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Utilidad de las formulaciones Vimang? en pacientes con osteoartrosis de rodilla
Valverde,S.; Duarte,E.M.; Ducangé,D.; Garrido,G.; García-Rivera,D.; Jáuregui,U.; Garrido,B.;
Revista de la Sociedad Espa?ola del Dolor , 2009,
Abstract: osteoarthrosis (oa) is the most common form of arthritis and localization in the knee is common. symptomatic slow acting drugs for osteoarthritis include antioxidant agents as possible modifiers of disease progression. vimang? is a registered brand name that covers several formulations of mangifera indica l., used for its antioxidant, antiinfl ammatory, analgesic and immunomodulatory properties. the aim of the present study was to determine the analgesic activity of vimang tablets and cream in patients with knee oa and identify possible posttreatment functional improvement. a further aim was to characterize the effects of vimang on the synovial infl ammation (effusion and proliferation) associated with this entity using ultrasonography. ten patients from hogar santovenia with a clinical-radiological diagnosis of knee oa were studied. mean daily pain scores on an 11-point likert scale were 4 or higher in the week prior to treatment initiation. the western ontario and mcmaster universities (womac) osteoarthritis index was evaluated in the initial consultation and at the end of the study. ultrasonographic examination (aloka device 1100 with a 7.5 mhz transducer) of the soft tissue of both knees was performed. the patients were randomly assigned to three groups. group 1 (n = 3) received a daily dose of 1,800 mg/day (tablets), group 2 (n = 4) received 900 mg/day (tablets) and group 3 (n = 3) received a combination of tablets 900 mg/day and vimang cream 1.2%. the tables were administered in three daily doses every 8 hours and the cream was applied three times per day every 8 hours on the affected knee. treatment duration was 3 months. satisfactory analgesia was achieved in all patients from days 15-21 until 3 months. this effect was at least partly related to the decrease in synovial effusion observed in most affected joints and was independent of the reduction in synovial thickness observed on ultrasound. both effects, the increase and decrease in synovial thickness, wer
Implante percutáneo de células mononucleares de sangre periférica movilizadas con factor estimulante de colonias granulocíticas, en la osteoartrosis de rodilla. Primer caso comunicado en Cuba Percutaneous implantation of peripheral blood mononuclear cells mobilized with granulocyte colony stimulating factor in osteoarthritis of the knee. First case reported in Cuba  [cached]
Aymara María Baganet Cobas,Porfirio Hernández Ramírez,Norma Fernández Delgado,Mariela Forrellat Barrios
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2010,
Abstract: La enfermedad articular degenerativa, también conocida como osteoartrosis, afecta al 10 % de los adultos mayores de 60 a os de edad. Se caracteriza principalmente por dolor de la articulación afectada, crepitación, rigidez matinal y limitación progresiva de los movimientos de esa articulación. Todo esto conduce a un desgaste parcial o completo del cartílago articular. El tratamiento de la osteoartrosis de la rodilla constituye un gran desafío. Los avances recientes en el uso de la medicina regenerativa sugieren que las células madre adultas pudieran representar una alternativa promisoria en el tratamiento de esta enfermedad. En una paciente femenina de 61 a os de edad con osteoartrosis de la rodilla, se realizó el implante percutáneo de células mononucleares autólogas movilizadas a la sangre periférica mediante el factor estimulante de colonias granulocíticas, y se logró una rápida mejoría clínica y radiológica. Este resultado sugiere que el proceder empleado es un método factible, simple, seguro y menos costoso, para el tratamiento de las lesiones degenerativas articulares. The degenerative joint disease, also known as osteoarthrosis affects to 10% of elderlies aged 60. It is mainly characterized by pain in the involved joint, crepitation, morning stiff and a progressive limitation of movement of that joint leading to a partial or total wear of articular cartilage. The treatment of the knee osteoarthrosis is a great challenge. The recent advances in use of regenerative medicine suggest that adult stem cells could represent a promisor alternative in the treatment of this entity. In a female patient aged 61 presenting with knee osteoarthrosis authors placed a percutaneous implant of autologous mononuclear cells mobilized to peripheral blood by granulocyte colony-stimulating factor achieving a fast clinical and radiological improvement. This result suggests that the procedure used is a feasible, simple, safe and less expensive method for treatment of articular degenerative lesions.
Introducción de la suplementación con formulaciones Vimang en el síndrome doloroso regional complejo: experiencia en 15 pacientes Introduction of supplementation with Vimang formulations in complex regional pain syndrome: Experience in 15 patients  [cached]
B. Garrido-Suárez,M.C. Rabí,F. Bosch,G. Garrido-Garrido
Revista de la Sociedad Espa?ola del Dolor , 2009,
Abstract: Introducción: En la actualidad el estrés oxidativo, la neuroinflamación y la activación glial han adquirido relevancia en la fisiopatología del síndrome doloroso regional complejo (SDRC), de ahí que la terapia con agentes antioxidantes e inhibidores de la producción de citocinas proinflamatorias ha comenzado a ensayarse. El Vimang es una marca comercial registrada que cubre varios tipos de formulaciones a partir del extracto de la corteza del árbol de mango con efecto inhibidor de la activación del factor de transcripción nuclear kB (NFkB), promotor de la expresión de mediadores y sistemas enzimáticos involucrados en la inflamación y el dolor, el estrés oxidativo y la plasticidad sináptica. Objetivo: El propósito del presente estudio fue determinar la actividad analgésica de la suplementación con formulaciones Vimang en 15 pacientes con SDRC y la posible mejoría de la capacidad funcional postratamiento. Material y métodos: Los pacientes recibieron Vimang tabletas 1.800 mg/día/8 h, crema 1,2% en el miembro afectado 3 veces/día y un bloqueo simpático semanal durante 4 meses. Se introdujo la fisioterapia al mes. Las variables evaluadas fueron las puntuaciones diarias medias de dolor (PDMD) mediante una escala de Likert, el área e intensidad de la alodinia mecánica dinámica, la alodinia al frío, somática profunda y la frecuencia del dolor paroxístico. Se aplicó la escala de Enneking et al. modificada para evaluar la funcionabilidad articular. Resultados: Las PDMD y el resto de las alteraciones sensoriales se redujeron significativamente desde la semana 2 a 3 de iniciado el tratamiento respecto a los valores iniciales. La funcionabilidad del miembro afectado aumentó de un promedio de 22,7 a 78,7%. Estas formulaciones pudieran introducirse en el tratamiento del SDRC, pero es necesario sistematizar los estudios. Introduction: Currently, oxidative stress, neuroinflammation and glial activation are accepted as playing a pathophysiological role in complex regional pain syndrome (CRPS) and consequently antioxidant agents and proinfl ammatory cytokine inhibitors have begun to be assessed in the treatment of this disorder. Vimang is a new phytodrug prepared from the stem bark of Mangifera indica L., registered in Cuba with inhibitory effect on nuclear transcription factor kB (NFkB), which induces expression of some mediators and enzymes involved in inflammation, oxidative stress, pain, and synaptic plasticity. Objective: To determine the analgesic effects of Vimang tablets and 1.2% cream as a topical agent in 15 patients with CRPS, as well as possible improvemen
Validez, fiabilidad y convergencia de COOP/WONCA y EUROQoL, administrados telefónicamente, en población con osteoartrosis de cadera y rodilla Validity, reliability and convergence of COOP/WONCA and EUROQoL, via telephone, on people suffering from hip and knee osteoarthritis
Sergio R. López Alonso,Félix Navarro Casado,Josefina González Rojo,Carmen M. Martínez Sánchez
Index de Enfermería , 2009,
Abstract: Objetivos: Determinar las propiedades métricas del EUROQoL y optimizar las del COOP/WONCA en personas con osteoartrosis de cadera o rodilla. Además, se pretende conocer la validez convergente entre ambos cuestionarios. Material y Método: Estudio descriptivo transversal realizado en los Hospitales "La Merced" (Osuna-Sevilla) y "Torrecárdenas" (Almería), mediante encuesta telefónica, incluyendo todas las personas en espera de artroplastia de cadera o rodilla por osteoartrosis, desde octubre 2004 hasta noviembre de 2006. Resultados: El COOP/WONCA presentó un máximo de 79,9% de frecuencia de endose. El análisis factorial por componentes principales desechó 2 ítems con valores inferiores a 0,5; logrando la mayor varianza total explicada 71,09% de CVRS, con dos componentes de 50,70% y 20,38%. Se realizó una rotación Promax, dada la correlación de factores (0,36). En fiabilidad obtuvo un a de Cronbach de 0,75. El EUROQoL presentó una frecuencia de endose de 96,8% para el ítem de movilidad. El análisis factorial por componentes principales encontró una varianza total explicada del 59,46%; con dos factores con 36,77% y 22,68%. La correlación de factores inferior a 0,2 determinó la rotación Varimax. La fiabilidad obtuvo un a de Cronbach de 0,53. El análisis de convergencia entre ambos cuestionarios mostró una baja correlación. Conclusiones: El COOP/WONCA con 5 ítems presenta unas propiedades métricas adecuadas, convirtiéndolo en instrumento de elección para medir la CVRS en población con osteoartrosis de cadera y rodilla, a diferencia de las insatisfactorias propiedades del EUROQoL. Ambos cuestionarios no presentan una convergencia de contenido suficientemente similar para usar las tablas de a os ajustados por calidad de vida del EUROQoL con el COOP/WONCA. Objectives: To determine the metric properties of EUROQoL and to optimize the metric properties of COOP/WONCA on people suffering from hip and knee osteoarthritis, via telephone. Also to identify the convergence validity between them. Methods: A descriptive study design is performed at "La Merced" (Osuna-Sevilla) and "Torrecárdenas" (Almería) Hospitals, via telephone interview since October 2004 to November 2006. The study included all people suffering from hip and knee osteoarthritis and awaiting for a surgical intervention. Results: COOP/WONCA obtained a maximum value of 79,9% on endorsement frequency. Main components factorial analysis resulted on two items with a value below 0,5; and the greatest explained total variance -71,09%- of Health Related Quality of Life (HRQoL) with two components of 50,70% and 20,
Introducción de la suplementación con formulaciones Vimang? en el síndrome doloroso regional complejo: experiencia en 15 pacientes
Garrido-Suárez,B.; Rabí,M.C.; Bosch,F.; Garrido-Garrido,G.; Delgado-Hernández,R.;
Revista de la Sociedad Espa?ola del Dolor , 2009,
Abstract: introduction: currently, oxidative stress, neuroinflammation and glial activation are accepted as playing a pathophysiological role in complex regional pain syndrome (crps) and consequently antioxidant agents and proinfl ammatory cytokine inhibitors have begun to be assessed in the treatment of this disorder. vimang? is a new phytodrug prepared from the stem bark of mangifera indica l., registered in cuba with inhibitory effect on nuclear transcription factor kb (nfkb), which induces expression of some mediators and enzymes involved in inflammation, oxidative stress, pain, and synaptic plasticity. objective: to determine the analgesic effects of vimang? tablets and 1.2% cream as a topical agent in 15 patients with crps, as well as possible improvement in post-treatment functional capacity. material and methods: the patients received a daily dose of 1800 mg of vimang? tablets for 120 days, 1.2% cream in the affected limb 3 times/day, and sympathetic blocks once a week for 4 months. physiotherapy was introduced after 30 days. the variables evaluated were changes in average daily pain score through a likert scale, the area and rate of dynamic mechanical allodynia, rate of cold allodynia, deep somatic allodynia and frequency of burning spontaneous pain. a modified scale of enneking et al. was applied to evaluate functional capacity. results: the average daily pain score and sensory abnormalities significantly improved from week 2-3. on average, the functional capacity of the affected limb increased from 22.7 % to 78.7%. our results suggest that vimang? formulations might be useful in crps treatment. however, further studies are required.
Implante percutáneo de células mononucleares de sangre periférica movilizadas con factor estimulante de colonias granulocíticas, en la osteoartrosis de rodilla. Primer caso comunicado en Cuba
Baganet Cobas,Aymara María; Hernández Ramírez,Porfirio; Fernández Delgado,Norma; Forrellat Barrios,Mariela; González Iglesias,Ana Iris; Pérez Fuentes,Enrique; Macías Abraham,Consuelo; Dorticós Balea,Elvira; Lam Díaz,Rosa M.; Salgado Arocena,Odalys; Villanueva Cagigas,Emilio; León Valladares,Dayneri; Smith García-Menocal,Héctor; Pozo Alonso,Desi; álvarez Hernández,Roberto; Simón Pita,Ana María;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2010,
Abstract: the degenerative joint disease, also known as osteoarthrosis affects to 10% of elderlies aged 60. it is mainly characterized by pain in the involved joint, crepitation, morning stiff and a progressive limitation of movement of that joint leading to a partial or total wear of articular cartilage. the treatment of the knee osteoarthrosis is a great challenge. the recent advances in use of regenerative medicine suggest that adult stem cells could represent a promisor alternative in the treatment of this entity. in a female patient aged 61 presenting with knee osteoarthrosis authors placed a percutaneous implant of autologous mononuclear cells mobilized to peripheral blood by granulocyte colony-stimulating factor achieving a fast clinical and radiological improvement. this result suggests that the procedure used is a feasible, simple, safe and less expensive method for treatment of articular degenerative lesions.
Cytokines in rheumatoid arthritis and osteoarthrosis  [PDF]
Petrovi?-Rackov Ljiljana
Medicinski Pregled , 2005, DOI: 10.2298/mpns0506245p
Abstract: The aim of this research was to determine the clinical significance of tumor necrosis factor-alpha (TNF-alpha), IL-12, IL-15 and IL-18 in evaluation of the activity of rheumatoid arthritis. Cytokine concentrations in serum samples and synovial fluid were measured by immnnoenzymatic methods using kits for human interleukins and the Disease Activity Score 28 in 64 patients with active disease. The control group consisted of 25 subjects with arthritis of the knee and osteoarthrosis. Patients with rheumatoid arthritis have significantly high (p<0.01) concentrations of examined cytokines in relation to patients with osteoarthritis. By comparing concentrations in 30 patients with high, 14 patients with moderate and 20 patients with mild activity of rheumatoid arthritis, it was established that patients with high degree of disease activity have significantly high (p<0.01; p<0.05) concentrations of examined cytokines in the blood and synovial fluid in relation to patients with moderate and mild disease. We have concluded that cytokine concentrations are good indicators of the degree of rheumatoid arthritis activity. This research is a contribution to understanding the insufficiently known pathogenetic mechanisms of cytokines, especially IL-18, in active disease. .
Gel del Vimang con actividad antifotoenvejecimiento: estudio histopatológico preliminar
Concepción,Angel R.; de la Pe?a,Roberto; Fari?as,Lucía;
Revista Cubana de Investigaciones Biom??dicas , 2003,
Abstract: studies of a new formulation (vimang's gel) were conducted to evaluate, in this case, histopathological parameters of a model in vivo, starting from the antecedent that, according to results in vitro, vimang has antioxidant properties.
Inflammation in knee osteoarthrosis: Cause of aggravation  [PDF]
?ivanovi? Sandra,Nikoli? Sandra,Jevti? Milorad,Koci? Sanja
Medicinski Pregled , 2010, DOI: 10.2298/mpns1010668z
Abstract: Introduction. Knee osteoarthrosis is a degenerative disease which induces intense trouble. Material and methods. The aim of the study was the parallel analysis of clinical and ultrasound examination in patients diagnosed with knee osteoarthrosis. A group of 88 patients underwent the clinical examination and the outflow and size of flexion were determined, the intensity of pain was assessed by the patient's mark on VAS, the functional ability by HAQ index, and the size of effusion and synovitis by arthrosonography. Results. The minimal outflow was diagnosed in 34.1% of patients, medium in 22.7%, and significant in 4.5%. Synovitis was evident in 67% of patients, 17.0% had nodular, 30.7% diffuse and 19.3% nodular-diffuse type. Effusion was observed in 75% of patients. The average size of synovitis in suprapatellar recess (SR) in the patients with significant, medium and lateral outflow was 6.68 (2.93-10.04) mm (p=0.000), 1.57 (0-5.53) mm (p=0.006) and 6.18 (3.44-7.10) mm (p=0.000), respectively. The grade of pain on VAS was the highest in patients with significant outflow 70(60-95) (p=0.014), effusion 60 (50-80) (p=0.024) and nodular type of synovitis 70 (50-90) (p=0.029). There was a significant correlation on VAS in the positive direction with the size of effusion (r=0.238, p=0.025) and synovitis in LR (r=0.215, p=0.044), HAQ index (r=0.502, p=0.000), and in the negative direction with the size of flexion (r=-0.346, p=0.001). The average size of flexion in the patients with significant outflow was 90 (82.5-90)°(p=0.000), HAQ index 1.99 (1.49-2.30) (p=0.078). HAQ index depended on effusion in LR in the positive direction (p=0.014). Discussion and Conclusion. Clinically significant outflow is shown by arthrosonography as the biggest in SR, moderate and minimal only in LR. Moderate or significant outflow, effusion and nodular type of synovitis lead to intensive pain. Patients with bigger functional disability had intense pain, significant outflow in LR and significantly limited motions.
Determinación cuantitativa por electroforesis capilar de zona de mangiferina en tabletas VIMANG 300 mg Quantitative determination through capillary zone electrophoresis of mangiferin in 300 mg VIMANG tablets
Harold Curiel Hernández,Hermán Vélez Castro,Janet Lora García
Revista Cubana de Farmacia , 2011,
Abstract: La mangiferina se seleccionó como marcador en el control de calidad del ingrediente farmacéutico activo VIMANG y sus formulaciones, que se han empleado como suplemento nutricional, cosmético y fitomedicamento. El trabajo tuvo como objetivo la validación del método electroforesis capilar para la determinación cuantitativa de mangiferina en la formulación farmacéutica tabletas VIMANG 300 mg. Se evaluaron la especificidad, linealidad, exactitud y precisión. Los resultados obtenidos demostraron que el método fue específico, al no existir interferencias de los excipientes o sus productos de degradación. La linealidad mostró un coeficiente de correlación de 0,9979 en el intervalo de concentraciones estudiado. Los coeficientes de variación para la repetibilidad y la precisión intermedia fueron menores de 2 %. La exactitud mostró un recobrado del 100,20 % que no difiere significativamente de 100 %. En conclusión, el método validado es específico, lineal, preciso y exacto, y constituye una alternativa ventajosa al método cromatografía líquida de alta resolución establecido con anterioridad en el laboratorio. Mangiferin was selected as marker in the quality control of active principle VIMANG and its formulations, which have been used as nutritional supplement, cosmetic, and phytomedication. This paper was aimed at validating the capillary electrophoresis method for the quantitative analysis of mangiferin in the pharmaceutical formulation 300 mg VIMANG tablets. The specificity, linearity, accuracy and precision were assessed. The results showed the method specificity owing to lack of interference by the excipients or their degradation products. Linearity showed a correlation coefficient of 0.9979 in the studied concentration range. The variation coefficients for repeatability and intermediate precision were less than 2 %. Accuracy reached a recovery rate of 100.20 % that is not statistically different from 100 %. It may be concluded that the validated method is specific, linear, precise and accurate and could be an advantageous alternative to the high resolution liquid chromatography method used at the lab setting.
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