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Brainstem auditory evoked response in normal term neonates
Guilhoto, Laura M. F. F.;Quintal, Virgínia S.;Costa, Maria T. Z. da;
Arquivos de Neuro-Psiquiatria , 2003, DOI: 10.1590/S0004-282X2003000600003
Abstract: brainstem auditory evoked response (baer) is a reliable test for neonatal auditory and neurological dysfunction and it permits early diagnosis and rehabilitation. the purpose of this study is to demonstrate latencies of baer in normal term neonates in order to obtain reference values in a university hospital. baer was performed in the second day of life in 47 normal newborns (25 male, 22 female) which gestational ages were higher than 37 and lower than or equal to 40 weeks that did not present familial history of deafness. the exam was performed with 80 dbhl alternating polarity 10/sec clicks presented monaurally. two thousand stimulus trials were averaged and duplicated for each ear. mean wave latencies in msec was: i, 1.79 (sd 0.20); ii, 2.88 (sd 0.28); iii, 4.54 (sd 0.31); iv, 5.86 (sd 0.36); v, 6.75 (sd 0.38); inter-peak latencies (ipl) i-iii, 2.75 (sd 0.36); ipl iii-v, 2.22 (sd 0.22); and ipl i-v, 4.97 (sd 0.43).
Brainstem auditory evoked response in normal term neonates
Guilhoto Laura M. F. F.,Quintal Virgínia S.,Costa Maria T. Z. da
Arquivos de Neuro-Psiquiatria , 2003,
Abstract: Brainstem auditory evoked response (BAER) is a reliable test for neonatal auditory and neurological dysfunction and it permits early diagnosis and rehabilitation. The purpose of this study is to demonstrate latencies of BAER in normal term neonates in order to obtain reference values in a university hospital. BAER was performed in the second day of life in 47 normal newborns (25 male, 22 female) which gestational ages were higher than 37 and lower than or equal to 40 weeks that did not present familial history of deafness. The exam was performed with 80 dBHL alternating polarity 10/sec clicks presented monaurally. Two thousand stimulus trials were averaged and duplicated for each ear. Mean wave latencies in msec was: I, 1.79 (SD 0.20); II, 2.88 (SD 0.28); III, 4.54 (SD 0.31); IV, 5.86 (SD 0.36); V, 6.75 (SD 0.38); inter-peak latencies (IPL) I-III, 2.75 (SD 0.36); IPL III-V, 2.22 (SD 0.22); and IPL I-V, 4.97 (SD 0.43).
Thermographical Measuring of the Skin Temperature Using Laser Needle Acupuncture in Preterm Neonates
Wolfgang Raith,Gerhard Litscher,Iris Sapetschnig,Sebastian Bauchinger,Evelyne Ziehenberger,Wilhelm Müller,Berndt Urlesberger
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/614210
Abstract: In children, laser acupuncture is used more often than needle acupuncture in Western countries, due to their aversion to needles. When applying laser acupuncture to premature babies and neonates, firstly the degree of the thermal increase to the skin has to be evaluated so as to guarantee safe application. The patients were premature neonates before their discharge from hospital. The measurements were carried out by means of a polygraphy while they were asleep shortly. The large intestine 4 acupoint (LI4, Hegu) was stimulated by a microlaser needle (10 mW, 685 nm) twice (5 and 10 min). Local thermographic pictures were taken with a thermal camera (Flir i5, Flir Systems Inc., Portland, USA), and the warmest point was determined and subsequently compared. The study included 10 premature neonates (7 male, 3 female). The measurements were carried out on the 33rd day of life (weight 2030 g, gestational age 36
Normal values of cerebral blood flow velocities in neonates  [PDF]
Vasiljevi? Brankica,Gojni? Miroslava,Maglajli?-?uki? Svjetlana,Antonovi? Olga
Srpski Arhiv za Celokupno Lekarstvo , 2010, DOI: 10.2298/sarh1004186v
Abstract: Introduction. There was used color Doppler ultrasonography (cD-USI), allowing simultaneous examination of parenchymal and vascular cerebral structures. The evaluation of blood flow velocities in cerebral arteries is important in the assessment of cerebral circulation in hypoxic-ischaemic and haemorrhagic brain damage in neonates. Objective. The aim of this study was to estimate normal values of cerebral blood flow velocities (CBFV) and Doppler indices - pulsatility index (PI) and resistance index (RI) - in the anterior cerebral artery (ACA) during the first days of life in infants. Methods. CBFV, PI and RI were obtained during the first week of life with cD-US in 70 infants divided in four groups of gestational age (GA): ≤28 gestational weeks (GW); 29-32 GW; 33-36 GW; and ≥37 GW. Infants with congenital malformations, severe perinatal asphyxia, cerebral haemorrhagic lesion, DAP or severe hypotension were excluded. Results. The mean GA of infants was 34.5±5.5 GW (range 26-40 GW) and the mean birth weight (BW) was 2540±950 g (range 750-4000 g). In the 1st group of 10 infants, ≤28 GW, the mean BW was 950±110 g and values of RI were 0.59±0.10 and PI 1.06±0.080. In the 2nd group of 20 infants, 29-32 GW, the mean BW was 1350±290 g and values of RI were 0.60±0.10 and PI 1.10±0.15. In the 3rd group of 20 infants, 33-36 GW, the mean BW was 1950±750 g and values of RI were 0.63±0.08 and PI 1.15±0.30. In the 4th group of 20 infants, ≥37 GW, the mean BW was 3540±950 g and values of RI were 0.65±0.05 and PI 1.18±0.35. Conclusion. Values of CBFV progressively increase with GA and BW due to progressive increase of cardiac output, blood pressure and closing of ductus arteriosus. Values of RI and PI gradually increase with GA and BW as a result of progressive maturation and opening of vascular cerebral bed with a reduction of the cerebrovascular resistance.
Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
Hongmei Nan, Abrar A Qureshi, David J Hunter, Jiali Han
BMC Cancer , 2009, DOI: 10.1186/1471-2407-9-172
Abstract: We evaluated the associations of four genetic variants in the FGFR2 gene highly related to breast cancer risk and the three common tag-SNPs in the FGFR4 gene with skin cancer risk in a nested case-control study of Caucasians within the Nurses' Health Study (NHS) among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 870 controls.We found no evidence for associations between these seven genetic variants and the risks of melanoma and nonmelanocytic skin cancer.Given the power of this study, we did not detect any contribution of genetic variants in the FGFR2 or FGFR4 genes to inherited predisposition to skin cancer among Caucasian women.The human fibroblast growth factor (FGF) and its receptor families consist of 22 structurally related FGF members and four high-affinity tyrosine kinase FGF receptors (FGFR1 to 4) [1,2]. The four FGFRs generate ligand-binding specific isoforms by tissue-specific alternative mRNA splicing of the genes [3-7]. FGFs and their receptors have an important role in cell signaling [8]. The formation of the FGF-FGFR complex activates the intracellular tyrosine kinase, which mediates signal transduction through the direct phosphorylation of adaptor proteins [9]. These complex FGF signaling networks are crucial in the multiple cell biological activities, such as proliferation, differentiation, mitogenesis, migration, and apoptosis, and are thus implicated in tumorigenesis [10-12].The FGFR2, known as a unique high-affinity receptor for keratinocyte growth factor (KGF or FGF7), is expressed in the keratinocytes of the skin epidermis, hair follicles, and mesenchymal tissues [5,13,14]. An experiment in transgenic mice with FGFR2 mutation in the keratinocyte showed that normal signal transduction was blocked by binding of its ligand KGF [15]. It has been reported that the FGFR2 plays a role in tumor suppression in the skin [16]. In addition, the increased FGFR2 gene expression has been related to the
Incidence of skin conditions in neonates born at a public hospital associated with some variables in pregnant women at risk
José Roberto Paes de Almeida,Mauricio Mota de Avelar Alchorne,Mauro Abrah?o Rozman
Einstein (S?o Paulo) , 2010,
Abstract: Objectives: To verify the incidence of skin diseases in newborns of pregnant women at risk of a public hospital in the city of Santos, Brazil (Hospital Guilherme Alvaro), determining the potential relation between these dermatoses and diseases presented by the mothers. Methods: A total of 1,000 neonates were examined in the first 36 hours of life. The examination was repeated daily in each child up to hospital discharge. The paternal and newborn variables were submitted to analysis to detect statistically significant associations. Results: The most frequent skin disorders were: Mongolian spot (69.8%), erythema toxicum neonatorum (19.7%), Port-wine stain (angiomatous naevi) (13.9%), and hypertrichosis lanuginose (10.3%). Conclusions: Minipuberty had a low incidence in neonates of diabetic mothers. The incidence of Mongolian spot was very low among newborns classified as caucasian.
Normal Variants of the Lower Limbs in Pediatric Orthopedics  [PDF]
Stanley Jones, Sumukh Khandekar, Emmanuel Tolessa
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.47A2004
Abstract: Normal variants of lower limb development such as in-toeing, out-toeing, flat feet, bow-legs and knock knees are a common cause for parental concern and also a common source of referral to pediatric clinics. A thorough history and clinical examination is usually all that is required to make the diagnosis of a normal variant. They also help to exclude pathological conditions that may present in a similar fashion. Radiological and other investigations are not routinely required in children with normal variants of the lower limb except to exclude pathological conditions. Shoe inserts, orthoses and physical therapy are not to be encouraged as they provide no benefit. In the majority of cases the natural history is one of spontaneous resolution of the deformity. Surgery may, however, be required in a small number of patients greater than eight years in whom severe in or out-toeing is present. Parental education and reassurance is an important part of the treatment and must be re-emphasized.
Non-normal modalities in variants of Linear Logic  [PDF]
Daniele Porello,Nicolas Troquard
Computer Science , 2015, DOI: 10.1080/11663081.2015.1080422
Abstract: This article presents modal versions of resource-conscious logics. We concentrate on extensions of variants of Linear Logic with one minimal non-normal modality. In earlier work, where we investigated agency in multi-agent systems, we have shown that the results scale up to logics with multiple non-minimal modalities. Here, we start with the language of propositional intuitionistic Linear Logic without the additive disjunction, to which we add a modality. We provide an interpretation of this language on a class of Kripke resource models extended with a neighbourhood function: modal Kripke resource models. We propose a Hilbert-style axiomatization and a Gentzen-style sequent calculus. We show that the proof theories are sound and complete with respect to the class of modal Kripke resource models. We show that the sequent calculus admits cut elimination and that proof-search is in PSPACE. We then show how to extend the results when non-commutative connectives are added to the language. Finally, we put the logical framework to use by instantiating it as logics of agency. In particular, we propose a logic to reason about the resource-sensitive use of artefacts and illustrate it with a variety of examples.
"Doppler-derived right ventricular myocardial performance index in neonates: Normal values "
"Malakan Rad E,Momtazmanesh N "
Acta Medica Iranica , 2002,
Abstract: Doppler-derived myocardial performance index (MPI), defined as the sum of isovolumetric contraction and relaxation durations divided by ejection time, is an easily measured and reproducible index that shows both systolic and diastolic myocardial function. The goal of this study was to define normal values of right ventricular (RV) MPI in neonates in the first 48 to 72 hours of life. Fifty-one quiet of asleep healthy and term neonates underwent complete M-mode, two-dimensional color-Doppler echocardiographic examination and RV MPI was calculated in them. Statistical analysis was performed, using a SPSS software, P value less than 0.05 was considered as significant. RV MPI was 0.23±0.14 in healthy neonates. There was no correlation between RV MPI and either age or weight of the newborn infants. RV MPI in healthy neonates was 0.23±0.14 in our study. While this closely resembles the results of some researchers, is lower than those previously reported by the other investigators in healthy children. The lower value of RV MPI in neonates may be possibly explained by its relation to the higher pulmonary arterial pressure of the lower ventricular mass in the first few days of life in neonates. Further study to evaluate the effect of pulmonary arterial pressure and right ventricular mass on RV MPI is recommended.
A Comparative Study in Sepsis and Normal Neonates-A Microbiological Perspective  [PDF]
Anchana Devi,Pushpa
Journal of Medical Sciences , 2008,
Abstract: The present study was designed to determine the incidence and causative organisms of bacterial sepsis in neonates by using blood culture techniques in the infected neonates and to evaluate the contribution made by C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white cell count (WCC) and haemoglobin in mothers. Of this CRP, ESR, WCC were very high, but hemoglobin count was low in most of the sepsis mothers. Assessing CRP, ESR, WCC is a more reliable way to indicate sepsis and it was noted that the gram-negative bacteria are responsible for septicemia in maximum number of cases.
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