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Is the existence of a softest point in the directed flow excitation function an unambiguous signal for the creation of a quark-gluon plasma?  [PDF]
Marcus Bleicher,J?rg Aichelin
Physics , 2002, DOI: 10.1016/j.physletb.2005.02.035
Abstract: The excitation function of the in-plane directed flow of nucleons is studied within a non-equilibrium transport approach. It is demonstrated that a local minimum in the excitation function of the directed flow develops, which is not related to a transition into a quark-gluon plasma (QGP) phase. It is a consequence of the dynamical softening of the underlying equation of state, due to the onset of resonance matter and particle production. Thus, the interpretation of this minimum as a 'smoking gun' signature for the creation of a QGP is premature.
摹仿与试验――论姚?g雏的短篇小说创作
Imitation and experiment: Yao Yuanchu’s short story creation
 [PDF]

孙超
- , 2016, DOI: 1672-3104(2016)06-0184-05
Abstract: 摘 要: 作为报人小说家,为了适应报刊这种现代化载体,为了满足民初读者越来越现代、多元的“兴味”阅读需要,姚?g雏在短篇小说创作上进行了多路向探索。其撰著的短篇小说既继承唐人小说追求“奇味”的一脉,兼具史笔与诗意;又借鉴外国小说的某些叙事技巧,结合读者的阅读兴味,自觉进行变革和试验,使有些小说呈现出显著的现代性特征,可谓现代短篇小说之前奏。姚?g雏的创作实践有力地推动了短篇小说的现代转型。
Abstract: As a journalist novelist, in order to adapt to the modern carrier of newspapers and periodicals and in order to satisfy the “Xing Wei” reading requirements in Early Republic of China which were more and more modern and diverse, Yao Yuanchu made multi-approach exploration in short story creation. His short stories not only inherited the “Qi Wei” style of Tang novels with both history and poetry, but learned from certain foreign narrative techniques. He combined with the reader’s reading interest, and consciously undertook reform and experiment so that some novels could bring out the remarkable characteristics of modernity, which can be considered as the prelude to modern short story. Yao Yuanchu’s creative practice vigorously promotes the modern transformation of short story
GPER Mediates Cardiotropic Effects in Spontaneously Hypertensive Rat Hearts  [PDF]
Ernestina Marianna De Francesco, Tommaso Angelone, Teresa Pasqua, Marco Pupo, Maria Carmela Cerra, Marcello Maggiolini
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069322
Abstract: Estrogens promote beneficial effects in the cardiovascular system mainly through the estrogen receptor (ER)α and ERβ, which act as ligand-gated transcription factors. Recently, the G protein-coupled estrogen receptor (GPER) has been implicated in the estrogenic signaling in diverse tissues, including the cardiovascular system. In this study, we demonstrate that left ventricles of male Spontaneously Hypertensive Rats (SHR) express higher levels of GPER compared to normotensive Wistar Kyoto (WKY) rats. In addition, we show that the selective GPER agonist G-1 induces negative inotropic and lusitropic effects to a higher extent in isolated and Langendorff perfused hearts of male SHR compared to WKY rats. These cardiotropic effects elicited by G-1 involved the GPER/eNOS transduction signaling, as determined by using the GPER antagonist G15 and the eNOS inhibitor L-NIO. Similarly, the G-1 induced activation of ERK1/2, AKT, GSK3β, c-Jun and eNOS was abrogated by G15, while L-NIO prevented only the eNOS phosphorylation. In hypoxic Langendorff perfused WKY rat heart preparations, we also found an increased expression of GPER along with that of the hypoxic mediator HIF-1α and the fibrotic marker CTGF. Interestingly, G15 and L-NIO prevented the ability of G-1 to down-regulate the expression of both HIF-1α and CTGF, which were found expressed to a higher extent in SHR compared to WKY rat hearts. Collectively, the present study provides novel data into the potential role played by GPER in hypertensive disease on the basis of its involvement in myocardial inotropism and lusitropism as well as the expression of the apoptotic HIF-1α and fibrotic CTGF factors. Hence, GPER may be considered as a useful target in the treatment of some cardiac dysfunctions associated with stressful conditions like the essential hypertension.
Energy in Commercially Available Ultra-Diluted Natural Cardiotropic Drug Digitalis purpurea: An UV Spectroscopic Study
Anup Sharma,Bulbul Purkait
Research Journal of Pharmacology , 2013,
Abstract: Ultra diluted drugs have a statistically significant medicinal effect compare to placebo but it is still unknown how they work. Extract of foxglove plant, Digitalis purpurea, Scrophulariaceae, an effective cardiotropic natural product, is one such compound, which is used by almost all prevalent systems of medicine. As a natural cardiotropic drug it is presumed to have an energy component involved in producing the effect. Since the effect of Digitalis purpurea depends on concentration and dilution, it motivated us to carry out a systematic study to explore an energy entity in less than micro volume, commercially available drug Digitalis purpurea, diluted with aqueous ethanol. The diluent and cleaning agent used was free from any possible contaminant whatsoever. We report a preliminary UV spectroscopy analysis on the effect of serial ultra dilution in the medicinal plant extract Digitalis purpurea. Well-known technique of UV spectroscopy has been used for identification/characterization and analytical evaluation of the medicinally active ingredients of Digitalis purpurea. The experimental results, although preliminary, provide significant and reliable information showing standard UV spectral absorption peak within expected range. It also shows, the diluted out effect on the active component of the drug Digitalis purpurea and provides information to compute energy on serial dilution of drugs. It is found that 4.5 eV is required to dislodge the bond in the group. The eV content of a drug may become important issue for pharmacological and posological considerations.
Biology of Adeno-Associated Viral Vectors in the Central Nervous System  [PDF]
Giridhar Murlidharan,Aravind Asokan
Frontiers in Molecular Neuroscience , 2014, DOI: 10.3389/fnmol.2014.00076
Abstract: Gene therapy is a promising approach for treating a spectrum of neurological and neurodegenerative disorders by delivering corrective genes to the central nervous system (CNS). In particular, Adeno-Associated Viruses (AAV) have emerged as promising tools for clinical gene transfer in a broad range of genetic disorders with neurological manifestations. In the current review, we have attempted to bridge our understanding of the biology of different AAV strains with their transduction profiles, cellular tropisms and transport mechanisms within the CNS. Continued efforts to dissect AAV-host interactions within the brain are likely to aid in the development of improved vectors for CNS-directed gene transfer applications in the clinic.
The relation between creation and salvation in the Trinitarian theology of Robert Jenson
Anné H. Verhoef
HTS Theological Studies/Teologiese Studies , 2013,
Abstract: This article explored the relation between creation and salvation as acts of God in the theology of Robert Jenson, an American Lutheran theologian. This is important due to Jenson’s growing importance as theologian and because of the current importance of ecotheology (and related themes that were implicated by the relation between creation and salvation). Jenson’s theology is an effort to tell God’s particular story and it can be described as a Trinitarian, narrative and eschatological theology. His starting point is that God’s eternity must not be understood as timeless (this is unbiblical and incompatible with the story of creation and redemption) and that creation (space and time) takes place somehow within the being of God. Jenson qualified this ‘withinness’, but also emphasised that creation is an intelligible whole, a history with an intended end. It is important for him that God’s story – a story of dramatic coherence – is not separated from our own and creation’s story. Within this understanding of God’s story (as dramatic coherence), creation found its own dramatic teleology because salvation also includes creation. Creation is therefore not subjected to pointlessness any longer, but will find its final place within God. The implication of this is that we must value creation much more and act with more responsibility towards it. According to Jenson we must enjoy creation in an aesthetic fashion and delight in creation as a whole because of its dramatic teleology.
Science as Story: Science Education by Story  [cached]
Peter FENSHAM
Asia-Pacific Forum on Science Learning and Teaching , 2001,
Abstract: Story telling has been a very traditional way for information to be passed on from one generation to another. Long before there were alphabets and methods of writing, the important information and the wisdom of a culture was passed from one generation to the next by stories. This is still evident today even in societies where written information has become very dominant. Parents in these societies still engage their very young children with stories, either read or orally, long before these children know about letters and reading. In less developed societies where written forms of the language are more recent and literacy rates are still low, story telling holds centre stage in the education of each new generation.
The story they missed
Gregory A Petsko
Genome Biology , 2008, DOI: 10.1186/gb-2008-9-1-101
Abstract: I started reading it with the same Schadenfreude that Boston-area faculty who aren't employed at Harvard or MIT often experience when either of these two 500-pound educational gorillas slips up. But as I read it, that feeling went away, replaced by one I hadn't expected in this context: compassion. I felt sorry for MIT because I thought the story missed the point, missed it in such a way that the institute was unfairly blamed. And by the time I was finished reading it, I was also convinced that the real story was so much more interesting, and so important, that it was worth writing about.The article starts with the statement that "just one out of 25 faculty members granted tenure this year at MIT is female" and continues, "a gender imbalance that appears to contrast with the university's decade-old effort to boost the status of women." There's much more, of course, including much gnashing of teeth on the part of the MIT administration and references to the history of gender inequality at MIT, where a famous effort, spearheaded by biology professor Nancy Hopkins, detailed systematic discrimination against women faculty through low pay, inadequate space, and a host of other inequalities. Since 2001, MIT has implemented policies designed to redress gender bias, and in fact, the institute is now headed by its first woman President, neurobiologist Susan Hockfield. So the Globe article caused consternation in its seeming demonstration that bias still existed in the matter of tenure.But does it really? A close examination of the data suggests otherwise. True, only one woman was granted tenure at MIT last year out of 25 total promoted faculty, but the year before the figure was 5 out of 19, and the year before that, 6 out of 19. During the past ten years, the number of junior faculty women granted tenure at MIT has ranged from zero to eight a year, while the number of junior faculty men granted tenure has ranged from 10 to 24. These are very small numbers, and small numbers
Story Parsing Grammar
Zhang Songmao,
Zhang
,Songmao

计算机科学技术学报 , 1994,
Abstract: Story understanding is one of the important branches of natural language under-standing research in AI techniques. A new approach to story understanding is proposedin this paper. The so-called Story Parsing Grammar (SPG) is used to represent thestory abstracting processes with different degrees in story understanding, and the storyunderstanding process is converted to the story recognizing process done by the syn-tactic parser of SPG. This kind of story understanding is called story parsing. In thispaper, firstly, a survey of story understanding research is given. Secondly, by the clas-sification of various kinds of story structures, the so-called Case Frame Forest (CFF) isproposed to represent the superficial meaning of story. Based on CFF, a high- dimen-sional grammar, called Forest Grammar (FG), is defined. Furthermore, SPG is definedas a subclass of context-sensitive FG. Considering the context-sensitivity of story con-tent, a type of context-sensitive derivation is defined in the definition of SPG. Lastly,data about runtime efficiency of the syntactic parsing algorithm of weak precedenceSPG, a subclass of SPG, are given and analysed.
The Story of Azithromycin  [PDF]
Bani? Tomi?i?, Z.
Kemija u Industriji , 2011,
Abstract: The invention of azithromycin (1, Figure 1), the active pharmaceutical ingredient of the antibiotic Sumamed (Croatian brand name by PLIVA; Zithromax by Pfizer in the USA) belongs among the great achievements in the history of science in Croatia. From the viewpoint of commercialization of research results, it may have been one of the greatest. In addition to contributing to science and to medicine, azithromycin has also brought about an improvement in the quality of life on the global level. Owing to its exceptional therapeutic properties, it has come to be one of the most successful antibiotics worldwide. Marking the 30th anniversary of the azithromycin Yugoslav patent application, this paper gives an overview of the research that led to its discovery and comes with a list of papers and patents through which the drug has been made known to the public (Table 1, Figures 4 and 6). The invention was due to the scientists from the Research Institute of the pharmaceutical company PLIVA in Zagreb, Croatia, D. Sc. S. oki , M. Sc. G. Kobrehel, D. Sc. G. Lazarevski, and D. Sc. Z. Tambura ev (Figure 3). Azithromycin became the first representative of the new class of 15-membered macrolides known as azalides after the introduction of nitrogen in the macrocycle of erythromycin A (2, Figure 1). Its synthesis involved several steps (Figure 2): oximation of erithromycin A, Beckmann rearrangement of erythromycin A oxime with aromatic sulphochlorides, reduction of the produced erithromycin A iminoether, and final methylation of the nitrogen introduced in the macrocycle of erythromycin A. Because of inadequate analytical support in the late 1970s and early 1980s, the precise structure of the LD product (Figure 5) in the Beckmann rearrangement step of azithromycin synthesis was confirmed only later as 7 and not 6 as assumed (Figure 5). Today, azithromycin is known under the common chemical name of 9-deoxo-9a-aza-9a-methyl-homoerythromycin A. This paper also deals with the negotiations and signing of a contract between PLIVA, Croatian pharmaceutical company, the patent holder, and Pfizer, one of the world largest pharmaceutical companies in the field of proprietary research. The dihydrate form of azithromycin is also discussed. The azithromycin (i.e. Sumamed and Zithromax) story, which dates from the second half of the last century, can be considered as the first and foremost example of successful knowledge and technology transfer in Croatia ever. On their web pages, the World Intellectual Property Organization (WIPO) reports the PLIVA azithromycin story as a case study an
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