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CONTENT OF POTASSIUM AND MAGNESIUM IN THE MUSCLE TISSUE OF FEMALE RABBITS AFTER NICKEL AND ZINC PERORAL ADMINISTRATION  [PDF]
Anna Kalafová,Jaroslav Ková?ik,Marcela Capcarová,Adriana Kolesárová
Journal of Microbiology, Biotechnology and Food Sciences , 2012, DOI: 13385178
Abstract: The aim of our study was to determine the effect of single nickel administration as well as co–administration with zinc on distribution of potassium and magnesium in the muscle tissue (musculus longissimus dorsi, musculus biceps femoris) of rabbits. In the experiment 25 female rabbits of broiler line Californian were involved. Animals were divided to three groups: K (n=5) – control; P1 (n=5) – received 17.5 g NiCl2.100 kg-1 of feed mixture, P2 (n=5) – received 35 g NiCl2.100 kg-1 of feed mixture (FM), P3 (n = 5) – received 17.5 g NiCl2.100 kg-1 and 30 g ZnCl2.100 kg-1 of feed mixture and P4 (n = 5) – received 35 g NiCl2.100 kg-1 and 30 g ZnCl2.100 kg-1 of feed mixture. Animals were fed ad libitum using KKV1 feeding mixture with or without nickel and zinc addition for 90 days. For analysis of the content of these trace elements in 50 samples of animals an atomic absorption spectrophotometry method was used. The significant higher value (p<0.05) of potassium in musculus longissimus dorsi in group P2 was detected (17141.70±3702.40 μg.g-1) in comparison with group P3 (9594.39±2205.10 μg.g-1). The significant higher value (p<0.05) of potassium in musculus biceps femoris in group P3 (24489.78±3977.98 μg.g-1) in comparison with group P4 (14986.14±3530.84 μg.g-1) and group K (13100.24±2597.61 μg.g-1) was measured. The average concentration of magnesium in musculus longissimus dorsi was significantly higher (P<0.05) in P2 (1434.10±172.49 μg.g-1) group than those in group P1 (802.50±209.98 μg.g-1). Other differences remained insignificant (P>0.05).
SERUM PROTEIN CHANGES IN RABBITS AFTER CHRONIC ADMINISTRATION OF LEAD AND CADMIUM  [PDF]
Hristo HRISTEV,Dimo PENKOV,Abdul Hallak,Maria Kirova
Journal of Central European Agriculture , 2008,
Abstract: The infl uence of lead (5mg/kg b.w) and cadmium (2mg/kg b.w) after chronic treatment of the rabbits on serum protein is investigated. Signifi cantly raised content of the cholesterol, ASAT and ALAT; hypo-albuminemia and hyperbetaglobulinemia of the background of one hypoproteinemia and low A/G coeffi cient are established. On basis of obtained result can to show degree of liver parenchyma damage and as trial for used the hyperbeta-globulinemia (at chronic treatment with cadmium is stronger markedly) as indicator for delimitation of enteral from parenteral toxication, at that is noted hypergamma-globulinemia.
Heavy metals in meat of Finnish city rabbits  [cached]
Damerau A.,Ven?l?inen E. R.,Peltonen K.
E3S Web of Conferences , 2013, DOI: 10.1051/e3sconf/20130115011
Abstract: Levels of cadmium, chromium, lead, copper, manganese, and zinc in city rabbits were determined to evaluate the edibility of the meat. Mean concentrations of toxic metals were 0.011 mg/kg for cadmium and 0.037 mg/kg for lead. Cadmium and lead concentrations were below the admissible maximum levels set by EU. Concentration of toxic metals in the meat was sufficiently low that consumption of the meat does not pose a health risk for human. Investigation of PAHs, pesticides, and other environmental pollutants is required before the meat can be declared safe.
Single Crystal Growth of Magnesium Diboride by Using Low Melting Point Alloy Flux  [PDF]
Wei Du,Xugang Xian,Xiangjin Zhao,Li Liu,Zhuo Wang,Rengen Xu
Physics , 2011,
Abstract: Magnesium diboride crystals were grown with low melting alloy flux. The sample with superconductivity at 38.3 K was prepared in the zinc-magnesium flux and another sample with superconductivity at 34.11 K was prepared in the cadmium-magnesium flux. MgB4 was found in both samples, and MgB4's magnetization curve being above zero line had not superconductivity. Magnesium diboride prepared by these two methods is all flaky and irregular shape and low quality of single crystal. However, these two metals should be the optional flux for magnesium diboride crystal growth. The study of single crystal growth is very helpful for the future applications.
A comparative study on the biochemical effect of ocular and oral cadmium administration in rabbits
SO Asagba
African Journal of Biotechnology , 2010,
Abstract: The objective of the present study was to compare the effect of oral and ocular exposure to cadmium for one and three months on some biochemical parameters using rabbits as animal model. The results obtained show that the kidney, femoral muscle, femur and brain of rabbits ocularly exposed to Cd had a significantly higher concentration of Cd relative to that of those administered the metal orally after both periods, except for the liver which was significantly lower. There was a significantly higher membrane lipid peroxidation (LPO) in the kidney of the one and three months exposed rabbits after both oral and ocular exposure to Cd relative to control with a corresponding decrease in the activities of superoxide dismutase (SOD) and catalase (CAT). Irrespective of the route and time of exposure to the metal, the activity of SOD and CAT were significantly higher in the brain relative to the control, but the level of LPO was not significantly altered. Liver damage induced by oral cadmium after one and three months exposure was clearly shown by the increased activities of plasma hepatic marker enzymes namely, L-aspartate aminotransferase activity (L-AST), L-alanine aminotransferase activity (L-ALT), alkaline phosphatase activity (ALP) along with increased level of LPO indices and a corresponding decrease in the activities of SOD and CAT in the liver. Similarly, liver damage induced by ocular exposure to Cd for one month was manifested as increased plasma L-AST, L-ALT and ALP activities with an increased LPO and a corresponding decrease in the activities of SOD and CAT in the liver. However, the plasma parameters did not significantly change after three months of exposure to ocular Cd, except plasma ALP activity which remained significantly higher. The liver LPO was also not significantly different from the control after three months exposure to ocular Cd, although the SOD and CAT activities significantly decreased. Thus the major finding of the present study was that in relation to ocular exposure, oral exposure to Cd was more toxic to the liver at the end of three months of exposure.
Magnesium Excretion in C. elegans Requires the Activity of the GTL-2 TRPM Channel  [PDF]
Takayuki Teramoto,Laura A. Sternick,Eriko Kage-Nakadai,Shirine Sajjadi,Jakub Siembida,Shohei Mitani,Kouichi Iwasaki,Eric J. Lambie
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009589
Abstract: Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C. elegans excretory cell to mediate the excretion of excess magnesium. Thus, the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1.
Investigations of microstructure and dislocations of cast magnesium alloys  [PDF]
T. Tański,L.A. Dobrzański,K. Labisz
Journal of Achievements in Materials and Manufacturing Engineering , 2010,
Abstract: Purpose: The microstructures and the dislocation arrangements in the cast magnesium alloy have been investigated using transmission electron microscopy and high-resolution transmission electron microscopy. In this paper are presented also the results of phase morphology investigation of an new developed Mg alloy. Such studies are of great interest for the metal industry, mainly the automobile industry, were the improvement of cast elements quality is crucial for economic and quality reason and depends mainly on properly performed controlling process of the production parameters. There are presented especially the effect of heat treatment on the size and distribution of the precipitation occurred in the matrix.Design/methodology/approach: The basic assumptions of this work are realised an Universal Metallurgical Simulator and Analyzer. The solidification process itself is analysed using the UMSA device by appliance of the Derivative Thermo Analysis. The thermal analysis was performed at a low but regulated cooling rate in a range of 0.2 oC to ca. 3 oC. Cooling curve for the thermal analysis was performed using a high sensitivity thermocouples of the K type, covered with a stainless steel sheath. The data were acquired by a high speed data acquisition system linked to a PC computer. Two different types of samples were used, bulk-cylindrical, and thin-walled cylindrical. Metallographic investigation were made on cross section samples of a engine bloc. Non-equilibrium heating and cooling process conditions were applied to achieve changes in shape and distribution of the phases such as Al2Cu and Si.Findings: During the investigation Dislocation networks are found to increase with deformation in all cases. The dislocation networks have been found in the g- Mg17Al12 phase as well as in the matrix in the investigation magnesium alloys. The crystallographic orientation relationship are: (1 01) α-Mg ║ (10 ) Mg17Al12 and [11 0] α-Mg ║ [111] Mg17Al12. Precipitation of the g-Mg17Al12 phase are mostly of the shape of roads, and the prevailing growing directions are the directions <110> α-Mg.Research limitations/implications: The investigations were performed using standard metallographic investigation as optical, scanning and transmission electron microscopy methods, also electron diffraction methods were applied for phase identification.Originality/value: The originality of this work is based on applying of regulated cooling rate of magnesium alloy for structure and mechanical properties changes. In this work the dependence between the regulated heat treatment, chem
Changes in Brain, Liver and Kidney Lipid Peroxidation, Antioxidant Enzymes and ATPases of Rabbits Exposed to Cadmium Ocularly  [PDF]
G.E. Eriyamremu,S.E. Ojimogho,S.O. Asagba,O. Lolodi
Journal of Biological Sciences , 2008,
Abstract: This study examined the effect of supplementing rabbit diet with Palm Oil (PO) on lipid peroxidation, antioxidant enzymes and ATPases of the brain, liver and kidney in ocular cadmium toxicity. New Zealand male rabbits were randomly assigned to 4 groups of 5 rabbits in a study that lasted for 4 weeks. A control group was given deionised water as eye drops and the other groups of rabbits were given eye drops of solution of 2 mg kg-1 body wt. cadmium (as 3CdSO4.8H2O). The control and a test group were fed with the normal chow and animals in the other test groups were fed with the chow fortified with either 5% or 10% palm oil. Treatment of the rabbit with cadmium significantly (p< 0.05) reduced their weight compared with the control and PO supplementations of the diets improved the weights of the animals. Brain, liver and kidney levels of lipid peroxidation were raised by cadmium and PO significantly (p< 0.05) reduced the level of lipid peroxidation of these tissues. Cadmium significantly (p< 0.05) reduced antioxidant enzymes and ATPases in the tissues compared with the control. Feeding the rabbits with PO significantly (p< 0.05) increased the activities of these enzymes to levels comparable with the control, with the 10% supplementation producing a more pronounced effect. The study shows that PO can alter brain, liver and kidney antioxidant enzymes and ATPases in ways which suggest that it offers protection of the rabbits from ocular exposure to cadmium.
Comparing the effect of multiple-dose and once-daily regimens of gentamicin therapy on fraction excretion of magnesium
Hossein Khalili,Simin Dashti-Khavidaki,Sirous Jafari,Zahra Vahedi
DARU : Journal of Pharmaceutical Sciences , 2006,
Abstract: This study was designed to compare the influence of ordinary (multiple-dose) and once-daily administration of gentamicin on tubular nephrotoxicity based on the urinary excretion of magnesium (Mg) as an indicator for this type of side effect. Thirty-two hospitalized patients, who were assigned to receive at least 5-days treatment with gentamicin at the infectious disease ward of Imam Hospital in Tehran, were prospectively studied. Seventeen patients received multiple-doses of gentamicin per day and 15 patients received once-daily regimen. At the beginning and at the end of of gentamicin therapy, blood urea, serum creatinine (Cr) and Mg levels were measured. Additionally 24-hour urine samples were collected for measurement of urinary volume, creatinine and Mg excretions. In both treatment groups serum Mg concentration was significantly lower and fraction excretion of (FEMg) were considerably higher at the end of gentamicin therapy compared with the beginning of the treatment. However, the serum and urinary creatinine levels did not change significantly in the two groups
Cadmium Induced Toxicity on Pregnant Mice and Their Offspring: Protection by Magnesium or Vitamin E  [PDF]
Karima Z. Wershana
Journal of Medical Sciences , 2001,
Abstract: The research work was conducted to investigate the toxic effects of cadmium (Cd+2), administered during gestation period, on female albino mice and their offspring. A sublethal dose of Cd+2 (0.2mg Cd+2 kg ̄1 b.wt, s.c.) was injected to pregnant mice on daily basis for 10 consecutive days as from the 3rd day of gestation and they were allowed to deliver normally. Cd+2 induced significant reduction in litter size, marked elevations in the numbers of dead newborns, externally malformed newborns per litter and increased the Cd+2 concentrations in their bodies. Cadmium injection also, caused growth retardation of the offspring at the day of birth as well as after two and four postnatal weeks. In addition, It increased their mortality percentages at the day of birth as well as during the first two postnatal weeks. It induced decreases in erythrocytic counts (RBCs), hemoglobin contents (Hb) and hematocrit values (packed cell volume, PCV) along with insignificant changes in mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) for female mice at the day of parturition as well as in their offspring after two and four postnatal weeks. It also evoked leucocytosis, granulocytosis and lymphopenia, while monocytes did not show significant alterations. The administration of Cd+2 induced hepatotoxicity as indicated by elevations in the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP). It, also, caused renal dysfunction as indicated by obvious rises in the concentrations of urea and creatinine in plasma. Also, this work aimed to investigate the assessment of the potential protective effect of either magnesium (Mg+2) (73mg Mg+2 kg ̄1 b.wt) or vitamin E (100mg vit. E. kg ̄1 b.wt.). The antidotes were injected as repeated s.c. daily doses starting from the 1st up to the 18th day of gestation. Magnesium administration prevented completely all defects that were induced by Cd+2 while vit. E supplementation exhibited only moderate improvement in these defects. This investigation demonstrates that Mg+2 is more potent then vit. E in protecting female mice and their offspring from Cd+2 induced defects. Mg+2 may be a promising protective agent against Cd+2 intoxication.
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