever, or alternating constipation. He had received anti tubercular treatment elsewhere thrice (1979 – 1 year, 1992 – 1 year, 2002 – 1 year) f
Extramedullary plasmacytoma of the larynx  [cached]
Pinto, José Ant?nio,S?nego, Thiago Branco,Artico, Marina Spadari,Leal, Carolina de Farias Aires
International Archives of Otorhinolaryngology , 2012,
Abstract: Introduction: The extramedullary plasmocytoma is one of the localized forms of malignancy of the plasma cells, which has multiple myeloma main diagnosis. Its main site to the head and neck, but with a rare presentation in the larynx. Objective: To describe a case of extramedullary plasmocytoma of the larynx, with literature review. Case Report: Patient female, 49, referring to intermittent dysphonia for 01 years with progressive worsening associated with vocal fatigue and vocal effort, with reddish lesion, smooth edges fold left ventricular endoscopy. Being subjected to excisional biopsy diagnosed with extramedullary histopathological plasmocytoma. Conclusion: Extramedullary Plasmocytoma must be considered in the differential diagnosis of rare tumors of the larynx. It is essential after the diagnosis of multiple myeloma research and a "follow up" appropriate.
Extramedullary Plasmacytoma of the Pancreas: A Rare Entity
Alexis Smith,Hassan Hal,Elizabeth Frauenhoffer
Case Reports in Radiology , 2012, DOI: 10.1155/2012/798264
Abstract: Extramedullary plasmacytomas are plasma cell neoplasms in organs other than the bone marrow. Most are found in the upper respiratory tract. Involvement of the pancreas is rare. We report a case of pancreatic plasmacytoma in association with advanced multiple myeloma.
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