Necrotizing scleritis is the most
severe form of scleritis with a significant threat to vision and globe
integrity. It can be infectious, surgically induced necrotizing scleritis
(SINS) or systemic autoimmune associated. We report a case of necrotizing
scleritis associated with 5-fluorouracil (5-FU) at the site of sub tenon’s
block in a patient with previous trabeculectomy. To our knowledge, this is the first reported case of
necrotizing scleritis associated with 5-FU. This may implicate alternative
approaches to local anaesthetic techniques when using adjunctive 5-FU.